Hanjoong Jo PhD
- Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory
Professor
- (404) 712-9654
- hjo@emory.edu
- Google Scholar publication
Overview
Dr. Hanjoong Jo is John and Jan Portman Professor in the Coulter Department of Biomedical Engineering (BME) at Georgia Tech and Emory University, and Professor of Medicine at Emory University. He is also the Associate Chair of Emory in BME Department. Upon graduation from Korea University, Dr. Jo received PhD under the co-mentorship of Professors John Tarbell (Chemical Engineering) and Ted Hollis (Physiology) at Pennsylvania State University in 1989. Following postdoctoral training in Jay McDonald Lab at Washington University in St. Louis and University of Alabama at Birmingham, he became Assistant Professor in Pathology and BME. Dr. Jo joined the BME Department at Georgia Tech and Emory University in 2000. He directs the Cardiovascular Mechanobiology and Nanomedicine lab. His lab studies how mechanical force associated with blood flow regulates vascular biology and cardiovascular disease, especially atherosclerosis, aortic valve (AV) calcification, and abdominal aortic aneurysms. He has published more than 150 peer-reviewed papers and edited two books. He developed the mouse model of atherosclerosis, known as partial carotid ligation model, induced by disturbed flow. His work led to the discovery of several genes (mechanosensitive genes and microRNAs) and epigenetic controlling mechanisms that are regulated by bad blood flow and play key roles in atherosclerosis and AAA. By targeting some of these mechanosensitive genes, his lab has been able to treat atherosclerosis and AAA in mice. His lab is now working on nanotechnologies to developing targeted gene and drug therapies in an effort to translate mouse studies toward clinical application. He is an elected fellow of American Institute of Medical and Biological Engineering, Biomedical Engineering Society, American Heart Association and American Physiological Society. He serves as associate editors and editorial board members of several cardiovascular and biomedical engineering journals including Scientific Reports, Circulation Research, Atherosclerosis Thrombosis Vascular Biology, Am J Physiology, Cell Molecular Bioengineering and Cardiovascular Engineering and Technology. He also has been serving as reviewers and chairs of study sections of the NIH, NSF, Veterans Administration and Am Heart Association. He also organized several international meetings, and in 2012, he served as the Chair of the Annual BME Society Meeting. He is also the founding President of Korean-American BME Society and Chairs of US-Korea Annual BMES Workshops since 2013. He has been a Distinguished Visiting Professor at Ewha Womans University and Chonbuk National University.
Academic Appointment
- Adjunct Professor, Department of Life Science, Ewha Womans University
- Professor, Division of Cardiology, Department of Medicine, Emory University
- Professor of Biomedical Engineering, Biomedical Engineering, Georgia Tech
- Professor of Biomedical Engineering, Emory University
- Member, Molecular and Systems Pharmacology Division, Emory University
Education
Degrees
- BA from Korea University
- PhD from Pennsylvania State University
Research
Focus
- The major focus of my research is on understanding the biological and pathophysiologic responses of vascular endothelial cells to mechanical force caused by blood flow (shear stress). My research activities are directed toward understanding the molecular mechanisms by which disturbed blood flow regulates vascular endothelial biology and how it controls cardiovascular diseases atherosclerosis, aortic aneurysm and aortic valve diseases.
Publications
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Lysyl-tRNA synthetase 1 promotes atherogenesis via autophagy-related secretion and inflammation.
Sci Rep Volume: 15 Page(s): 11099
04/01/2025 Authors: Yun K; Seo Y; Oh Y; Kim S; Maeng HS; Cho JG; Son YB; Son DJ; Kwon K; Kim S -
Endothelial cell (EC)-specific Ctgf/Ccn2 expression increases EC reprogramming and atherosclerosis.
Matrix Biol Volume: 136 Page(s): 102 - 110
04/01/2025 Authors: Li F; Kumar S; Pokutta-Paskaleva A; Kang D-W; Kim C; Raykin J; Omojola V; Hoffmann C; Zhao F; Teichmann M -
Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis.
03/07/2025 Authors: Park C; Baek KI; Hung R-C; Choi L; Jeong K; Kim P; Jahng AK; Kim JH; Meselhe M; Kannan A -
Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis.
bioRxiv
03/06/2025 Authors: Park C; Baek KI; Hung R-C; Choi L; Jeong K; Kim P; Jahng AK; Kim JH; Meselhe M; Kannan A -
Inhibiting MiR-33a-3p Expression Fails to Enhance ApoAI-Mediated Cholesterol Efflux in Pro-Inflammatory Endothelial Cells.
Medicina (Kaunas) Volume: 61
02/13/2025 Authors: Huang K; Pokhrel A; Echesabal-Chen J; Scott J; Bruce T; Jo H; Stamatikos A -
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis.
Nat Cardiovasc Res Volume: 4 Page(s): 145 - 162
02/01/2025 Authors: Su M; Zhao W; Jiang H; Zhao Y; Liao Z; Liu Z; Xu M; Jiang S; Wu L; Yang Y -
Side- and Disease-Dependent Changes in Human Aortic Valve Cell Population and Transcriptomic Heterogeneity Determined by Single-Cell RNA Sequencing.
Genes (Basel) Volume: 15
12/19/2024 Authors: Villa-Roel N; Park C; Andueza A; Baek KI; Su A; Blaser MC; Leshnower BG; Yoganathan A; Aikawa E; Jo H -
FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-Cbl-NF-B signaling.
bioRxiv
12/08/2024 Authors: Murphy JM; Tran DTK; Jeong K; Nguyen L; Nguyen MT; Tambe D; Jo H; Ahn E-YE; Lim S-TS -
Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier.
Nat Commun Volume: 15 Page(s): 8021
09/13/2024 Authors: Guo Y; Lee H; Kim C; Park C; Yamamichi A; Chuntova P; Gallus M; Bernabeu MO; Okada H; Jo H -
A Biomimetic Leaflet Scaffold for Aortic Valve Remodeling.
Adv Healthc Mater Volume: 13 Page(s): e2303972
09/01/2024 Authors: De Jesus Morales KJ; Santosa U; Brazhkina O; Rajurkar P; Jo H; Davis ME