Emory University School of Medicine
Emory University School of Medicine
Department of Medicine

Division of Cardiology section navigation

Department of Medicine

Yoon Cardiovascular Lab

The Yoon basic and translational cardiovascular lab is working on projects targeting cardiovascular regeneration.

The overall goal of Dr. Yoon’s laboratory is to develop regenerative therapy for ischemic cardiovascular diseases using stem or progenitor cells and tissue engineering technologies. Over the past 20 years, our research has focused on developing cell-based therapy for cardiovascular disease. Our research has shown the generation of stem cells, their differentiation into the cardiac and vascular lineages, generation of reprogrammed cardiovascular cells and tissues, and investigation of their therapeutic effects and mechanisms in cardiovascular diseases.

We have developed systems to differentiate human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells (hiPSCs), into cardiomyocytes and endothelial cells (ECs) including lymphatic endothelial cells. In addition, we have developed bioengineering approaches to enhance cell survival and function of the implanted cells in cardiovascular tissues. As a new approach, we have also developed a reprogramming system, which can covert human fibroblasts into endothelial cells (ECs), called directly reprogrammed ECs (rECs); into smooth muscle cells (SMCs), called reprogrammed SMCs; and cardiovascular tissue which include reprogrammed cardiovascular cells and extracellular matrix. We have also explored novel therapeutic options for treating diabetic neuropathy and lymphedema using stem cells and small molecules.

Yoon lab is also heavily committed to training next generation scientists and physicians. Thus far, Dr. Yoon have mentored more than 90 undergraduate student interns (among whom almost have entered medical or dental schools, more than 10 entered Ph.D programs), 4 basic science cardiology fellows, 5 medical students, 14 Ph.D students, and 33 post-doctoral fellows.

Current Research Topics include but are not limited to:

  • Stem-based therapy for cardiac regeneration and vascular regeneration
  • Direct Reprogramming of human cells toward endothelial cells and cardiovascular tissues
  • Regenerative tissue engineering approaches with novel synthetic biomaterials: injectable and patch
  • Regenerative therapy for lymphatic vascular disease such as lymphedema or wound healing
  • Cell and small molecule therapy for diabetic neurovascular complications
  • Epigenetic studies for cardiac development and drug discovery


Publications

  1. Cho KW, Andrade M, Zhang Y, Yoon YS. Mammalian CBX7 isoforms p36 and p22 exhibit differential responses to serum, varying functions for proliferation, and distinct subcellular localization. Sci Rep. 2020 May 15;10(1):8061. doi: 10.1038/s41598-020-64908-2. PMID: 32415167; PMCID: PMC7228926.
  2. Shin JI, Oh J, Kim HC, Choi D, Yoon YS. Current State of Cardiovascular Research in Korea. Circ Res. 2019 Dec 6;125(12):1141-1145. doi: 10.1161/CIRCRESAHA.119.310859. Epub 2019 Dec 5. PMID: 31804914; PMCID: PMC7008968.
  3. Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH. Engineering of human brain organoids with a functional vascular-like system. Nat Methods. 2019 Nov;16(11):1169-1175. doi: 1038/s41592-019-0586-5. Epub 2019 Oct 7. PMID: 31591580; PMCID: PMC6918722.
  4. Lee S, Lee SJ, Yoon YS. Vascular Regeneration With New Sources of Endothelial Cells. Circ Res. 2019 Jan 4;124(1):29-31. doi: 10.1161/CIRCRESAHA.118.314195. PMID: 30605418; PMCID: PMC6421855.
  5. Kang B, Shin J, Park HJ, Rhyou C, Kang D, Lee SJ, Yoon YS, Cho SW, Lee H. High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy. Nat Commun. 2018 Dec 20;9(1):5402. doi: 10.1038/s41467-018-07823-5. PMID: 30573732; PMCID: PMC6302096.
  6. Huang NF, Serpooshan V, Morris VB, Sayed N, Pardon G, Abilez OJ, Nakayama KH, Pruitt BL, Wu SM, Yoon YS, Zhang J, Wu JC. Big bottlenecks in cardiovascular tissue engineering. Commun Biol. 2018 Nov 21;1:199. doi: 10.1038/s42003-018-0202-8. PMID: 30480100; PMCID: PMC6249300.
  7. Park M, Yoon YS. Cardiac Regeneration with Human Pluripotent Stem Cell-Derived Cardiomyocytes. Korean Circ J. 2018 Nov;48(11):974-988. doi: 10.4070/kcj.2018.0312. PMID: 30334384; PMCID: PMC6196153.
  8. Lee SJ, Kim KH, Yoon YS. Generation of Human Pluripotent Stem Cell-derived Endothelial Cells and Their Therapeutic Utility. Curr Cardiol Rep. 2018 May 5;20(6):45. doi: 10.1007/s11886-018-0985-8. PMID: 29730842; PMCID: PMC5956226.
  9. Kwon BJ, Wang X, Kang ML, You J, Lee SJ, Kim WS, Yoon YS, Park JC, Sung HJ. Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells. Macromol Biosci. 2018 Feb;18(2). doi: 10.1002/mabi.201700340. Epub 2017 Dec 29. PMID: 29285899.
  10. Lee SJ, Sohn YD, Andukuri A, Kim S, Byun J, Han JW, Park IH, Jun HW, Yoon YS. Enhanced Therapeutic and Long-Term Dynamic Vascularization Effects of Human Pluripotent Stem Cell-Derived Endothelial Cells Encapsulated in a Nanomatrix Gel. Circulation. 2017 Nov 14;136(20):1939-1954. doi: 10.1161/CIRCULATIONAHA.116.026329. Epub 2017 Sep 29. PMID: 28972000; PMCID: PMC5685906.
  11. Yanamandala M, Zhu W, Garry DJ, Kamp TJ, Hare JM, Jun HW, Yoon YS, Bursac N, Prabhu SD, Dorn GW 2nd, Bolli R, Kitsis RN, Zhang J. Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering. J Am Coll Cardiol. 2017 Aug 8;70(6):766-775. doi: 10.1016/j.jacc.2017.06.012. PMID: 28774384; PMCID: PMC5553556.
  12. Ban K, Bae S, Yoon YS. Current Strategies and Challenges for Purification of Cardiomyocytes Derived from Human Pluripotent Stem Cells. Theranostics. 2017 May 17;7(7):2067-2077. doi: 10.7150/thno.19427. PMID: 28638487; PMCID: PMC5479288.
  13. Lee S, Kim JE, Johnson BA, Andukuri A, Yoon YS. Direct reprogramming into endothelial cells: a new source for vascular regeneration. Regen Med. 2017 Apr;12(4):317-320. doi: 10.2217/rme-2017-0022. Epub 2017 Jun 16. PMID: 28621172; PMCID: PMC5532960.
  14. Jun H, Lee JY, Kim JH, Noh M, Kwon TW, Cho YP, Yoon YS. Modified Mouse Models of Chronic Secondary Lymphedema: Tail and Hind Limb Models. Ann Vasc Surg. 2017 Aug;43:288-295. doi: 10.1016/j.avsg.2017.01.023. Epub 2017 May 4. PMID: 28479437.
  15. Lee S, Park C, Han JW, Kim JY, Cho K, Kim EJ, Kim S, Lee SJ, Oh SY, Tanaka Y, Park IH, An HJ, Shin CM, Sharma S, Yoon YS. Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2. Circ Res. 2017 Mar 3;120(5):848-861. doi: 10.1161/CIRCRESAHA.116.309833. Epub 2016 Dec 21. PMID: 28003219; PMCID: PMC5336520.
  16. Alexander GC, Vines JB, Hwang P, Kim T, Kim JA, Brott BC, Yoon YS, Jun HW. Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo. ACS Appl Mater Interfaces. 2016 Mar 2;8(8):5178-87. doi: 10.1021/acsami.6b00565. Epub 2016 Feb 17. PMID: 26849167; PMCID: PMC5179142.
  17. Ban K, Wile B, Cho KW, Kim S, Song MK, Kim SY, Singer J, Syed A, Yu SP, Wagner M, Bao G, Yoon YS. Non-genetic Purification of Ventricular Cardiomyocyte from Differentiating Embryonic Stem Cells through Molecular Beacons Targeting IRX-4. Stem Cell Reports. 2015 Dec 8;5(6):1239-1249. doi: 10.1016/j.stemcr.2015.10.021. PMID: 26651608; PMCID: PMC4682289.
  18. Kim SW, Jin HL, Kang SM, Kim S, Yoo KJ, Jang Y, Kim HO, Yoon YS. Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair. Int J Cardiol. 2016 Jan 15;203:498-507. doi: 10.1016/j.ijcard.2015.10.110. Epub 2015 Oct 23. PMID: 26551883; PMCID: PMC4688096.
  19. Lee S, Valmikinathan CM, Byun J, Kim S, Lee G, Mokarram N, Pai SB, Um E, Bellamkonda RV, Yoon YS. Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes. Biomaterials. 2015 Sep;63:158-67. doi: 10.1016/j.biomaterials.2015.06.009. Epub 2015 Jun 11. PMID: 26102992; PMCID: PMC4489430.
  20. Lee SJ, Park C, Lee JY, Kim S, Kwon PJ, Kim W, Jeon YH, Lee E, Yoon YS. Generation of pure lymphatic endothelial cells from human pluripotent stem cells and their therapeutic effects on wound repair. Sci Rep. 2015 Jun 12;5:11019. doi: 10.1038/srep11019. PMID: 26066093; PMCID: PMC4464258.
  21. Han JW, Choi D, Lee MY, Huh YH, Yoon YS. Bone Marrow-Derived Mesenchymal Stem Cells Improve Diabetic Neuropathy by Direct Modulation of Both Angiogenesis and Myelination in Peripheral Nerves. Cell Transplant. 2016;25(2):313-26. doi: 10.3727/096368915X688209. Epub 2015 May 13. PMID: 25975801; PMCID: PMC4889908.
  22. Kim SW, Houge M, Brown M, Davis ME, Yoon YS. Cultured human bone marrow- derived CD31(+) cells are effective for cardiac and vascular repair through enhanced angiogenic, adhesion, and anti-inflammatory effects. J Am Coll Cardiol. 2014 Oct 21;64(16):1681-94. doi: 10.1016/j.jacc.2014.06.1204. PMID: 25323256; PMCID: PMC4201782.
  23. Wile BM, Ban K, Yoon YS, Bao G. Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs. Nat Protoc. 2014 Oct;9(10):2411-24. doi: 10.1038/nprot.2014.154. Epub 2014 Sep 18. PMID: 25232937; PMCID: PMC4326061.
  24. Ban K, Park HJ, Kim S, Andukuri A, Cho KW, Hwang JW, Cha HJ, Kim SY, Kim WS, Jun HW, Yoon YS. Cell therapy with embryonic stem cell-derived cardiomyocytes encapsulated in injectable nanomatrix gel enhances cell engraftment and promotes cardiac repair. ACS Nano. 2014 Oct 28;8(10):10815-25. doi: 10.1021/nn504617g. Epub 2014 Sep 15. PMID: 25210842; PMCID: PMC4212793.
  25. Andukuri A, Min I, Hwang P, Alexander G, Marshall LE, Berry JL, Wick TM, Joung YK, Yoon YS, Brott BC, Han DK, Jun HW. Evaluation of the effect of expansion and shear stress on a self-assembled endothelium mimicking nanomatrix coating for drug eluting stents in vitro and in vivo. Biofabrication. 2014 Sep;6(3):035019. doi: 10.1088/1758-5082/6/3/035019. Epub 2014 Jul 22. PMID: 25048693; PMCID: PMC4156883.
  26. Kim H, Han JW, Lee JY, Choi YJ, Sohn YD, Song M, Yoon YS. Diabetic Mesenchymal Stem Cells Are Ineffective for Improving Limb Ischemia Due to Their Impaired Angiogenic Capability. Cell Transplant. 2015;24(8):1571-84. doi: 10.3727/096368914X682792. Epub 2014 Jul 8. PMID: 25008576; PMCID: PMC4621803.
  27. Boopathy AV, Che PL, Somasuntharam I, Fiore VF, Cabigas EB, Ban K, Brown ME, Narui Y, Barker TH, Yoon YS, Salaita K, García AJ, Davis ME. The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation. Biomaterials. 2014 Sep;35(28):8103-12. doi: 10.1016/j.biomaterials.2014.05.082. Epub 2014 Jun 25. PMID: 24974008; PMCID: PMC4150689.
  28. Poole J, Mavromatis K, Binongo JN, Khan A, Li Q, Khayata M, Rocco E, Topel M, Zhang X, Brown C, Corriere MA, Murrow J, Sher S, Clement S, Ashraf K, Rashed A, Kabbany T, Neuman R, Morris A, Ali A, Hayek S, Oshinski J, Yoon YS, Waller EK, Quyyumi AA. Effect of progenitor cell mobilization with granulocyte-macrophage colony-stimulating factor in patients with peripheral artery disease: a randomized clinical trial. JAMA. 2013 Dec 25;310(24):2631-9. doi: 10.1001/jama.2013.282540. PMID: 24247554.
  29. Ban K, Wile B, Kim S, Park HJ, Byun J, Cho KW, Saafir T, Song MK, Yu SP, Wagner M, Bao G, Yoon YS. Purification of cardiomyocytes from differentiating pluripotent stem cells using molecular beacons that target cardiomyocyte-specific mRNA. Circulation. 2013 Oct 22;128(17):1897-909. doi: 10.1161/CIRCULATIONAHA.113.004228. Epub 2013 Aug 30. PMID: 23995537; PMCID: PMC3878656.
  30. Kim WS, Lee S, Yoon YS. Cardiovascular repair with bone marrow-derived cells. Blood Res. 2013 Jun;48(2):76-86. doi: 10.5045/br.2013.48.2.76. Epub 2013 Jun 25. PMID: 23826576; PMCID: PMC3698412.
  31. Wang T, Wu H, Li Y, Szulwach KE, Lin L, Li X, Chen IP, Goldlust IS, Chamberlain SJ, Dodd A, Gong H, Ananiev G, Han JW, Yoon YS, Rudd MK, Yu M, Song CX, He C, Chang Q, Warren ST, Jin P. Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol. 2013 Jun;15(6):700-11. doi: 10.1038/ncb2748. Epub 2013 May 19. PMID: 23685628; PMCID: PMC3998089.
  32. Han JW, Sin MY, Yoon YS. Cell therapy for diabetic neuropathy using adult stem or progenitor cells. Diabetes Metab J. 2013 Apr;37(2):91-105. doi: 10.4093/dmj.2013.37.2.91. PMID: 23641349; PMCID: PMC3638231.
  33. Boopathy AV, Pendergrass KD, Che PL, Yoon YS, Davis ME. Oxidative stress- induced Notch1 signaling promotes cardiogenic gene expression in mesenchymal stem cells. Stem Cell Res Ther. 2013 Apr 18;4(2):43. doi: 10.1186/scrt190. PMID: 23597145; PMCID: PMC3706823.
  34. Sohn YD, Somasuntharam I, Che PL, Jayswal R, Murthy N, Davis ME, Yoon YS. Induction of pluripotency in bone marrow mononuclear cells via polyketal nanoparticle-mediated delivery of mature microRNAs. Biomaterials. 2013 Jun;34(17):4235-41. doi: 10.1016/j.biomaterials.2013.02.005. Epub 2013 Mar 9. PMID: 23489923; PMCID: PMC3740735.
  35. Andukuri A, Sohn YD, Anakwenze CP, Lim DJ, Brott BC, Yoon YS, Jun HW. Enhanced human endothelial progenitor cell adhesion and differentiation by a bioinspired multifunctional nanomatrix. Tissue Eng Part C Methods. 2013 May;19(5):375-85. doi: 10.1089/ten.TEC.2012.0312. Epub 2012 Dec 19. PMID: 23126402; PMCID: PMC3603564.
  36. Moon SH, Ban K, Kim C, Kim SS, Byun J, Song MK, Park IH, Yu SP, Yoon YS. Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cells. Int J Cardiol. 2013 Sep 20;168(1):41-52. doi: 10.1016/j.ijcard.2012.09.077. Epub 2012 Oct 6. PMID: 23044428; PMCID: PMC3556195.
  37. Sohn YD, Han JW, Yoon YS. Generation of induced pluripotent stem cells from somatic cells. Prog Mol Biol Transl Sci. 2012;111:1-26. doi: 10.1016/B978-0-12-398459-3.00001-0. PMID: 22917224.
  38. Park C, Lee JY, Yoon YS. Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization. Trends Cardiovasc Med. 2011 Jul;21(5):135-40. doi: 10.1016/j.tcm.2012.04.002. PMID: 22732548; PMCID: PMC3384483.
  39. Lee S, Yoon YS. Revisiting cardiovascular regeneration with bone marrow- derived angiogenic and vasculogenic cells. Br J Pharmacol. 2013 May;169(2):290-303. doi: 10.1111/j.1476-5381.2012.01857.x. PMID: 22250888; PMCID: PMC3651656.
  40. Kim H, Kim JJ, Yoon YS. Emerging therapy for diabetic neuropathy: cell therapy targeting vessels and nerves. Endocr Metab Immune Disord Drug Targets. 2012 Jun;12(2):168-78. doi: 10.2174/187153012800493486. PMID: 22236028; PMCID: PMC4598945.
  41. Upadhyay AK, Rotili D, Han JW, Hu R, Chang Y, Labella D, Zhang X, Yoon YS, Mai A, Cheng X. An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases. J Mol Biol. 2012 Feb 24;416(3):319-27. doi: 10.1016/j.jmb.2011.12.036. Epub 2011 Dec 29. PMID: 22227394; PMCID: PMC3280428.
  42. Han JW, Yoon YS. Epigenetic landscape of pluripotent stem cells. Antioxid Redox Signal. 2012 Jul 15;17(2):205-23. doi: 10.1089/ars.2011.4375. Epub 2012 Jan 11. PMID: 22044221; PMCID: PMC3353817.
  43. Hodara R, Weiss D, Joseph G, Velasquez-Castano JC, Landázuri N, Han JW, Yoon YS, Taylor WR. Overexpression of catalase in myeloid cells causes impaired postischemic neovascularization. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2203-9. doi: 10.1161/ATVBAHA.111.233247. Epub 2011 Jul 28. PMID: 21799178; PMCID: PMC3880802.
  44. Szulwach KE, Li X, Li Y, Song CX, Han JW, Kim S, Namburi S, Hermetz K, Kim JJ, Rudd MK, Yoon YS, Ren B, He C, Jin P. Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet. 2011 Jun;7(6):e1002154. doi: 10.1371/journal.pgen.1002154. Epub 2011 Jun 23. PMID: 21731508; PMCID: PMC3121778.
  45. Kim SW, Kim H, Yoon YS. Advances in bone marrow-derived cell therapy: CD31-expressing cells as next generation cardiovascular cell therapy. Regen Med. 2011 May;6(3):335-49. doi: 10.2217/rme.11.24. PMID: 21548739; PMCID: PMC3129287.
  46. Jeong JO, Han JW, Kim JM, Cho HJ, Park C, Lee N, Kim DW, Yoon YS. Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy. Circ Res. 2011 May 27;108(11):1340-7. doi: 10.1161/CIRCRESAHA.110.239848. Epub 2011 Apr 14. PMID: 21493893; PMCID: PMC3109741.
  47. Han JW, Yoon YS. Induced pluripotent stem cells: emerging techniques for nuclear reprogramming. Antioxid Redox Signal. 2011 Oct 1;15(7):1799-820. doi: 10.1089/ars.2010.3814. Epub 2011 May 5. PMID: 21194386; PMCID: PMC3159104.
  48. Kishore R, Tkebuchava T, Sasi SP, Silver M, Gilbert HY, Yoon YS, Park HY, Thorne T, Losordo DW, Goukassian DA. Tumor necrosis factor-α signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium. Adv Exp Med Biol. 2011;691:433-48. doi: 10.1007/978-1-4419-6612-4_45. PMID: 21153348; PMCID: PMC3076133.
  49. Lee JY, Park C, Cho YP, Lee E, Kim H, Kim P, Yun SH, Yoon YS. Podoplanin-expressing cells derived from bone marrow play a crucial role in postnatal lymphatic neovascularization. Circulation. 2010 Oct 5;122(14):1413-25. doi: 10.1161/CIRCULATIONAHA.110.941468. Epub 2010 Sep 20. PMID: 20855662; PMCID: PMC2989430.
  50. Andukuri A, Kushwaha M, Tambralli A, Anderson JM, Dean DR, Berry JL, Sohn YD, Yoon YS, Brott BC, Jun HW. A hybrid biomimetic nanomatrix composed of electrospun polycaprolactone and bioactive peptide amphiphiles for cardiovascular implants. Acta Biomater. 2011 Jan;7(1):225-33. doi: 10.1016/j.actbio.2010.08.013. Epub 2010 Aug 20. PMID: 20728588; PMCID: PMC2967669.
  51. Kim SW, Kim H, Cho HJ, Lee JU, Levit R, Yoon YS. Human peripheral blood-derived CD31+ cells have robust angiogenic and vasculogenic properties and are effective for treating ischemic vascular disease. J Am Coll Cardiol. 2010 Aug 10;56(7):593-607. doi: 10.1016/j.jacc.2010.01.070. PMID: 20688215; PMCID: PMC2917842.
  52. Kim H, Cho HJ, Kim SW, Liu B, Choi YJ, Lee J, Sohn YD, Lee MY, Houge MA, Yoon YS. CD31+ cells represent highly angiogenic and vasculogenic cells in bone marrow: novel role of nonendothelial CD31+ cells in neovascularization and their therapeutic effects on ischemic vascular disease. Circ Res. 2010 Sep 3;107(5):602-14. doi: 10.1161/CIRCRESAHA.110.218396. Epub 2010 Jul 15. PMID: 20634489; PMCID: PMC2938961.
  53. Sen S, Merchan J, Dean J, Ii M, Gavin M, Silver M, Tkebuchava T, Yoon YS, Rasko JE, Aikawa R. Autologous transplantation of endothelial progenitor cells genetically modified by adeno-associated viral vector delivering insulin-like growth factor-1 gene after myocardial infarction. Hum Gene Ther. 2010 Oct;21(10):1327-34. doi: 10.1089/hum.2010.006. PMID: 20497036.
  54. Kim SW, Yoon YS. True autologous approach in cell therapy. - Using your own serum for cell culture -. Circ J. 2010 May;74(5):852-3. doi: 10.1253/circj.cj-10-0301. Epub 2010 Apr 17. PMID: 20431230; PMCID: PMC4617651.
  55. Kim H, Park JS, Choi YJ, Kim MO, Huh YH, Kim SW, Han JW, Lee J, Kim S, Houge MA, Ii M, Yoon YS. Bone marrow mononuclear cells have neurovascular tropism and improve diabetic neuropathy. Stem Cells. 2009 Jul;27(7):1686-96. doi: 10.1002/stem.87. PMID: 19544451; PMCID: PMC2746563.
  56. Kim H, Kim SW, Nam D, Kim S, Yoon YS. Cell therapy with bone marrow cells for myocardial regeneration. Antioxid Redox Signal. 2009 Aug;11(8):1897-911. doi: 10.1089/ars.2009.2486. PMID: 19203213; PMCID: PMC2788115.
  57. Jeong JO, Kim MO, Kim H, Lee MY, Kim SW, Ii M, Lee JU, Lee J, Choi YJ, Cho HJ, Lee N, Silver M, Wecker A, Kim DW, Yoon YS. Dual angiogenic and neurotrophic effects of bone marrow-derived endothelial progenitor cells on diabetic neuropathy. Circulation. 2009 Feb 10;119(5):699-708. doi: 10.1161/CIRCULATIONAHA.108.789297. Epub 2009 Jan 26. PMID: 19171856; PMCID: PMC2746559.
  58. Tressel SL, Kim H, Ni CW, Chang K, Velasquez-Castano JC, Taylor WR, Yoon YS, Jo H. Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis. Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1989-95. doi: 10.1161/ATVBAHA.108.175463. Epub 2008 Sep 4. PMID: 18772493; PMCID: PMC2613177.