ECOG-InPact
International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)
Inclusion Criteria:
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Histologically-proven squamous cell carcinoma of the penis
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Stage:
– any T, N1 (i.e. a palpable mobile unilateral inguinal lymph node), M0 or;
– any T, N2 (i.e. palpable mobile multiple or bilateral inguinal lymph nodes), M0 or;
– any T, N3 (i.e. fixed inguinal nodal mass or any pelvic lymphadenopathy), M0 -
Measurable disease as determined by RECIST (version 1.1) criteri
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Performance Status ECOG 0, 1 or 2
Exclusion Criteria:
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Pure verrucous carcinoma of the penis
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Non-squamous malignancy of the penis
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Squamous carcinoma of the urethra
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Stage M1
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Previous chemotherapy or chemoradiotherapy outside of the InPACT trial
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Concurrent malignancy (other than SCC or basal cell carcinoma of non-penile skin) that has required surgical or non-surgical treatment in the last three years
Principal Investigator:
Co-Investigators & Collaborators:
Department of Urology: Kenneth Ogan, MD, Department of Hematology and Medical Oncology: Mehmet Bilen, MD, Bradley Carthon, MD, PhD, Omer Kucuk, MD, David Lawson, MD, Department of Radiation Oncology: Joseph Shelton, MD, Ashesh Jani, MD