Milton Brown PhD

Department of Pediatrics
Assistant Professor, Emeritus

mbrow05@emory.edu

Emory University, Atlanta
Pediatrics, Div. Pulmolnology, Asthma, Cystic Fibrosis & Sleep
2015 Uppergate Dr

Academic Appointment

Assistant Professor, Emory University

Education

Degrees

BS from Lenoir Rhyne College
M.S. from Mercer University
PhD from St. Louis University

Research

Focus

I assist with clinical studies to improve the diagnosis and treatment of Type I diabetes. My previous research concerned the genetic components that contribute to normal and impaired growth in children. We identified mutations and normal variations in genes that control pituitary development and function and in the genes that determine responses of target tissues to pituitary hormones. I served as lab coordinator for Pediatric Rheumatology Research Lab and collaborated in studies of normal variations in genes that affect juvenile arthritis.

Publications

Customized Loading of microRNA-126 to Small Extracellular Vesicle-Derived Vehicles Improves Cardiac Function after Myocardial Infarction.
ACS Nano Volume: 17 Page(s): 19613 - 19624
10/24/2023 Authors: Bheri S; Brown ME; Park H-J; Brazhkina O; Takaesu F; Davis ME
Knockdown of deleterious miRNA in progenitor cell-derived small extracellular vesicles enhances tissue repair in myocardial infarction.
Sci Adv Volume: 9 Page(s): eabo4616
03/03/2023 Authors: Park H-J; Hoffman JR; Brown ME; Bheri S; Brazhkina O; Son YH; Davis ME
Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease.
J Cyst Fibros Volume: 21 Page(s): 967 - 976
11/01/2022 Authors: Margaroli C; Horati H; Garratt LW; Giacalone VD; Schofield C; Dittrich AS; Rosenow T; Dobosh BS; Lim HS; Frey DL
Neutrophil-derived extracellular vesicles promote feed-forward inflammasome signaling in cystic fibrosis airways.
J Leukoc Biol Volume: 112 Page(s): 707 - 716
10/01/2022 Authors: Forrest OA; Dobosh B; Ingersoll SA; Rao S; Rojas A; Laval J; Alvarez JA; Brown MR; Tangpricha V; Tirouvanziam R
Pilot study of inflammatory biomarkers in matched induced sputum and bronchoalveolar lavage of 2-year-olds with cystic fibrosis.
Pediatr Pulmonol Volume: 57 Page(s): 2189 - 2198
09/01/2022 Authors: Giacalone VD; Moncada-Giraldo D; Margaroli C; Brown MR; Silva GL; Chandler JD; Peng L; Tirouvanziam R; Guglani L; IMPEDE-CF Program
Using computational methods to design patient-specific electrospun cardiac patches for pediatric heart failure.
Biomaterials Volume: 283 Page(s): 121421
04/01/2022 Authors: Streeter BW; Brown ME; Shakya P; Park H-J; Qiu J; Xia Y; Davis ME
In vivo evaluation of bioprinted cardiac patches composed of cardiac-specific extracellular matrix and progenitor cells in a model of pediatric heart failure.
Biomater Sci Volume: 10 Page(s): 444 - 456
01/18/2022 Authors: Bejleri D; Robeson MJ; Brown ME; Hunter J; Maxwell JT; Streeter BW; Brazhkina O; Park H-J; Christman KL; Davis ME
Encapsulation of Pediatric Cardiac-Derived C-Kit+ Cells in Cardiac Extracellular Matrix Hydrogel for Echocardiography-Directed Intramyocardial Injection in Rodents.
Methods Mol Biol Volume: 2485 Page(s): 269 - 278
01/01/2022 Authors: Shakya P; Brown ME; Davis ME
Functional and Transcriptional Adaptations of Blood Monocytes Recruited to the Cystic Fibrosis Airway Microenvironment In Vitro.
Int J Mol Sci Volume: 22
03/03/2021 Authors: Ford BD; Moncada Giraldo D; Margaroli C; Giacalone VD; Brown MR; Peng L; Tirouvanziam R
Distinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease.
Exp Dermatol Volume: 29 Page(s): 1191 - 1198
12/01/2020 Authors: Margaroli C; Bradley B; Thompson C; Brown MR; Giacalone VD; Bhatt L; Stoff B; Ahuja S; Springman E; Tirouvanziam R
MCUb Induction Protects the Heart From Postischemic Remodeling.
Circ Res Volume: 127 Page(s): 379 - 390
07/17/2020 Authors: Huo J; Lu S; Kwong JQ; Bround MJ; Grimes KM; Sargent MA; Brown ME; Davis ME; Bers DM; Molkentin JD
Imaging the Activation of Low-Boiling-Point Phase-Change Contrast Agents in the Presence of Tissue Motion Using Ultrafast Inter-frame Activation Ultrasound Imaging.
Ultrasound Med Biol Volume: 46 Page(s): 1474 - 1489
06/01/2020 Authors: Jing B; Brown ME; Davis ME; Lindsey BD
Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis.
Am J Respir Crit Care Med Volume: 199 Page(s): 873 - 881
04/01/2019 Authors: Margaroli C; Garratt LW; Horati H; Dittrich AS; Rosenow T; Montgomery ST; Frey DL; Brown MR; Schultz C; Guglani L
Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections.
Sci Rep Volume: 9 Page(s): 2874
02/27/2019 Authors: Grunwell JR; Giacalone VD; Stephenson S; Margaroli C; Dobosh BS; Brown MR; Fitzpatrick AM; Tirouvanziam R
Children with Neutrophil-Predominant Severe Asthma Have Proinflammatory Neutrophils With Enhanced Survival and Impaired Clearance.
J Allergy Clin Immunol Pract Volume: 7 Page(s): 516 - 525.e6
02/01/2019 Authors: Grunwell JR; Stephenson ST; Tirouvanziam R; Brown LAS; Brown MR; Fitzpatrick AM
Genetic Polymorphisms Associated with Idiopathic Short Stature and First-Year Response to Growth Hormone Treatment.
Horm Res Paediatr Volume: 91 Page(s): 164 - 174
01/01/2019 Authors: Quigley CA; Li YG; Brown MR; Pillai SG; Banerjee P; Scott RS; Blum WF; Parks JS
Resistin is elevated in cystic fibrosis sputum and correlates negatively with lung function.
J Cyst Fibros Volume: 18 Page(s): 64 - 70
01/01/2019 Authors: Forrest OA; Chopyk DM; Gernez Y; Brown MR; Conrad CK; Moss RB; Tangpricha V; Peng L; Tirouvanziam R
Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis.
J Leukoc Biol Volume: 104 Page(s): 665 - 675
10/01/2018 Authors: Forrest OA; Ingersoll SA; Preininger MK; Laval J; Limoli DH; Brown MR; Lee FE; Bedi B; Sadikot RT; Goldberg JB
Case-control Association Study of Autoimmunity Associated Variants in PDCD1 and Juvenile Idiopathic Arthritis.
Curr Rheumatol Rev Volume: 13 Page(s): 219 - 223
01/01/2017 Authors: Tejeda C; Broadaway AK; Ombrello MJ; Brown MR; Ponder LA; Pichavant MR; Wang G; Angeles-Han S; Hersh A; Bohnsack J
Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features.
J Allergy Clin Immunol Pract Volume: 5 Page(s): 410 - 419.e4
01/01/2017 Authors: Fitzpatrick AM; Stephenson ST; Brown MR; Nguyen K; Douglas S; Brown LAS
EFFECT OF INHALED CORTICOSTEROID THERAPY WITHDRAWAL ON CF LUNG FUNCTION AND INFLAMMATORY MARKERS
Volume: 51 Page(s): 236 - 236
10/01/2016 Authors: Beaty TC; Brown MR; Forrest OA; Ingersoll S; Stecenko A; Tirouvanziam R
RESISTIN, A NEUTROPHIL-DERIVED IMMUNOMETABOLIC MEDIATOR, IS A CELL-SURFACE ASSOCIATED AND SOLUBLE MARKER OF EARLY AND CHRONIC CF AIRWAY DISEASE
Volume: 51 Page(s): 297 - 297
10/01/2016 Authors: Forrest OA; Chopyk D; Ingersoll S; Brown MR; Scholte BJ; Janssens H; Alvarez JA; Tangpricha V; Tirouvanziam R
IN VITRO TRANSMIGRATION OF NEUTROPHILS INTO CF AIRWAY FLUID INDUCES FUNCTIONAL AND METABOLIC REPROGRAMMING CHARACTERISTIC OF CF AIRWAY NEUTROPHILS IN VIVO
Volume: 51 Page(s): 241 - 241
10/01/2016 Authors: Forrest OA; Ingersoll S; Preininger M; Laval J; Limoli D; Brown MR; Lee F; Bedi B; Bedi B; Sadikot RT
Low Anti-Mllerian Hormone in Pediatric Cancer Survivors in the Early Years after Gonadotoxic Therapy.
J Pediatr Adolesc Gynecol Volume: 29 Page(s): 393 - 399
08/01/2016 Authors: Elchuri SV; Patterson BC; Brown M; Bedient C; Record E; Wasilewski-Masker K; Mertens AC; Meacham LR
Genesis of two most prevalent PROP1 gene variants causing combined pituitary hormone deficiency in 21 populations.
Eur J Hum Genet Volume: 24 Page(s): 415 - 420
03/01/2016 Authors: Dusatkova P; Pfffle R; Brown MR; Akulevich N; Arnhold IJP; Kalina MA; Kot K; Krzisnik C; Lemos MC; Malikova J
SPHINGOSINE 1-PHOSPHATE RECEPTOR 3 IS HIGHLY UPREGULATED ON HUMAN NEUTROPHILS UPON MIGRATION TO THE AIRWAYS
Volume: 50 Page(s): 243 - 243
10/01/2015 Authors: Ingersoll S; Forrest OA; Brown MR; Tirouvanziam R
Cysteine oxidation impairs systemic glucocorticoid responsiveness in children with difficult-to-treat asthma.
J Allergy Clin Immunol Volume: 136 Page(s): 454 - 61.e9
08/01/2015 Authors: Stephenson ST; Brown LAS; Helms MN; Qu H; Brown SD; Brown MR; Fitzpatrick AM
Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.
J Immunol Volume: 194 Page(s): 5520 - 5528
06/01/2015 Authors: Ingersoll SA; Laval J; Forrest OA; Preininger M; Brown MR; Arafat D; Gibson G; Tangpricha V; Tirouvanziam R
The effects of hydroxyurea and bone marrow transplant on Anti-Mllerian hormone (AMH) levels in females with sickle cell anemia.
Blood Cells Mol Dis Volume: 55 Page(s): 56 - 61
06/01/2015 Authors: Elchuri SV; Williamson RS; Clark Brown R; Haight AE; Spencer JB; Buchanan I; Hassen-Schilling L; Brown MR; Mertens AC; Meacham LR
Anti-Mullerian hormone levels in American girls by age and race/ethnicity.
J Pediatr Endocrinol Metab Volume: 28 Page(s): 189 - 193
01/01/2015 Authors: Elchuri SV; Patterson BC; Brown MR; Buchanan I; Mertens AC; Meacham LR
Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA.
Pediatr Rheumatol Online J Volume: 11 Page(s): 40
10/25/2013 Authors: Kaalla MJ; Broadaway KA; Rohani-Pichavant M; Conneely KN; Whiting A; Ponder L; Okou DT; Angeles-Han S; Rouster-Stevens K; Brown MR
Faster pharmacokinetics and increased patient acceptance of intradermal insulin delivery using a single hollow microneedle in children and adolescents with type 1 diabetes.
Pediatr Diabetes Volume: 14 Page(s): 459 - 465
09/01/2013 Authors: Norman JJ; Brown MR; Raviele NA; Prausnitz MR; Felner EI
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
Nat Genet Volume: 45 Page(s): 664 - 669
06/01/2013 Authors: Hinks A; Cobb J; Marion MC; Prahalad S; Sudman M; Bowes J; Martin P; Comeau ME; Sajuthi S; Andrews R
Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.
Arthritis Rheum Volume: 65 Page(s): 1663 - 1667
06/01/2013 Authors: Prahalad S; Conneely KN; Jiang Y; Sudman M; Wallace CA; Brown MR; Ponder LA; Rohani-Pichavant M; Zwick ME; Cutler DJ
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
Nat Genet Volume: 44 Page(s): 1341 - 1348
12/01/2012 Authors: Tsoi LC; Spain SL; Knight J; Ellinghaus E; Stuart PE; Capon F; Ding J; Li Y; Tejasvi T; Gudjonsson JE
Do obese children with diabetic ketoacidosis have type 1 or type 2 diabetes?
Prim Care Diabetes Volume: 6 Page(s): 61 - 65
04/01/2012 Authors: Low JC; Felner EI; Muir AB; Brown M; Dorcelet M; Peng L; Umpierrez GE
Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.
Arthritis Rheum Volume: 64 Page(s): 925 - 930
03/01/2012 Authors: Prahalad S; Thompson SD; Conneely KN; Jiang Y; Leong T; Prozonic J; Brown MR; Ponder LA; Angeles-Han ST; Vogler LB
Common polymorphisms in the GH/IGF-1 axis contribute to growth in extremely tall subjects.
Growth Horm IGF Res Volume: 21 Page(s): 318 - 324
12/01/2011 Authors: Hendriks AEJ; Brown MR; Boot AM; Oostra BA; de Jong FH; Drop SLS; Parks JS
Markers of Maternal Perinatal Nutrition Are Associated with Infant Weight Gain during the First Six Postnatal Months in Rhesus Monkeys
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE Volume: 2 Page(s): S144 - S145
09/01/2011 Authors: Villar JA; Brutto NA; Higgins M; Brown MR; Wilson ME; Muir A
Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise.
Am J Physiol Regul Integr Comp Physiol Volume: 300 Page(s): R605 - R615
03/01/2011 Authors: Brown MB; Haack KKV; Pollack BP; Millard-Stafford M; McCarty NA
Short stature and metabolic abnormalities in two sisters with a 7.6-kb GH1 gene deletion.
Growth Horm IGF Res Volume: 21 Page(s): 37 - 43
02/01/2011 Authors: Ahmad T; Geffner M; Parks J; Brown M; Fisher L; Costin G
Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma.
Pediatr Res Volume: 69 Page(s): 154 - 159
02/01/2011 Authors: Fitzpatrick AM; Teague WG; Burwell L; Brown MS; Brown LAS; NIH/NHLBI Severe Asthma Research Program
Genetic variation in candidate genes like the HMGA2 gene in the extremely tall.
Horm Res Paediatr Volume: 76 Page(s): 307 - 313
01/01/2011 Authors: Hendriks AEJ; Brown MR; Boot AM; Oostra BA; Drop SLS; Parks JS
Do Obese Children with Diabetic Ketoacidosis Have Type 1 or Type 2 Diabetes?
Volume: 59 Page(s): A505 - A505
06/01/2010 Authors: Low JC; Umpierrez GE; Muir AB; Felner EI; Brown MR; Dorcelet M
PEG Warm Autoadsorption Is Useful for Removal of Both Warm and Cold Autoantibodies
Volume: 49 Page(s): 142A - 142A
09/01/2009 Authors: Clark M; Brown MR; Huang ST
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nat Genet Volume: 41 Page(s): 703 - 707
06/01/2009 Authors: Barrett JC; Clayton DG; Concannon P; Akolkar B; Cooper JD; Erlich HA; Julier C; Morahan G; Nerup J; Nierras C
Single channel studies of heteromer formation between Slick and Slack K(Na) subunits
Volume: 96 Page(s): 482A - 482A
02/01/2009 Authors: Kronengold J; Brown MR; Chen H; Salkoff LB; Kaczmarek LK
Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy.
BMC Biochem Volume: 9 Page(s): 22
09/10/2008 Authors: Mayorov VI; Lowrey AJ; Biousse V; Newman NJ; Cline SD; Brown MD
Common Polymorphisms in the GH/IGF-I Axis contribute to growth in the extremely tall
HORMONE RESEARCH Volume: 70 Page(s): 85 - 85
01/01/2008 Authors: Hendriks AEJ; Brown MR; Boot AM; Parks JS; Drop SLS
A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia.
Am J Med Genet A Volume: 143A Page(s): 33 - 41
01/01/2007 Authors: Sarzi E; Brown MD; Lebon S; Chretien D; Munnich A; Rotig A; Procaccio V
OPA1 mutations and mitochondrial DNA haplotypes in autosomal dominant optic atrophy.
Genet Med Volume: 8 Page(s): 217 - 225
04/01/2006 Authors: Han J; Thompson-Lowrey AJ; Reiss A; Mayorov V; Jia H; Biousse V; Newman NJ; Brown MD
North American white mitochondrial haplogroups in prostate and renal cancer.
J Urol Volume: 175 Page(s): 468 - 472
02/01/2006 Authors: Booker LM; Habermacher GM; Jessie BC; Sun QC; Baumann AK; Amin M; Lim SD; Fernandez-Golarz C; Lyles RH; Brown MD
The role of the ND5 gene in LHON: characterization of a new, heteroplasmic LHON mutation.
Ann Neurol Volume: 58 Page(s): 807 - 811
11/01/2005 Authors: Mayorov V; Biousse V; Newman NJ; Brown MD
Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups.
Ann Hum Genet Volume: 69 Page(s): 67 - 89
01/01/2005 Authors: Starikovskaya EB; Sukernik RI; Derbeneva OA; Volodko NV; Ruiz-Pesini E; Torroni A; Brown MD; Lott MT; Hosseini SH; Huoponen K
Association of glutathione-S-transferase-P1 (GSTP1) polymorphism 105 Ile>val with chronic lung disease in preterm infants.
J Perinatol Volume: 24 Page(s): 800
12/01/2004 Authors: Cooke RW; Drury JA; Beresford MW; Shaw NJ
Complete mitochondrial DNA sequence analysis in a family with early-onset dystonia and optic atrophy.
Mov Disord Volume: 19 Page(s): 235 - 237
02/01/2004 Authors: Brown MD; Hosseini S; Steiner I; Wallace DC; Korn-Lubetzki I
Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia.
J Perinatol Volume: 24 Page(s): 30 - 35
01/01/2004 Authors: Manar MH; Brown MR; Gauthier TW; Brown LAS
QTL mapping in biological anthropology: Skeletal maturation
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY Page(s): 196 - 197
01/01/2004 Authors: Towne B; Blangero J; Parks JS; Dyer T; Cole SA; Brown MR; Duren DL; Roche AF; Siervogel RM
A case of sporadic infantile histiocytoid cardiomyopathy caused by the A8344G (MERRF) mitochondrial DNA mutation.
Pediatr Cardiol Volume: 25 Page(s): 538 - 540
01/01/2004 Authors: Vallance HD; Jeven G; Wallace DC; Brown MD
CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice.
Vaccine Volume: 21 Page(s): 2964 - 2979
06/20/2003 Authors: Harcourt JL; Brown MP; Anderson LJ; Tripp RA
Natural selection shaped regional mtDNA variation in humans.
Proc Natl Acad Sci U S A Volume: 100 Page(s): 171 - 176
01/07/2003 Authors: Mishmar D; Ruiz-Pesini E; Golik P; Macaulay V; Clark AG; Hosseini S; Brandon M; Easley K; Chen E; Brown MD
Regional and urban Victorian diabetic youth: clinical and quality-of-life outcomes.
J Paediatr Child Health Volume: 38 Page(s): 593 - 596
12/01/2002 Authors: Cameron FJ; Clarke C; Hesketh K; White EL; Boyce DF; Dalton VL; Cross J; Brown M; Thies NH; Pallas G
The spectrum of hypopituitarism caused by PROP1 mutations.
Best Pract Res Clin Endocrinol Metab Volume: 16 Page(s): 421 - 431
09/01/2002 Authors: Mody S; Brown MR; Parks JS
The role of mtDNA background in disease expression: a new primary LHON mutation associated with Western Eurasian haplogroup J.
Hum Genet Volume: 110 Page(s): 130 - 138
02/01/2002 Authors: Brown MD; Starikovskaya E; Derbeneva O; Hosseini S; Allen JC; Mikhailovskaya IE; Sukernik RI; Wallace DC
[The mitochondrial genome and human mitochondrial diseases].
Genetika Volume: 38 Page(s): 161 - 170
02/01/2002 Authors: Sukernik RI; Derbeneva OA; Starikovskaia EB; Volod'ko NV; Mikhalovskaia IE; Bychkov II; Lott M; Brown M; Wallace D
Clinical, genetic, and biochemical characterization of a Leber hereditary optic neuropathy family containing both the 11778 and 14484 primary mutations.
Am J Med Genet Volume: 104 Page(s): 331 - 338
12/15/2001 Authors: Brown MD; Allen JC; Van Stavern GP; Newman NJ; Wallace DC
Genetic associations between pubertal growth and skeletal maturity in healthy boys and girls.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 69 Page(s): 398 - 398
10/01/2001 Authors: Towne B; Czerwinski SA; Demerath EW; Roche AF; Blangero J; Parks JS; Brown MR; Siervogel RM
Novel mtDNA mutations and oxidative phosphorylation dysfunction in Russian LHON families.
Hum Genet Volume: 109 Page(s): 33 - 39
07/01/2001 Authors: Brown MD; Zhadanov S; Allen JC; Hosseini S; Newman NJ; Atamonov VV; Mikhailovskaya IE; Sukernik RI; Wallace DC
Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction.
J Clin Endocrinol Metab Volume: 86 Page(s): 3097 - 3107
07/01/2001 Authors: Evans CO; Young AN; Brown MR; Brat DJ; Parks JS; Neish AS; Oyesiku NM
Functional analysis of lymphoblast and cybrid mitochondria containing the 3460, 11778, or 14484 Leber's hereditary optic neuropathy mitochondrial DNA mutation.
J Biol Chem Volume: 275 Page(s): 39831 - 39836
12/22/2000 Authors: Brown MD; Trounce IA; Jun AS; Allen JC; Wallace DC
Mitochondrial DNA sequence diversity in bipolar affective disorder.
Volume: 157 Page(s): 1058 - 1064
07/01/2000 Authors: McMahon FJ; Chen YS; Patel S; Kokoszka J; Brown MD; Torroni A; DePaulo JR; Wallace DC
Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells.
Nucleic Acids Res Volume: 28 Page(s): 2164 - 2170
05/15/2000 Authors: Trounce I; Schmiedel J; Yen HC; Hosseini S; Brown MD; Olson JJ; Wallace DC
Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors.
J Endocrinol Invest Volume: 23 Page(s): 304 - 309
05/01/2000 Authors: Evans CO; Brown MR; Parks JS; Oyesiku NM
PROP1 mutations in children with isolated deficiency of growth hormone
PEDIATRIC RESEARCH Volume: 47 Page(s): 137A - 137A
04/01/2000 Authors: Parks JS; Brown MR; Oltarzewski M; Lenartowska I
Effect of Helicobacter pylori infection on mucin gene regulation in vitro.
GASTROENTEROLOGY Volume: 118 Page(s): A1215 - A1215
04/01/2000 Authors: Barnes PJ; Brown MR; Owens ML; Harris F; Ashktorab H; Smoot DT; Gold BD
Short stature in carriers of recessive mutation causing familial isolated growth hormone deficiency.
Am J Med Genet Volume: 90 Page(s): 188 - 192
01/31/2000 Authors: Leiberman E; Pesler D; Parvari R; Elbedour K; Abdul-Latif H; Brown MR; Parks JS; Carmi R
Growth hormone deficiency type IB caused by cryptic splicing of the GH-1 gene.
J Pediatr Endocrinol Metab Volume: 13 Page(s): 21 - 28
01/01/2000 Authors: Abdul-Latif H; Leiberman E; Brown MR; Carmi R; Parks JS
Heritable disorders of pituitary development.
J Clin Endocrinol Metab Volume: 84 Page(s): 4362 - 4370
12/01/1999 Authors: Parks JS; Brown MR; Hurley DL; Phelps CJ; Wajnrajch MP
Genetic regulation of skeletal maturation from 3 to 15 years.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 65 Page(s): A401 - A401
10/01/1999 Authors: Towne B; Siervogel RM; Parks JS; Brown MR; Roche AF; Blangero J
Mitochondrial DNA variation in human evolution and disease.
Gene Volume: 238 Page(s): 211 - 230
09/30/1999 Authors: Wallace DC; Brown MD; Lott MT
Transcription factors regulating pituitary development.
Growth Horm IGF Res Volume: 9 Suppl B Page(s): 2 - 8
06/01/1999 Authors: Parks JS; Brown MR
The enigmatic relationship between mitochondrial dysfunction and Leber's hereditary optic neuropathy.
J Neurol Sci Volume: 165 Page(s): 1 - 5
05/01/1999 Authors: Brown MD
Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene.
J Clin Endocrinol Metab Volume: 84 Page(s): 50 - 57
01/01/1999 Authors: Rosenbloom AL; Almonte AS; Brown MR; Fisher DA; Baumbach L; Parks JS
Large scale screening of the mitochondrial DNA reveals no pathogenic mutations but a haplotype associated with multiple sclerosis in Caucasians.
Acta Neurol Scand Volume: 99 Page(s): 16 - 25
01/01/1999 Authors: Kalman B; Li S; Chatterjee D; O'Connor J; Voehl MR; Brown MD; Alder H
mtDNA haplogroup X: An ancient link between Europe/Western Asia and North America?
Am J Hum Genet Volume: 63 Page(s): 1852 - 1861
12/01/1998 Authors: Brown MD; Hosseini SH; Torroni A; Bandelt HJ; Allen JC; Schurr TG; Scozzari R; Cruciani F; Wallace DC
Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency.
J Clin Endocrinol Metab Volume: 83 Page(s): 2601 - 2604
07/01/1998 Authors: Fofanova O; Takamura N; Kinoshita E; Parks JS; Brown MR; Peterkova VA; Evgrafov OV; Goncharov NP; Bulatov AA; Dedov II
A mutational hot spot in the Prop-1 gene in Russian children with combined pituitary hormone deficiency.
Pituitary Volume: 1 Page(s): 45 - 49
04/01/1998 Authors: Fofanova OV; Takamura N; Kinoshita E; Parks JS; Brown MR; Peterkova VA; Evgrafov OV; Goncharov NP; Bulatov AA; Dedov II
Exogenous nitric oxide enhances neutrophil cell death and DNA fragmentation.
Am J Respir Cell Mol Biol Volume: 18 Page(s): 421 - 428
03/01/1998 Authors: Fortenberry JD; Owens ML; Brown MR; Atkinson D; Brown LA
Mutations in PROP1 cause familial combined pituitary hormone deficiency.
Nat Genet Volume: 18 Page(s): 147 - 149
02/01/1998 Authors: Wu W; Cogan JD; Pfffle RW; Dasen JS; Frisch H; O'Connell SM; Flynn SE; Brown MR; Mullis PE; Parks JS
Central hypothyroidism reveals compound heterozygous mutations in the Pit-1 gene.
Horm Res Volume: 49 Page(s): 98 - 102
01/01/1998 Authors: Brown MR; Parks JS; Adess ME; Rich BH; Rosenthal IM; Voss TC; VanderHeyden TC; Hurley DL
Clinical and molecular characterization of a Brazilian patient with Pit-1 deficiency.
J Pediatr Endocrinol Metab Volume: 11 Page(s): 623 - 630
01/01/1998 Authors: Arnhold IJ; Nery M; Brown MR; Voss TC; VanderHeyden TC; Adess ME; Hurley DL; Wajchenberg BL; Parks JS
MITOMAP: a human mitochondrial genome database--1998 update.
Nucleic Acids Res Volume: 26 Page(s): 112 - 115
01/01/1998 Authors: Kogelnik AM; Lott MT; Brown MD; Navathe SB; Wallace DC
Mitochondrial biology, degenerative diseases and aging.
Volume: 7 Page(s): 187 - 190
01/01/1998 Authors: Wallace DC; Brown MD; Melov S; Graham B; Lott M
Ancient mtDNA sequences in the human nuclear genome: a potential source of errors in identifying pathogenic mutations.
Proc Natl Acad Sci U S A Volume: 94 Page(s): 14900 - 14905
12/23/1997 Authors: Wallace DC; Stugard C; Murdock D; Schurr T; Brown MD
Pituitary adenomas: screening for G alpha q mutations.
J Clin Endocrinol Metab Volume: 82 Page(s): 4184 - 4188
12/01/1997 Authors: Oyesiku NM; Evans CO; Brown MR; Blevins LS; Tindall GT; Parks JS
Genes regulating hypothalamic and pituitary development.
Acta Paediatr Suppl Volume: 423 Page(s): 28 - 32
11/01/1997 Authors: Parks JS; Adess ME; Brown MR
Y chromosome polymorphisms in native American and Siberian populations: identification of native American Y chromosome haplotypes.
Hum Genet Volume: 100 Page(s): 536 - 543
10/01/1997 Authors: Lell JT; Brown MD; Schurr TG; Sukernik RI; Starikovskaya YB; Torroni A; Moore LG; Troup GM; Wallace DC
Associations between luteinizing hormone-beta gene polymorphism and skeletal maturation and growth before and during puberty.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 61 Page(s): A214 - A214
10/01/1997 Authors: Towne B; Parks JS; Blangero J; Almasy L; Brown MR; Murphy TC; Demerath EW; Roche AF; Siervogel RM
The spectrum of growth-hormone insensitivity.
J Pediatr Volume: 131 Page(s): S45 - S50
07/01/1997 Authors: Parks JS; Brown MR; Faase ME
Clinical, biochemical, and molecular investigations of a genetic isolate of growth hormone insensitivity (Laron's syndrome).
J Clin Endocrinol Metab Volume: 82 Page(s): 444 - 451
02/01/1997 Authors: Baumbach L; Schiavi A; Bartlett R; Perera E; Day J; Brown MR; Stein S; Eidson M; Parks JS; Cleveland W
Clustering of Caucasian Leber hereditary optic neuropathy patients containing the 11778 or 14484 mutations on an mtDNA lineage.
Am J Hum Genet Volume: 60 Page(s): 381 - 387
02/01/1997 Authors: Brown MD; Sun F; Wallace DC
MITOMAP: an update on the status of the human mitochondrial genome database.
Nucleic Acids Res Volume: 25 Page(s): 196 - 199
01/01/1997 Authors: Kogelnik AM; Lott MT; Brown MD; Navathe SB; Wallace DC
Fast capillary electrophoresis-laser induced fluorescence analysis of ligase chain reaction products: human mitochondrial DNA point mutations causing Leber's hereditary optic neuropathy.
Volume: 17 Page(s): 1875 - 1883
12/01/1996 Authors: Muth J; Williams PM; Williams SJ; Brown MD; Wallace DC; Karger BL
Mechanisms responsible for dominant expression of human growth hormone gene mutations.
J Clin Endocrinol Metab Volume: 81 Page(s): 4047 - 4050
11/01/1996 Authors: Binder G; Brown M; Parks JS
Multiple mutations in a GH-R allele.
PEDIATRIC RESEARCH Volume: 39 Page(s): 514 - 514
04/01/1996 Authors: Faase E; Brown MR; Laron Z; Parks JS
Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patients.
Am J Med Genet Volume: 61 Page(s): 283 - 289
01/22/1996 Authors: Brown MD; Shoffner JM; Kim YL; Jun AS; Graham BH; Cabell MF; Gurley DS; Wallace DC
MITOMAP: a human mitochondrial genome database.
Nucleic Acids Res Volume: 24 Page(s): 177 - 179
01/01/1996 Authors: Kogelnik AM; Lott MT; Brown MD; Navathe SB; Wallace DC
Cuban optic neuropathy.
Neurology Volume: 45 Page(s): 397
02/01/1995 Authors: Newman NJ; Torroni A; Brown MD; Lott MT; Wallace DC; Philen R; Roman GC
Mitochondrial diseases and aging
Volume: 5 Page(s): 249 - 252
01/01/1995 Authors: Wallace DC; Lott MT; Trounce I; Brown MD; Huoponen K; Krawiecki N; Shoffner JM
Phylogenetic analysis of Leber's hereditary optic neuropathy mitochondrial DNA's indicates multiple independent occurrences of the common mutations.
Hum Mutat Volume: 6 Page(s): 311 - 325
01/01/1995 Authors: Brown MD; Torroni A; Reckord CL; Wallace DC
African, Native American, and European mitochondrial DNAs in Cubans from Pinar del Rio Province and implications for the recent epidemic neuropathy in Cuba. Cuba Neuropathy Field Investigation Team.
Hum Mutat Volume: 5 Page(s): 310 - 317
01/01/1995 Authors: Torroni A; Brown MD; Lott MT; Newman NJ; Wallace DC
Pathological significance of the mtDNA COX III mutation at nucleotide pair 9438 in Leber hereditary optic neuropathy.
Am J Hum Genet Volume: 55 Page(s): 410 - 412
08/01/1994 Authors: Brown MD; Torroni A; Huoponen K; Chen YS; Lott MT; Wallace DC
A non-directed, hydroxylamine-generated suppressor mutation in the P3 pairing region of the bacteriophage T4 td intron partially restores self-splicing capability.
Mol Microbiol Volume: 13 Page(s): 89 - 95
07/01/1994 Authors: Brown MD; DeYoung KL; Hall DH
A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia.
Proc Natl Acad Sci U S A Volume: 91 Page(s): 6206 - 6210
06/21/1994 Authors: Jun AS; Brown MD; Wallace DC
Molecular basis of mitochondrial DNA disease.
J Bioenerg Biomembr Volume: 26 Page(s): 273 - 289
06/01/1994 Authors: Brown MD; Wallace DC
Distribution and characterization of mutations induced by nitrous acid or hydroxylamine in the intron-containing thymidylate synthase gene of bacteriophage T4.
Biochem Genet Volume: 31 Page(s): 507 - 520
12/01/1993 Authors: Brown MD; Povinelli CM; Hall DH
Characterization of a noncontiguous gene deletion of the growth hormone receptor in Laron's syndrome.
J Clin Endocrinol Metab Volume: 77 Page(s): 1379 - 1383
11/01/1993 Authors: Meacham LR; Brown MR; Murphy TL; Keret R; Silbergeld A; Laron Z; Parks JS
Asian affinities and continental radiation of the four founding Native American mtDNAs.
Am J Hum Genet Volume: 53 Page(s): 563 - 590
09/01/1993 Authors: Torroni A; Schurr TG; Cabell MF; Brown MD; Neel JV; Larsen M; Smith DG; Vullo CM; Wallace DC
MEASURED GENOTYPE ANALYSIS OF A BGL-II CHORIONIC SOMATOMAMMOTROPIN RFLP AND ADULT STATURE
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 53 Page(s): 1666 - 1666
09/01/1993 Authors: TOWNE B; PARKS JS; BROWN MR; MURPHY TC; SIERVOGEL RM
A proflavin-induced frameshift hotspot in the thymidylate synthase gene of bacteriophage T4.
Mutat Res Volume: 286 Page(s): 189 - 197
04/01/1993 Authors: Brown MD; Ripley LS; Hall DH
THE MOLECULAR DEFECT IN LARON SYNDROME - EXON DELETIONS
Volume: 24 Page(s): 127 - 131
01/01/1993 Authors: BROWN MR; MEACHAM LR; PFAFFLE RW; MURPHY TC; KERET R; KLINGER B; LARON Z; PARKS JS
Genetics of growth hormone gene expression.
Horm Res Volume: 40 Page(s): 54 - 61
01/01/1993 Authors: Parks JS; Abdul-Latif H; Kinoshita E; Meacham LR; Pfffle RW; Brown MR
Pit-1 and pituitary function.
J Pediatr Endocrinol Volume: 6 Page(s): 229 - 233
01/01/1993 Authors: Pfffle RW; Parks JS; Brown MR; Heimann G
New genetic findings in old syndromes.
Acta Paediatr Suppl Volume: 383 Page(s): 73 - 77
09/01/1992 Authors: Parks JS; Pfffle RW; Brown MR
Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.
Science Volume: 257 Page(s): 1118 - 1121
08/21/1992 Authors: Pfffle RW; DiMattia GE; Parks JS; Brown MR; Wit JM; Jansen M; Van der Nat H; Van den Brande JL; Rosenfeld MG; Ingraham HA
Mitochondrial tRNA(Thr) mutations and lethal infantile mitochondrial myopathy.
Am J Hum Genet Volume: 51 Page(s): 446 - 447
08/01/1992 Authors: Brown MD; Torroni A; Shoffner JM; Wallace DC
A mitochondrial DNA variant, identified in Leber hereditary optic neuropathy patients, which extends the amino acid sequence of cytochrome c oxidase subunit I.
Am J Hum Genet Volume: 51 Page(s): 378 - 385
08/01/1992 Authors: Brown MD; Yang CC; Trounce I; Torroni A; Lott MT; Wallace DC
Leber's hereditary optic neuropathy: a model for mitochondrial neurodegenerative diseases.
FASEB J Volume: 6 Page(s): 2791 - 2799
07/01/1992 Authors: Brown MD; Voljavec AS; Lott MT; MacDonald I; Wallace DC
Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy.
Genetics Volume: 130 Page(s): 163 - 173
01/01/1992 Authors: Brown MD; Voljavec AS; Lott MT; Torroni A; Yang CC; Wallace DC
Carbachol-induced protein phosphorylation in parietal cells: regulation by [Ca2+]i.
Am J Physiol Volume: 257 Page(s): G99 - 110
07/01/1989 Authors: Brown MR; Chew CS
Primary culture of secretagogue-responsive parietal cells from rabbit gastric mucosa.
Am J Physiol Volume: 256 Page(s): G254 - G263
01/01/1989 Authors: Chew CS; Ljungstrm M; Smolka A; Brown MR
PHOSPHORYLATION OF A 36-KDA PROTEIN IN PARIETAL AND CHIEF CELLS IN RESPONSE TO CARBACHOL, CCK-8 AND PHORBOL ESTER
FASEB JOURNAL Volume: 2 Page(s): A732 - A732
03/15/1988 Authors: BROWN MR; CHEW CS
Histamine increases phosphorylation of 27- and 40-kDa parietal cell proteins.
Am J Physiol Volume: 253 Page(s): G823 - G829
12/01/1987 Authors: Chew CS; Brown MR
Multiple effects of phorbol ester on secretory activity in rabbit gastric glands and parietal cells.
Can J Physiol Pharmacol Volume: 65 Page(s): 1840 - 1847
09/01/1987 Authors: Brown MR; Chew CS
HISTAMINE-STIMULATED PHOSPHORYLATION OF GASTRIC PARIETAL-CELL PROTEINS
FEDERATION PROCEEDINGS Volume: 46 Page(s): 2189 - 2189
05/01/1987 Authors: CHEW CS; BROWN MR
COMPARTMENTALIZATION OF FURA-2 IN PARIETAL-CELLS
FEDERATION PROCEEDINGS Volume: 46 Page(s): 1082 - 1082
03/05/1987 Authors: CHEW CS; BROWN MR
Release of intracellular Ca2+ and elevation of inositol trisphosphate by secretagogues in parietal and chief cells isolated from rabbit gastric mucosa.
Biochim Biophys Acta Volume: 888 Page(s): 116 - 125
08/29/1986 Authors: Chew CS; Brown MR
DECREASED CHOLESTASIS WITH ORAL INSTEAD OF INTRAVENOUS PROTEIN IN THE VERY-LOW-BIRTH-WEIGHT INFANT
Volume: 20 Page(s): A236 - A236
04/01/1986 Authors: BROWN MR; THUNBERG BJ; GOLUB L; MANISCALCO WM; SHAPIRO DL
PHORBOL ESTER STIMULATES SECRETORY ACTIVITY WHILE INHIBITING RECEPTOR-ACTIVATED AMINOPYRINE UPTAKE BY GASTRIC GLANDS
FEDERATION PROCEEDINGS Volume: 45 Page(s): 1042 - 1042
03/05/1986 Authors: BROWN MR; CHEW CS
ACTIVITY OF ACYL COA-LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE IN A RAT LUNG GOLGI PREPARATION
FEDERATION PROCEEDINGS Volume: 42 Page(s): 1865 - 1865
01/01/1983 Authors: BROWN MR; LONGMORE WJ
Effect of duration of exposure on diarrhea due to enterotoxigenic Escherichia coli in travelers from the United States to Mexico.
J Infect Dis Volume: 145 Page(s): 582
04/01/1982 Authors: Brown MR; DuPont HL; Sullivan PS
ISOLATION OF A GOLGI ENRICHED FRACTION (GEF) FROM RAT LUNG
FEDERATION PROCEEDINGS Volume: 40 Page(s): 1804 - 1804
01/01/1981 Authors: BROWN MR; LONGMORE WJ

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Milton Brown PhD

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