Publications

Li, L., Schuchard, M., Palma, A., Pradier, L., and McNamee, M. G. Functional role of the Cys-451 thiol group in the M4 helix of the gamma subunit of Torpedo californica acetylcholine receptor. Biochemistry (1990) 29: 5428-5436

Ochoa, E.L.M., Li, L., Plummer, A., and McNamee, M. G. Direct effects of thymopentin (Arg-Lys-Asp-Val-Tyr) on cholinergic agonist-induced slow inactivation of nicotinic acetylcholine receptor function.  Molecular Pharmacology (1990) 38: 863-871

Eterovic, V. A., Li, L. Palma, A., and McNamee, M. G. Regulation of nicotinic acetylcholine receptor function by adenine nucleotides.  Cell. Mol. Neurobiology (1990) 10: 423-433

Ochoa, E.L.M., Li, L., and McNamee, M. G. Desensitization of central cholinergic mechanisms and neuroadaptation to nicotine.  Molecular Neurobiology (1990) 4: 251-287

Palma, A., Li, L., Chen, X. Pappone, P., and McNamee, M. G. Effects of pH on acetylcholine receptor function.  J. Membrane Biology (1991) 120: 67-73

Li, L. and McNamee, M. G. Modulation of nicotinic acetylcholine receptor channel by pH:  A difference in pH sensitivity of Torpedo and mouse receptors expressed in Xenopus oocytes. Cell. Mol. Neurobiology (1992) 12: 83-93

Li, L., Lee, Y-H., Pappone, P., Palma, A., and McNamee, M. G. Site-specific mutations of nicotinic acetylcholine receptor at the lipid-protein interface dramatically alter ion channel gating. Biophys. J. (1992) 62: 61-63

Eterovic, V. A., Li, L. Ferchmin, P. A., Lee, Y. H., Hann, R. M., and McNamee, M. G. The ion channel of muscle and electric organ acetylcholine receptors: differing affinities for noncompetitive inhibitors. Cell Mol. Neurobiology (1993) 13: 111-121

Eterovic, V. A., Hann, R. M., Ferchmin, P. A., Rodriguez, A. D., Li, L. Lee, Y. H., and McNamee, M. G. Diterpenoids from Caribbean gorgonians act as noncompetitive inhibitors of the nicotinic acetylcholine receptor.  Cell. and Mol. Neurobiology (1993) 13: 99-110

Li, L., Suzuki, T., Mori, N., and Greengard, P. Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. Proc. Natl. Acad. Sci. USA (1993) 90: 1460-1464

Lee, Y-H., Li, L., Lasalde, J., Rojas, L., McNamee, M. G., Ortiz-Miranda, S., and Pappone, P. Mutations in the M4 domain at the lipid-protein interface of Torpedo californica acetylcholine receptor dramatically alter ion channel Function. Biophys. J. (1994) 66: 646-653

Chin, L.-S., Li, L., and Greengard, P., Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements. J. Biol. Chem. (1994) 269: 18507-18513.

Li, L., Chin, L.-S., Greengard, P., Copeland, N. G., Gilbert, D. J., and Jenkins, N. A., Localization of the synapsin II gene to human chromosome 3 and mouse chromosome 6. Genomics (1995) 28: 365-366.

Chin, L.-S., Li, L., Ferreira, A., Kosik, K. S., and Greengard, P., Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc. Natl. Acad. Sci. USA (1995) 92: 9230-9234.

Li, L., Chin, L.-S., Shupliakow, O., Brodin L., Sihra, T., Hvalby, O., Jensen, V., Zheng, D., McNamara, J. O., Greengard, P., and Andersen, P., Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice.  Proc. Natl. Acad. Sci. USA (1995) 92: 9235-9239.

Ferreira, A., Li, L., Chin, L.-S., Greengard,P., and Kosik, K. S.,  Postsynaptic element contributes to the delay in synaptogenesis in synapsin I-deficient neurons. Molec. and Cell. Neurosci. (1996) 8: 286-299

Ryan, T. A., Li, L., Chin, L.-S., Greengard, P., and Smith, S. J., Synaptic vesicle recycling in synapsin I knockout mice. (1996) J. Cell Biol.  134: 1219-1228.

Ferreira, A., Chin, L.-S., Li, L., Lanier, L. M., Kosik, K. S., and Greengard, P., Distinct roles of synapsin I and synapsin II during neuronal development. (1998) Molecular Medicine 4:22-28.

Chin, L.-S., Fu, Q., Kachinsky, A. M., Jabren, G., Niu, Y., and Li, L., Neuron-specific and developmental regulation of the synapsin II gene expression in transgenic mice. Brain Res. Mol. Brain Res. (1999) 67: 239-246.

Walaas, S. I., Hilfiker, S., Li, L., Chin, L.-S., and Greengard, P., Decrease in phorbol ester-induced potentiation of noradrenaline release in synapsin I-deficient mice. Synapse (2000) 36:114-119.

Chin, L.-S., Nugent, R. D., Raynor, M. C., Vavalle, J. P., and Li, L., SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis.  J. Biol. Chem. (2000) 275: 1191-1200.

Kwong, J., Roudabush, F. L., Moore, P. H., Montague, M., Oldham, W., Li, Y., Chin, L.-S., and Li, L., Hrs interacts with SNAP-25 and regulates Ca²⁺-dependent exocytosis. J. Cell Sci. (2000) 113:2273-2284.

Chin, L.-S., Weigel, C., and Li, L., Transcriptional regulation of gene expression of Sec6, a component of mammalian exocyst complex at the synapse. Brain Res. Mol. Brain Res. (2000) 79: 127-137.

Chin, L.-S., Raynor, M. C., Wei, X., Chen, H-Q., and Li, L., Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J. Biol. Chem. (2001) 276: 7069-7078.

Li, Y., Chin, L.-S., Weigel, C., and Li, L., Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis. J. Biol. Chem.  (2001) 276: 40824-40833.

Wheeler, T. C., Chin, L.-S., Li, Y., Roudabush, F. L., and Li, L., Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J. Biol. Chem. (2002) 277: 10273-10282.

Li, Y., Chin, L.-S., Levey, A. I., and Li, L., Huntingtin-associated protein 1 interacts with Hrs and functions in endosomal trafficking. J. Biol. Chem. (2002) 277: 28212-28221.

Ahn, K., Yeyeodu, S., Collette, J., Madden, V., Arthur, J., Li, L., & Erickson, A. H. An alternate targeting pathway for procathepsin L in mouse fibroblasts. Traffic (2002) 3:147-159

Chin, L.-S., Vavalle J. P., and Li, L., Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. J. Biol. Chem. (2002) 277: 35071-35079.

Huai, Q., Sun, Y., Wang, H., Chin L.-S., Li, L., Robinson, H., and Ke, H., Crystal structure of DJ-1/RS and implication on familial Parkinson’s disease. FEBS Lett. (2003) 549: 171-175.

Li, L., and Chin, L.-S., The molecular machinery of synaptic vesicle exocytosis. Cell. Mol. Life Sci. (2003)  60: 942-960.

Choi, J., Levey, A. I., Weintraub, S. T., Rees, H. D., Gearing, M., Chin, L.-S., and Li, L., Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J. Biol. Chem. (2004) 279: 13256-13264.

Olzmann, J. A., Brown, K., Wilkinson, K. D., Rees, H. D., Huai, Q., Ke, H., Levey, A. I., Li, L.^*, and Chin L-S, Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.  J. Biol. Chem. (2004) 279: 8506-8515. (^*Corresponding author)

Choi, J., Rees, H. D., Weintraub, S. T., Levey, A. I., Chin, L.-S., and Li, L., Oxidative modifications and aggregation of Cu/Zn superoxide dismutase associated with Alzheimer's and Parkinson's diseases.  J. Biol. Chem.  (2005) 280: 11648-11655. (Featured in Faculty of 1000)

Choi, J., Sullards, M. C., Olzmann, J. A., Rees, H. D., Weintraub, S. T., Bostwick, D. E., Gearing, M., Levey, A. I., Chin, L.-S., and Li, L., Oxidative damage to DJ-1 is associated with sporadic Parkinson and Alzheimer diseases.  J. Biol. Chem. (2006) 281: 10816-10824.  PMCID: PMC1850953

Kirk, E. A., Chin, L.-S., and Li, L., GRIF1 binds Hrs and is a novel regulator of endosomal trafficking.  J. Cell Sci.  (2006)119: 4689-4701. (Highlighted by a preview in the same issue).

Olzmann, J. A., Bordelon, J. R., Muly, E. C., Rees, H. E., Levey, A. I., Li, L., and Chin L.-S., Selective enrichment of DJ-1 in primate striatal neuronal processes: Implications for Parkinson's disease.  J. Comp. Neurol. (2007) 500: 585-599.

Kim, B., Olzmann, J. A., Barsh, G. S., Chin, L-S., & Li, L. Spongiform neurodegeneration-associated E3 ligase mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol. Biol. Cell. (2007) 18: 1129–1142. PMCID: PMC1838976. (Featured in Faculty of 1000)

Pridgeon, J. W., Olzmann, J. A., Chin, L-S., & Li, L. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1.  PLoS Biol. (2007) 5: 1494-1503. [Featured in Faculty of 1000; Highlighted by Nature News & Views commentary (Nature 448:759-60) and by PLoS Biology Primer article (PLoS Biol. 5: e206)].

Olzmann, J. A., Li, L., Chudaev, M. V., Chen, J., Perez, F. A., Palmiter, R. D and Chin L.-S., Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J. Cell Biol. (2007) 178: 1025-1038. PMCID: PMC2064625

Li, L. and Chin, L.-S., Impairment of the ubiquitin-proteasome system: A common pathogenic mechanism in neurodegenerative disorders.  In The Ubiquitin Proteasome System in Nervous System: From Physiology to Pathology (2007) Edited by M. Di Napoli and C. Wojcik.  Nova Science Publishers, Inc.  Pages 553-577

Lee, C. M., Kim, B. Y., Li, L., & Morgan, E. T. Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins.  J. Biol. Chem. (2008) 283: 889-898

Lee, J. T., Wheeler, T. C., Li, L., and Chin, L.-S., Ubiquitination of a-synuclein by Siah-1 promotes a-synuclein aggregation and apoptotic cell death. Hum. Mol. Genet. (2008) 17: 906-917.

Giles, L.M., Chen, J., Li, L., and Chin, L.-S., Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type specific mislocalization to the nuclear envelope. Hum. Mol. Genet. (2008) 17:  2712-2722. PMCID: PMC2574948

Webber, E. A., Li, L., and Chin, L.-S., Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. J. Mol. Biol. (2008) 382: 638-651. PMCID: PMC2575741

Olzmann, J. A., Li, L., and Chin, L.-S., Aggresome formation and neurodegenerative diseases: therapeutic implications.  Curr. Med. Chem. (2008) 15: 47-60

Whatley, B. R., Li, L.*, & Chin, L-S. The ubiquitin-proteasome system in spongiform degenerative disorders.  Biochim. Biophys. Acta (2008) 1782: 700-712 (*corresponding author). PMCID: PMC2612938

Pridgeon, J. W., Webber, E. A., Sha, D., Li, L., and Chin, L.-S., Proteomic analysis reveals Hrs UIM-mediated ubiquitin signaling in multiple cellular processes.  FEBS J. (2009) 276: 118-131. PMCID: PMC2647816

Giles, L.M., Li, L.*, and Chin, L-S.*, Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. J. Biol. Chem. (2009) 284: 21765-21775. (*co-corresponding author) PMCID: PMC2755898

Giles, L.M., Li, L., and Chin, L.-S., TorsinA protein degradation and autophagy in DYT1 dystonia. Autophagy (2009) 5: 82-84. PMCID: PMC2606915

Sha, D., Chin, L.-S., and Li, L. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kB signaling. Hum. Mol. Genet. (2010) 19: 352-363. PMCID: PMC2796895

Chen, J., Li, L., and Chin, L.-S., Parkinson disease protein DJ-1 converts from a zymogen into a protease by carboxyl-terminal cleavage. Hum. Mol. Genet. (2010) 19: 2395-2408. PMCID: PMC2876885

Chin, L.-S., Olzmann, J. A., and Li, L., Parkin-mediated ubiquitin signaling in aggresome formation and autophagy.  Biochem. Soc. Trans. (2010) 38: 144-149. PMCID: PMC2796895

Olzmann, J. A., Chin, L.-S., and Li, L., The ubiquitin-proteasome system and the aggresome-autophagy pathway: Intersecting mechanisms of misfolded protein clearance in neurodegenerative disease.  In The Ubiquitin Proteasome System in the Central Nervous System (2010) Edited by M. Di Napoli and C. Wojcik.  Nova Science Publishers, Inc. Pages: 271-302

Lee, S. M., Olzmann, J. A., Chin L-S., & Li, L., Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. J. Cell Sci. (2011) 124: 3319–3331. PMCID: PMC3178453

Lee, S. M., Chin L-S., & Li, L. Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking.  J. Cell Biol. (2012) 199: 799-816. PMCID: PMC3514783. (Highlighted by a preview in the same issue).

Lee, S. M., Chin, L.-S.*, and Li, L.*, Protein misfolding and clearance in demyelinating peripheral neuropathies: therapeutic implications. Commun Integr Biol. (2012) 5: 107-110. (*Co-corresponding author). PMCID: PMC3291304

Klionsky, D. J., Abdalla, F.C., Abeliovich, H., ... Li, L. et al, Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 8: 445-544.  PMCID: PMC3404883

Hurst-Kennedy, J., Chin, L.-S., and Li, L., Ubiquitin C-terminal hydrolase L1 in tumorigenesis.  Biochem. Res. Int. (2012) 2012: 123706. PMCID: PMC3395355.

Lee, S. M., Chin, L.-S., and Li, L., Therapeutic implications of protein homeostasis in demyelinating peripheral neuropathies.  Expert Rev. Neurother. (2012) 12: 1041-1043.

Lee, S. M., Sha, D., Mohammed, A. A., Asress, S., Glass, J.D., Chin L-S., & Li, L. Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C. Hum Mol Genet. (2013) 22:1755-70. PMCID: PMC3613163.

Chin, L.-S., Lee, S. M., and Li, L., SIMPLE: a new regulator of endosomal trafficking and signaling in health and disease. Commun Integr Biol. (2013) 6: e24214. PMCID: PMC3656027

McKeon, J., Sha, D., Li, L., and Chin L.-S., Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.  Cell. Mol. Life Sci. (2015) 72:1811-1824.  PMCID: PMC439552

Fallaize, D.V., Chin, L.-S., and Li, L., Differential submitochondrial localization of PINK1 as a molecular switch for mediating distinct mitochondrial signaling pathways. Cell Signal. (2015) 27: 2543-2554. PMCID: PMC4684445

Yung, C., Sha, D., Li, L., and Chin L.-S., Parkin protects against misfolded SOD1 toxicity by promoting its aggresome formation and autophagic clearance. Mol. Neurobiol. (2016) 53: 6270-6287. PMCID: PMC4866905.

Chin L.-S., and Li, L., Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment. Transl. Neurodegener. (2016) 5:1 PMCID: PMC4702311

Shimizu, Y., Lambert, J.P., Nicholson, C.K., Kim, J.J., Husain, A., Naqvi, N.N., Chin, L.-S., Li, L., and Calvert, J.W., DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission. J Mol Cell Cardiol. (2016) 97:56-66. PMCID: PMC5002379

Klionsky, D. J., Abdelmohsen, K., Abdalla, F.C., Abedin, M. J., ... Li, L. et al, Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2016) 12:1-222

Lee, C., Chin L.-S., and Li, L., Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.  Protein Cell (2018) 9:693-716. PMCID: PMC6053349

Lee, S. M., Chin L.-S., and Li, L., Dysregulation of ErbB receptor trafficking and signaling in demyelinating Charcot-Marie-Tooth disease. Mol. Neurobiol. (2017) 54:87-100. PMCID: PMC4935639

Zlatic SA, Vrailas-Mortimer A, Gokhale A, Carey, LJ, Scott E, Burch R, McCall MM, Rudin-Rush S, Davis JB, Hartwig C, Werner E, Li, L., Petris M, and Faundez, V. Rare disease mechanisms identified by genealogical proteomics of copper homeostasis mutant pedigrees.  Cell Syst. (2018) 6:368-380. PMCID: PMC5876136

Zhang, Q., Ma, C., Gearing, M., Wang, P. G., Chin, L.-S., and Li, L., Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease.  Acta Neuropathol Commun. (2018) 6(1):19. doi: 10.1186/s40478-018-0524-2. PMCID: PMC5831854

Lee, S. M., Asress, S., Hales, C.M., Gearing, M., Vizcarra, J.C., Fournier, C.N., Gutman, D.A., Chin L.-S., Li, L.*, & Glass, J.D.*, TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration. Brain Commun. (2019) 1(1):fcz014. doi: 10.1093/braincomms/fcz014. (*corresponding author). PMCID: PMC6788139

Shimizu, Y., Nicholson, C.K., Polavarapu, R. Pantner, Y., Husain, A., Naqvi, N.N., Chin, L.-S., Li, L., and Calvert, J.W., Role of DJ-1 in Modulating Glycative Stress in Heart Failure.  J. Am Heart Assoc. (2020) 9(4): e014691. doi: 10.1161/JAHA.119.014691.  PMCID: PMC7070196

Zhang, Q., Ma, C., Chin, L.-S., and Li, L., Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer’s disease.  Sci. Adv. (2020) 6(40): eabc5802. doi: 10.1126/sciadv.abc5802. PMCID: PMC7852392.

Pantner, Y., Polavarapu, R., Chin, L.-S., Li, L., Shimizu, Y., and Calvert, J.W., DJ-1 attenuates the glycation of mitochondrial complex I and complex III in the post-ischemic heart. Sci. Rep. (2021) 11(1): 19408. doi: 10.1038/s41598-021-98722-1

Zhang, Q., Ma, C., Li, L.*, & Chin L-S.*, Differential analysis of N-glycopeptide abundance and N-glycosylation site occupancy for studying protein N-glycosylation dysregulation in human disease.  Bio-Protocol (2021) 11(12): e4059.  (*corresponding author). PMCID: PMC8260255

Ma, C., Tsai, H. Zhang, Q., Senavirathna, L. Li, L., Chin, L.-S., Chen, R., and Pan, S., Integrated proteomic and glycoproteomic investigation reveals alterations in N-glycoproteomic network induced by 2-deoxy-D-glucose in colorectal cancer cells. Int. J. Mol. Sci. (2022) 23, 8251. PMCID: PMC9331968

Zhang, Q., Ma, C., Chin L-S., Pan, S., & Li, L. Human brain glycoform co-regulation network and glycan modification alterations in Alzheimer’s disease.  bioRxiv. Preprint. (2023) doi: 10.1101/2023. 11.13.566889. PMCID: PMC10680592

Zhang, Q., Ma, C., Chin, L.-S., Pan, S., Li, L., Human brain glycoform coregulation network and glycan modification alterations in Alzheimer’s disease. Sci. Adv. (2024) 10(14): eadk6911. doi: 10.1126/ sciadv.adk6911  PMCID: PMC10997212

Chen, R-H., Costa-Filho, A.J., Debnath, J., Galli, T., Ge, L., Goberdhan, D., Guo, W., He, K., Jacob, R., Kang, T., Lee, M.G., Li, L. et al., Beyond the Secretory Pathway: New Insights into Protein Release. Traffic (2025) 26(10-12): e70022. doi: 10.1111/tra.70022. PMCID: PMC12590341