Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology. Goettemoeller AM, Banks E, McCann KE, Kumar P, South K, Olah VJ, Ramelow CC, Duong DM, Seyfried NT, Rangaraju S, Weinshenker D, Rowan MJ. Res Sq [Preprint]. 2023 Nov 6:rs.3.rs-3370607. doi: 10.21203/rs.3.rs-3370607/v1. PMID: 37987015; PMCID: PMC10659529.
A novel enhancer-AAV approach selectively targeting dentate granule cells. Banks E, Gutekunst CA, Vargish GA, Eaton A, Pelkey KA, McBain CJ, Zheng JQ, Oláh VJ, Rowan MJ. bioRxiv [Preprint]. 2023 May 11:2023.02.03.527045. doi: 10.1101/2023.02.03.527045. Update in: Cell Rep Methods. 2024 Jan 1;:100684. PMID: 37214904; PMCID: PMC10197561.Excitatory and Inhibitory Descending Commissural Interneurons Differentially Integrate Supraspinal and Segmental Sensory Signals. Giorgi A, Cer AT, Mohan S, Perreault MC. J Neurosci. 2023 Jul 5;43(27):5014-5029. doi: 10.1523/JNEUROSCI.2015-22.2023. Epub 2023 Jun 7. PMID: 37286348; PMCID: PMC10324999.
Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion. Purcell RH, Sefik E, Werner E, King AT, Mosley TJ, Merritt-Garza ME, Chopra P, McEachin ZT, Karne S, Raj N, Vaglio BJ, Sullivan D, Firestein BL, Tilahun K, Robinette MI, Warren ST, Wen Z, Faundez V, Sloan SA, Bassell GJ, Mulle JG. Sci Adv. 2023 Aug 18;9(33):eadh0558. doi: 10.1126/sciadv.adh0558. Epub 2023 Aug 16. PMID: 37585521; PMCID: PMC10431714.
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Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation. Sivasami P, Elkins C, Diaz-Saldana PP, Goss K, Peng A, Hamersky M 4th, Bae J, Xu M, Pollack BP, Horwitz EM, Scharer CD, Seldin L, Li C. Immunity. 2023 Aug 8;56(8):1844-1861.e6. doi: 10.1016/j.immuni.2023.06.021. Epub 2023 Jul 20. PMID: 37478855.
Streamlined Intravital Imaging Approach for Long-Term Monitoring of Epithelial Tissue Dynamics on an Inverted Confocal Microscope. Hamersky M 4th, Tekale K, Winfree LM, Rowan MJM, Seldin L. J Vis Exp. 2023 Jun 30;(196):10.3791/65529. doi: 10.3791/65529. PMID: 37458444; PMCID: PMC10442707.
Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes. Hildebrandt RP, Moss KR, Janusz-Kaminska A, Knudson LA, Denes LT, Saxena T, Boggupalli DP, Li Z, Lin K, Bassell GJ, Wang ET. Nat Commun. 2023;14(1):3427. Published 2023 Jun 9. doi:10.1038/s41467-023-38923-6.
Residency Program Directors' Views on Research Conducted During Medical School: A National Survey. Wolfson RK, Fairchild PC, Bahner I, Baxa DM, Birnbaum DR, Chaudhry SI, Chretien KC, DeFranco DB, Deptola AZ, LaConte LEW, Lin JJ, Petch Lee L, Powers MA, Ropson IJ, Sankaran SM, Sawarynski KE, Sozio SM. Acad Med. 2023 Apr 21. doi: 10.1097/ACM.0000000000005256. Epub ahead of print. PMID: 37099328.
Systemic Metabolic and Mitochondrial Defects in Rett Syndrome Models. Zlatic SA, Werner E, Surapaneni V, Lee CE, Gokhale A, Singleton K, Duong D, Crocker A, Gentile K, Middleton F, Patgiri A, Tarquinio D, Carpenter R, Faundez V. bioRxiv. 2023 Apr 4:2023.04.03.535431. doi: 10.1101/2023.04.03.535431. Preprint. PMID: 37066332 Free PMC article.
APOE expression and secretion are modulated by mitochondrial dysfunction. Wynne ME, Ogunbona O, Lane AR, Gokhale A, Zlatic SA, Xu C, Wen Z, Duong DM, Rayaprolu S, Ivanova A, Ortlund EA, Dammer EB, Seyfried NT, Roberts BR, Crocker A, Shanbhag V, Petris M, Senoo N, Kandasamy S, Claypool SM, Barrientos A, Wingo A, Wingo TS, Rangaraju S, Levey AI, Werner E, Faundez V. Elife. 2023 May 12;12:e85779. doi: 10.7554/eLife.85779. Online ahead of print. PMID: 37171075
Phosphatidylserine exposure modulates adhesion GPCR BAI1 (ADGRB1) signaling activity. Lala T, Doan JK, Takatsu H, Hartzell HC, Shin HW, Hall RA. J Biol Chem. 2022 Dec;298(12):102685. doi: 10.1016/j.jbc.2022.102685. Epub 2022 Nov 9. PMID: 36370845; PMCID: PMC9723945.
Sex differences in the involvement of skeletal and cardiac muscles in myopathic Ano5-/- mice. Foltz S, Wu F, Ghazal N, Kwong JQ, Hartzell HC, Choo HJ. Am J Physiol Cell Physiol. 2022 Feb 1;322(2):C283-C295. doi: 10.1152/ajpcell.00350.2021. Epub 2022 Jan 12. PMID: 35020501; PMCID: PMC8836717.
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS. Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J. Elife. 2023 Apr 19;12:e85902. doi: 10.7554/eLife.85902. PMID: 37073950; PMCID: PMC10188109.
FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination. Wilkerson JR, Ifrim MF, Valdez-Sinon AN, Hahn P, Bowles JE, Molinaro G, Janusz-Kaminska A, Bassell GJ, Huber KM. Neurobiol Dis. 2023 Apr 28;182:106136. doi: 10.1016/j.nbd.2023.106136. Epub ahead of print. PMID: 37120096.
Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF.
Calvo PM, de la Cruz RR, Pastor AM, Alvarez FJ. Brain Struct Funct. 2023 Apr 1; doi: 10.1007/s00429-023-02635-w. Online ahead of print.
Massive Loss of Proprioceptive Ia Synapses in Rat Spinal Motoneurons after Nerve Crush Injuries in the Postnatal Period. Arbat-Plana A, Bolvar S, Navarro X, Udina E, Alvarez FJ. eNeuro. 2023 Feb 16;10(2):ENEURO.0436-22.2023. doi: 10.1523/ENEURO.0436-22.2023. Print 2023 Feb.
Encoding of environmental illumination by primate melanopsin neurons. Liu A, Milner ES, Peng Y-R, Blume HA, Brown MC, Bryman GS, Emanuel AJ, Morquette P, Viet N-M, Sanes JR. Science. 2023 Jan 27;379(6630):376-381. doi: 10.1126/science.ade2024. Epub 2023 Jan 26.
Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion. Purcell RH, Sefik E, Werner E, King AT, Mosley TJ, Merritt-Garza ME, Chopra P, McEachin ZT, Karne S, Raj N, Tilahun K, Robinette M, Warren ST, Wen Z, Faundez V, Sloan SA, Bassell GJ, Mulle JG. bioRxiv [Preprint]. 2023 Jan 28:2023.01.27.525748. doi: 10.1101/2023.01.27.525748. PMID: 36747819; PMCID: PMC9901184.
TMEM16E regulates endothelial cell procoagulant activity and thrombosis. Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S. J Clin Invest. 2023 Mar 23:e163808. doi: 10.1172/JCI163808. Epub ahead of print. PMID: 36951953.
Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye. Zhao H, Moberg KH, Veraksa A. Dev Cell. 2023 Mar 13;58(5):416-434.e12. doi: 10.1016/j.devcel.2023.02.005. Epub 2023 Mar 2. PMID: 36868234; PMCID: PMC10023510.
Revealing gut microbiome associations with CFS. Sampson TR. Cell Host Microbe. 2023 Feb 8;31(2):171-172. doi: 10.1016/j.chom.2023.01.011. PMID: 36758517.
Conditioning electrical stimulation fails to enhance sympathetic axon regeneration. Tian T, Harris A, Owyoung J, SiMa H, Ward PJ. bioRxiv [Preprint]. 2023 Feb 4:2023.02.03.527071. doi: 10.1101/2023.02.03.527071. PMID: 36778305; PMCID: PMC9915730.
Ecdysone acts through cortex glia to regulate sleep in Drosophila. Li Y, Haynes P, Zhang SL, Yue Z, Sehgal A. Elife. 2023 Jan 31;12:e81723. doi: 10.7554/eLife.81723. PMID: 36719183; PMCID: PMC9928426.