Hui-Kuo Shu MD/PhD
Overview
Hui-Kuo Shu, MD, PhD, FASTRO, is a board certified radiation oncologist specializing in the treatment of brain and spine tumors. He treats patients at Winship Cancer Institute of Emory University and Emory Proton Therapy Center.
Dr. Shu has extensive expertise in the use of advanced radiotherapy techniques including intensity-modulated radiation therapy, stereotactic radiosurgery, fractionated stereotactic radiotherapy, extracranial radiosurgery and image-guided radiation therapy.
Prior to coming to Emory, Dr. Shu was appointed assistant professor in radiation oncology at the University of Pennsylvania in 1999. He also served as the main radiation oncologist for the treatment of pediatric brain tumors at the Children's Hospital of Philadelphia from 2001 to 2005. He was recruited to Emory University as a physician-scientist and was appointed associate professor in the department of radiation oncology in 2005.
Dr. Shu is a Fellow of the American Society for Radiation Oncology. He is a member of the American Society for Clinical Oncology, Pediatric Brain Tumor Consortium, American Association for Cancer Research and Society for Neuro-Oncology, among other organizations.
Dr. Shu received his MD and PhD degrees in the NIH-sponsored Medical Scientist Training Program at Case Western Reserve University in Cleveland, Ohio. He completed post-graduate training with a year in internal medicine at University Hospitals of Cleveland, followed by a 5-year radiation oncology residency and fellowship at the University of California in San Francisco (UCSF).
At UCSF, he received grants from the American Society for Therapeutic Radiology and Oncology and the Radiological Society of North America to fund his fellowship research on malignant nervous system tumors. He was honored with awards and appointments during his training including the American Radium Societys Young Oncologist Essay Award, the RSNA Roentgen Resident/Fellow Research Award at UCSF and chief resident in radiation oncology.
Dr. Shu was listed as one of Atlanta Magazine's "Top Doctors" and appeared on the cover of the special issue in 2017.
In the area of clinical research, Dr. Shu is a member of the neuro-oncology working group at Emory University and is actively conducting brain tumor-related clinical trials sponsored by the National Institutes of Health (NIH) directly and by cooperative groups such as New Agents for Brain Tumor Treatment and Radiation Therapy Oncology GroupNRG Oncology. His main research focus involves the study of glioblastomas and how to better treat these aggressive brain tumors. His most recent area of research interest involves development of novel MRI techniques that may be able to better identify infiltrative glial tumors and facilitate improved therapeutic targeting. His research has been funded by the NIH and a number of brain tumor organizations including the Brain Tumor Foundation, American Brain Tumor Association, and Childhood Brain Tumor Foundation and Southwest Brain Tumor Foundation.
Dr. Shu has published numerous articles in peer-reviewed journals including Proceedings of the National Academy of Sciences and Cancer Research. He also serves as a regular reviewer for several journals including Cancer Research and Cancer. His research has been funded by a number of brain tumor organizations including the Brain Tumor Foundation, American Brain Tumor Association and Childhood Brain Tumor Foundation.
Academic Appointment
- Professor, Department of Radiation Oncology, Emory University School of Medicine
Education
Degrees
- PhD from Case Western Reserve University, Cleveland
- MD from Case Western Reserve University, Cleveland
- BA from Washington University in St. Louis, St Louis
Research
Focus
- My main research focus involves the study of glioblastomas and how to better treat these aggressive brain tumors. I also have some other interest in other brain tumors and other selected topics in radiation oncology/radiobiology. My overall research activities involves both clinical and laboratory components. Clinically, I have been involved in the development and conduct of trials that actively seeks to improve outcomes in a range of CNS tumors.
Publications
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Risk of late radiation necrosis more than 5 years after stereotactic radiosurgery.
J Neurosurg Volume: 142 Page(s): 1117 - 1124
04/01/2025 Authors: McCall NS; Lu A; Hopkins BD; Qian D; Hoang KB; Olson JJ; Zhong J; Eaton BR; Shu H-KG -
T1-contrast enhanced MRI generation from multi-parametric MRI for glioma patients with latent tumor conditioning.
Med Phys Volume: 52 Page(s): 2064 - 2073
04/01/2025 Authors: Eidex Z; Safari M; Qiu RLJ; Yu DS; Shu H-K; Mao H; Yang X -
Incidental High-Grade Sellar Solitary Fibrous Tumor Mimicking Non-Functioning Pituitary Adenoma: A Case Report and Literature Review.
Am J Case Rep Volume: 26 Page(s): e946592
03/15/2025 Authors: Persico M; Weinberg BD; Neill SG; Shu H-K; Zhong J -
Impact of Systemic and Radiation Therapy on Survival of Primary Central Nervous System Lymphoma.
Cancers (Basel) Volume: 17
02/12/2025 Authors: Janopaul-Naylor JR; Patel JS; Rupji M; Hoang KB; McCall NS; Qian DC; Shoaf ML; Kothari S; Olson JJ; Shu H-KG -
Deep learning based apparent diffusion coefficient map generation from multi-parametric MR images for patients with diffuse gliomas.
Med Phys Volume: 52 Page(s): 847 - 855
02/01/2025 Authors: Eidex Z; Safari M; Wynne J; Qiu RLJ; Wang T; Viar-Hernandez D; Shu H-K; Mao H; Yang X -
Conference Report: Review of Clinical Implementation of Advanced Quantitative Imaging Techniques for Personalized Radiotherapy.
Tomography Volume: 10 Page(s): 1798 - 1813
11/14/2024 Authors: Vinogradskiy Y; Bahig H; Bucknell NW; Buchsbaum J; Shu H-KG -
Prediction of early recurrence of adult-type diffuse gliomas following radiotherapy using multi-modal magnetic resonance images.
Med Phys Volume: 51 Page(s): 8638 - 8648
11/01/2024 Authors: Salari E; Chen X; Wynne JF; Qiu RLJ; Roper J; Shu H-K; Yang X -
The Impact of Social Determinants on Receipt of Adjuvant Radiation Nationally Following Atypical Meningioma Surgery.
World Neurosurg Volume: 190 Page(s): e364 - e372
10/01/2024 Authors: Chisango Z; Ugochukwu O; Zhi XJ; Zhong J; Eaton B; Shu H-K; Jahangiri A; Bray D; Hoang K -
Radiomic Analysis of Treatment Effect for Patients with Radiation Necrosis Treated with Pentoxifylline and Vitamin E.
Tomography Volume: 10 Page(s): 1501 - 1512
09/09/2024 Authors: Patel JS; Salari E; Chen X; Switchenko J; Eaton BR; Zhong J; Yang X; Shu H-KG; Sudmeier LJ -
Patterns of Treatment Failure in Primary Central Nervous System Lymphoma.
Am J Clin Oncol Volume: 47 Page(s): 333 - 338
07/01/2024 Authors: Janopaul-Naylor JR; Patel JS; Rupji M; Qian DC; Hoang KB; McCall NS; Schlafstein AJ; Shoaf ML; Kothari S; Olson JJ