Pallas Lab

The Pallas Lab is part of the Department of Biochemistry

Welcome to the Pallas Lab

We are interested in elucidating mechanisms of regulation of protein phosphatase 2A (PP2A), a tumor suppressor, with the goal of novel therapeutics for cancer and Alzheimer’s Disease and understanding the role of the protein phosphatase methyltransferase, LCMT-1, in development.

Research

Publications

Integrin 51 regulates PP2A complex assembly through PDE4D in atherosclerosis.
J Clin Invest Volume: 129 Page(s): 4863 - 4874
08/13/2019 Authors: Yun S; Hu R; Schwaemmle ME; Scherer AN; Zhuang Z; Koleske AJ; Pallas DC; Schwartz MA
p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma.
Mol Cancer Res Volume: 17 Page(s): 186 - 198
01/01/2019 Authors: Wei Y; Maximov V; Morrissy SA; Taylor MD; Pallas DC; Kenney AM
Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle.
Mol Biol Cell Volume: 29 Page(s): 2084 - 2097
08/15/2018 Authors: Qadota H; Matsunaga Y; Bagchi P; Lange KI; Carrier KJ; Pols WV; Swartzbaugh E; Wilson KJ; Srayko M; Pallas DC
Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.
J Biol Chem Volume: 293 Page(s): 9636 - 9650
06/22/2018 Authors: Lee JA; Wang Z; Sambo D; Bunting KD; Pallas DC