Publications

• Tissue elasticity modulates cardiac pacemaker cell automaticity.
  Am J Physiol Heart Circ Physiol Volume: 328 Page(s): H978 - H990
  04/01/2025 Authors: Choi YH; Leng J; Fan J; Ramirez RJ; Cho HC
• Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18.
  Nat Biomed Eng Volume: 8 Page(s): 1124 - 1141
  09/01/2024 Authors: Wolfson DW; Kim NK; Lee KH; Beyersdorf JP; Langberg JJ; Fernandez N; Choi D; Zureick N; Kim TY; Bae S
• Simulated microgravity improves maturation of cardiomyocytes derived from human induced pluripotent stem cells.
  Sci Rep Volume: 14 Page(s): 2243
  01/26/2024 Authors: Forghani P; Rashid A; Armand LC; Wolfson D; Liu R; Cho HC; Maxwell JT; Jo H; Salaita K; Xu C
• AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling.
  Stem Cell Res Ther Volume: 14 Page(s): 322
  11/08/2023 Authors: Li D; Armand LC; Sun F; Hwang H; Wolfson D; Rampoldi A; Liu R; Forghani P; Hu X; Yu W-M
• Tbx18 Orchestrates Cytostructural Transdifferentiation of Cardiomyocytes to Pacemaker Cells by Recruiting the Epithelial-Mesenchymal Transition Program.
  J Proteome Res Volume: 21 Page(s): 2277 - 2292
  10/07/2022 Authors: Foster DB; Gu J-M; Kim EH; Wolfson DW; O'Meally R; Cole RN; Cho HC
• DNA Tension Probes Show that Cardiomyocyte Maturation Is Sensitive to the Piconewton Traction Forces Transmitted by Integrins.
  ACS Nano Volume: 16 Page(s): 5335 - 5348
  04/26/2022 Authors: Rashid SA; Blanchard AT; Combs JD; Fernandez N; Dong Y; Cho HC; Salaita K
• Methodology for Cross-Talk Elimination in Simultaneous Voltage and Calcium Optical Mapping Measurements With Semasbestic Wavelengths.
  Front Physiol Volume: 13 Page(s): 812968
  01/01/2022 Authors: Uzelac I; Crowley CJ; Iravanian S; Kim TY; Cho HC; Fenton FH
• Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants.
  Nat Commun Volume: 12 Page(s): 6103
  10/20/2021 Authors: Han P; Su C; Zhang Y; Bai C; Zheng A; Qiao C; Wang Q; Niu S; Chen Q; Zhang Y
• Implementing Biological Pacemakers: Design Criteria for Successful.
  Circ Arrhythm Electrophysiol Volume: 14 Page(s): e009957
  10/01/2021 Authors: Komosa ER; Wolfson DW; Bressan M; Cho HC; Ogle BM
• Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts.
  Nat Biomed Eng Volume: 5 Page(s): 880 - 896
  08/01/2021 Authors: Cho J; Kim S; Lee H; Rah W; Cho HC; Kim NK; Bae S; Shin DH; Lee MG; Park I-H
• A CMOS Multi-Modal Electrochemical and Impedance Cellular Sensing Array for Massively Paralleled Exoelectrogen Screening.
  IEEE Trans Biomed Circuits Syst Volume: 15 Page(s): 221 - 234
  04/01/2021 Authors: Kumashi S; Jung D; Park J; Tejedor-Sanz S; Grijalva S; Wang A; Li S; Cho HC; Ajo-Franklin C; Wang H
• Zika virus induces myocardial immune response and myocarditis in mice.
  J Mol Cell Cardiol Volume: 148 Page(s): 103 - 105
  11/01/2020 Authors: Bai C; Li S; Song S; Wang Q; Cho H; Gao GF; Nie Y; Han P
• Cellular Reprogramming Approaches to Engineer Cardiac Pacemakers.
  Curr Cardiol Rep Volume: 22 Page(s): 29
  03/30/2020 Authors: Xiao A; Cho HC
• Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells.
  Stem Cells Volume: 38 Page(s): 352 - 368
  03/01/2020 Authors: Liang W; Han P; Kim EH; Mak J; Zhang R; Torrente AG; Goldhaber JI; Marbn E; Cho HC
• Spotlight on recent advances in cardiovascular biology.
  Exp Mol Med Volume: 51 Page(s): 1 - 2
  12/19/2019 Authors: Kook H; Cho HC
• Intracellular cardiomyocytes potential recording by planar electrode array and fibroblasts co-culturing on multi-modal CMOS chip.
  Biosens Bioelectron Volume: 144 Page(s): 111626
  11/01/2019 Authors: Park JS; Grijalva SI; Jung D; Li S; Junek GV; Chi T; Cho HC; Wang H
• Engineered Cardiac Pacemaker Nodes Created by TBX18 Gene Transfer Overcome Source-Sink Mismatch.
  Adv Sci (Weinh) Volume: 6 Page(s): 1901099
  11/01/2019 Authors: Grijalva SI; Gu J-M; Li J; Fernandez N; Fan J; Sung JH; Lee SY; Herndon C; Buckley EM; Park S-J
• Induced cardiac pacemaker cells survive metabolic stress owing to their low metabolic demand.
  Exp Mol Med Volume: 51 Page(s): 1 - 12
  09/13/2019 Authors: Gu J-M; Grijalva SI; Fernandez N; Kim E; Foster DB; Cho HC
• All-in-One, Wireless, Stretchable Hybrid Electronics for Smart, Connected, and Ambulatory Physiological Monitoring.
  Adv Sci (Weinh) Volume: 6 Page(s): 1900939
  09/04/2019 Authors: Kim Y-S; Mahmood M; Lee Y; Kim NK; Kwon S; Herbert R; Kim D; Cho HC; Yeo W-H
• Novel method for action potential measurements from intact cardiac monolayers with multiwell microelectrode array technology.
  Sci Rep Volume: 9 Page(s): 11893
  08/15/2019 Authors: Hayes HB; Nicolini AM; Arrowood CA; Chvatal SA; Wolfson DW; Cho HC; Sullivan DD; Chal J; Fermini B; Clements M
• Biphasic Reprogramming of Ventricular Cardiomyocytes to Pacemaker Cells by Tbx18
  Volume: 125
  08/02/2019 Authors: Fan J; Fernandez N; Cho HC
• Strength-duration relationship as a tool to prioritize cardiac tissue properties that govern electrical excitability.
  Am J Physiol Heart Circ Physiol Volume: 317 Page(s): H13 - H25
  07/01/2019 Authors: Sayegh MN; Fernandez N; Cho HC
• A rat model of complete atrioventricular block recapitulates clinical indices of bradycardia and provides a platform to test disease-modifying therapies.
  Sci Rep Volume: 9 Page(s): 6930
  05/06/2019 Authors: Kim NK; Wolfson D; Fernandez N; Shin M; Cho HC
• Gene Therapy Approaches to Biological Pacemakers.
  J Cardiovasc Dev Dis Volume: 5
  10/19/2018 Authors: Farraha M; Kumar S; Chong J; Cho HC; Kizana E
• Multi-parametric cell profiling with a CMOS quad-modality cellular interfacing array for label-free fully automated drug screening.
  Lab Chip Volume: 18 Page(s): 3037 - 3050
  09/26/2018 Authors: Park JS; Grijalva SI; Aziz MK; Chi T; Li S; Sayegh MN; Wang A; Cho HC; Wang H
• 1024-Pixel CMOS Multimodality Joint Cellular Sensor/Stimulator Array for Real-Time Holistic Cellular Characterization and Cell-Based Drug Screening.
  IEEE Trans Biomed Circuits Syst Volume: 12 Page(s): 80 - 94
  02/01/2018 Authors: Park JS; Aziz MK; Li S; Chi T; Grijalva SI; Sung JH; Cho HC; Wang H
• Induced Pacemaker Spheroids As A Model To Reverse-Engineer The Native Sinoatrial Node
  Volume: 121 Page(s): E94 - E94
  12/08/2017 Authors: Grijalva SI; Sung JH; Furman BW; Han P; Li J; Cho HC
• Age is just a number: frailty better evaluates age-dependent heart rhythm defects.
  J Physiol Volume: 594 Page(s): 6805
  12/01/2016 Authors: Cho HC
• Engineered Biological Pacing Nodes Created From Induced Pacemaker Cells
  Volume: 134
  11/11/2016 Authors: Sung JH; Gonzalez S; Li J; Wolfson D; Cho HC
• Modeling and Genome-Editing Brugada Syndrome in a Dish.
  J Am Coll Cardiol Volume: 68 Page(s): 2097 - 2098
  11/08/2016 Authors: Cho HC
• Simulated Microgravity and 3D Culture Enhance Induction, Viability, Proliferation and Differentiation of Cardiac Progenitors from Human Pluripotent Stem Cells.
  Sci Rep Volume: 6 Page(s): 30956
  08/05/2016 Authors: Jha R; Wu Q; Singh M; Preininger MK; Han P; Ding G; Cho HC; Jo H; Maher KO; Wagner MB
• DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission.
  J Mol Cell Cardiol Volume: 97 Page(s): 56 - 66
  08/01/2016 Authors: Shimizu Y; Lambert JP; Nicholson CK; Kim JJ; Wolfson DW; Cho HC; Husain A; Naqvi N; Chin L-S; Li L
• Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan.
  Cell Volume: 166 Page(s): 624 - 636
  07/28/2016 Authors: Wolf AJ; Reyes CN; Liang W; Becker C; Shimada K; Wheeler ML; Cho HC; Popescu NI; Coggeshall KM; Arditi M
• Pacing the Heart with Genes: Recent Progress in Biological Pacing.
  Curr Cardiol Rep Volume: 17 Page(s): 65
  08/01/2015 Authors: Cho HC
• Wnt signalling suppresses voltage-dependent Na channel expression in postnatal rat cardiomyocytes.
  J Physiol Volume: 593 Page(s): 1147 - 1157
  03/01/2015 Authors: Liang W; Cho HC; Marbn E
• SHOX2 overexpression favors differentiation of embryonic stem cells into cardiac pacemaker cells, improving biological pacing ability.
  Stem Cell Reports Volume: 4 Page(s): 129 - 142
  01/13/2015 Authors: Ionta V; Liang W; Kim EH; Rafie R; Giacomello A; Marbn E; Cho HC
• Engineered electrical conduction tract restores conduction in complete heart block: from in vitro to in vivo proof of concept.
  J Am Coll Cardiol Volume: 64 Page(s): 2575 - 2585
  12/23/2014 Authors: Cingolani E; Ionta V; Cheng K; Giacomello A; Cho HC; Marbn E
• Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells.
  Stem Cells Volume: 32 Page(s): 2397 - 2406
  09/01/2014 Authors: Xie Y; Ibrahim A; Cheng K; Wu Z; Liang W; Malliaras K; Sun B; Liu W; Shen D; Cheol Cho H
• Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block.
  Sci Transl Med Volume: 6 Page(s): 245ra94
  07/16/2014 Authors: Hu Y-F; Dawkins JF; Cho HC; Marbn E; Cingolani E
• Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
  Nat Med Volume: 20 Page(s): 624 - 632
  06/01/2014 Authors: Hong T; Yang H; Zhang S-S; Cho HC; Kalashnikova M; Sun B; Zhang H; Bhargava A; Grabe M; Olgin J
• Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells.
  J Hypertens Volume: 32 Page(s): 318 - 330
  02/01/2014 Authors: Liang W; Huang L; Zhao D; He JZ; Sharma P; Liu J; Gramolini AO; Ward ME; Cho HC; Backx PH
• Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.
  Nat Biotechnol Volume: 31 Page(s): 54 - 62
  01/01/2013 Authors: Kapoor N; Liang W; Marbn E; Cho HC
• Transcription Factor-Driven Conversion of Quiescent Cardiomyocytes to Pacemaker Cells
  CIRCULATION Volume: 126
  11/20/2012 Authors: Cho HC; Kapoor N; Liang W; Marban E
• Enhanced Embryonic Stem Cell Differentiation to Cardiac Pacemaker Cells by Transduction with a Single Transcription Factor
  CIRCULATION Volume: 126
  11/20/2012 Authors: Ionta V; Marban E; Cho HC
• Taking the cells out of cell therapy.
  J Am Coll Cardiol Volume: 60 Page(s): 1707 - 1708
  10/23/2012 Authors: Marbn E; Cho HC; Cingolani E
• Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block.
  Heart Rhythm Volume: 9 Page(s): 1310 - 1318
  08/01/2012 Authors: Cingolani E; Yee K; Shehata M; Chugh SS; Marbn E; Cho HC
• Human Cardiosphere-Derived Cells Stimulate Cardiomyocyte Proliferation in vivo and in Co-Culture
  CIRCULATION Volume: 124
  11/22/2011 Authors: Xie Y; Cheng K; Cho HC; Malliaras K; Ibrahim A; Sun B; Galang G; Ionta V; Shen D; Zhang Y
• Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes.
  J Biol Chem Volume: 286 Page(s): 14073 - 14079
  04/22/2011 Authors: Kapoor N; Galang G; Marbn E; Cho HC
• Transcriptional Suppression of Connexin 43 by Tbx18 Undermines Cell-Cell Electrical Coupling in Postnatal Cardiomyocytes
  Volume: 100 Page(s): 563 - 563
  02/02/2011 Authors: Kapur N; Marban E; Cho HC
• Biological therapies for cardiac arrhythmias: can genes and cells replace drugs and devices?
  Circ Res Volume: 106 Page(s): 674 - 685
  03/05/2010 Authors: Cho HC; Marbn E
• IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers.
  Circ Res Volume: 104 Page(s): 355 - 364
  02/13/2009 Authors: Sekar RB; Kizana E; Cho HC; Molitoris JM; Hesketh GG; Eaton BP; Marbn E; Tung L
• Biological pacemakers as a therapy for cardiac arrhythmias.
  Curr Opin Cardiol Volume: 23 Page(s): 46 - 54
  01/01/2008 Authors: Marbn E; Cho HC
• Gene therapy to inhibit the calcium channel beta subunit: physiological consequences and pathophysiological effects in models of cardiac hypertrophy.
  Circ Res Volume: 101 Page(s): 166 - 175
  07/20/2007 Authors: Cingolani E; Ramirez Correa GA; Kizana E; Murata M; Cho HC; Marbn E
• Creation of a biological pacemaker by cell fusion.
  Circ Res Volume: 100 Page(s): 1112 - 1115
  04/27/2007 Authors: Cho HC; Kashiwakura Y; Marbn E
• Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.
  Circulation Volume: 115 Page(s): 896 - 908
  02/20/2007 Authors: Smith RR; Barile L; Cho HC; Leppo MK; Hare JM; Messina E; Giacomello A; Abraham MR; Marbn E
• Creation of a biological pacemaker by gene- or cell-based approaches.
  Med Biol Eng Comput Volume: 45 Page(s): 133 - 144
  02/01/2007 Authors: Marbn E; Cho HC
• CAPON, a nitric oxide synthase regulator associated with QT interval variation in humans, modulates cardiac repolarization in ventricular myocytes
  Volume: 114 Page(s): 167 - 167
  10/31/2006 Authors: Chang K-C; Barth AS; Kizana E; Kashiwakura Y; Sasano T; Zhang Y; Cho HC; Liu T; Marban E
• Cardiogenicity and regenerative potential of cardiac-derived stem cells isolated from adult human and porcine endomyocardial biopsy specimens
  Volume: 114 Page(s): 51 - 51
  10/31/2006 Authors: Smith RR; Barile L; Cho HC; Leppo MK; Hare JM; Messina E; Giacomello A; Abraham MR; Marban E
• Biopacemakers induced by gene transfer of a dual-functional Kir2.1 mutant
  Volume: 114 Page(s): 8 - 8
  10/31/2006 Authors: Kashiwakura Y; Chang K-C; Zhang Y; Barth A; Cho HC; Sasano T; Marban E
• Gene transfer of a synthetic pacemaker channel into the heart: a novel strategy for biological pacing.
  Circulation Volume: 114 Page(s): 1682 - 1686
  10/17/2006 Authors: Kashiwakura Y; Cho HC; Barth AS; Azene E; Marbn E
• Gene Transfer of a Synthetic Pacemaker Channel into the Heart: A Novel Strategy for Biological Pacing
  MOLECULAR THERAPY Volume: 13 Page(s): S89 - S89
  05/01/2006 Authors: Kashiwakura Y; Cho HC; Azene E; Marban E
• Creation of a Biological Pacemaker by Cell Fusion
  MOLECULAR THERAPY Volume: 13 Page(s): S9 - S10
  05/01/2006 Authors: Cho HC; Kashiwakura Y; Marban E
• Engraftment, migration and functional improvement in ischemic mouse hearts injected with human cardiosphere-derived stem cells
  Volume: 97 Page(s): 1202 - 1202
  11/25/2005 Authors: Barile L; Messina E; Smith RR; Leppo MK; Cho HC; Abraham MR; Pittenger M; Glacomello A; Marban E
• Posttranscriptional gene silencing of the L-type calcium channel accessory beta-subunit suppresses cardiac hypertrophy response in vitro and in vivo
  Volume: 112 Page(s): U30 - U30
  10/25/2005 Authors: Cingolani E; Correa GAR; Kizana E; Cho HC; Leppo MK; Marban E
• Creation of a synthetic pacemaker channel
  Volume: 112 Page(s): U147 - U147
  10/25/2005 Authors: Kashiwakura Y; Cho HC; Azene E; Marban E
• Post-transcriptional gene silencing of the L-type calcium channel accessory beta subunit suppresses cardiac hypertrophy response in vitro and in vivo
  Volume: 112 Page(s): U49 - U49
  10/25/2005 Authors: Cingolani E; Correa GAR; Kizana E; Cho HC; Leppo MK; Marban E
• Unique phenotype of cardiospheres derived from human endomyocardial biopsies
  Volume: 112 Page(s): U105 - U106
  10/25/2005 Authors: Smith RR; Barile L; Cho HC; Abraham MR; Messina E; Giacomello A; Marban E
• Conduction through the inward rectifier potassium channel, Kir2.1, is increased by negatively charged extracellular residues.
  J Gen Physiol Volume: 125 Page(s): 493 - 503
  05/01/2005 Authors: D'Avanzo N; Cho HC; Tolokh I; Pekhletski R; Tolokh I; Gray C; Goldman S; Backx PH
• Electrophysiology of human and porcine adult cardiac stem cells isolated from endomyocardial biopsies
  Volume: 111 Page(s): 1720 - 1720
  04/05/2005 Authors: Smith RR; Abraham MR; Messina E; Cho HC; Giacomello A; Marban E
• Non-Michaelis-Menten kinetics model for conductance of low-conductance potassium ion channels.
  Phys Rev E Stat Nonlin Soft Matter Phys Volume: 71 Page(s): 021912
  02/01/2005 Authors: Tolokh IS; Tolokh II; Cho HC; D'Avanzo N; Backx PH; Goldman S; Gray CG
• Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers.
  Circulation Volume: 111 Page(s): 11 - 20
  01/04/2005 Authors: Xue T; Cho HC; Akar FG; Tsang S-Y; Jones SP; Marbn E; Tomaselli GF; Li RA
• Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes.
  Circ Res Volume: 95 Page(s): 325 - 332
  08/06/2004 Authors: Diaz RJ; Zobel C; Cho HC; Batthish M; Hinek A; Backx PH; Wilson GJ
• Hyperpolarization-activated currents in pancreatic beta-cells mediate insulin secretion
  Volume: 86 Page(s): 293A - 293A
  01/01/2004 Authors: El-kholy W; Xue T; Cho HC; Tsushimal RG; Li R; Wheeler MB
• Surface electrostatics in the conduction rate of an inward rectifier potassium channel, Kir2.1
  Volume: 86 Page(s): 124A - 124A
  01/01/2004 Authors: D'Avanzo N; Cho HC; Tolokh I; Gray C; Goldman S; Backx PH
• Multiple Ba2+ sites in selectivity filter of inwardly rectifying K+-channels Kir2.1
  Volume: 86 Page(s): 124A - 124A
  01/01/2004 Authors: Pekhletski R; D'Avanzo N; Cho HC; Backx P
• Genetically-engineered human embryonic stem cell-derived cardiomyocytes can form a functional electrical syncytium with normally-quiescent recipient ventricular cells after transplantation.
  Volume: 86 Page(s): 293A - 293A
  01/01/2004 Authors: Cho HC; Xue T; Akar FG; Jones SP; Tomaselli GF; Marban E; Li RA
• Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2.
  J Physiol Volume: 550 Page(s): 365 - 372
  07/15/2003 Authors: Zobel C; Cho HC; Nguyen T-T; Pekhletski R; Diaz RJ; Wilson GJ; Backx PH
• Two critical cysteine residues implicated in disulfide bond formation and proper folding of Kir2.1.
  Biochemistry Volume: 39 Page(s): 4649 - 4657
  04/25/2000 Authors: Cho HC; Tsushima RG; Nguyen TT; Guy HR; Backx PH