Yu Laboratory

Led by principal investigator David Yu, MD, PhD, the Yu Laboratory is located at Winship Cancer Institute and is part of the Department of Radiation Oncology at Emory University School of Medicine in Atlanta, Georgia.

Principal Investigator

David S. Yu, MD, PhD is a physician-scientist actively engaged in basic, translational, and clinical research. Dr. Yu is the Jerome Landry MD Chair in Cancer Research and an associate professor in the Department of Radiation Oncology at Emory University School of Medicine where he also serves as director of the Division of Cancer Biology.

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Research

The focus of our lab's research is to understand how cells respond to DNA replication stress, why this process is deregulated in cancer cells, and how we can translate this knowledge to improvements in cancer diagnosis and treatment.

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Publications

Dr. Yu has authored a number of publications in high impact journals, including Nature, Cell, Molecular Cell, Cell Reports, and PNAS. He is associate editor of International Journal of Radiation Biology.

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Lab Life

A glimpse at life in the Yu Lab and the celebrations of team member milestones and achievements.

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Department of Radiation Oncology Winship Cancer Institute of Emory University

Lab Team Announcements

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Priya Kapoor published her first author paper in Nature Communications on how SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.

David Yu was awarded as MPI a NIH/NCI U54 to establish a Radiation Biology Integration Network (ROBIN) Center on the Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies. The Emory team in collaboration with the Cleveland Clinic Foundation is one of only three teams nationally to receive this highly competitive award of $7.5 million in total costs.

Hui Zhang published her first author paper in Scientific Reports on a quantitative proteomic analysis of the lysine acetylome in revealing diverse SIRT2 substates.

Elizabeth Minten published her first author paper in STAR Protocols on a protocol for in vitro lysine deacetylation to test putative substrates of class III deacetylases.