Dmitry Shayakhmetov PhD
Overview
Dr. Shayakhmetov obtained his BS degree in biochemistry and PhD degree in molecular biology and virology under the supervision of one of the leading virologists in Russia, Professor Thomas Tikchonenko. He obtained his postdoctoral training in virology and immunology in the laboratory of Dr. Andre Lieber, in the Department of Medicine at the University of Washington, in Seattle, where he was appointed to faculty as an Assistant Professor (2005) and later promoted to an Associate Professor (2010). Dr. Shayakhmetov joined the Lowance Center for Human Immunology at Emory University in April of 2014.
The main focus of Dr. Shayakhmetovs research program has been on improving our understanding of the role of innate immunity in initiating and exacerbating inflammation in response to viral (adenovirus) and bacterial pathogens, and tissue damage. The interplay between pro-inflammatory IL-1- and TNF-dependent signaling pathways in the context of infection and sterile tissue damage is the current focus of his research. Specifically, he is interested to understand the role of non-apoptotic pro-inflammatory cell death in triggering devastating local and systemic inflammation, associated with severe acute bacterial infections, sepsis, and several autoimmune and autoinflammatory disorders.
In 2008, Dr. Shayakhmetov was awarded the Outstanding New Investigator Award by the American Society of Gene and Cell Therapy for his contribution to deciphering molecular mechanisms triggering severe inflammation to adenovirus vectors in clinically-relevant settings.
Dr. Shayakhmetov is a member of several professional societies, including American Association of Immunologists, American Society for Microbiology, American Association for the Advancement of Science, and American Society of Gene and Cell Therapy. He serves as an Editorial Board member of Molecular Therapy, Cancer Gene Therapy, and Genes and Immunity journals, as well as participating as an ad hoc reviewer at the NIH study sections (VIR-A, GDD, and III) and many international grant review panels. Dr. Shayakhmetov has served as a regular member (2012-2014) and as a Chair (2014-2016) of the NIH Innate Immunity and Inflammation study section.
Over the years, Dr. Shayakhmetovs research program has been supported by the grants from the National Institutes of Health and private foundations, including Cystic Fibrosis Foundation and the Bill and Melinda Gates Foundation.
Academic Appointment
- Professor of Pediatrics, Pediatrics - Rheumatology, Emory University School of Medicine
- Professor of Medicine, Medicine - Rheumatology, Emory University School of Medicine
Education
Degrees
- PHD from National Scientific Research Institute of Applied Biotechnology
Research
Publications
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Improving efficacy of invivo therapy of sickle cell disease by hijacking natural biology of hematopoietic stem cells.
Mol Ther Volume: 32 Page(s): 4167 - 4169
12/04/2024 Authors: Yao J; Shayakhmetov DM -
Targeted, safe, and efficient gene delivery to human hematopoietic stem and progenitor cells invivo using the engineered AVID adenovirus vector platform.
Mol Ther Volume: 32 Page(s): 3743 - 3745
10/02/2024 Authors: Yao J; Atasheva S; Wagner N; Di Paolo NC; Stewart PL; Shayakhmetov DM -
TLR9-independent CD8+ Tcell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.
Mol Ther Volume: 32 Page(s): 325 - 339
02/07/2024 Authors: Kumar SRP; Biswas M; Cao D; Arisa S; Muoz-Melero M; Lam AK; Pieros AR; Kapur R; Kaisho T; Kaufman RJ -
Targeted, safe, and efficient gene delivery to human hematopoietic stem and progenitor cells in vivo using the engineered AVID adenovirus vector platform.
Mol Ther Volume: 32 Page(s): 103 - 123
01/03/2024 Authors: Yao J; Atasheva S; Wagner N; Di Paolo NC; Stewart PL; Shayakhmetov DM -
A paracrine circuit of IL-1/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.
J Clin Invest Volume: 133
11/15/2023 Authors: Chen Z; Giotti B; Kaluzova M; Vallcorba MP; Rawat K; Price G; Herting CJ; Pinero G; Cristea S; Ross JL -
Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus.
Viruses Volume: 15
06/09/2023 Authors: Wagner N; Shayakhmetov DM; Stewart PL -
p38MAPK guards the integrity of endosomal compartments through regulating necrotic death.
Sci Rep Volume: 12 Page(s): 16357
09/29/2022 Authors: Yao J; Atasheva S; Toy R; Blanchard EL; Santangelo PJ; Roy K; Mocarski ES; Shayakhmetov DM -
Adenovirus-based vaccines-a platform for pandemic preparedness against emerging viral pathogens.
Mol Ther Volume: 30 Page(s): 1822 - 1849
05/04/2022 Authors: Coughlan L; Kremer EJ; Shayakhmetov DM -
Cytokine Responses to Adenovirus and Adenovirus Vectors.
Viruses Volume: 14
04/24/2022 Authors: Atasheva S; Shayakhmetov DM -
Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation.
Apoptosis Volume: 26 Page(s): 361 - 370
06/01/2021 Authors: Kolachala VL; Lopez C; Shen M; Shayakhmetov D; Gupta NA