Publications

• Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques.
  J Virol Page(s): e0006225
  04/07/2025 Authors: Viox EG; Richard J; Grandea AG; Nguyen K; Harper J; Auger J; Ding S; Gasser R; Prvost J; Marchitto L
• Immune-mediated strategies to solving the HIV reservoir problem.
  Nat Rev Immunol
  02/13/2025 Authors: Kulpa DA; Paiardini M; Silvestri G
• SIV infection in sooty mangabeys does not impact survival but changes the relative frequency of the main cause of death.
  mBio Volume: 15 Page(s): e0163924
  10/16/2024 Authors: Ceriani C; Beisner B; Crane M; Cohen J; Moore IN; Kulpa DA; Hahn BH; Silvestri G
• Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.
  Nat Immunol Volume: 25 Page(s): 1245 - 1256
  07/01/2024 Authors: Strongin Z; Raymond Marchand L; Deleage C; Pampena MB; Cardenas MA; Beusch CM; Hoang TN; Urban EA; Gourves M; Nguyen K
• Application of ultrasensitive digital ELISA for p24 enables improved evaluation of HIV-1 reservoir diversity and growth kinetics in viral outgrowth assays.
  Sci Rep Volume: 13 Page(s): 10958
  07/06/2023 Authors: Kuzmichev YV; Lackman-Smith C; Bakkour S; Wiegand A; Bale MJ; Musick A; Bernstein W; Aronson N; Ake J; Tovanabutra S
• Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.
  AIDS Res Hum Retroviruses
  06/19/2023 Authors: Sanders-Beer BE; Archin NM; Brumme ZL; Busch MP; Deleage C; O'Doherty U; Hughes SH; Jerome KR; Jones RB; Karn J
• CD8+ Tcells promote HIV latency by remodeling CD4+ Tcell metabolism to enhance their survival, quiescence, and stemness.
  Immunity Volume: 56 Page(s): 1132 - 1147.e6
  05/09/2023 Authors: Mutascio S; Mota T; Franchitti L; Sharma AA; Willemse A; Bergstresser SN; Wang H; Statzu M; Tharp GK; Weiler J
• Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19.
  Nat Commun Volume: 14 Page(s): 1638
  04/04/2023 Authors: Druzak S; Iffrig E; Roberts BR; Zhang T; Fibben KS; Sakurai Y; Verkerke HP; Rostad CA; Chahroudi A; Schneider F
• CD8+ lymphocytes do not impact SIV reservoir establishment under ART.
  Nat Microbiol Volume: 8 Page(s): 299 - 308
  02/01/2023 Authors: Statzu M; Jin W; Fray EJ; Wong AKH; Kumar MR; Ferrer E; Docken SS; Pinkevych M; McBrien JB; Fennessey CM
• Erratum to: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner?
  Pathog Immun Volume: 8 Page(s): 179 - 222
  01/01/2023 Authors: Harper J; Betts MR; Lichterfeld M; Mller-Trutwin M; Margolis D; Bar KJ; Li JZ; McCune JM; Lewin SR; Kulpa D
• Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner?
  Pathog Immun Volume: 8 Page(s): 115 - 157
  01/01/2023 Authors: Harper J; Betts MR; Lichterfeld M; Mller-Trutwin M; Margolis D; Bar KJ; Li JZ; McCune JM; Lewin SR; Kulpa D
• CD8(+) T cell depletion does not affect viral reservoir size, but influences the rebound after ART interruption in SIV-infected rhesus macaques
  Volume: 51 Page(s): 323 - 324
  10/01/2022 Authors: Statzu M; Wong A; McBrien J; Choe Y; Enemuo C; Ngo J; Jimenez L; Wang J; Pinkevych M; Docken S
• Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques.
  Nat Commun Volume: 13 Page(s): 5055
  08/27/2022 Authors: Pino M; Pagliuzza A; Pampena MB; Deleage C; Viox EG; Nguyen K; Shim I; Zhang A; Harper JL; Samer S
• The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence.
  PLoS Pathog Volume: 18 Page(s): e1010723
  07/01/2022 Authors: Strongin Z; Hoang TN; Tharp GK; Rahmberg AR; Harper JL; Nguyen K; Franchitti L; Cervasi B; Lee M; Zhang Z
• Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.
  J Clin Invest Volume: 132
  04/15/2022 Authors: Harper J; Ribeiro SP; Chan CN; Aid M; Deleage C; Micci L; Pino M; Cervasi B; Raghunathan G; Rimmer E
• Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections.
  Front Immunol Volume: 13 Page(s): 1033672
  01/01/2022 Authors: Reece MD; Song C; Hancock SC; Pereira Ribeiro S; Kulpa DA; Gavegnano C
• Ex Vivo Differentiation of Resting CD4+ T Lymphocytes Enhances Detection of Replication Competent HIV-1 in Viral Outgrowth Assays.
  Methods Mol Biol Volume: 2407 Page(s): 315 - 331
  01/01/2022 Authors: Wonderlich ER; Reece MD; Kulpa DA
• TGF- Signaling Supports HIV Latency in a Memory CD4+ T Cell Based In Vitro Model.
  Methods Mol Biol Volume: 2407 Page(s): 69 - 79
  01/01/2022 Authors: Bergstresser S; Kulpa DA
• A flow-cytometry-based protocol using diverse cell types for detecting autoantibodies from human plasma and serum samples.
  STAR Protoc Volume: 2 Page(s): 100924
  12/17/2021 Authors: Wong AKH; Kulpa DA; Silvestri G; Maier CL
• CD8+lymphocyte mediated suppression of HIV expression in CD4(+) T cells
  Volume: 51 Page(s): 104 - 104
  08/01/2021 Authors: Franchitti L; Sharma AA; Yoon J; White E; Zhang Z; Wang H; Statzu M; Willemse AE; Bateganya L; Silvestri G
• Potential Utility of Natural Killer Cells for Eliminating Cells Harboring Reactivated Latent HIV-1 Following the Removal of CD8+ T Cell-Mediated Pro-Latency Effect(s).
  Viruses Volume: 13
  07/26/2021 Authors: Khoury G; Kulpa DA; Parsons MS
• Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19.
  Cell Rep Med Volume: 2 Page(s): 100321
  06/15/2021 Authors: Wong AKH; Woodhouse I; Schneider F; Kulpa DA; Silvestri G; Maier CL
• CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques.
  J Virol Volume: 95
  03/25/2021 Authors: Mavigner M; Liao LE; Brooks AD; Ke R; Mattingly C; Schoof N; McBrien J; Carnathan D; Liang S; Vanderford TH
• Unprimed CD8+lymphocytes promote the maintenance of HIV latency in CD4+T cells
  Volume: 24
  02/01/2021 Authors: Franchitti L; Zhang Z; Statzu M; Wang H; Paiardini M; Silvestri G; Kulpa D
• Introduction to the Special Issue: Immunology of HIV and SIV infection.
  Semin Immunol Volume: 51 Page(s): 101484
  01/01/2021 Authors: Kulpa DA; Silvestri G
• Broad Auto-Reactive IgM Responses Are Common In Critically Ill COVID-19 Patients.
  Res Sq
  12/31/2020 Authors: Maier C; Wong A; Woodhouse I; Schneider F; Kulpa D; Silvestri G
• Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription.
  PLoS Pathog Volume: 16 Page(s): e1008821
  09/01/2020 Authors: Zanoni M; Palesch D; Pinacchio C; Statzu M; Tharp GK; Paiardini M; Chahroudi A; Bosinger SE; Yoon J; Cox B
• Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.
  Nature Volume: 578 Page(s): E21
  02/01/2020 Authors: McBrien JB; Mavigner M; Franchitti L; Smith SA; White E; Tharp GK; Walum H; Busman-Sahay K; Aguilera-Sandoval CR; Thayer WO
• Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.
  Nature Volume: 578 Page(s): 154 - 159
  02/01/2020 Authors: McBrien JB; Mavigner M; Franchitti L; Smith SA; White E; Tharp GK; Walum H; Busman-Sahay K; Aguilera-Sandoval CR; Thayer WO
• Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4+ T Cells.
  J Virol Volume: 93
  12/15/2019 Authors: Kulpa DA; Talla A; Brehm JH; Ribeiro SP; Yuan S; Bebin-Blackwell A-G; Miller M; Barnard R; Deeks SG; Hazuda D
• Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.
  PLoS Pathog Volume: 15 Page(s): e1008074
  10/01/2019 Authors: Wonderlich ER; Subramanian K; Cox B; Wiegand A; Lackman-Smith C; Bale MJ; Stone M; Hoh R; Kearney MF; Maldarelli F
• CD8+lymphocyte mediated suppression of HIV expression in CD4+T cells
  Volume: 22 Page(s): 105 - 105
  07/01/2019 Authors: Franchitti L; Willemse A; Yoon J; White E; Cox B; Silvestri G; Kulpa D
• Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size.
  PLoS Comput Biol Volume: 15 Page(s): e1006849
  04/01/2019 Authors: Rosenbloom DIS; Bacchetti P; Stone M; Deng X; Bosch RJ; Richman DD; Siliciano JD; Mellors JW; Deeks SG; Ptak RG
• The Contribution of Memory CD4+T cell subset phenotype to latency reversal efficiency
  Volume: 77 Page(s): 35 - 35
  04/01/2018 Authors: Kulpa D; Talla A; Ribeiro S; Barnard R; Hazuda D; Chomont N; Sekaly R
• Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.
  PLoS Pathog Volume: 13 Page(s): e1006740
  12/01/2017 Authors: Gavegnano C; Brehm JH; Dupuy FP; Talla A; Ribeiro SP; Kulpa DA; Cameron C; Santos S; Hurwitz SJ; Marconi VC
• A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.
  EBioMedicine Volume: 2 Page(s): 874 - 883
  08/01/2015 Authors: Procopio FA; Fromentin R; Kulpa DA; Brehm JH; Bebin A-G; Strain MC; Richman DD; O'Doherty U; Palmer S; Hecht FM
• HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?
  J Virus Erad Volume: 1 Page(s): 59 - 66
  04/01/2015 Authors: Kulpa DA; Chomont N
• PD-1 coinhibitory signals: the link between pathogenesis and protection.
  Semin Immunol Volume: 25 Page(s): 219 - 227
  10/31/2013 Authors: Kulpa DA; Lawani M; Cooper A; Peretz Y; Ahlers J; Skaly R-P
• The immunological synapse: the gateway to the HIV reservoir.
  Immunol Rev Volume: 254 Page(s): 305 - 325
  07/01/2013 Authors: Kulpa DA; Brehm JH; Fromentin R; Cooper A; Cooper C; Ahlers J; Chomont N; Skaly R-P
• Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1.
  J Virol Volume: 87 Page(s): 8085 - 8098
  07/01/2013 Authors: Kulpa DA; Del Cid N; Peterson KA; Collins KL
• ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells.
  J Virol Volume: 85 Page(s): 12216 - 12226
  12/01/2011 Authors: Wonderlich ER; Leonard JA; Kulpa DA; Leopold KE; Norman JM; Collins KL
• The emerging role of HLA-C in HIV-1 infection.
  Immunology Volume: 134 Page(s): 116 - 122
  10/01/2011 Authors: Kulpa DA; Collins KL
• Characterization of LINE-1 ribonucleoprotein particles.
  PLoS Genet Volume: 6
  10/07/2010 Authors: Doucet AJ; Hulme AE; Sahinovic E; Kulpa DA; Moldovan JB; Kopera HC; Athanikar JN; Hasnaoui M; Bucheton A; Moran JV
• Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells.
  Nature Volume: 466 Page(s): 769 - 773
  08/05/2010 Authors: Garcia-Perez JL; Morell M; Scheys JO; Kulpa DA; Morell S; Carter CC; Hammer GD; Collins KL; O'Shea KS; Menendez P
• A novel trafficking signal within the HLA-C cytoplasmic tail allows regulated expression upon differentiation of macrophages.
  J Immunol Volume: 180 Page(s): 7804 - 7817
  06/15/2008 Authors: Schaefer MR; Williams M; Kulpa DA; Blakely PK; Yaffee AQ; Collins KL
• Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles.
  Nat Struct Mol Biol Volume: 13 Page(s): 655 - 660
  07/01/2006 Authors: Kulpa DA; Moran JV
• Ribonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition.
  Hum Mol Genet Volume: 14 Page(s): 3237 - 3248
  11/01/2005 Authors: Kulpa DA; Moran JV
• Multiple roles for the ORF1-encoded protein in LINE-1 retrotransposition.
  Volume: 71 Page(s): 167 - 167
  10/01/2002 Authors: Kulpa DA; Moran JV
• In search of L1 retrotransposition intermediates.
  Volume: 69 Page(s): 371 - 371
  10/01/2001 Authors: Kulpa DA; Athanikar JN; Moran JV
• Determination of the site of first strand transfer during Moloney murine leukemia virus reverse transcription and identification of strand transfer-associated reverse transcriptase errors.
  EMBO J Volume: 16 Page(s): 856 - 865
  02/17/1997 Authors: Kulpa D; Topping R; Telesnitsky A
• Clinical scale ex vivo production of hematopoietic stem and progenitor cells.
  Volume: 88 Page(s): 3715 - 3715
  11/15/1996 Authors: Mandalam RK; Brott DA; Weber S; Kulpa DA; Armstrong RD; Smith AK
• Molecular and genetic characterization of the rhizopine catabolism (mocABRC) genes of Rhizobium meliloti L5-30.
  Mol Gen Genet Volume: 245 Page(s): 11 - 24
  10/17/1994 Authors: Rossbach S; Kulpa DA; Rossbach U; de Bruijn FJ
• Charcot-Marie-Tooth disease type 1A. Association with a spontaneous point mutation in the PMP22 gene.
  N Engl J Med Volume: 329 Page(s): 96 - 101
  07/08/1993 Authors: Roa BB; Garcia CA; Suter U; Kulpa DA; Wise CA; Mueller J; Welcher AA; Snipes GJ; Shooter EM; Patel PI