Joanna Goldberg PhD
Overview
The Goldberg laboratory focuses on the strategies used by bacteria to cause diseases in humans, in particular respiratory infections in individuals with the genetic disease cystic fibrosis. We study various bacterial factors, especially surface polysaccharides and other potential adhesins. We assess their contribution to virulence and the physiology of the bacterium and their effects on host. We also examine and dissect essential metabolic pathways in these bacteria as targets for the development of novel therapeutics and vaccines to combat naturally antibiotic-resistant pathogens.
See also: https://scholarblogs.emory.edu/goldberglab/
Academic Appointment
- Professor, Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine
Education
Degrees
- BA from Boston University
- PhD from University of California
Research
Focus
- Dr. Goldbergs research is focused on mechanisms of bacterial pathogenesis. In particular, she studies bacteria that cause life-shortening lung infections in individuals with cystic fibrosis (CF). The goal of this work is to develop new approaches to inhibit these infections and thereby improve the quality of life of CF patients.
Publications
-
The impact of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the pulmonary microbiota.
Microbiology (Reading) Volume: 171
04/01/2025 Authors: Robertson JK; Goldberg JB -
R-pyocins as targeted antimicrobials against Pseudomonas aeruginosa.
NPJ Antimicrob Resist Volume: 3 Page(s): 17
02/28/2025 Authors: Mei M; Estrada I; Diggle SP; Goldberg JB -
RNA-seq reproducibility of Pseudomonas aeruginosa in laboratory models of cystic fibrosis.
Microbiol Spectr Volume: 13 Page(s): e0151324
01/07/2025 Authors: Duncan RP; Lewin GR; Cornforth DM; Diggle FL; Kapur A; Moustafa DA; Hilliam Y; Bomberger JM; Whiteley M; Goldberg JB -
The dominant lineage of an emerging pathogen harbours contact-dependent inhibition systems.
Microb Genom Volume: 11
01/01/2025 Authors: Crisan CV; Goldberg JB -
Pseudomonas aeruginosa elongation factor-Tu (EF-Tu) is an immunogenic protective protein antigen.
Vaccine Volume: 42 Page(s): 126476
12/02/2024 Authors: Moustafa DA; Lou E; Schafer-Kestenman ME; Mateu-Borrs M; Domnech-Sanchez A; Albert S; Goldberg JB -
Serotype switching in Pseudomonas aeruginosa ST111 enhances adhesion and virulence.
PLoS Pathog Volume: 20 Page(s): e1012221
12/01/2024 Authors: Anbo M; Lubna MA; Moustafa DA; Paiva TO; Serioli L; Zor K; Sternberg C; Jeannot K; Ciofu O; Dufrne YF -
Intraspecific Diversity of Staphylococcus aureus Populations Isolated from Cystic Fibrosis Respiratory Infections.
11/16/2024 Authors: Alexander AM; Loo HQ; Askew L; Raghuram V; Read TD; Goldberg JB -
Characterization of Pseudomonas aeruginosa from subjects with diffuse panbronchiolitis.
Microbiol Spectr Volume: 12 Page(s): e0053024
11/05/2024 Authors: Met CM; Hofstaedter CE; O'Keefe IP; Yang H; Moustafa DA; Sherman ME; Doi Y; Rasko DA; Sweet CR; Goldberg JB -
Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice.
bioRxiv
10/09/2024 Authors: Hale M; Takehara KK; Thouvenel CD; Moustafa DA; Repele A; Fontana MF; Netland J; McNamara S; Gibson RL; Goldberg JB -
Flagellum-deficient Pseudomonas aeruginosa is more virulent than non-motile but flagellated mutants in a cystic fibrosis mouse model.
Microbiol Spectr Volume: 12 Page(s): e0132524
10/03/2024 Authors: Moustafa DA; Fantone KM; Tucker SL; McCarty NA; Stecenko AA; Goldberg JB; Rada B