Faculty Publications

Ryder PV, Fang J, Lerit DA. c entrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis. J Cell Biol. 2020 219 (12):e202004101. https://doi.org/10.1083/jcb.202004101

*Highlight of article in JBC Spotlight.

Rui Y, Pollitt SL, Myers KR, Feng Y, Zheng JQ. Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store-Operated Ca²⁺ Entry and Release. eNeuro. 2020 Aug 17;7(4):ENEURO.0347-19.2020. doi: 10.1523/ENEURO.0347-19.2020. PMID: 32409508; PMCID: PMC7438061.

McEachin ZT, Parameswaran J, Raj N, Bassell GJ, Jiang J. RNA-mediated toxicity in C9orf72 ALS and FTD. Neurobiology of Disease, Volume 145, November 2020, 105055. https://doi.org/10.1016/j.nbd.2020.105055

Pollitt SL, Meyers KR, Yoo J, Zheng JQ. LIM and SH3 Protein 1 Localizes to the Leading Edge of Protruding Lamellipodia and Regulates Axon Development. Mol Biol Cell. 2020 Sep 30;mbcE20060366. doi: 10.1091/mbc.E20-06-0366. *Stephanie Pollitt is first author

Todd TW, McEachin ZT, Chew J, Burch AR, Jansen-West K, Tong J, Yue M, Song Y, Castanedes-Casey M, Kurti A, Dunmore JH, Fryer JD, Zhang YJ, San Millan B, Teijeira Bautista S, Arias M, Dickson D, Gendron TF, Sobrido MJ, Disney MD, Bassell GJ, Rossoll W, Petrucelli L. Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo. Cell Rep. 2020 May 5;31(5):107616. doi: 10.1016/j.celrep.2020.107616. PMID: 32375043.

Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons Through an FMRP-Dependent Mechanism. iScience (2020), DOI

Chimeric peptides contribute to divergent DPR pathology in c9ALS/FTD and SCA36. McEachin ZT, Gendron TF, Raj N, García-Murias M, Banerjee A, Purcell RH, Ward PJ,Todd TW, Merritt-Garza ME, Jansen-West K, Hales CM, García-Sobrino T, Quintáns B, Holler CJ, Taylor G, San Millán B, Teijeira S, Yamashita T, Ohkubo R, Boulis NM, Xu C, Wen Z, Streichenberger N, Fogel BL, Kukar T, Abe K, Dickson DW, Arias M, Glass JD, Jiang J, Tansey MG, Sobrido M, Petrucelli L, Rossoll W, Bassell GJ.
Neuron 2020 May 05, DOI

VE-cadherin endocytosis controls vascular integrity and patterning during development. Grimsley-Myers CM, Isaacson RH, Cadwell CM, Campos J, Hernandes MS, Myers KR, Seo T, Giang W, Griendling KK, Kowalczyk AP. J Cell Biol (2020) 219 (5): e201909081.

Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans. Lee TW, David HS, Engstrom AK, Carpenter BS, Katz DJ. Elife. 2019 Dec 9;8. pii: e48498. doi: 10.7554/eLife.48498.

Drosophila pericentrin-like protein promotes the formation of primordial germ cells. Fang J, Lerit DA. Genesis. 2019 Nov 27:e23347. doi: 10.1002/dvg.23347. [Epub ahead of print]

Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary. Benner L, Castro EA, Whitworth C, Venken KJT, Yang H, Fang J, Oliver B, Cook KR, Lerit DA. Genetics. 2019 Nov;213(3):877-895. doi: 10.1534/genetics.119.302590. Epub 2019 Sep 26.

A Network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca²⁺-activated Cl⁻ channel ANO1 (TMEM16A) Yu K, Jiang T, Cui Y, Tajkhorshid E, Hartzell HC. Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19952-19962. doi: 10.1073/pnas.1904012116. Epub 2019 Sep 12.

Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum. Rowan MJ, Bonnan A*, Zheng K, Amat SB, Augustine GJ, Christie JM (2018). Neuron. 99, 999-1015.

Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Rutkowski TP, Purcell RH, Pollak RM, Grewenow SM, Gafford GM, Malone T, Khan UA, Schroeder JP, Epstein MP, Bassell GJ, Warren ST, Weinshenker D, Caspary T, Mulle JG. Mol Psychiatry. 2019 Apr 11. doi: 10.1038/s41380-019-0413-5. [Epub ahead of print]

Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior. Gokhale A, Hartwig C, Freeman AAH, Bassell JL, Zlatic SA, Sapp Savas C, Vadlamudi T, Abudulai F, Pham TT, Crocker A, Werner E, Wen Z, Repetto GM, Gogos JA, Claypool SM¹, Forsyth JK, Bearden CE, Glausier J, Lewis DA, Seyfried NT, Kwong J, Faundez V. J Neurosci. 2019 Mar 4. pii: 1983-18. doi: 10.1523/JNEUROSCI.1983-18.2019. [Epub ahead of print]

Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons. Bülow P, Murphy TJ, Bassell GJ, Wenner P. Cell Reports; Volume 26, Issue 6, P1378-1388.E3, February 05, 2019.

Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.  Zlatic SA, Vrailas-Mortimer A, Gokhale A, Carey LJ, Scott E, Burch R, McCall MM, Rudin-Rush S, Davis JB, Hartwig C, Werner E, Li L, Petris M, Faundez V. Cell Systems, January 31, 2018; DOI:https://doi.org/10.1016/j.cels.2018.01.008.

The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length. Hunter EL, Lechtreck K, Fu G, Hwang J, Lin H, Gokhale A, Alford LM, Lewis B, Yamamoto R, Kamiya R, Yang F, Nicastro D, Dutcher SK, Wirschell M, Sale WS. Mol Biol Cell. 2018 Apr 15;29(8):886-896. doi: 10.1091/mbc.E17-12-0729. Epub 2018 Mar 29.

Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model. Gross C, Banerjee A, Tiwari D, Longo F, White AR, Allen AG, Schroeder-Carter LM, Krzeski JC, Elsayed NA, Puckett R, Klann E, Rivero RA, Gourley, Bassell GJ. Neuropsychopharmacology. 2019 Jan;44(2):324-333. doi: 10.1038/s41386-018-0150-5. Epub 2018 Jul 13.

microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease. Thomas KT, Gross C, Bassell GJ. Front. Mol. Neurosci., 12 December 2018;

LSD1 protects against hippocampal and cortical neurodegeneration. Christopher MA, Myrick DA, Barwick BG, Engstrom AK, Porter-Stransky KA, Boss JM, Weinshenker D, Levey AI, Katz DJ. Nat Commun. 2017 Oct 9;8(1):805. doi: 10.1038/s41467-017-00922-9.

Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction. Thomas KT, Anderson BR, Shah N, Zimmer SE, Hawkins D, Valdez AN, Gu Q, Bassell GJ. Cell Rep. 2017 Jul 5;20(1):1-12. doi: 10.1016/j.celrep.2017.06.038.

Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms. Yamamoto R, Obbineni JM, Alford LM, Ide T, Owa M, Hwang J, Kon T, Inaba K, James N, King SM, Ishikawa T, Sale WS, Dutcher SK. PLoS Genet. 2017 Sep 11;13(9):e1006996. doi: 10.1371/journal.pgen.1006996. eCollection 2017 Sep.

Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity. Lei W, Myers KR, Rui Y, Hladyshau S, Tsygankov D, Zheng JQ. J Cell Biol. 2017 Jun 28. pii: jcb.201612042. doi: 10.1083/jcb.201612042. [Epub ahead of print]

The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors.Comstra HS, McArthy J, Rudin-Rush S, Hartwig C, Gokhale A, Zlatic SA, Blackburn JB, Werner E, Petris M, D'Souza P, Panuwet P, Barr DB, Lupashin V, Vrailas-Mortimer A, Faundez V. Elife. 2017 Mar 29;6. pii: e24722. doi: 10.7554/eLife.24722. PMID: 28355134.

Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus.Larimore J, Zlatic SA, Arnold M, Singleton KS, Cross R, Rudolph H, Bruegge MV, Sweetman A, Garza C, Whisnant E, Faundez V. Front Genet. 2017 Mar 10;8:28. doi: 10.3389/fgene.2017.00028. eCollection 2017. PMID: 28344592.

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly. Donlin-Asp PG, Fallini C, Campos J, Chou CC, Merritt ME, Phan HC, Bassell GJ, Rossoll W. Cell Rep. 2017 Feb 14;18(7):1660-1673. doi: 10.1016/j.celrep.2017.01.059. PubMed PMID: 28199839.

Germ Cell-less Promotes Centrosome Segregation to Induce Germ Cell Formation. Lerit DA, Shebelut CW, Lawlor KJ, Rusan NM, Gavis ER, Schedl P, Deshpande G. Cell Rep. 2017 Jan 24;18(4):831-839. doi: 10.1016/j.celrep.2016.12.074. PubMed PMID: 28122234; PubMed Central PMCID: PMC5327791.

MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset. Gross C, Yao X, Engel T, Tiwari D, Xing L, Rowley S, Danielson SW, Thomas KT, Jimenez-Mateos EM, Schroeder LM, Pun RY, Danzer SC, Henshall DC, Bassell GJ. Cell Rep. 2016 Sep 27;17(1):37-45. doi: 10.1016/j.celrep.2016.08.074. PubMed PMID: 27681419; PubMed Central PMCID: PMC5061042.

Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner. Rui Y, Zheng JQ. Mol Brain. 2016 Aug 17;9(1):79. PMID: 27535553.

Molecular organization of the desmosome as revealed by direct stochastic optical reconstruction microscopy. Stahley SN, Bartle EI, Atkinson CE, Kowalczyk AP, Mattheyses AL. J Cell Sci. 2016 Aug 1;129(15):2897-904. doi: 10.1242/jcs.185785. Epub 2016 Jun 17. PMID: 27505428.

Identification of consensus binding sites clarifies FMRP binding determinants. Anderson BR, Chopra P, Suhl JA, Warren ST, Bassell GJ. Nucleic Acids Res. 2016 Aug 19;44(14):6649-59. Epub 2016 Jul 4. PMID: 27378784.

Upslope treadmill exercise enhances motor axon regeneration but not functional recovery following peripheral nerve injury. Cannoy J, Crowley S, Jarratt A, Werts KL, Osborne K, Park S, English AW. J Neurophysiol. 2016 Jul 27:jn.00129.2016. [Epub ahead of print] PMID: 27466130.

Selective Requirement for Maintenance of Synaptic Contacts onto Motoneurons by Target-Derived trkB Receptors. Zhu X, Ward PJ, English AW. Neural Plast. 2016;2016:2371893. Epub 2016 Jun 28. PMID: 27433358.

Optically-Induced Neuronal Activity Is Sufficient to Promote Functional Motor Axon Regeneration In Vivo. Ward PJ, Jones LN, Mulligan A, Goolsby W, Wilhelm JC, English AW. PLoS One. 2016 May 6;11(5):PMID: 27152611.

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons. Fallini C, Donlin-Asp PG, Rouanet JP, Bassell GJ, Rossoll W. J Neurosci. 2016 Mar 30;36(13):3811-20. PMID: 27030765.

hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation. Williams KR, McAninch DS, Stefanovic S, Xing L, Allen M, Li W, Feng Y, Mihailescu MR, Bassell GJ. Mol Biol Cell. 2016 Feb 1;27(3):518-34. Epub 2015 Dec 10. PMID: 26658614.

Super-Resolution Microscopy Reveals Altered Desmosomal Protein Organization in Tissue from Patients with Pemphigus Vulgaris. Stahley SN, Warren MF, Feldman RJ, Swerlick RA, Mattheyses AL, Kowalczyk AP. J Invest Dermatol. 2016 Jan;136(1):59-66. doi: 10.1038/JID.2015.353. PMID: 26763424.

Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally. Wasson JA, Simon AK, Myrick DA, Wolf G, Driscoll S, Pfaff SL, Macfarlan TS, Katz DJ. Elife. 2016 Jan 27;5. PMID: 26814574 .

A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR. Suhl JA, Muddashetty RS, Anderson BR, Ifrim MF, Visootsak J, Bassell GJ, Warren ST., Proc Natl Acad Sci U S A. 2015 Nov 9. pii: 201514260. [Epub ahead of print]

Dysregulation and restoration of translational homeostasis in fragile X syndrome. Richter JD, Bassell GJ, Klann E. Nat Rev Neurosci. 2015 Oct;16(10):595-605. Epub 2015 Sep 9.

Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor. Gokhale A, Vrailas-Mortimer A, Larimore J, Comstra HS, Zlatic SA, Werner E, Manvich DF, Iuvone PM, Weinshenker D, Faundez V. Hum Mol Genet. 2015 Oct 1;24(19):5512-23. Epub 2015 Jul 21. PMID: 26199316.

Fragile X mental retardation protein interactions with a G quadruplex structure in the 3'-untranslated region of NR2B mRNA. Stefanovic S, DeMarco BA, Underwood A, Williams KR, Bassell GJ, Mihailescu MR. Mol Biosyst. 2015 Sep 28. [Epub ahead of print] PMID:26412477.

Real-time fluorescence imaging with 20 nm axial resolution. Stabley DR, Oh T, Simon SM, Mattheyses AL, Salaita K. Nat Commun. 2015 Sep 22;6:8307. PMID: 26392382.

PABPN1 suppresses TDP-43 toxicity in ALS disease models. Chou CC, Alexeeva OM, Yamada S, Pribadi A, Zhang Y, Mo B, Williams KR, Zarnescu DC, Rossoll W. Hum Mol Genet. 2015 Sep 15;24(18):5154-73. Epub 2015 Jun 30. PMID: 26130692.

The ecdysone receptor coactivator Taiman links Yorkie to transcriptional control of germline stem cell factors in somatic tissue. Zhang C, Robinson BS, Xu W, Yang L, Yao B, Zhao H, Byun PK, Jin P, Veraksa A, Moberg KH. Dev Cell. 2015 Jul 27;34(2):168-80. doi: 10.1016/j.devcel.2015.05.010. Epub 2015 Jul 2. PMID: 26143992.

The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. Gokhale A, Mullin AP, Zlatic SA, Easley CA 4th, Merritt ME, Raj N, Larimore J, Gordon DE, Peden AA, Sanyal S, Faundez V. J Neurosci. 2015 May 13;35(19):7643-53. PMID: 25972187.