David Yu MD/PhD

Department of Radiation Oncology
Professor

Overview

David S. Yu, MD, PhD, is a board certified radiation oncologist and physician-scientist specializing in the treatment of head and neck cancer, breast cancer, and lung cancer. He treats patients at Winship Cancer Institute of Emory University and Loughlin Radiation Oncology Center at Grady.

The goal of Dr. Yu's work is to translate insights gained from interactions with his patients and his research in the laboratory to innovative therapies to improve the quality of care for patients with cancer. He serves as Director of the Division of Cancer Biology and Vice Chair for Biology Research in the Department of Radiation Oncology at Emory University School of Medicine.

Dr. Yu received his MD from the University of Texas at Southwestern Medical School and PhD from the University of Cambridge prior to completing residency training in Radiation Oncology at Vanderbilt University Medical Center. He graduated with honors from Stanford University with a BS in Biology.

Dr. Yu has received recognition as a Georgia Research Alliance Cancer Scientist and was awarded the Michael Fry Research Award from the Radiation Research Society, which recognizes the most outstanding junior scientist who has made exceptional contributions to the field of radiation research. Dr. Yu is currently funded by NIH/NCI R01, Department of Defense, and foundation awards. He has authored a number of publications in high impact journals, including Nature, Cell, Molecular Cell, Cell Reports, and PNAS. During his residency training, Dr. Yu was an American Board of Radiology (ABR) Holman Research Pathway fellow.

Dr. Yu is a member of the ASTRO Radiation and Cancer Biology Committee Research Council, ASTRO Research Evaluation Committee Research Council, American Society for Clinical Investigation, American Society of Clinical Oncology, American Association for Cancer Research, Radiation Research Society, and RSNA among others. He is also a member of Winship Cancer Institute Cancer Genetics and Epigenetics Research Program, Emory Graduate Programs in Cancer Biology and Genetics and Molecular Biology, and the Emory MD/PhD Program.

Academic Appointment

Professor, Department of Radiation Oncology, Emory University School of Medicine

Education

Degrees

MD from University of Texas Southwestern Medical School
PhD from University of Cambridge
BS from Stanford University, Stanford

Research

Focus

The focus of my research is to understand how cells respond to replication stress, why this process is deregulated in cancer cells, and how we can translate this knowledge to improvements in cancer diagnosis and treatment.

Publications

Combination radiation and PD-L1 enhance tumor control by stimulating CD8+PD-1+TCF-1+T cells in the tumor-draining lymph node.
Nat Commun Volume: 16 Page(s): 3522
04/14/2025 Authors: Shen Y; Connolly E; Aiello M; Zhou C; Chappa P; Song H; Tippitak P; Clark T; Cardenas M; Prokhnevska N
Correction: EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair.
Oncogene Volume: 44 Page(s): 928 - 930
04/01/2025 Authors: Koyen AE; Madden MZ; Park D; Minten EV; Kapoor-Vazirani P; Werner E; Pfister NT; Haji-Seyed-Javadi R; Zhang H; Xu J
T1-contrast enhanced MRI generation from multi-parametric MRI for glioma patients with latent tumor conditioning.
Med Phys Volume: 52 Page(s): 2064 - 2073
04/01/2025 Authors: Eidex Z; Safari M; Qiu RLJ; Yu DS; Shu H-K; Mao H; Yang X
Unsupervised Bayesian generation of synthetic CT from CBCT using patient-specific score-based prior.
Med Phys Volume: 52 Page(s): 2238 - 2246
04/01/2025 Authors: Peng J; Gao Y; Chang C-W; Qiu R; Wang T; Kesarwala A; Yang K; Scott J; Yu D; Yang X
Automatic medical imaging segmentation via self-supervising large-scale convolutional neural networks.
Radiother Oncol Volume: 204 Page(s): 110711
03/01/2025 Authors: Li Y; Wynne JF; Wu Y; Qiu RLJ; Tian S; Wang T; Patel PR; Yu DS; Yang X
Exploration of an adaptive proton therapy strategy using CBCT with the concept of digital twins.
Phys Med Biol Volume: 70
01/17/2025 Authors: Chang C-W; Tian Z; Qiu RLJ; Scott Mcginnis H; Bohannon D; Patel P; Wang Y; Yu DS; Patel SA; Zhou J
Feasibility study of modularized pin ridge filter implementation in proton FLASH planning for liver stereotactic ablative body radiotherapy.
Phys Med Biol Volume: 69
12/03/2024 Authors: Ma C; Yang X; Setianegara J; Wang Y; Gao Y; Yu D; Patel P; Zhou J
Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response.
Clin Epigenetics Volume: 16 Page(s): 119
08/27/2024 Authors: Rath SK; Nyamsuren G; Tampe B; Yu DS-W; Hulshoff MS; Schlsser D; Maamari S; Zeisberg M; Zeisberg EM
PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer.
Nat Commun Volume: 15 Page(s): 6830
08/09/2024 Authors: Shu Z; Dwivedi B; Switchenko JM; Yu DS; Deng X
Feasibility Study for Controlled Radiation Capsule for High Source Activity for Low Dose Radiation Brachytherapy.
Volume: 2024 Page(s): 1 - 4
07/01/2024 Authors: Nguyen J; Roque D; Hesketh P; Yu D; Lee H
A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer.
J Appl Clin Med Phys Volume: 25 Page(s): e14308
05/01/2024 Authors: Chang C-W; Bohannon D; Tian Z; Wang Y; Mcdonald MW; Yu DS; Liu T; Zhou J; Yang X
Streamlined pin-ridge-filter design for single-energy proton FLASH planning.
Med Phys Volume: 51 Page(s): 2955 - 2966
04/01/2024 Authors: Ma C; Zhou J; Chang C-W; Wang Y; Patel PR; Yu DS; Tian S; Yang X
Synthetic CT generation from MRI using 3D transformer-based denoising diffusion model.
Med Phys Volume: 51 Page(s): 2538 - 2548
04/01/2024 Authors: Pan S; Abouei E; Wynne J; Chang C-W; Wang T; Qiu RLJ; Li Y; Peng J; Roper J; Patel P
Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node.
Res Sq
03/06/2024 Authors: Shen Y; Connolly E; Aiello M; Zhou C; Chappa P; Song H; Tippitak P; Clark T; Cardenas M; Prokhnevska N
SAMHD1 expression contributes to doxorubicin resistance and predicts survival outcomes in diffuse large B-cell lymphoma patients.
NAR Cancer Volume: 6 Page(s): zcae007
03/01/2024 Authors: Daddacha W; Monroe D; Schlafstein AJ; Withers AE; Thompson EB; Danelia D; Luong NC; Sesay F; Rath SK; Usoro ER
CBCT-Based synthetic CT image generation using conditional denoising diffusion probabilistic model.
Med Phys Volume: 51 Page(s): 1847 - 1859
03/01/2024 Authors: Peng J; Qiu RLJ; Wynne JF; Chang C-W; Pan S; Wang T; Roper J; Liu T; Patel PR; Yu DS
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops).
J Biol Chem Volume: 300 Page(s): 105646
02/01/2024 Authors: de Amorim JL; Leung SW; Haji-Seyed-Javadi R; Hou Y; Yu DS; Ghalei H; Khoshnevis S; Yao B; Corbett AH
ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair.
Int J Radiat Biol Volume: 100 Page(s): 724 - 735
01/01/2024 Authors: Luong NC; Kawamura H; Ikeda H; Roppongi RT; Shibata A; Hu J; Jiang JG; Yu DS; Held KD
HELZ promotes R loop resolution to facilitate DNA double-strand break repair by homologous recombination.
bioRxiv
12/15/2023 Authors: Haji-Seyed-Javadi R; Koyen AE; Rath SK; Madden MZ; Hou Y; Song BS; Kenney AM; Lan L; Yao B; Yu DS
Correction to 'DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining'.
Nucleic Acids Res Volume: 51 Page(s): 9507
09/22/2023
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.
Nucleic Acids Res Volume: 51 Page(s): 7972 - 7987
08/25/2023 Authors: Head PE; Kapoor-Vazirani P; Nagaraju GP; Zhang H; Rath SK; Luong NC; Haji-Seyed-Javadi R; Sesay F; Wang S-Y; Duong DM
Author Correction: YB1 modulates the DNA damage response in medulloblastoma.
Sci Rep Volume: 13 Page(s): 9717
06/15/2023 Authors: McSwain LF; Pillsbury CE; Haji-Seyed-Javadi R; Rath SK; Chen V; Huang T; Shahab SW; Kunhiraman H; Ross J; Price GA
YB1 modulates the DNA damage response in medulloblastoma.
Sci Rep Volume: 13 Page(s): 8087
05/19/2023 Authors: McSwain LF; Pillsbury CE; Haji-Seyed-Javadi R; Rath SK; Chen V; Huang T; Shahab SW; Kunhiraman H; Ross J; Price GA
The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops.
bioRxiv
04/17/2023 Authors: de Amorim JL; Leung SW; Haji-Seyed-Javadi R; Hou Y; Yu DS; Ghalei H; Khoshnevis S; Yao B; Corbett AH
Deformable CT image registration via a dual feasible neural network.
Med Phys Volume: 49 Page(s): 7545 - 7554
12/01/2022 Authors: Lei Y; Fu Y; Tian Z; Wang T; Dai X; Roper J; Yu DS; McDonald M; Bradley JD; Liu T
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.
Nat Commun Volume: 13 Page(s): 6707
11/07/2022 Authors: Kapoor-Vazirani P; Rath SK; Liu X; Shu Z; Bowen NE; Chen Y; Haji-Seyed-Javadi R; Daddacha W; Minten EV; Danelia D
Protocol for in vitro lysine deacetylation to test putative substrates of class III deacetylases.
STAR Protoc Volume: 3 Page(s): 101313
06/17/2022 Authors: Minten EV; Yu DS
Synthesizing Iodine Map From Non-Contrast Enhanced CT Via Deep-Learning Network
Volume: 49 Page(s): E606 - E606
06/01/2022 Authors: Xie H; Lei Y; Wang T; Roper J; Ghavidel B; McDonald M; Yu D; Tang X; Bradley J; Liu T
Deep Learning-Based Contrast Enhanced Dual-Energy CT Imaging From Non-Enhanced Single-Energy CT
Volume: 49 Page(s): E181 - E182
06/01/2022 Authors: Xie H; Lei Y; Wang T; Roper J; Ghavidel B; McDonald M; Yu D; Tang X; Bradley J; Liu T
Predictors of Occult Nodal Involvement in Clinically Node Negative Primary Parotid Carcinoma: An NCDB Analysis
Volume: 112 Page(s): E16 - E17
04/01/2022 Authors: Lorenz J; Liu Y; Goyal S; Remick JS; Rudra S; Hanasoge S; Yu DS; Steuer C; Stokes WA
Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates.
Sci Rep Volume: 12 Page(s): 3822
03/09/2022 Authors: Zhang H; Dammer EB; Duong DM; Danelia D; Seyfried NT; Yu DS
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
J Biol Chem Volume: 297 Page(s): 101170
10/01/2021 Authors: Bowen NE; Temple J; Shepard C; Oo A; Arizaga F; Kapoor-Vazirani P; Persaud M; Yu CH; Kim D-H; Schinazi RF
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation.
Volume: 27
04/01/2021 Authors: Minten EV; Kappor-Vazirani P; Li C; Zhang H; Balakrishnan K; Yu DS
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation.
Cell Rep Volume: 34 Page(s): 108921
03/30/2021 Authors: Minten EV; Kapoor-Vazirani P; Li C; Zhang H; Balakrishnan K; Yu DS
EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair.
Oncogene Volume: 39 Page(s): 4798 - 4813
06/01/2020 Authors: Koyen AE; Madden MZ; Park D; Minten EV; Kapoor-Vazirani P; Werner E; Pfister NT; Haji-Seyed-Javadi R; Zhang H; Xu J
Improving provider practice patterns in ordering FDG PET/CT for breast cancer patients at a safety-net hospital.
Volume: 38
05/20/2020 Authors: Abolghasemi D; Ho T; Short J; Subhedar P; Okoli J; Gogineni K; Lin JY; Yu DS; Carter T; Yang S
Replication stress and FOXM1 drive radiation induced genomic instability and cell transformation.
PLoS One Volume: 15 Page(s): e0235998
01/01/2020 Authors: Li Z; Yu DS; Doetsch PW; Werner E
Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.
Sci Rep Volume: 9 Page(s): 12546
08/29/2019 Authors: Werner E; Alter A; Deng Q; Dammer EB; Wang Y; Yu DS; Duong DM; Seyfried NT; Doetsch PW
Survival outcomes by high-risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity-scored analysis of the National Cancer Data Base.
Cancer Volume: 125 Page(s): 2782 - 2793
08/15/2019 Authors: Tian S; Switchenko JM; Jhaveri J; Cassidy RJ; Ferris MJ; Press RH; Pfister NT; Patel MR; Saba NF; McDonald MW
Acetylation regulates ribonucleotide reductase activity and cancer cell growth.
Nat Commun Volume: 10 Page(s): 3213
07/19/2019 Authors: Chen G; Luo Y; Warncke K; Sun Y; Yu DS; Fu H; Behera M; Ramalingam SS; Doetsch PW; Duong DM
hnRNPUL1 regulation by ATR in DNA damage response
Volume: 79
07/01/2019 Authors: Zhang H; Head PE; Duong DM; Seyfried NT; Yu DS
DNA-PKCS deacetylation by SIRT2 promotes DNA double-strand break repair by non-homologous end joining
CANCER RESEARCH Volume: 79
07/01/2019 Authors: Head PE; Ganji NP; Wang S-Y; Duong D; Zhang H; Daddacha W; Li S; Seyfried NT; Smalley DM; Wang Y
The role of SIRT2 in BRCA1 regulation
Volume: 79
07/01/2019 Authors: Minten E; Zhang H; Li C; Head P; Yu DS
DNA Repair: Translation to the Clinic.
Clin Oncol (R Coll Radiol) Volume: 31 Page(s): 303 - 310
05/01/2019 Authors: Minten EV; Yu DS
Regulation of BRCA1 by SIRT2
Volume: 79
02/01/2019 Authors: Minten EV; Zhang H; Li C; Head PE; Yu DS
Disparities in Postoperative Therapy for Salivary Gland Adenoid Cystic Carcinomas.
Laryngoscope Volume: 129 Page(s): 377 - 386
02/01/2019 Authors: Cassidy RJ; Switchenko JM; El-Deiry MW; Belcher RH; Zhong J; Steuer CE; Saba NF; McDonald MW; Yu DS; Gillespie TW
Hypofractionated Radiation is Associated with Less Long-Term Breast Retraction Following Breast Conserving Therapy
Volume: 102 Page(s): S227 - S227
11/01/2018 Authors: Wang D; Yang X; He J; Mister D; Brown G; Henry S; Lin JY; Yu DS; Kahn ST; Godette KD
Survival outcomes by HPV status in non-oropharyngeal head and neck cancers: A propensity score matched analysis of population level data.
Volume: 36
05/20/2018 Authors: Tian S; Switchenko JM; Jhaveri J; Cassidy RJ; Ferris MJ; Press RH; Pfister NT; Patel M; Saba NF; McDonald MW
Postoperative Therapy for Salivary Gland Adenoid Cystic Carcinomas
Volume: 100 Page(s): 1382 - 1382
04/01/2018 Authors: Cassidy RJ; Switchenko J; El-Deiry MW; Belcher RH; Zhong J; Steuer C; Saba NF; McDonald MW; Yu DS; Gillespie T
Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy.
J Clin Invest Volume: 128 Page(s): 500 - 516
01/02/2018 Authors: Chen G; Magis AT; Xu K; Park D; Yu DS; Owonikoko TK; Sica GL; Satola SW; Ramalingam SS; Curran WJ
CDK9 Expression Shows Role as a Potential Prognostic Biomarker in Breast Cancer Patients Who Fail to Achieve Pathologic Complete Response after Neoadjuvant Chemotherapy.
Int J Breast Cancer Volume: 2018 Page(s): 6945129
01/01/2018 Authors: Schlafstein AJ; Withers AE; Rudra S; Danelia D; Switchenko JM; Mister D; Harari S; Zhang H; Daddacha W; Ehdaivand S
SIRT2 directs DNA-PKcs in the DNA damage response
Volume: 17
01/01/2018 Authors: Head PE; Zhang H; Yu DS
SAMHD1 is a Novel Biomarker and Therapeutic Target for Radiation Therapy and PARP Inhibition
Volume: 58 Page(s): S83 - S83
09/01/2017 Authors: Schlafstein A; Daddacha W; Kowalski J; Yu DS
SAMHD1 Promotes DNA End Resection to Facilitate DNA Double-Strand Break Repair by Homologous Recombination
Volume: 58 Page(s): S84 - S84
09/01/2017 Authors: Yu DS; Daddacha W; Koyen AE; Bastien AJ; Head PE; Dhere VR; Nabeta GN; Connolly EC; Werner E; Madden MZ
SIRT2 Directs DNA-PKcs in the DNA Damage Response.
Volume: 58 Page(s): S47 - S47
09/01/2017 Authors: Head PE; Zhang H; Yu DS
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Cell Rep Volume: 20 Page(s): 1921 - 1935
08/22/2017 Authors: Daddacha W; Koyen AE; Bastien AJ; Head PE; Dhere VR; Nabeta GN; Connolly EC; Werner E; Madden MZ; Daly MB
Sirtuin 2 mutations in human cancers impair its function in genome maintenance.
J Biol Chem Volume: 292 Page(s): 9919 - 9931
06/16/2017 Authors: Head PE; Zhang H; Bastien AJ; Koyen AE; Withers AE; Daddacha WB; Cheng X; Yu DS
SIRT2 orchestrates the DNA damage response.
Cell Cycle Volume: 15 Page(s): 2089 - 2090
08/17/2016 Authors: Zhang H; Head PE; Yu DS
TNFRSF10C copy number variation is associated with metastatic colorectal cancer.
J Gastrointest Oncol Volume: 7 Page(s): 306 - 314
06/01/2016 Authors: Tanenbaum DG; Hall WA; Colbert LE; Bastien AJ; Brat DJ; Kong J; Kim S; Dwivedi B; Kowalski J; Landry JC
Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas.
World J Gastrointest Oncol Volume: 8 Page(s): 358 - 365
04/15/2016 Authors: Seldon CS; Colbert LE; Hall WA; Fisher SB; Yu DS; Landry JC
Angiotensin Blockade Reduces Quantitative and Qualitative Radiation-Induced Neck Fibrosis: Interim Analysis of Prospective Trial
Volume: 94 Page(s): 956 - 957
03/15/2016 Authors: Okwan-Duodu D; Yang X; Yu DS; Patel K; Switchenko J; Beitler JJ; Curran WJ; Liu T
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Cell Rep Volume: 14 Page(s): 1435 - 1447
02/16/2016 Authors: Zhang H; Head PE; Daddacha W; Park S-H; Li X; Pan Y; Madden MZ; Duong DM; Xie M; Yu B
Progesterone to improve neurocognitive outcomes following cranial irradiation.
Volume: 34 Page(s): 128
01/20/2016 Authors: Atif F; Yu DS; Yousuf S; Bruner D; Curran WJ; Stein DG
Cholangiocarcinoma size on magnetic resonance imaging versus pathologic specimen: Implications for radiation treatment planning.
Pract Radiat Oncol Volume: 6 Page(s): 201 - 206
01/01/2016 Authors: Tanenbaum DG; Hall WA; Mittal P; Nickleach DC; Mikell JL; Colbert LE; Moreno CC; Squires MH; Fisher SB; Yu DS
Radiotherapy patterns of care in gastric adenocarcinoma: a single institution experience.
J Gastrointest Oncol Volume: 6 Page(s): 247 - 253
06/01/2015 Authors: Cheng J; Squires MH; Mikell JL; Fisher SB; Staley CA; Kooby DA; El-Rayes BF; Curran WJ; Hall WA; Colbert LE
Quantitative Ultrasonic Nakagami Imaging ofNeck Fibrosis After Head and Neck Radiation Therapy.
Int J Radiat Oncol Biol Phys Volume: 92 Page(s): 407 - 414
06/01/2015 Authors: Yang X; Yoshida E; Cassidy RJ; Beitler JJ; Yu DS; Curran WJ; Liu T
The 21-gene recurrence score and locoregional recurrence in breast cancer patients.
Ann Surg Oncol Volume: 22 Page(s): 1088 - 1094
04/01/2015 Authors: Jegadeesh NK; Kim S; Prabhu RS; Oprea GM; Yu DS; Godette KG; Zelnak AB; Mister D; Switchenko JM; Torres MA
Locoregional Recurrence Risk in Breast Cancer Patients with Estrogen Receptor Positive Tumors and Residual Nodal Disease following Neoadjuvant Chemotherapy and Mastectomy without Radiation Therapy.
Int J Breast Cancer Volume: 2015 Page(s): 147476
01/01/2015 Authors: Kandula S; Switchenko JM; Harari S; Fasola C; Mister D; Yu DS; Zelnak AB; Torres MA
Locoregional and Distant Recurrence Patterns in Young versus Elderly Women Treated for Breast Cancer.
Int J Breast Cancer Volume: 2015 Page(s): 213123
01/01/2015 Authors: Rudra S; Yu DS; Yu ES; Switchenko JM; Mister D; Torres MA
Automated segmentation of the parotid gland based on atlas registration and machine learning: a longitudinal MRI study in head-and-neck radiation therapy.
Int J Radiat Oncol Biol Phys Volume: 90 Page(s): 1225 - 1233
12/01/2014 Authors: Yang X; Wu N; Cheng G; Zhou Z; Yu DS; Beitler JJ; Curran WJ; Liu T
Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.
Oncogene Volume: 33 Page(s): 5450 - 5456
11/20/2014 Authors: Hall WA; Petrova AV; Colbert LE; Hardy CW; Fisher SB; Saka B; Shelton JW; Warren MD; Pantazides BG; Gandhi K
Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing.
J Biol Chem Volume: 289 Page(s): 30635 - 30644
10/31/2014 Authors: Wang H; Wang X; Chen G; Zhang X; Tang X; Park D; Cucinotta FA; Yu DS; Deng X; Dynan WS
Diagnostic accuracy of ultrasonic histogram features to evaluate radiation toxicity of the parotid glands: a clinical study of xerostomia following head-and-neck cancer radiotherapy.
Acad Radiol Volume: 21 Page(s): 1304 - 1313
10/01/2014 Authors: Yang X; Tridandapani S; Beitler JJ; Yu DS; Chen Z; Kim S; Bruner DW; Curran WJ; Liu T
A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response.
Nucleic Acids Res Volume: 42 Page(s): 11517 - 11527
10/01/2014 Authors: Smith SC; Petrova AV; Madden MZ; Wang H; Pan Y; Warren MD; Hardy CW; Liang D; Liu EA; Robinson MH
Abdominal MRI Radiographic to Pathologic Agreement in Patients With Resected Cholangiocarcinoma
Volume: 90 Page(s): S373 - S373
09/01/2014 Authors: Hall WA; Mittal P; Tanenbaum D; Nickleach DC; Mikell JL; Colbert LE; Moreno CC; Squires MH; Fisher SB; Yu DS
Radiation Therapy Patterns of Care in Gastric Adenocarcinoma: A Single-Institution Experience
Volume: 90 Page(s): S352 - S352
09/01/2014 Authors: Cheng J; Squires MH; Mikell JL; Fisher SB; Hall WA; Colbert LE; Shelton JW; Staley CA; Kooby DA; El-Reyes BF
The Use of MRI for GTV Delineation in Borderline and Locally Advanced Pancreatic Cancer Increases Local Control in Patients Treated With Intensity Modulated Radiation Therapy
Volume: 90 Page(s): S354 - S355
09/01/2014 Authors: Colbert L; Hall WA; Mosley C; Seldon C; Mittal P; Switchenko J; Mikell J; Mavraj G; Yu DS; Landry JC
Indocyanine green loaded liposome nanocarriers for photodynamic therapy using human triple negative breast cancer cells.
Photodiagnosis Photodyn Ther Volume: 11 Page(s): 193 - 203
06/01/2014 Authors: Shemesh CS; Hardy CW; Yu DS; Fernandez B; Zhang H
CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer.
Cancer Res Volume: 74 Page(s): 2677 - 2687
05/15/2014 Authors: Colbert LE; Petrova AV; Fisher SB; Pantazides BG; Madden MZ; Hardy CW; Warren MD; Pan Y; Nagaraju GP; Liu EA
Ultrasonic Nakagami-parameter characterization of parotid-gland injury following head-and-neck radiotherapy: a feasibility study of late toxicity.
Med Phys Volume: 41 Page(s): 022903
02/01/2014 Authors: Yang X; Tridandapani S; Beitler JJ; Yu DS; Wu N; Wang Y; Bruner DW; Curran WJ; Liu T
Chromodomain Helicase DNA Binding Protein 5 (CHD5) Is Associated With Improved Overall Survival in Patients Undergoing Adjuvant Therapy for Resected Pancreatic Adenocarcinoma
Volume: 87 Page(s): S665 - S665
10/01/2013 Authors: Hall WA; Hardy CW; Colbert LE; Fisher S; Kooby DA; Adsay V; Shelton J; Maithel S; Landry JC; Yu D
Quantitative Ultrasound Evaluation of Post-Radiation Therapy Sialadenitis and Fibrosis of the Parotid Glands in Patients Following Head-and-Neck Radiation Therapy
Volume: 87 Page(s): S459 - S459
10/01/2013 Authors: Yang X; Beitler JJ; Yu DS; Tridandapani S; Bruner DW; Curran WJ; Liu T
Pronecrotic Mixed Lineage Kinase Domain-Like (MLKL) Protein Expression Is a Prognostic Biomarker in Patients With Resected Pancreatic Adenocarcinoma
Volume: 87 Page(s): S186 - S187
10/01/2013 Authors: Colbert L; Fisher SB; Hardy CW; Hall WA; Saka B; Adsay NV; Landry JC; Shelton JW; Maithel SK; Yu DS
Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma.
Cancer Volume: 119 Page(s): 3148 - 3155
09/01/2013 Authors: Colbert LE; Fisher SB; Hardy CW; Hall WA; Saka B; Shelton JW; Petrova AV; Warren MD; Pantazides BG; Gandhi K
SIRT2 directs the replication stress response through CDK9 deacetylation.
Proc Natl Acad Sci U S A Volume: 110 Page(s): 13546 - 13551
08/13/2013 Authors: Zhang H; Park S-H; Pantazides BG; Karpiuk O; Warren MD; Hardy CW; Duong DM; Park S-J; Kim H-S; Vassilopoulos A
Segmentation editing improves efficiency while reducing inter-expert variation and maintaining accuracy for normal brain tissues in the presence of space-occupying lesions.
Phys Med Biol Volume: 58 Page(s): 4071 - 4097
06/21/2013 Authors: Deeley MA; Chen A; Datteri RD; Noble J; Cmelak A; Donnelly E; Malcolm A; Moretti L; Jaboin J; Niermann K
A synthetic lethal screen identifies determinants of gemcitabine sensitivity in pancreatic cancer.
Volume: 73
04/15/2013 Authors: Warren MD; Hardy CW; Pantazides BG; Gandhi K; Landry JC; Shelton JW; Maithel SK; El-Rayes B; Kowalski J; Yu DS
A pilot clinical trial of chromodomain-helicase-DNA-binding protein 7 (CHD7) expression as a prognostic and predictive biomarker in patients with early-stage pancreatic adenocarcinoma.
Volume: 73
04/15/2013 Authors: Colbert LE; Hall WA; Hardy CW; Fisher SB; Yu DS; Maithel SK; El-Rayes B; Saka B; Adsay NV; Petrova A
A Synthetic Lethal Screen Identifies Genes That Mediate Gemcitabine Resistance in Pancreatic Cancer
Volume: 84 Page(s): S88 - S88
11/01/2012 Authors: Pantazides B; Hardy C; Gandhi K; Landry J; Shelton J; Maithel S; El-Rayes B; Kowalski J; Yu D
SIRT2 Directs the Replication Stress Response Through CDK9 Deacetylation
Volume: 84 Page(s): S677 - S677
11/01/2012 Authors: Zhang H; Park S; Pantazides BG; Hardy CW; Seyfried NT; Duong D; Yu DS
A Loss of Function Genetic Screen Identifies Determinants of Sensitivity to PARP Inhibitor ABT-888 in Pancreatic Cancer
Volume: 84 Page(s): S325 - S325
11/01/2012 Authors: Park W; Pantazides BG; El-Rayes BF; Shelton JW; Yu DS
Ultrasound Histogram Assessment of Acute and Late Parotid Gland Injury Following Head-and-Neck Radiation Therapy
Volume: 84 Page(s): S500 - S500
11/01/2012 Authors: Yang X; Beitler JJ; Yu D; Tridandapani S; Curran WJ; Liu T
Ultrasound Nakagami Imaging to Evaluate Neck Fibrosis Following Head and Neck Radiation Therapy: A Feasibility and Reproducibility Study
Volume: 84 Page(s): S31 - S31
11/01/2012 Authors: Yang X; Beitler JJ; Yu D; Tridandapani S; Curran WJ; Liu T
Ultrasound histogram assessment of parotid gland injury following head-and-neck radiotherapy: a feasibility study.
Ultrasound Med Biol Volume: 38 Page(s): 1514 - 1521
09/01/2012 Authors: Yang X; Tridandapani S; Beitler JJ; Yu DS; Yoshida EJ; Curran WJ; Liu T
Ultrasound GLCM texture analysis of radiation-induced parotid-gland injury in head-and-neck cancer radiotherapy: an in vivo study of late toxicity.
Med Phys Volume: 39 Page(s): 5732 - 5739
09/01/2012 Authors: Yang X; Tridandapani S; Beitler JJ; Yu DS; Yoshida EJ; Curran WJ; Liu T
One stone, two birds: CDK9-directed activation of UBE2A regulates monoubiquitination of both H2B and PCNA.
Cell Cycle Volume: 11 Page(s): 2418
07/01/2012 Authors: Zhang H; Yu DS
Ultrasound Texture Analysis of Radiation-Induced Parotid-Gland Injury in Post-Radiotherapy Head-And-Neck Patients: Feasibility Study
Volume: 39 Page(s): 4003 - 4003
06/01/2012 Authors: Yang X; Tridandapani S; Beitler J; Yu D; Henry S; Chen H; Curran W; Liu T
The negative effect of triple-negative breast cancer on outcome after breast-conserving therapy.
Ann Surg Oncol Volume: 18 Page(s): 2858 - 2865
10/01/2011 Authors: Zaky SS; Lund M; May KA; Godette KD; Beitler JJ; Holmes LR; O'Regan RM; Yu ES; Yu DS; Landry JC
Comparison of manual and automatic segmentation methods for brain structures in the presence of space-occupying lesions: a multi-expert study.
Phys Med Biol Volume: 56 Page(s): 4557 - 4577
07/21/2011 Authors: Deeley MA; Chen A; Datteri R; Noble JH; Cmelak AJ; Donnelly EF; Malcolm AW; Moretti L; Jaboin J; Niermann K
A role for CDK9-cyclin K in maintaining genome integrity.
Cell Cycle Volume: 10 Page(s): 28 - 32
01/01/2011 Authors: Yu DS; Cortez D
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.
EMBO Rep Volume: 11 Page(s): 876 - 882
11/01/2010 Authors: Yu DS; Zhao R; Hsu EL; Cayer J; Ye F; Guo Y; Shyr Y; Cortez D
Prognostic factors for resected non-small cell lung cancer with pN2 status: implications for use of postoperative radiotherapy.
Oncologist Volume: 14 Page(s): 1106 - 1115
11/01/2009 Authors: Moretti L; Yu DS; Chen H; Carbone DP; Johnson DH; Keedy VL; Putnam JB; Sandler AB; Shyr Y; Lu B
A Synthetic Lethal Screen Identifies CDK9 as a Novel Replication Stress Response Protein
Volume: 75 Page(s): S18 - S18
01/01/2009 Authors: Yu DS; Zhao R; Cortez D
Factors predicting outcome after postoperative radiotherapy in non-small cell lung cancer with pN2 status.
J Clin Oncol Volume: 26 Page(s): 7562
05/20/2008 Authors: Yu DS; Moretti L; Chen H; Lu B
Regulation of DNA replication fork stabilization and recovery in response to DNA damage
Volume: 72 Page(s): S694 - S695
01/01/2008 Authors: Yu DS; Zhao R; Cortez D
Exonuclease activity is essential for Mre11 in controlling microhomology mediated end joining of DNA double-strand breaks
Volume: 69 Page(s): S598 - S599
01/01/2007 Authors: Yu DS; Zhuang J; Nam E; Willers H; Xia F
A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair.
Mol Cell Volume: 19 Page(s): 841 - 847
09/16/2005 Authors: Matsushita N; Kitao H; Ishiai M; Nagashima N; Hirano S; Okawa K; Ohta T; Yu DS; McHugh PJ; Hickson ID
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Cell Volume: 115 Page(s): 523 - 535
11/26/2003 Authors: Hughes-Davies L; Huntsman D; Ruas M; Fuks F; Bye J; Chin S-F; Milner J; Brown LA; Hsu F; Gilks B
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2.
Mol Cell Volume: 12 Page(s): 1029 - 1041
10/01/2003 Authors: Yu DS; Sonoda E; Takeda S; Huang CLH; Pellegrini L; Blundell TL; Venkitaraman AR
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
EMBO J Volume: 22 Page(s): 4566 - 4576
09/01/2003 Authors: Shin DS; Pellegrini L; Daniels DS; Yelent B; Craig L; Bates D; Yu DS; Shivji MK; Hitomi C; Arvai AS
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Nature Volume: 420 Page(s): 287 - 293
11/21/2002 Authors: Pellegrini L; Yu DS; Lo T; Anand S; Lee M; Blundell TL; Venkitaraman AR
A functional comparison of BRCA1 C-terminal domains in transcription activation and chromatin remodeling.
J Biol Chem Volume: 275 Page(s): 40169 - 40173
12/22/2000 Authors: Miyake T; Hu YF; Yu DS; Li R
Activation of chromosomal DNA replication in Saccharomyces cerevisiae by acidic transcriptional activation domains.
Mol Cell Biol Volume: 18 Page(s): 1296 - 1302
03/01/1998 Authors: Li R; Yu DS; Tanaka M; Zheng L; Berger SL; Stillman B
Association of a 14-3-3 protein with CMP-NeuAc:GM1 alpha 2,3-sialyltransferase.
Biochem Biophys Res Commun Volume: 224 Page(s): 103 - 107
07/05/1996 Authors: Gao L; Gu XB; Yu DS; Yu RK; Zeng G
Molecular cloning of rat brain cDNA for 14-3-3 protein
JOURNAL OF NEUROCHEMISTRY Volume: 66 Page(s): S43 - S43
01/01/1996 Authors: Gao LY; Zeng GC; Yu DS; Shieh S; Yu RK
Molecular cloning of rat 14-3-3 cDNA associated with sialyltransferases
JOURNAL OF NEUROCHEMISTRY Volume: 67 Page(s): S2 - S2
01/01/1996 Authors: Gao LY; Zeng GC; Yu DS; Yu RK
Morphometric analysis of the developing optic nerve of the F1 heterotic mouse and its parental strains.
Neurosci Lett Volume: 119 Page(s): 179 - 181
11/13/1990 Authors: Bigbee JW; Yu DS; Yu RK

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