Representative Ortlund Lab Publications

MoTrPAC Study Group, Lead Analysts, & MoTrPAC Study Group. Temporal dynamics of the multi-omic response to endurance exercise training. Nature. 2024 May;629(8010):174-183. doi: 10.1038/s41586-023-06877-w. Epub 2024 May 1. PMID: 38693412; PMCID: PMC11062907.

Many GM, Sanford JA, Sagendorf TJ, Hou Z, Nigro P, Whytock KL, Amar D, Caputo T, Gay NR, Gaul DA, Hirshman MF, Jimenez-Morales D, Lindholm ME, Muehlbauer MJ, Vamvini M, Bergman BC, Fernández FM, Goodyear LJ, Hevener AL, Ortlund EA, Sparks LM, Xia A, Adkins JN, Bodine SC, Newgard CB, Schenk S; MoTrPAC Study Group. Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. Nat Metab. 2024 May;6(5):963-979. doi: 10.1038/s42255-023-00959-9. Epub 2024 May 1. PMID: 38693320; PMCID: PMC11132991.

Cato ML, D'Agostino EH, Spurlin RM, Flynn AR, Cornelison JL, Johnson AM, Fujita RA, Abraham SM, Jui NT, Ortlund EA. Structure and Dynamics of SF-1 Complexed with Small Molecule Agonists. Journal of Biological Chemistry, 2023, Jun 14;104921.

Mays SG, Hercules D, Ortlund EA, Okafor CD. The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits. Protein Science. 2023 Aug 12:e4754. doi: 10.1002/pro.4754. Epub ahead of print. PMID: 37572334.

Proffitt MR, Liu X, Ortlund EA, Smith GT. Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes. Mol Cell Endocrinol. 2023 Sep 13:112068. doi: 10.1016/j.mce.2023.112068. PMID: 37714403.

Patel A, Kumar S, Lai L, Keen M, Valanparambil R, Chakravarthy C, Laughlin Z, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Sharma A, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund E. Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron. Cell Rep. 2023 Sep 13;42(9):113150. doi: 10.1016/j.celrep.2023.113150. PMID: 37708028.

Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R'Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH. APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Nature. 2022 Nov;611(7937):769-779. doi: 10.1038/s41586-022-05439-w. Epub 2022 Nov 16. PMID: 36385529. 

Cato ML, Cornelison JL, Spurlin RM, Courouble VV, Patel AB, Flynn AR, Johnson AM, Okafor CD, Frank F, D'Agostino EH, Griffin PR, Jui NT, Ortlund EA. Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. J Med Chem. 2022;65(9):6888-902. Epub 20220503. doi: 10.1021/acs.jmedchem.2c00235. PubMed PMID: 35503419.

Cheedarla N, Verkerke H, Potlapalli S, McLendon K, Patel AB, Frank F, Damhorst G, Wu H, O'Sick W, Graciaa D, Hudaib F, Alter D, Bryksin J, Ortlund EA, Guarner J, Auld S, Shah S, Lam W, Mattoon D, Johnson J, Wilson D, Dhodapkar M, Stowell S, Neish A, Roback J. Rapid, High Throughput, Automated Detection Of SARS-Cov-2 Neutralizing Antibodies Against Native-Like Vaccine And Delta Variant Spike Trimers. Res Sq. 2022. Epub 20220216. doi: 10.21203/rs.3.rs-1322411/v1. PubMed PMID: 35194599; PMCID: PMC8863158.

Farmer S, Razin V, Peagler AF, Strickler S, Fain WB, Damhorst GL, Kempker RR, Pollock NR, Brand O, Seitter B, Heilman SS, Nehl EJ, Levy JM, Gottfried DS, Martin GS, Greenleaf M, Ku DN, Waggoner JJ, Iffrig E, Mannino RG, Y FW, Ortlund EA, Sullivan J, Rebolledo PA, Claveria V, Roback JD, Benoit M, Stone C, Esper A, Frank F, Lam WA. Don't forget about human factors: Lessons learned from COVID-19 point-of-care testing. Cell Rep Methods. 2022;2(5):100222. Epub 20220503. doi: 10.1016/j.crmeth.2022.100222. PubMed PMID: 35527805; PMCID: PMC9061138.

Frank F, Keen MM, Rao A, Bassit L, Liu X, Bowers HB, Patel AB, Cato ML, Sullivan JA, Greenleaf M, Piantadosi A, Lam WA, Hudson WH, Ortlund EA. Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests. Cell. 2022;185(19):3603-16 e13. Epub 20220829. doi: 10.1016/j.cell.2022.08.010. PubMed PMID: 36084631; PMCID: PMC9420710.

Heintz MM, Kumar R, Maner-Smith KM, Ortlund EA, Baldwin WS. Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice. J Lipids. 2022;2022:7122738. Epub 20220329. doi: 10.1155/2022/7122738. PubMed PMID: 35391786; PMCID: PMC8983274.

Imai N, Nicholls HT, Alves-Bezerra M, Li Y, Ivanova AA, Ortlund EA, Cohen DE. Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice. Hepatology. 2022;75(1):154-69. Epub 20211208. doi: 10.1002/hep.32122. PubMed PMID: 34433228.

Kapoor-Vazirani P, Rath SK, Liu X, Shu Z, Bowen NE, Chen Y, Haji-Seyed-Javadi R, Daddacha W, Minten EV, Danelia D, Farchi D, Duong DM, Seyfried NT, Deng X, Ortlund EA, Kim B, Yu DS. SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks. Nat Commun. 2022;13(1):6707. Epub 20221107. doi: 10.1038/s41467-022-34578-x. PubMed PMID: 36344525; PMCID: PMC9640623.

Kumar S, Patel AB, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Davis-Gardner ME, Edara VV, Linderman S, Nayak K, Dixit K, Sharma P, Bajpai P, Singh V, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Mantus G, Goel PK, Rahi M, Davis CW, Wrammert J, Godbole S, Henry AR, Douek DC, Suthar MS, Ahmed R, Ortlund EA, Sharma A, Murali-Krishna K, Chandele A. Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody. Sci Adv. 2022;8(40):eadd2032. Epub 20221005. doi: 10.1126/sciadv.add2032. PubMed PMID: 36197988.

Mays SG, D'Agostino EH, Flynn AR, Huang X, Wang G, Liu X, Millings EJ, Okafor CD, Patel AB, Cato ML, Cornelison JL, Melchers D, Houtman R, Moore DD, Calvert JW, Jui NT, Ortlund EA. A phospholipid mimetic targeting LRH-1 ameliorates colitis. Cell Chem Biol. 2022;29(7):1174-86 e7. Epub 20220321. doi: 10.1016/j.chembiol.2022.03.001. PubMed PMID: 35316658.

Savini M, Folick A, Lee YT, Jin F, Cuevas A, Tillman MC, Duffy JD, Zhao Q, Neve IA, Hu PW, Yu Y, Zhang Q, Ye Y, Mair WB, Wang J, Han L, Ortlund EA, Wang MC. Lysosome lipid signalling from the periphery to neurons regulates longevity. Nat Cell Biol. 2022;24(6):906-16. Epub 20220609. doi: 10.1038/s41556-022-00926-8. PubMed PMID: 35681008; PMCID: PMC9203275.

Frank F, Ortlund EA, Liu X. Structural insights into glucocorticoid receptor function. Biochem Soc Trans. 2021 Oct 28. PMID: 34709368.

Collins JM, Jones DP, Sharma A, Khadka M, Liu KH, Kempker RR, Prideaux B, Maner-Smith K, Tukvadze N, Shah NS, Brust JCM, Sékaly RP, Gandhi NR, Blumberg HM, Ortlund EA, Ziegler TR. TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis. PLoS Pathology. 2021 Sep 24. PMID: 34559866.

Imani N, Nicholls HT, Alves-Bezerra M, Li Y, Ivanova AA, Ortlund EA, Cohen DE. Upregulation of Thioesterase Superfamily Member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance. Hepatology. 2021 Aug 25. PMID: 34433228.

Frank, F; Liu, X; Ortlund, E. Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation. Proc. Nat. Acad. Sci. 2021 June 10: 118(30). Doi: 10.1073.

Liu X, Weikum ER, Tilo D, Vinson C, Ortlund EA. Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element. Nucleic Acids Res. 2021 Jul 21:gkab605. doi: 10.1093/nar/gkab605. Epub ahead of print. PMID: 34289059.

Bruno NE, Nwachukwu JC, Srinivasan S, Nettles CC, Izard T, Jin Z, Nowak J, Cameron MD, Boregowda SV, Phinney DG, Elemento O, Liu X, Ortlund EA, Houtman R, Stavreva DA, Hager GL, Kamenecka TM, Kojetin DJ, Nettles KW. Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling. Nat Chem Biol. 2021 Jan 28. doi: 10.1038/s41589-020-00719-w. Epub ahead of print. PMID: 33510451.

Tillman, MC; Khadka, M; Duffy, J; Wang, MC; Ortlund, EA. "Structural Characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8". Scientific Reports. 

Khadka, M., Todor, Andrei, A., Maner-Smith, K.M., Colucci, J.K., Tran, ViLinh, T., Gaul, D.A., Anderson, E., Natrajan, M., Rouphael, N., Mulligan, M.J., McDonald, C., Suthar, M., Li, S., Ortlund, E.A., "The effect of anticoagulants, temperature and time on the human plasma metabolome and lipidome from healthy donors as determined by liquid chromatography-mass spectrometry". Biomolecules.

Regina Joice Cordy, Rapatbhorn Patrapuvich, Loukia N. Lili, Monica Cabrera-Mora, Jung-Ting Chien, Gregory K. Tharp, Manoj Khadka, Esmeralda V.S. Meyer, Stacey A. Lapp, Chester J. Joyner, AnaPatricia Garcia, Sophia Banton, ViLinh Tran, Viravarn Luvira, Siriwan Rungin, Teerawat Saeseu, Nattawan Rachaphaew, Suman B. Pakala, Jeremy D. DeBarry, MaHPIC Consortium, Jessica C. Kissinger, Eric A. Ortlund, Steven E. Bosinger, John W. Barnwell, Dean P. Jones, Karan Uppal, Shuzhao Li, Jetsumon Sattabongkot, Alberto Moreno, and Mary R. Galinski. "Distinct amino acid and lipid perturbations characterize acute versus chronic malaria". JCI Insight. 

Liu, X; Wang, Y; Ortlund, EA. "First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand Binding Domain-PGC1alpha Complex with Endogenous and Synthetic Glucocorticoids". Molecular Pharmacology. 

C. Denise Okafor, Manish C. Pathak, Crystal E. Fagan, Nicholas C. Bauer, Megan F. Cole, Eric A. Gaucher, Eric A. Ortlund. 2018. "Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus". Cell: Structure.

William H. Hudson, Ian Mitchelle S. de Vera, Jerome C. Nwachukwu, Emily R. Weikum, Austin G. Herbst, Qin Yang, David L. Bain, Kendall W. Nettles, Douglas J. Kojetin & Eric A. Ortlund. 2018. "Cryptic glucocorticoid receptor-binding sites pervade genomic NF-KB response elements". Nature Communications. Press release available here.

Wei Deng, Kaleigh Voos, Jennifer Colucci, Emily Legan, Eric Ortlund, Peter Lollar, Renhao Li. 2018. "Delimiting the autoinhibitory module of von Willebrand factor". J Thromb Haemost.

Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES. 2018. "Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock". Immunity.

Emily R. Weikum, Xu Liu, Eric A. Ortlund. 2018. "The nuclear receptor superfamily: A structural perspective". Protein Science.

Filipp Frank, C. Denise Okafor, Eric A. Ortlund. 2018. "The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor". Scientific Reports

Autumn R. Flynn, Suzanne G. Mays, Eric A. Ortlund, Nathan T. Jui. 2018. "Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homogue-1". ACS Med. Chem. Lett.

Collins JM, Walker DI, Jones DP, Tukvadze N, Liu KH, Tran VT, Uppal K, Frediani JK, Easley KA, Shenvi N, Khadka M, Ortlund EA, Kempker RR, Blumberg HM, Ziegler TR. 2018. "High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans". PLoS One.

Alvez-Bezerra M, Li Y, Acuna M, Ivanova AA, Corey KE, Ortlund EA, Cohen DE. 2018. "Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis". Hepatology.

Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA, 2017. "Nucleotide binding to ARL2 in the TBCD-ARL2-beta-tubulin complex drives conformation changes in beta-tubulin". Journal of Molecular Biology.

Weikum, E.R., S. de Vera, I.M., Nwachukwu, J.C., Nettles, K.W., Kojetin, D. K., Ortlund E.A., 2017. "Tethering not required: The glucocorticoid receptor binds directly to GR half-site sequences embedded within AP-1 recognition motifs". Nucleic Acids Research.

Weikum ER, Okafor DC, D'Agostino EH, Colucci JK, Ortlund EA, 2017. "Structural analysis of the glucocorticoid receptor ligand-binding domain in complex with triamcinolone acetonide and a fragment of the atypical coregulator, SHP". Molecular Pharmacology.

Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. 2017. "Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex". Molecular Pharmacology.

Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR. 2017. "Glucocorticoid receptor control of transcription: precision and plasticity via allostery". Nature Reviews Molecular Cell Biology.

Weikum, E.R., Knuesel, M.T., Ortlund E.A.*, Yamamoto, K.R.* "Invited Review: Control of transcription by the glucocorticoid receptor: Precision, plasticity, and allostery". 2016. Nature Reviews Molecular Cell Biology.

Weikum E.R., Tuntland, M.L., Murphy, M.N., Ortlund, E.A., "Structure of GCNF and LRH-1 DNA Binding domains in complex with Oct4 promoter reveals overlapping binding sites". 2016. Journal of Molecular Biology

Mays, S.G., Okafor, C.D., Whitby, R.J., Goswami, D., Stec, J., Flynn, A.R., Dugan, M.C., Jui, N.T., Griffin, P.R., Ortlund, E.A. "Crystal Structures of LRH-1 with Synthetic Agonists Reveal a Novel Mechanism of Receptor Activation". 2016. Journal of Biological Chemistry, *JBC paper of the week and Cover Image

Hudson W.H., Kossmann, B.R., S. de Vera, I.M., Chuo, S., Weikum, E.R., Eick, G., Thornton, J.W., Ivanov, I., Kojetin, D. K., Ortlund E.A., "Distal substitutions drive divergent DNA specificity among paralogous transcription factors through a subdivision of conformational space". 2016. Proceedings of the National Academy of Sciences.

PM Musille, BR Kossmann, JA Kohn, I Ivanov, EA Ortlund. "Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity". 2016. Journal of Biological Chemistry.

Yu, K., Whitlock, J.M., Lee, K., Ortlund, E.A., Yui, C. C., Hartzell, C. 2015. "Identification of a Lipid Scrambling Domain in ANO6/TMEM16F", eLIFE.

Brown, N.E., Goswami, D., Branch, M.R., Ramineni, S., Ortlund, E.A., Griffin, P.R., Hepler, J.R. 2015. "Integration of G Protein Alpha (Gα) Signaling by the Regulator of G Protein Signaling 14", Journal of Biological Chemistry.

Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC. 2015. "Lysosomal signaling molecules regulate longevity in Caenorhabditis Elegans", Science.

Qiang G., Xue, S., Yang J.J., Du, G., Pang X., Li X., Goswami D., Griffin P.R., Ortlund E.A., Chan C.B., Ye K., "Identification of a Small Molecular Insulin Receptor Agonist with Potent Anti-diabetic Activity". Diabetes.

Hudson W.H., Ortlund E.A., "Analysis: The dual nature of DNA/ RNA binding proteins". Nature Reviews Molecular Biology.

Hudson W.H., Ortlund E.A., "X-ray crystal structure of the mineralocorticoid receptor DNA binding domain – DNA complex". PLoS One.

Armstrong, E.H., Noy, N., Ortlund, E.A. "Structural basis for ligand regulation of the FABP5-PPARβ/δ signaling pathway". JBC.

Ren, J., Pathak, M.C., Temple, B.R.S., Lin, C., Nile, A.H., Mousley, C.J., Duncan, M.C., Eckert, D.M., Leiker, T.J., Ivanova, P.T., Meyers, M.S., Murphy, R.C., Brown, H.A., Verdaasdonk, J., Bloom, K.S., Ortlund, E.A., Neiman, A.M., Bankaitis, V.A. "A Phosphatidylinositol Transfer Protein Integrates Phosphoinositide Signaling With Lipid Droplet Metabolism To Regulate a Developmental Program of Nutrient Stress-Induced Membrane Biogenesis". Mol Cell Bio.

Kratzer, J.T., Miguel, L.A., Murphy, M.N., Cicerchi, C., Graves, C.L., Tipton, P.A., Ortlund, E.A.*, Johnson, R.J.*, Gaucher, E.A.* "Evolutionary history and metabolic insights of ancient mammalian uricases"., Proc Natl Acad Sci U S A

Musille, P.M and Ortlund E.A. "The structure determination of glycerol dehydrogenase from Serratia". Acta Crystallogr F Struct Biol Cryst Commun.

Bridgham, J.T., Keay, J, Ortlund, E.A. and Thornton, J.W. "Vestigialization of an allosteric switch: Genetic and structural mechanisms for the evolution of constitutive activity in the steroid receptor". PLoS Genetics

Hudson WH, Pickard MR, de Vera IM, Kuiper EG, Mourtada-Maarabouni M, Conn GL, Kojetin DJ, Williams GT, Ortlund EA. "Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate". Nature Communications.

Brent M. Horton, William H. Hudson, Eric A. Ortlund, Sandra Shirk, James W. Thomas, Emily R. Young, Wendy Zinzow-Kramer, and Donna L. Maney. "Promoter Polymorphism and Differential Expression of Estrogen Receptor α in a Species with Alternative Behavioral Phenotypes". Proc Natl Acad Sci (2013).

Michael J. Harms, Geeta N. Eick, Dev Goswami, Jennifer K. Colucci, Patrick R. Griffin, Eric A. Ortlund, Joseph W. Thornton. "Biophysical mechanisms for large-effect mutations in the evolution of sterid hormone receptors". Proc Natl Acad Sci [PMID: 23798447].

Paul M. Musille, Manish C. Pathak, Jeni L. Lauer, Pattrick R. Griffin, Eric A. Ortlund. "Divergent sequence tunes ligand sensitivity in Phospholipid-regulated hormone receptors". JBC. [PMID: 23737522]

Colucci JK, Ortlund EA. "X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface". PLoS One. [PMID: 24260475]

Paul M. Musille, Jeffrey A. Kohn, Eric A. Ortlund. "Phospholipid-driven gene regulation". FEBS Letters [PMID: 23333623].

William H. Hudson, Christine Youn, Eric A. Ortlund. "The structural basis of direct glucocorticoid-mediated transrepression". Nature Structural & Molecular Biology. [PMID: 23222642]

Geeta N. Elick, Jennifer K. Colucci, Michael J. Harms, Eric A. Ortlund, Joseph W. Thornton. "Evolution of minimal specificity and promiscuity in steroid hormone receptors". Plos Genetics 8(11) [PMID:23166518]

Paul M. Musille, Manish Pathak, Janelle L. Lauer, William H. Hudson, Patrick R. Griffin, Eric A. Ortlund. Antidiabetic Phospholipid – "Nuclear Receptor Complex Reveals the Mechanism for Phospholipid Driven Gene Regulation". Nature Structural & Molecular Biology 19, 532-7 (2012). [PMID: 22504882]

Jeffrey A. Kohn, Kirti Desphande, Eric A. Ortlund. "Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors". Journal of Biological Chemistry 20, 16267-75. [PMID: 22437833]

Jae Man Lee, Yoon Kwang Lee Jennifer L. Mamrosh, Manish Pathak, Eric A. Ortlund, David D. Moore. "Antidiabetic Effects of a Novel Agonist Ligand for the Nuclear Receptor LRH-1". Nature 474, 506-U135. [PMID: 21614002]

Paul T. R. Thiruchelvam, Chun-Fui Lai, Hui Hua, Ross S. Thomas, Antoni Hurtado, William Hudson, Andrew R. Bayly, Fiona J. Kyle, Manikandan Periyasamy, Andrew Photiou, Alan C. Spivey, Eric A. Ortlund, Richard J. Whitby, Jason S. Carroll, R. Charles Coombes, Laki Buluwela, Simak, Ali. "The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells". Breast Cancer Research and Treatment 127, 385-396. [PMID: 20607599]

Gabriel Schaaf, Marek Dynowski, Carl J. Mousley, Sweety D. Shah, Peihua Yuan, Eva M. Winklbauer, Marilia K. F. de Campos, Kyle Trettin, Mary-Chely Quinones, Tatyana I. Smirnova, Lora L. Yanagisawa, Eric A. Ortlund*, Vytas A. Bankaitis*. "Resurrection of a Functional Phosphatidylinositol Transfer Protein from a Pseudo-Sec14 Scaffold by Directed Evolution". Molecular Biology of the Cell 22, 892-905. [PMID: 21248202].

Jihui Ren, Gabriel Schaaf, Vytas Bankatis, Manish Pathak, Eric A. Ortlund. "Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily". Acta Crystallographica Section F 67, 1239-1243. [PMID: 22102037]

Sean M. Carroll, Eric A. Ortlund*, Joseph W. Thornton*. "Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor". Plos Genetics 7. [PMID:21698144]

Jamie T. Bridgham, Geeta N. Eick, Claire Larroux, Kirti Deshpande, Michael J. Harms, Marie E. A. Gauthier, Eric A. Ortlund, Bernard M. Degnan, Joseph W. Thornton. "Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor". Plos Biology 8. [PMID: 20957188]

Fei Chen, Eric A Gaucher, Nicole A Leal, Daniel Hutter, Stephanie A Havemann, Sridhar Govindarajan, Eric Ortlund, Steven Benner. "Reconstructed Evolutionary Adaptive Paths (REAP) give Polymerases Accepting Reversible Terminators for Sequencing and SNP Detection". Proceedings of the National Academy of Sciences of the United States of America 107, 1948-1953. [PMID: 20080675]

Jamie Bridgham, Eric Ortlund, Joseph Thornton. "An Epistatic Ratchet Constrains the Direction of Glucocorticoid Receptor Evolution". Nature 461, 515-U78. [PMID: 19779450]

Eric Ortlund*, Gabriel Schaaf*, Kimberly R. Tyeryar, Carl J. Mousley, Kristina E. Ile, Teresa A. Garrett, Jihui Ren, Melissa J. Woolls, Christian R.H. Raetz, Matthew R. Redinbo, Vytas A. Bankaitis. "Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Members of the Sec14 Protein Superfamily". Molecular Cell 29, 191-206. [PMID: 18243114]