Young-Mi Go PhD
- Department of Medicine
Professor
- (404) 727-5984
- ygo@emory.edu
-
Emory University
Medicine
615 Michael street, RM225
Overview
Dr. Go studied Biology for undergraduate at Korea University, Seoul, Korea. She joined graduate program at the University of Alabama at Birmingham and received a PhD in Molecular Pathology in 2000. She moved to Atlanta, GA in 2001and completed postdoctoral training in Biochemistry at Emory University. She then joined a faculty member in the Department of Medicine in 2009 and became Professor in 2023.
Dr. Go's research career has focused on identifying redox signaling and control mechanisms associated with pulmonary and cardiovascular diseases in response to environmental stressors. Her research aims to understand the redox communication between subcellular compartments that impact critical mechanisms of oxidative stress-associated disease initiation and progression specifically using integrative omics method-based systems biology. This strategy uses multi-omics platform, redox proteomics, metabolomics and transcriptomics to study communications between subcellular compartments that impact oxidative stress-associated cell signaling in pathologic conditions. Using this strategy, her studies are able to identify central hubs and networks of redox-sensitive proteins and metabolites, transcripts, and determine further interaction to pathologic outcome features.
Dr. Go's current research is focused on studying metabolic and mechanistic responses in pulmonary system to environmental and nutritional metal exposures with several sub-aims: 1) mechanistic studies of environmental heavy metals -caused lung inflammation and fibrosis, 2) investigation of cause-effect relationships by clinical metabolomics using complementary experimental metabolomics, and 3) the study of subcellular redox communication.
She has over 150 peer-reviewed publications including original research articles, reviews and book chapters. A complete list of published work can be found in direct URL: https://www.ncbi.nlm.nih.gov/sites/myncbi/young-mi.go kang.1/collections/52000406/public/.
Academic Appointment
- Professor of Medicine, Emory University School of Medicine
- Professor, Biomedical Informatics, Emory University
- Professor, James T. Laney School of Graduate Studies
Education
Degrees
- PhD from University of Alabama at Birmingham
- BS from Korea University
Research
Focus
- My research has been focused on identifying mechanisms of oxidative stress and signal transduction in atherosclerosis. Following my PhD in studying shear stress-induced signal transduction in endothelial cells, I pursued post-doctoral studies with Dr. Dean Jones to investigate thiol/disulfide redox-dependent regulatory mechanism in endothelial cell signaling.
Publications
-
Cadmium exposure following early-life respiratory syncytial virus infection promotes lung fibrosis through autophagy inhibition.
Toxicol Sci
04/23/2025 Authors: Jarrell ZR; Lee C-M; Lee HY; Kim K-H; Lim G; Orr M; Kang S-M; Chen Y; Jones DP; Go Y-M -
Untargeted metabolomics of 3xTg-AD neurotoxic astrocytes.
J Proteomics Volume: 310 Page(s): 105336
01/06/2025 Authors: Carvalho D; Diaz-Amarilla P; Smith MR; Santi MD; Martinez-Busi M; Go Y-M; Jones DP; Duarte P; Savio E; Abin-Carriquiry JA -
Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog.
J Biol Chem Volume: 301 Page(s): 108074
01/01/2025 Authors: Weinberg J; Liu KH; Lee C-M; Crandall WJ; Cuevas AR; Druzak SA; Morgan ET; Jarrell ZR; Ortlund EA; Martin GS -
Mechanistic role for mTORC1 signaling in profibrotic toxicity of low-dose cadmium.
Toxicol Appl Pharmacol Volume: 494 Page(s): 117159
01/01/2025 Authors: Lee C-M; Lee HY; Jarrell ZR; Smith MR; Jones DP; Go Y-M -
A pilot metabolomics study across the continuum of interstitial lung disease fibrosis severity.
Physiol Rep Volume: 12 Page(s): e70093
10/01/2024 Authors: Zhan J; Jarrell ZR; Hu X; Weinberg J; Orr M; Marts L; Jones DP; Go Y-M -
Pyrimidine Biosynthesis in Branching Morphogenesis Defects Induced by Prenatal Heavy Metal Exposure.
Am J Respir Cell Mol Biol Volume: 71 Page(s): 372 - 375
09/01/2024 Authors: Wongtrakool C; Ma J; Jarrell ZR; Liu KH; Orr M; Tran V; Gauthier TW; Marsit CJ; Jones DP; Go Y-M -
Metabolic alterations and mitochondrial dysfunction in human airway BEAS-2B cells exposed to vanadium pentoxide.
Toxicology Volume: 504 Page(s): 153772
05/01/2024 Authors: He X; Smith MR; Jarrell ZR; Thi Ly V; Liang Y; Lee C-M; Orr M; Go Y-M; Jones DP -
Protein S-palmitoylation enhances profibrotic signaling in response to cadmium.
Toxicol Appl Pharmacol Volume: 483 Page(s): 116806
02/01/2024 Authors: Lee C-M; Jarrell ZR; Lee HY; Singer G; Tran VT; Orr M; Jones DP; Go Y-M -
Metabolic reprograming and increased inflammation by cadmium exposure following early-life respiratory syncytial virus infection-the involvement of protein S-palmitoylation.
Toxicol Sci Volume: 197 Page(s): 186 - 196
11/06/2023 Authors: Jarrell ZR; Lee C-M; Kim K-H; He X; Smith MR; Raha JR; Bhatnagasr N; Orr M; Kang S-M; Chen Y -
Discovery of phytochelatins in human urine: Evidence for function in selenium disposition and protection against cadmium.
FASEB Bioadv Volume: 5 Page(s): 367 - 375
09/01/2023 Authors: Jarrell ZR; Liu KH; Dennis KK; Hu X; Martin GS; Jones DP; Go Y-M