Tatiana Chernova PhD

Department of Biochemistry
Assistant Professor

(404) 376-3989
tcherno@emory.edu

Emory University School of Medicine
Biochemistry
1510 Clifton Rd., Room 4011 RRC

Academic Appointment

Assistant Professor, Department of Biochemistry, Emory University

Education

Degrees

PhD from Institute of Agricultural Microbiology, Academy of Agricultural Sciences
BS from St. Petersburg University

Research

Focus

Ubiquitin-dependent proteolysis as a regulator of protein homeostasis and its role in formation of prions and other amyloid-like protein aggregates associated with neurodegenerative diseases.

Publications

Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologies.
Cell Volume: 187 Page(s): 6994 - 7007.e12
11/27/2024 Authors: Sastre DE; Bournazos S; Du J; Boder EJ; Edgar JE; Azzam T; Sultana N; Huliciak M; Flowers M; Yoza L
Profiling and verifying the substrates of E3 ubiquitin ligase Rsp5 in yeast cells.
STAR Protoc Volume: 4 Page(s): 102489
09/15/2023 Authors: Fang S; Chen G; Wang Y; Ganti R; Chernova TA; Zhou L; Jacobs SE; Duong D; Kiyokawa H; Chernoff YO
Yeast Chaperone Hsp70-Ssb Modulates a Variety of Protein-Based Heritable Elements.
Int J Mol Sci Volume: 24
05/12/2023 Authors: Jay-Garcia LM; Cornell JL; Howie RL; Faber QL; Salas A; Chernova TA; Chernoff YO
Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer.
Cell Chem Biol Volume: 28 Page(s): 1283 - 1297.e8
09/16/2021 Authors: Wang Y; Fang S; Chen G; Ganti R; Chernova TA; Zhou L; Duong D; Kiyokawa H; Li M; Zhao B
Cellular O-Glycome Reporter/Amplification (CORA): Analytical and Preparative Tools to Study Mucin-Type O-Glycans of Living Cells.
Curr Protoc Volume: 1 Page(s): e142
06/01/2021 Authors: Kudelka MR; Li Z; Chernova TA; Smith DF; Song X; Cummings RD; Ju T
Amplification and Preparation of Cellular O-Glycomes for Functional Glycomics.
Anal Chem Volume: 92 Page(s): 10390 - 10401
08/04/2020 Authors: Li Z; Zhang Q; Ashline D; Zhu Y; Lasanajak Y; Chernova T; Reinhold V; Cummings RD; Wang PG; Ju T
Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
Int J Mol Sci Volume: 21
07/16/2020 Authors: Chernova TA; Yang Z; Karpova TS; Shanks JR; Shcherbik N; Wilkinson KD; Chernoff YO
Application of yeast to studying amyloid and prion diseases.
Adv Genet Volume: 105 Page(s): 293 - 380
01/01/2020 Authors: Chernoff YO; Grizel AV; Rubel AA; Zelinsky AA; Chandramowlishwaran P; Chernova TA
Synthesis and Characterization of Versatile O-Glycan Precursors for Cellular O-Glycomics.
ACS Synth Biol Volume: 8 Page(s): 2507 - 2513
11/15/2019 Authors: Zhang Q; Li Z; Chernova T; Saikam V; Cummings R; Song X; Ju T; Smith DF; Wang PG
Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery.
Molecules Volume: 24
09/18/2019 Authors: Chernova TA; Chernoff YO; Wilkinson KD
Novel Technologies for Quantitative O-Glycomics and Amplification/Preparation of Cellular O-Glycans
Volume: 11 Page(s): 370 - 392
01/01/2019 Authors: Li Z; Chernova TA; Ju T
Development of a novel yeast cell-based system for studying Core 1-beta 3Galactosyltransferase and its Molecular Chaperone Cosmc
Volume: 28 Page(s): 1088 - 1088
12/01/2018 Authors: Chernova TA; Wang Q; Smith DF; Ju T
A Yeast Model to Define the Molecular Interactions between Core 1 b3GalT and its Molecular Chaperone Cosmc
Volume: 27 Page(s): 1213 - 1213
12/01/2017 Authors: Chernova TA; Wang Q; Jiang Y; Smith DF; Ju T
Quantitative O-Glycomics: metabolic Stable Isotopic Labeling of O-glycomes of cultured Cells (SILOC)
Volume: 27 Page(s): 1214 - 1214
12/01/2017 Authors: Chernova TA; Li Z; Jiang Y; Wang Q; Smith DF; Ju T
Amplification and Preparation of Cellular O-glycans using Cellular O-glycome Reporter/Amplification (CORA)
Volume: 27 Page(s): 1212 - 1213
12/01/2017 Authors: Li Z; Zhang Q; Chernova T; Wang G; Song X; Smith DF; Richard CD; Ju T
To CURe or not to CURe? Differential effects of the chaperone sorting factor Cur1 on yeast prions are mediated by the chaperone Sis1.
Mol Microbiol Volume: 105 Page(s): 242 - 257
07/01/2017 Authors: Barbitoff YA; Matveenko AG; Moskalenko SE; Zemlyanko OM; Newnam GP; Patel A; Chernova TA; Chernoff YO; Zhouravleva GA
Prion-based memory of heat stress in yeast.
Prion Volume: 11 Page(s): 151 - 161
05/04/2017 Authors: Chernova TA; Chernoff YO; Wilkinson KD
Prions, Chaperones, and Proteostasis in Yeast.
Cold Spring Harb Perspect Biol Volume: 9
02/01/2017 Authors: Chernova TA; Wilkinson KD; Chernoff YO
Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress.
Cell Rep Volume: 18 Page(s): 751 - 761
01/17/2017 Authors: Chernova TA; Kiktev DA; Romanyuk AV; Shanks JR; Laur O; Ali M; Ghosh A; Kim D; Yang Z; Mang M
Distinct types of translation termination generate substrates for ribosome-associated quality control.
Nucleic Acids Res Volume: 44 Page(s): 6840 - 6852
08/19/2016 Authors: Shcherbik N; Chernova TA; Chernoff YO; Pestov DG
Formation of a metastable stress-inducible prion by the yeast short-lived actin associated protein
PRION Volume: 10 Page(s): S66 - S67
01/01/2016 Authors: Chernova TA; Kiktev DA; Romanyuk AV; Shanks JR; Ali M; Ghosh A; Yang Z; Kim D; Mang M; Chernoff YO
Formation of a Metastable Prion by the Yeast Actin Associated Protein Lsb2
Volume: 32 Page(s): S206 - S207
09/01/2015 Authors: Chernova TA; Shanks J; Chernoff YO; Wilkinson KD
Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.
J Biol Chem Volume: 289 Page(s): 27625 - 27639
10/03/2014 Authors: Ali M; Chernova TA; Newnam GP; Yin L; Shanks J; Karpova TS; Lee A; Laur O; Subramanian S; Kim D
Yeast studies reveal moonlighting functions of the ancient actin cytoskeleton.
IUBMB Life Volume: 66 Page(s): 538 - 545
08/01/2014 Authors: Sattlegger E; Chernova TA; Gogoi NM; Pillai IV; Chernoff YO; Munn AL
Physiological and environmental control of yeast prions.
FEMS Microbiol Rev Volume: 38 Page(s): 326 - 344
03/01/2014 Authors: Chernova TA; Wilkinson KD; Chernoff YO
Proteolytic processing of the actin assembly protein Lsb1 is stress dependent and modulates aggregation of other proteins
Volume: 30 Page(s): 62 - 62
09/01/2013 Authors: Chernova T; Ali M; Yin L; Newnam GP; Chernoff YO; Wilkinson KD
Integration of chaperone networks acting in stress defense, protein folding, trafficking and prion propagation
Volume: 280 Page(s): 227 - 228
07/01/2013 Authors: Chernoff Y; Kiktev D; Howie R; Newnam G; Chernova T; Ali M; Wilkinson K
Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton.
Mol Cell Volume: 43 Page(s): 242 - 252
07/22/2011 Authors: Chernova TA; Romanyuk AV; Karpova TS; Shanks JR; Ali M; Moffatt N; Howie RL; O'Dell A; McNally JG; Liebman SW
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
Cancer Res Volume: 68 Page(s): 6953 - 6962
09/01/2008 Authors: Ventii KH; Devi NS; Friedrich KL; Chernova TA; Tighiouart M; Van Meir EG; Wilkinson KD
Prion formation in yeast is influenced by alterations of the ubiquitin proteolysis
FASEB JOURNAL Volume: 22
04/01/2008 Authors: Chernova TA; Allen KD; Chernoff YO; Wilkinson KD
Effects of ubiquitin system alterations on the formation and loss of a yeast prion.
J Biol Chem Volume: 282 Page(s): 3004 - 3013
02/02/2007 Authors: Allen KD; Chernova TA; Tennant EP; Wilkinson KD; Chernoff YO
Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain
Volume: 20 Page(s): A1353 - A1353
03/07/2006 Authors: Mullally JE; Chernova T; Wilkinson KD
Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain.
Mol Cell Biol Volume: 26 Page(s): 822 - 830
02/01/2006 Authors: Mullally JE; Chernova T; Wilkinson KD
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
EMBO J Volume: 24 Page(s): 3747 - 3756
11/02/2005 Authors: Hu M; Li P; Song L; Jeffrey PD; Chenova TA; Wilkinson KD; Cohen RE; Shi Y
Novel effects of ubiquitin system and chaperone proteins on the prion "life cycle" in yeast
Volume: 272 Page(s): 152 - 152
07/01/2005 Authors: Chernova TA; Allen KD; Tennant EP; Wilkinson KD; Chernoff YO
Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+].
Genetics Volume: 169 Page(s): 1227 - 1242
03/01/2005 Authors: Allen KD; Wegrzyn RD; Chernova TA; Mller S; Newnam GP; Winslett PA; Wittich KB; Wilkinson KD; Chernoff YO
Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of free ubiquitin pool (vol 278, pg 52102, 2003)
JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 279 Page(s): 16894 - 16894
04/16/2004 Authors: Chernova TA; Allen KD; Wesoloski LM; Shanks JR; Chernoff YO; Wilkinson KD
Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool.
J Biol Chem Volume: 278 Page(s): 52102 - 52115
12/26/2003 Authors: Chernova TA; Allen KD; Wesoloski LM; Shanks JR; Chernoff YO; Wilkinson KD
Deubiquitinating enzymes in the pathogenesis of neurodegenerative diseases: the view from the yeast system.
Volume: 20 Page(s): S298 - S298
07/01/2003 Authors: Chernova TA; Allen KD; Shanks JR; Chernoff YO; Wilkinson KD
Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein.
Mol Microbiol Volume: 35 Page(s): 865 - 876
02/01/2000 Authors: Chernoff YO; Galkin AP; Lewitin E; Chernova TA; Newnam GP; Belenkiy SM
The ubiquitin pathway in Parkinson's disease.
Nature Volume: 395 Page(s): 451 - 452
10/01/1998 Authors: Leroy E; Boyer R; Auburger G; Leube B; Ulm G; Mezey E; Harta G; Brownstein MJ; Jonnalagada S; Chernova T

Department of Biochemistry section navigation

Profile

Tatiana Chernova PhD

Academic Appointment

Education

Degrees

Research

Focus

Publications