Publications

• Mechanism of Inhibition of the Active Triphosphate Form of 2'--Fluoro,2'--bromouridine against Yellow Fever Virus RNA-Dependent RNA Polymerase.
  ACS Infect Dis Volume: 11 Page(s): 1528 - 1538
  06/13/2025 Authors: Gordon CJ; Walker SM; LeCher JC; Amblard F; Schinazi RF; Gtte M
• Combating yellow fever virus with 7-deaza-7-fluoro-2'-C-methyladenosine.
  Antimicrob Agents Chemother Volume: 69 Page(s): e0188924
  05/07/2025 Authors: LeCher JC; Costa VV; Rust LN; Bassit LC; Patel D; Rezaei S; Moua J; Santos FRDS; Goncalves MR; Queroz-Junior CM
• Development of robust antiviral assays using relevant apical-out human airway organoids.
  bioRxiv
  07/12/2024 Authors: Lee J-H; LeCher JC; Parigoris E; Shinagawa N; Sentosa J; Manfredi C; Goh SL; De R; Tao S; Zandi K
• Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections.
  Viruses Volume: 16
  04/22/2024 Authors: Hurwitz SJ; De R; LeCher JC; Downs-Bowen JA; Goh SL; Zandi K; McBrayer T; Amblard F; Patel D; Kohler JJ
• Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
  Eur J Med Chem Volume: 268 Page(s): 116263
  03/15/2024 Authors: Amblard F; LeCher JC; De R; Zhou S; Liu P; Goh SL; Tao S; Patel D; Downs-Bowen J; Zandi K
• Utilization of a cell-penetrating peptide-adaptor for delivery of human papillomavirus protein E2 into cervical cancer cells to arrest cell growth and promote cell death.
  Cancer Rep (Hoboken) Volume: 6 Page(s): e1810
  05/01/2023 Authors: LeCher JC; Didier HL; Dickson RL; Slaughter LR; Bejarano JC; Ho S; Nowak SJ; Chrestensen CA; McMurry JL
• Synthesis of 4'-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents.
  Viruses Volume: 15
  02/16/2023 Authors: Biteau NG; Amichai SA; Azadi N; De R; Downs-Bowen J; Lecher JC; MacBrayer T; Schinazi RF; Amblard F
• Discovery of a 2'-Fluoro,2'-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice.
  Microorganisms Volume: 10
  10/22/2022 Authors: LeCher JC; Zandi K; Costa VV; Amblard F; Tao S; Patel D; Lee S; da Silva Santos FR; Goncalves MR; Queroz-Junior CM
• Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents.
  Pharmaceuticals (Basel) Volume: 15
  09/14/2022 Authors: Amblard F; LeCher JC; De R; Goh SL; Li C; Kasthuri M; Biteau N; Zhou L; Tber Z; Downs-Bowen J
• Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytes.
  Cell Rep Volume: 39 Page(s): 110945
  06/14/2022 Authors: Dobosh B; Zandi K; Giraldo DM; Goh SL; Musall K; Aldeco M; LeCher J; Giacalone VD; Yang J; Eddins DJ
• Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
  Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
  01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ
• Genistein Has Antiviral Activity against Herpes B Virus and Acts Synergistically with Antiviral Treatments to Reduce Effective Dose.
  Viruses Volume: 11
  05/31/2019 Authors: LeCher JC; Diep N; Krug PW; Hilliard JK
• Breaking in and busting out: cell-penetrating peptides and the endosomal escape problem.
  Biomol Concepts Volume: 8 Page(s): 131 - 141
  09/26/2017 Authors: LeCher JC; Nowak SJ; McMurry JL
• B Virus (Macacine Herpesvirus 1) Divergence: Variations in Glycoprotein D from Clinical and Laboratory Isolates Diversify Virus Entry Strategies.
  J Virol Volume: 90 Page(s): 9420 - 9432
  10/15/2016 Authors: Patrusheva I; Perelygina L; Torshin I; LeCher J; Hilliard J
• 2015 Colorado Alphaherpesvirus Latency Society Symposium.
  J Neurovirol Volume: 21 Page(s): 706 - 716
  12/01/2015 Authors: Cohrs RJ; Gilden D