![Structure and binding pose of LRH-1 agonists. A. Chemical structures of LRH-1 small molecule agonist RJW100 (top), phospholipid agonist DLPC (middle), and small molecule agonist 6N-10CA (bottom). Major substituents of synthetic ligands are highlighte](../../../_images/news/2023/ortlund-lab-jbc-pub-2023.png)
Congratulations to Lee Cato, Emma D’Agostino, Racheal Spurlin, Sarah Abraham, and Eric Ortlund on their publication, "Comparison of Activity, Structure, and Dynamics of SF-1 and LRH-1 Complexed with Small Molecule Modulators," in the Journal of Biological Chemistry.