David Guidot MD
- Department of Medicine
Professor
- (404) 712-2970
- dguidot@emory.edu
-
Emory University
Medicine/Division of Pulmonary, Allergy, Critical Care & Sleep Medicine
615 Michael Street, Suite 205
Overview
Dr. Guidot completed undergraduate and medical school education at the University of Michigan, obtaining his MD in 1984. He trained in Internal Medicine at the University of Minnesota from 1984-1987 and then served an additional year as Chief Medical Resident. After his chief residency, he moved to the University of Colorado for clinical and research fellowship training in Pulmonary & Critical Care Medicine from 1988-1992 where he worked in the laboratories of John Repine and Joe McCord. After three years as Assistant Professor at Colorado, he was recruited to Emory University in 1995 by Dr. Roland Ingram and started an independent research laboratory at the Atlanta VA Medical Center. In 1999, he was promoted to Associate Professor of Medicine with tenure, and in 2006 was promoted to the rank of Professor of Medicine with tenure. He has served in numerous leadership positions since joining the Emory faculty, including Pulmonary Section Chief at the VA, Director of the Pulmonary and Critical Care Medicine Fellowship Training Program, and Associate Division Director for Research. In 2009, he became Division Director and in 2010 was appointed as the Jeffrey R. Pine Chaired Professor of Medicine through the generous endowment of the Amos family.
Dr. Guidot has focused his research on the mechanisms by which chronic insults such as alcohol abuse and HIV infection cause oxidative stress and render individuals susceptible to pneumonia and acute lung injury. He has been continuously funded by extramural sources including the NIH for three decades and directs a large multidisciplinary research program that spans experimental laboratory studies to clinical trials. He is a dedicated mentor who has trained more than twenty-five post-doctoral MD and PhD fellows, many of whom remain in academic careers, and has directed an NIH T32 training program since 2002. He has also mentored multiple junior faculty investigators on their NIH- or VA-funded career development awards. In addition to his research and administrative activities, he continues to see patients and supervise students, residents and fellows at Grady Memorial Hospital.
Academic Appointment
- Professor of Medicine with tenure, Division of Pulmonary, Allergy & Critical Care Medicine, Emory University
Education
Degrees
- BS from University of Michigan
- MD from University of Michigan
Research
Focus
- My research focus is identifying mechanisms by which oxidative stress injures the lung. Currently, a significant aspect of this work involves the study of how chronic alcohol ingestion and/or HIV-1 perturbs the homeostasis of the critical antioxidant, glutathione, and how glutathione depletion leads to an array of cellular defects that render the lung susceptible to acute edematous injury and infection. More recently, we have focused on the roles of zinc depletion and down-regulation of the transcription factor Nrf2
Publications
-
Ethanol-exposed lung fibroblasts cause airway epithelial barrier dysfunction.
Alcohol Clin Exp Res (Hoboken) Volume: 47 Page(s): 1839 - 1849
10/01/2023 Authors: Sueblinvong V; Fan X; Hart C; Molina S; Koval M; Guidot DM -
MYOSIN LIGHT CHAIN KINASE DELETION WORSENS LUNG PERMEABILITY AND INCREASES MORTALITY IN PNEUMONIA-INDUCED SEPSIS.
Shock Volume: 59 Page(s): 612 - 620
04/01/2023 Authors: Chihade DB; Smith P; Swift DA; Otani S; Zhang W; Chen C-W; Jeffers LA; Liang Z; Shimazui T; Burd EM -
Alcohol impairs recognition and uptake of Mycobacterium tuberculosis by suppressing toll-like receptor 2 expression.
Alcohol Clin Exp Res Volume: 46 Page(s): 2214 - 2224
12/01/2022 Authors: Wigger GW; Khani D; Ahmed M; Sayegh L; Auld SC; Fan X; Guidot DM; Staitieh BS -
Chronic Alcohol Exposure Impairs Alveolar Macrophage Effector Function and Heme Oxygenase-1 Expression in Response to Mycobacterium Tuberculosis
Volume: 205
05/01/2022 Authors: Wigger GW; Khani D; Auld S; Fan X; Guidot DM; Staitieh BS -
ARDS - Paradigms Lost and Found.
Am J Med Sci Volume: 362 Page(s): 535 - 536
12/01/2021 Authors: Guidot DM -
Alcohol impairs alveolar macrophages responses to Mycobacterium tuberculosis
Volume: 203
05/01/2021 Authors: Sayegh L; Ahmed M; Fan X; Auld S; Guidot DM; Staitieh BS -
ALCOHOL IMPAIRS ALVEOLAR MACROPHAGES RESPONSES TO MYCOBACTERIUM TUBERCULOSIS
Volume: 69 Page(s): 458 - 458
02/01/2021 Authors: Sayegh L; Ahmed M; Fan X; Auld SC; Guidot D; Staitieh BS -
HIV Impairs Alveolar Macrophage Function via MicroRNA-144-Induced Suppression of Nrf2.
Am J Med Sci Volume: 361 Page(s): 90 - 97
01/01/2021 Authors: Fan X; Murray SC; Staitieh BS; Spearman P; Guidot DM -
HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension.
Sci Rep Volume: 10 Page(s): 11696
07/16/2020 Authors: Almodovar S; Wade BE; Porter KM; Smith JM; Lopez-Astacio RA; Bijli K; Kang B-Y; Cribbs SK; Guidot DM; Molehin D -
CHRONIC ALCOHOL INGESTION INDUCES CIRCADIAN DYSREGULATION OF PROFIBROTIC GENES IN THE MURINE LUNG
Volume: 44 Page(s): 48 - 48
06/01/2020 Authors: Stephens D; Fan X; Staitieh B; Guidot DM; Sueblinvong V