Welcome to the Ortlund Lab
We use sophisticated structural biology techniques such as x-ray crystallography and mass spectrometry coupled with an array of biochemical techniques to gain a molecular level understanding of transcriptional signaling - with a particular focus on lipid mediated signaling and transport. We currently pursue structural and biochemical studies of human nuclear receptors, which are lipid regulated transcription factors that play central roles in development, cancer, stress and metabolism. We have also made seminal contributions to the field of molecular evolution using nuclear receptors as a model system to study how tight molecular partnerships evolve.
Latest News
- April 2022, New Award. Graduate Student Michael “Cato” Lee received the John B. Lyon Memorial Scholarship.
- November 2021, New Publication. Congratulations to the Ortlund Lab for their publication, "TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis." in PLoS Pathology.
- November 2021, New Lab Member. The Ortlund Lab welcomes new postdoc Zhenxin Hou, PhD to the team.
- September 2021, New Publication. Congratulations to Filip Frank, Xu Liu and Eric Ortlund for their publication, "Structural insights into glucocorticoid receptor function," in Biochem Soc Trans.
- August 2021, New Publication. Congratulations to the Ortlund lab for their publication, "Upregulation of Thioesterase Superfamily Member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance," in Hepatology.
- July 2021, New Publication. Congratulations to Dr. Filipp Frank, Dr. Xu Liu, and Prof. Ortlund on their recent publilcation in PNAS, “Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation.”
- July 2021, New Publication. Congratulations to Dr. Xu Liu, Dr. Emily Weikum, and Prof. Ortlund on their publication in Nucleic Acids Research titled, "Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element."
- July 2021, New Award: Instructor Dr. Xu Liu Receives the American Heart Association Career Development Award
- January 2021, New Publication. Congratulations to the Ortlund Lab for their publication in Nat Chem Biol. titled, "Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling".
- January 2021, New Award. Congratulations to the Ortlund Lab on being awarded a Lilly Research Award Program (LRAP) grant from Eli Lilly Pharmaceuticals to pursue the structure and function of LRH-1 modulators.
- January 2021, New Award. Congratulations to the Xu Liu on being awarded a grant from the Foundation to Eradicate Duchenne’s. Award title: "Vamorolone and DMD heart: Elucidating the molecular mechanism of action as a mineralocorticoid receptor antagonist".
- January 2021, New Lab Member. New BCDB Graduate Student, André Cuevas, joins the lab.
