Emory Urology Penile Cancer Research & Clinical Trials

International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)

Inclusion Criteria:

• Histologically-proven squamous cell carcinoma of the penis

• Stage:
  – any T, N1 (i.e. a palpable mobile unilateral inguinal lymph node), M0 or;
  – any T, N2 (i.e. palpable mobile multiple or bilateral inguinal lymph nodes), M0 or;
  – any T, N3 (i.e. fixed inguinal nodal mass or any pelvic lymphadenopathy), M0

• Measurable disease as determined by RECIST (version 1.1) criteria

• Performance Status ECOG 0, 1 or 2

Exclusion Criteria:

• Pure verrucous carcinoma of the penis

• Non-squamous malignancy of the penis

• Squamous carcinoma of the urethra

• Stage M1

• Previous chemotherapy or chemoradiotherapy outside of the InPACT trial

• Concurrent malignancy (other than SCC or basal cell carcinoma of non-penile skin) that has required surgical or non-surgical treatment in the last three years

Principal Investigator: 

Viraj Master, MD, PhD

Co-Investigators & Collaborators: 

Department of Urology: Kenneth Ogan, MD, Department of Hematology and Medical Oncology: Mehmet Bilen, MD, Bradley Carthon, MD, PhD, Omer Kucuk, MD, David Lawson, MD, Department of Radiation Oncology: Joseph Shelton, MD, Ashesh Jani, MD