Ann Chahroudi MD, PhD

SOM: Peds: Infectious Disease
Professor

(404) 727-9209
ann.m.chahroudi@emory.edu

Academic Appointment

Professor of Pediatrics, Emory University School of Medicine

Education

Degrees

PhD from Emory University School of Medicine
MD from Emory University School of Medicine
BA from Brown University

Research

Focus

Viral pathogenesis and cure
My research is centered on viral pathogenesis and treatment for HIV, Zika virus, and SARS-CoV-2. We aim to discover mechanisms of HIV persistence and test translational cure-directed strategies as well as uncover immunopathologies caused by Zika virus and SARS-CoV-2 infections using pediatric models and patient samples.

Publications

Divergent populations of HIV-infected naive and memory CD4+ T cell clones in children on antiretroviral therapy.
J Clin Invest Volume: 135
05/01/2025 Authors: Katusiime MG; Neer V; Guo S; Patro SC; Wang W; Luke B; Capoferri AA; Wu X; Horner AM; Rausch JW
Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection.
Lancet Microbe Page(s): 101030
02/20/2025 Authors: Li A; Coffey LL; Mohr EL; Raper J; Chahroudi A; Ausderau KK; Aliota MT; Friedrich TC; Mitzey AM; Koenig MR
SIV Env RhmAbs + N-803 at ART initiation prolongs viral decay without disrupting reservoir establishment in SIV-infected infant macaques.
PLoS Pathog Volume: 21 Page(s): e1012863
01/01/2025 Authors: Farinre O; Anaya T; King AC; Endrias K; Hbert AH; Hill AL; Jean S; Wood JS; Ehnert S; Liang S
Perinatal HIV: Past, Present, and Future.
Clin Perinatol Volume: 51 Page(s): xix - xx
12/01/2024 Authors: Violari A; Chahroudi A
A gut check: understanding the interplay of the gastrointestinal microbiome and the developing immune system towards the goal of pediatric HIV remission.
Retrovirology Volume: 21 Page(s): 15
10/18/2024 Authors: Soo N; Farinre O; Chahroudi A; Boliar S; Goswami R
Assessing the impact of autologous virus neutralizing antibodies on viral rebound time in postnatally SHIV-infected ART-treated infant rhesus macaques.
Epidemics Volume: 48 Page(s): 100780
09/01/2024 Authors: Mainou E; Berendam SJ; Obregon-Perko V; Uffman EA; Phan CT; Shaw GM; Bar KJ; Kumar MR; Fray EJ; Siliciano JM
Prevalence of detectable HIV-DNA and HIV-RNA in cerebrospinal fluid of youth with perinatal HIV and impaired cognition on antiretroviral therapy.
AIDS Volume: 38 Page(s): 1494 - 1504
08/01/2024 Authors: Wagner TA; Tierney C; Huang S; Nichols S; Malee KM; Montaez NA; Coletti A; Spiegel HML; Krotje C; Bone F
Pediatric immunotherapy and HIV control.
Curr Opin HIV AIDS Volume: 19 Page(s): 201 - 211
07/01/2024 Authors: Chinunga TT; Chahroudi A; Ribeiro SP
Assessing the impact of autologous neutralizing antibodies on rebound dynamics in postnatally SHIV-infected ART-treated infant rhesus macaques.
bioRxiv
06/03/2024 Authors: Mainou E; Berendam SJ; Obregon-Perko V; Uffman EA; Phan CT; Shaw GM; Bar KJ; Kumar MR; Fray EJ; Siliciano JM
Comparative analysis of within-host dynamics of acute infection and viral rebound dynamics in postnatally SHIV-infected ART-treated infant rhesus macaques.
bioRxiv
05/23/2024 Authors: Mainou E; Berendam SJ; Obregon-Perko V; Uffman EA; Phan CT; Shaw GM; Bar KJ; Kumar MR; Fray EJ; Siliciano JM
More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure.
Curr HIV/AIDS Rep Volume: 21 Page(s): 11 - 29
02/01/2024 Authors: Fonseca JA; King AC; Chahroudi A
A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.
PLoS One Volume: 19 Page(s): e0312411
01/01/2024 Authors: Dankwa S; Kosman C; Dennis M; Giorgi EE; Vuong K; Pahountis I; Garza A; Binuya C; McCarthy J; Mayer BT
Impact of the IL-15 superagonist N-803 on latency reversal induced by AZD5582 and on immune cells in ART-suppressed rhesus macaques
Volume: 52 Page(s): 308 - 309
10/01/2023 Authors: Dashti A; Sukkestad S; Horner AM; Neja M; Lin A; Schoof N; Singh V; Mavigner M; King H; Mason RD
Pilot study of a cIAP inhibitor ( AZD5582) + BCL-2 inhibitor (ABT199) in SIV-infected, art-suppressed rhesus macaques
Volume: 52 Page(s): 333 - 333
10/01/2023 Authors: Ukhueduan BO; Lopez LL; Bricker K; Schoof N; Singh V; Dashti A; Mavigner M; Schauer A; Tompkin L; Cottrell ML
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques.
Nat Med Volume: 29 Page(s): 2535 - 2546
10/01/2023 Authors: Dashti A; Sukkestad S; Horner AM; Neja M; Siddiqi Z; Waller C; Goldy J; Monroe D; Lin A; Schoof N
Assessing the impact of autologous neutralizing antibodies on viral rebound in postnatally SHIV-infected ART-treated infant rhesus macaques.
bioRxiv
09/14/2023 Authors: Mainou E; Berendam SJ; Obregon-Perko V; Uffman EA; Phan CT; Shaw GM; Bar KJ; Kumar MR; Fray EJ; Siliciano JM
Treatment with sofosbuvir attenuates the adverse neurodevelopmental consequences of Zika virus infection in infant rhesus macaques.
J Neuroimmunol Volume: 381 Page(s): 578148
08/15/2023 Authors: Medina A; Rusnak R; Richardson R; Zimmerman MG; Suthar M; Schoof N; Kovacs-Balint Z; Mavigner M; Sanchez M; Chahroudi A
Anti-SIV Env RhmAbs +/-CD8a depletion and N-803 in ART-suppressed rhesus macaques leads to post-treatment control of viremia in a subset of animals
Volume: 26
08/01/2023 Authors: Singh V; Burgess D; Dashti A; McBrien J; King H; Mason R; Safrit J; Lifson J; Tuyishime M; Ferrari G
Broadly neutralizing antibodies: "The next thing" to treat children with HIV?
Sci Transl Med Volume: 15 Page(s): eadi0293
07/05/2023 Authors: Mavigner M; Chahroudi A
Nucleic acid biomarkers of immune response and cell and tissue damage in children with COVID-19 and MIS-C.
Cell Rep Med Volume: 4 Page(s): 101034
06/20/2023 Authors: Loy CJ; Sotomayor-Gonzalez A; Servellita V; Nguyen J; Lenz J; Bhattacharya S; Williams ME; Cheng AP; Bliss A; Saldhi P
Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy.
J Clin Invest Volume: 133
06/15/2023 Authors: Tang Y; Chaillon A; Gianella S; Wong LM; Li D; Simermeyer TL; Porrachia M; Ignacio C; Woodworth B; Zhong D
Serologic responses to COVID-19 vaccination in children with history of multisystem inflammatory syndrome (MIS-C).
Vaccine Volume: 41 Page(s): 2743 - 2748
04/24/2023 Authors: Perez MA; Hsiao H-M; Chen X; Kunkel A; Baida N; Hussaini L; Lu AT; Kao CM; Laham FR; Hunstad DA
Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19.
Nat Commun Volume: 14 Page(s): 1638
04/04/2023 Authors: Druzak S; Iffrig E; Roberts BR; Zhang T; Fibben KS; Sakurai Y; Verkerke HP; Rostad CA; Chahroudi A; Schneider F
How CD4+ T Cells Transcriptional Profile Is Affected by Culture Conditions: Towards the Design of Optimal In Vitro HIV Reactivation Assays.
Biomedicines Volume: 11
03/13/2023 Authors: Pascucci GR; Morrocchi E; Pighi C; Rotili A; Neri A; Medri C; Olivieri G; Sanna M; Rasi G; Persaud D
Highlights from the Tenth International Workshop on HIV Persistence during Therapy, December 13-16, 2022, Miami, Florida-USA.
J Virus Erad Volume: 9 Page(s): 100315
03/01/2023 Authors: Archin N; Bar KJ; Burdo T; Caskey M; Chahroudi A; Farzan M; Ho Y-C; Jones RB; Kearney M; Kuritzkes D
CD8+ lymphocytes do not impact SIV reservoir establishment under ART.
Nat Microbiol Volume: 8 Page(s): 299 - 308
02/01/2023 Authors: Statzu M; Jin W; Fray EJ; Wong AKH; Kumar MR; Ferrer E; Docken SS; Pinkevych M; McBrien JB; Fennessey CM
A simple model for viral decay dynamics and the distribution of infected cell life spans in SHIV-infected infant rhesus macaques.
Math Biosci Volume: 356 Page(s): 108958
02/01/2023 Authors: Sass J; Awasthi A; Obregon-Perko V; McCarthy J; Lloyd AL; Chahroudi A; Permar S; Chan C
Genetic variations in the envelope of SHIV-infected ART-treated infant macaques rebound viruses that escape neutralization by autologous antibodies
Volume: 51 Page(s): 301 - 301
10/01/2022 Authors: Berendam S; Uffman E; Kumar A; Obregon-Perko V; Styles T; Bar K; Shaw G; Silvestri G; Amara R; Chahroudi A
Comparison of Mid-turbinate Nasal Swabs, Saliva, and Nasopharyngeal Swabs for SARS-CoV-2 Reverse Transcription-Polymerase Chain Reaction Testing in Pediatric Outpatients.
Arch Pathol Lab Med Volume: 146 Page(s): 1056 - 1061
09/01/2022 Authors: Vos MB; Gonzalez MD; Stone C; Cleeton R; Figueroa J; Jerris R; Park SI; Heilman S; Nayee R; Chahroudi A
SARS-CoV-2 Infection and Racial Disparities in Children: Protective Mechanisms and Severe Complications Related to MIS-C.
J Racial Ethn Health Disparities Volume: 9 Page(s): 1536 - 1542
08/01/2022 Authors: Kurup S; Burgess R; Tine F; Chahroudi A; Lee DL
High prevalence of HIV persistence in CSF of adolescents and young adults with perinatally-acquired HIV and cognitive impairment in the IMPAACT 2015 study
Volume: 25 Page(s): 115 - 116
08/01/2022 Authors: Wagner T; Tierney C; Huang S; Nichols S; Malee K; Montanez N; Coletti A; Spiegel H; Wilkins M; Abuogi L
AZD5582 and SIV Env-targeting rhesus monoclonal antibodies (RhmAbs) +/- N-803 in SIV-infected ART-suppressed rhesus macaques
Volume: 25 Page(s): 7 - 7
08/01/2022 Authors: Dashti A; Sukkestad S; Horner AM; Neja M; Lin A; Schoof N; Mavigner M; Lifson JD; Falcinelli SD; Sacha J
CD8 depletion and N-803 plus anti-SIV Env RhmAbs in ART-suppressed rhesus macaques
Volume: 25 Page(s): 237 - 237
08/01/2022 Authors: Singh V; Burgess D; Dashti A; McBrien J; King H; Mason R; Safrit J; Lifson J; Tuyishime M; Ferrari G
Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants.
J Virol Volume: 96 Page(s): e0169921
04/13/2022 Authors: Bricker KM; Obregon-Perko V; Williams B; Oliver D; Uddin F; Neja M; Hopkins L; Dashti A; Jean S; Wood JS
Support for Establishing Best Practices for Breastfeeding in the Current HIV/ART Era.
J Pediatric Infect Dis Soc Volume: 11 Page(s): 90 - 91
03/24/2022 Authors: Cranmer LM; Chung MH; Chahroudi A
Serologic and Cytokine Signatures in Children With Multisystem Inflammatory Syndrome and Coronavirus Disease 2019.
Open Forum Infect Dis Volume: 9 Page(s): ofac070
03/01/2022 Authors: Lapp SA; Abrams J; Lu AT; Hussaini L; Kao CM; Hunstad DA; Rosenberg RB; Zafferani MJ; Ede KC; Ballan W
Limited induction of SARS-CoV-2-specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19.
JCI Insight Volume: 7
02/22/2022 Authors: Singh V; Obregon-Perko V; Lapp SA; Horner AM; Brooks A; Macoy L; Hussaini L; Lu A; Gibson T; Silvestri G
HIV Reservoirs: Modeling, Quantification, and Approaches to a Cure.
Methods Mol Biol Volume: 2407 Page(s): 215 - 228
01/01/2022 Authors: Dashti A; Singh V; Chahroudi A
Correction to: Designing Cure Studies in NHPs.
Methods Mol Biol Volume: 2407 Page(s): C1
01/01/2022 Authors: Dashti A; Singh V; Chahroudi A
Challenges and Opportunities of Therapies Targeting Early Life Immunity for Pediatric HIV Cure.
Front Immunol Volume: 13 Page(s): 885272
01/01/2022 Authors: Berendam SJ; Nelson AN; Yagnik B; Goswami R; Styles TM; Neja MA; Phan CT; Dankwa S; Byrd AU; Garrido C
The rectal mucosal immune environment and HIV susceptibility among young men who have sex with men.
Front Immunol Volume: 13 Page(s): 972170
01/01/2022 Authors: Ackerley CG; Smith SA; Murray PM; Amancha PK; Arthur RA; Zhu Z; Chahroudi A; Amara RR; Hu Y-J; Kelley CF
Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART.
JCI Insight Volume: 6
12/08/2021 Authors: Obregon-Perko V; Bricker KM; Mensah G; Uddin F; Rotolo L; Vanover D; Desai Y; Santangelo PJ; Jean S; Wood JS
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021.
Nat Med Volume: 27 Page(s): 2085 - 2098
12/01/2021 Authors: Deeks SG; Archin N; Cannon P; Collins S; Jones RB; de Jong MAWP; Lambotte O; Lamplough R; Ndung'u T; Sugarman J
Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C).
Exp Biol Med (Maywood) Volume: 246 Page(s): 2543 - 2552
12/01/2021 Authors: Kuypers FA; Rostad CA; Anderson EJ; Chahroudi A; Jaggi P; Wrammert J; Mantus G; Basu R; Harris F; Hanberry B
Single-Amplicon Multiplex Real-Time Reverse Transcription-PCR with Tiled Probes To Detect SARS-CoV-2 spike Mutations Associated with Variants of Concern.
J Clin Microbiol Volume: 59 Page(s): e0144621
11/18/2021 Authors: Babiker A; Immergluck K; Stampfer SD; Rao A; Bassit L; Su M; Nguyen V; Stittleburg V; Ingersoll JM; Bradley HL
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19.
Nat Immunol Volume: 22 Page(s): 1452 - 1464
11/01/2021 Authors: Ravichandran S; Tang J; Grubbs G; Lee Y; Pourhashemi S; Hussaini L; Lapp SA; Jerris RC; Singh V; Chahroudi A
The need for new test verification and regulatory support for innovative diagnostics.
Nat Biotechnol Volume: 39 Page(s): 1060 - 1062
09/01/2021 Authors: Roback JD; Tyburski EA; Alter D; Asakrah S; Chahroudi A; Esper A; Farmer S; Figueroa J; K Frediani J; D Gonzalez M
New Latency Reversing Agents for HIV-1 Cure: Insights from Nonhuman Primate Models.
Viruses Volume: 13
08/06/2021 Authors: Bricker KM; Chahroudi A; Mavigner M
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration.
Sci Rep Volume: 11 Page(s): 14604
07/16/2021 Authors: Frediani JK; Levy JM; Rao A; Bassit L; Figueroa J; Vos MB; Wood A; Jerris R; Van Leung-Pineda; Gonzalez MD
Altered amino acid profile in patients with SARS-CoV-2 infection.
Proc Natl Acad Sci U S A Volume: 118
06/22/2021 Authors: Rees CA; Rostad CA; Mantus G; Anderson EJ; Chahroudi A; Jaggi P; Wrammert J; Ochoa JB; Ochoa A; Basu RK
RIFAXIMIN TO PREVENT BLOODSTREAM INFECTIONS IN PEDIATRIC HEMATOPOIETIC CELL TRANSPLANTATION (HCT)
Volume: 68 Page(s): S105 - S105
06/01/2021 Authors: Teherani M; Gillespie S; Pratte Z; Banksota S; Gulick D; Djeddar N; Chahroudi A; Horan J; Gibson G; Qayed M
Will We Have the Tools to Address a Reemergent Zika Virus Epidemic?
Ann Intern Med Volume: 174 Page(s): 708 - 709
05/01/2021 Authors: Chahroudi A; Permar S
Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques.
PLoS Pathog Volume: 17 Page(s): e1009575
05/01/2021 Authors: Wood MP; Jones CI; Lippy A; Oliver BG; Walund B; Fancher KA; Fisher BS; Wright PJ; Fuller JT; Murapa P
The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change.
IEEE Open J Eng Med Biol Volume: 2 Page(s): 142 - 151
04/28/2021 Authors: Nehl E; Heilman S; Ku D; Gottfried D; Farmer S; Mannino R; Tyburski E; Sullivan J; Suessmith A; Bassit L
Latency Reversal 2.0: Giving the Immune System a Seat at the Table.
Curr HIV/AIDS Rep Volume: 18 Page(s): 117 - 127
04/01/2021 Authors: Singh V; Dashti A; Mavigner M; Chahroudi A
CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques.
J Virol Volume: 95
03/25/2021 Authors: Mavigner M; Liao LE; Brooks AD; Ke R; Mattingly C; Schoof N; McBrien J; Carnathan D; Liang S; Vanderford TH
Covid-19 will not "magically disappear": Why access to widespread testing is paramount.
Am J Hematol Volume: 96 Page(s): 174 - 178
02/01/2021 Authors: George PE; Stokes CL; Bassit LC; Chahroudi A; Figueroa J; Griffiths MA; Heilman S; Ku DN; Nehl EJ; Leong T
Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses.
J Virol Volume: 95
01/13/2021 Authors: Berendam SJ; Styles TM; Morgan-Asiedu PK; Tenney D; Kumar A; Obregon-Perko V; Bar KJ; Saunders KO; Santra S; De Paris K
Clinical and Preclinical Evidence for Adverse Neurodevelopment after Postnatal Zika Virus Infection.
Trop Med Infect Dis Volume: 6
01/12/2021 Authors: Raper J; Chahroudi A
Non-human Primate Models to Investigate Mechanisms of Infection-Associated Fetal and Pediatric Injury, Teratogenesis and Stillbirth.
Front Genet Volume: 12 Page(s): 680342
01/01/2021 Authors: Li M; Brokaw A; Furuta AM; Coler B; Obregon-Perko V; Chahroudi A; Wang H-Y; Permar SR; Hotchkiss CE; Golos TG
Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART Molecules.
Front Immunol Volume: 12 Page(s): 710273
01/01/2021 Authors: Tuyishime M; Dashti A; Faircloth K; Jha S; Nordstrom JL; Haynes BF; Silvestri G; Chahroudi A; Margolis DM; Ferrari G
Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure.
Front Immunol Volume: 12 Page(s): 757400
01/01/2021 Authors: Amin O; Powers J; Bricker KM; Chahroudi A
Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection.
PLoS One Volume: 16 Page(s): e0256482
01/01/2021 Authors: Lapp SA; Edara VV; Lu A; Lai L; Hussaini L; Chahroudi A; Anderson LJ; Suthar MS; Anderson EJ; Rostad CA
Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4+ T Cells.
J Virol Volume: 95
12/22/2020 Authors: Obregon-Perko V; Bricker KM; Mensah G; Uddin F; Kumar MR; Fray EJ; Siliciano RF; Schoof N; Horner A; Mavigner M
Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C).
Pediatrics Volume: 146
12/01/2020 Authors: Rostad CA; Chahroudi A; Mantus G; Lapp SA; Teherani M; Macoy L; Tarquinio KM; Basu RK; Kao C; Linam WM
SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques.
Volume: 94
10/14/2020 Authors: Dashti A; Waller C; Mavigner M; Schoof N; Bar KJ; Shaw GM; Vanderford TH; Liang S; Lifson JD; Dunham RM
Therapeutic vaccination of SIV-infected, ART-treated infant rhesus macaques using Ad48/MVA in combination with TLR-7 stimulation.
PLoS Pathog Volume: 16 Page(s): e1008954
10/01/2020 Authors: Bricker KM; Obregon-Perko V; Uddin F; Williams B; Uffman EA; Garrido C; Fouda GG; Geleziunas R; Robb M; Michael N
Therapeutic vaccination induces antiviral T-cell response in SIV-infected ART-treated infant macaques
Volume: 49 Page(s): 248 - 248
10/01/2020 Authors: Bricker K; Obregon-Perko V; Uddin F; Hesselgesser J; Robb M; Michael N; Barouch D; Chahroudi A
Rapid progression in SIV-infected infant rhesus macaques is associated with failure to increase CXCL13 during acute infection, B-cell dysfunction and early viral replication
Volume: 49 Page(s): 227 - 228
10/01/2020 Authors: Wood M; Jones CI; Fisher B; Lippy A; Oliver BG; Walund B; Fancher K; Murapa P; Fuller JT; Habib J
Development of a polyfunctional antiviral broadly neutralizing antibody combination for passive immunization of in Simian Human Immunodeficiency Virus (SHIV)-infected infant Rhesus macaques
Volume: 49 Page(s): 246 - 247
10/01/2020 Authors: Berendam SJ; Styles TM; Morgan-Asiedu PK; Bar KJ; Shaw GM; Saunders KO; DeParis K; Chahroudi A; Permar SR; Amara RR
Viral & immune dynamics in an NHP model of pediatric HIV infection: studies to inform cure strategies
Volume: 49 Page(s): 236 - 236
10/01/2020 Authors: Obregon-Perko V; Bricker K; Uddin F; Berendam S; Fouda G; Bar K; Shaw G; Silvestri G; Permar S; Chahroudi A
Combination of CD8 Depletion and Interleukin-15 Superagonist N-803 Induces Virus Reactivation in Simian-Human Immunodeficiency Virus-Infected, Long-Term ART-Treated Rhesus Macaques.
J Virol Volume: 94
09/15/2020 Authors: McBrien JB; Wong AKH; White E; Carnathan DG; Lee JH; Safrit JT; Vanderford TH; Paiardini M; Chahroudi A; Silvestri G
Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription.
PLoS Pathog Volume: 16 Page(s): e1008821
09/01/2020 Authors: Zanoni M; Palesch D; Pinacchio C; Statzu M; Tharp GK; Paiardini M; Chahroudi A; Bosinger SE; Yoon J; Cox B
The Brain Retains: Nonhuman Primate Models for Pediatric HIV-1 in the CNS.
Curr HIV/AIDS Rep Volume: 17 Page(s): 343 - 353
08/01/2020 Authors: Obregon-Perko V; Bricker K; Chahroudi A
The VACCINES Act: Deciphering Vaccine Hesitancy in the Time of COVID-19.
Clin Infect Dis Volume: 71 Page(s): 703 - 705
07/28/2020 Authors: McAteer J; Yildirim I; Chahroudi A
Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing Human Immunodeficiency Virus (HIV)-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants.
J Infect Dis Volume: 222 Page(s): 628 - 636
07/23/2020 Authors: Cunningham CK; McFarland EJ; Morrison RL; Capparelli EV; Safrit JT; Mofenson LM; Mathieson B; Valentine ME; Perlowski C; Smith B
Pediatric HIV: the Potential of Immune Therapeutics to Achieve Viral Remission and Functional Cure.
Curr HIV/AIDS Rep Volume: 17 Page(s): 237 - 248
06/01/2020 Authors: Berendam SJ; Nelson AN; Goswami R; Persaud D; Haigwood NL; Chahroudi A; Fouda GG; Permar SR
Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques.
Nat Commun Volume: 11 Page(s): 2534
05/21/2020 Authors: Raper J; Kovacs-Balint Z; Mavigner M; Gumber S; Burke MW; Habib J; Mattingly C; Fair D; Earl E; Feczko E
Therapeutic vaccination with Ad48/MVA and TLR7 stimulation in SIV-infected, ART-treated infant rhesus macaques
Volume: 204
05/01/2020 Authors: Bricker KM; Obregon-Perko V; Uddin F; Williams B; Hesselgesser J; Robb M; Michael N; Barouch DH; Chahroudi A
Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".
J Virol Volume: 94
03/31/2020 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B
Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.
Nature Volume: 578 Page(s): E21
02/01/2020 Authors: McBrien JB; Mavigner M; Franchitti L; Smith SA; White E; Tharp GK; Walum H; Busman-Sahay K; Aguilera-Sandoval CR; Thayer WO
Systemic HIV and SIV latency reversal via non-canonical NF-B signalling in vivo.
Nature Volume: 578 Page(s): 160 - 165
02/01/2020 Authors: Nixon CC; Mavigner M; Sampey GC; Brooks AD; Spagnuolo RA; Irlbeck DM; Mattingly C; Ho PT; Schoof N; Cammon CG
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.
Nature Volume: 578 Page(s): 154 - 159
02/01/2020 Authors: McBrien JB; Mavigner M; Franchitti L; Smith SA; White E; Tharp GK; Walum H; Busman-Sahay K; Aguilera-Sandoval CR; Thayer WO
Upward Trends of Parotitis and Mumps in Atlanta over a Decade.
Glob Pediatr Health Volume: 7 Page(s): 2333794X20968676
01/01/2020 Authors: Reddy LM; Bloch D; Mallino A; Kumari P; Figueroa J; Kendrick L; Chahroudi A; Tuttle J; Thomas E; Morris CR
Pharmacological Modulation of the Wnt/-Catenin Pathway Inhibits Proliferation and Promotes Differentiation of Long-Lived Memory CD4+ T Cells in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques.
J Virol Volume: 94
12/12/2019 Authors: Mavigner M; Zanoni M; Tharp GK; Habib J; Mattingly CR; Lichterfeld M; Nega MT; Vanderford TH; Bosinger SE; Chahroudi A
An NHP model of pediatric oral HIV infection and ART treatment
Volume: 48 Page(s): 285 - 285
10/01/2019 Authors: Obregon-Perko V; Bricker K; Fouda G; Bar K; Shaw G; Silvestri G; Permar S; Chahroudi A
Immunological effects of the IL-15 superagonist N-803 in SIV-infected ART-treated rhesus macaques
Volume: 48 Page(s): 307 - 308
10/01/2019 Authors: McBrien J; White E; Tharp G; Jeng E; Wong H; Safrit J; Paiardini M; Vanderford T; Lifson J; Bosinger S
Postnatal Zika virus infection causes persistent abnormalities in brain structure, function, and behavior in infant macaques: one year follow-up study
Volume: 48 Page(s): 277 - 277
10/01/2019 Authors: Mavigner M; Raper J; Kovacs-Balint Z; Gumber S; Sanchez M; Alvarado M; Chahroudi A
Similar frequency of infection of naive and memory CD4(+) T-cells in ART-suppressed SIV/SHIV-infected infant rhesus macaques
Volume: 48 Page(s): 292 - 293
10/01/2019 Authors: Mattingly C; Goswami R; Nelson A; Schoof N; Shaw G; Bar K; Mavigner M; Van Rompay K; Permar S; Chahroudi A
Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model.
mBio Volume: 10
09/05/2019 Authors: Goswami R; Nelson AN; Tu JJ; Dennis M; Feng L; Kumar A; Mangold J; Mangan RJ; Mattingly C; Curtis AD
Oral TLR7 agonist administration induces an immunostimulatory response in SIV-infected ART-suppressed infant Rhesus macaques
Volume: 22 Page(s): 40 - 40
07/01/2019 Authors: Bricker K; Obregon-Perko V; Hesselgesser J; Chahroudi A
Sting agonist as a kick and kill agent to target the HIV reservoir
Volume: 22 Page(s): 42 - 42
07/01/2019 Authors: Mavigner M; Brooks AD; Koblansky A; Galardi C; Madsen H; Margolis DM; Silvestri G; Chahroudi A
Improved Perinatal and Postpartum Human Immunodeficiency Virus Outcomes After Use of a Perinatal Care Coordination Team.
Open Forum Infect Dis Volume: 6 Page(s): ofz183
06/01/2019 Authors: Hackett S; Badell ML; Meade CM; Davis JM; Blue J; Curtin L; Camacho-Gonzalez A; Chahroudi A; Chakraborty R; Nguyen MLT
Poverty and chronic illness: why safety net programs matter.
Pediatr Res Volume: 85 Page(s): 743 - 744
05/01/2019 Authors: Bloch D; Chahroudi A
Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".
J Virol Volume: 93
02/01/2019 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B
Antibody-Mediated CD4 Depletion Induces Homeostatic CD4+ T Cell Proliferation without Detectable Virus Reactivation in Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Infected Macaques.
J Virol Volume: 92
11/15/2018 Authors: Kumar NA; McBrien JB; Carnathan DG; Mavigner M; Mattingly C; White ER; Viviano F; Bosinger SE; Chahroudi A; Silvestri G
Liver Bacterial Dysbiosis Persists During Antiretroviral Therapy of SIV plus Macaques
Volume: 34 Page(s): 308 - 308
10/01/2018 Authors: Fisher B; Fisher C; Wood M; Driscoll C; Hensley-McBain T; Smith E; Green R; Gale M; Silvestri G; Chahroudi A
A dose-escalation study of pharmacologic inhibition of beta-catenin signaling in healthy rhesus macaques
Volume: 47 Page(s): 351 - 351
10/01/2018 Authors: Zanoni M; Mayigner M; Habib J; Mattingly C; Easley K; Kouji H; Chahroudi A
Overview of vaccine approaches in adult and infant macaques
Volume: 47 Page(s): 310 - 310
10/01/2018 Authors: Chahroudi A
CNS Persistence of HIV-1 in Children: the Untapped Reservoir.
Curr HIV/AIDS Rep Volume: 15 Page(s): 382 - 387
10/01/2018 Authors: Chahroudi A; Wagner TA; Persaud D
An Unusual Cause of Fever and Headache in a School-Aged Male.
Clin Pediatr (Phila) Volume: 57 Page(s): 1359 - 1362
10/01/2018 Authors: Joo SJ; Thompson AB; Philipsborn R; Emrath E; Camacho-Gonzalez AF; Chahroudi A; Miller J; Ali I; Cope J
Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.
J Virol Volume: 92
09/15/2018 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B
Evaluating Facility Infrastructure for Prevention of Mother-to-Child Transmission of HIV-A 2015 Assessment of Major Delivery Hospitals in Atlanta, Georgia.
J Pediatric Infect Dis Soc Volume: 7 Page(s): e102 - e106
08/17/2018 Authors: Smith SL; Chahroudi AM; Camacho-Gonzalez AF; Gillespie S; Wynn BA; Badell ML; Swartzendruber A; Hazra R; Wortley P; Chakraborty R
Short-Term Pegylated Interferon 2a Treatment Does Not Significantly Reduce the Viral Reservoir of Simian Immunodeficiency Virus-Infected, Antiretroviral Therapy-Treated Rhesus Macaques.
J Virol Volume: 92
07/15/2018 Authors: Palesch D; Bosinger SE; Mavigner M; Billingsley JM; Mattingly C; Carnathan DG; Paiardini M; Chahroudi A; Vanderford TH; Silvestri G
Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques.
Sci Transl Med Volume: 10
04/04/2018 Authors: Mavigner M; Raper J; Kovacs-Balint Z; Gumber S; O'Neal JT; Bhaumik SK; Zhang X; Habib J; Mattingly C; McDonald CE
Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.
PLoS Pathog Volume: 14 Page(s): e1006871
02/01/2018 Authors: Fisher BS; Green RR; Brown RR; Wood MP; Hensley-McBain T; Fisher C; Chang J; Miller AD; Bosche WJ; Lifson JD
Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.
Nature Volume: 553 Page(s): 77 - 81
01/03/2018 Authors: Palesch D; Bosinger SE; Tharp GK; Vanderford TH; Paiardini M; Chahroudi A; Johnson ZP; Kirchhoff F; Hahn BH; Norgren RB
Effects of vitamin D supplementation on carotid intima-media thickness in HIV-infected youth.
Virulence Volume: 9 Page(s): 294 - 305
01/01/2018 Authors: Eckard AR; Raggi P; O'Riordan MA; Rosebush JC; Labbato D; Chahroudi A; Ruff JH; Longenecker CT; Tangpricha V; McComsey GA
Vitamin D supplementation decreases immune activation and exhaustion in HIV-1-infected youth.
Antivir Ther Volume: 23 Page(s): 315 - 324
01/01/2018 Authors: Eckard AR; O'Riordan MA; Rosebush JC; Lee ST; Habib JG; Ruff JH; Labbato D; Daniels JE; Uribe-Leitz M; Tangpricha V
Effects of Vitamin D Supplementation on Bone Mineral Density and Bone Markers in HIV-Infected Youth.
J Acquir Immune Defic Syndr Volume: 76 Page(s): 539 - 546
12/15/2017 Authors: Eckard AR; ORiordan MA; Rosebush JC; Ruff JH; Chahroudi A; Labbato D; Daniels JE; Uribe-Leitz M; Tangpricha V; McComsey GA
Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques.
Sci Transl Med Volume: 9
10/04/2017 Authors: Magnani DM; Rogers TF; Beutler N; Ricciardi MJ; Bailey VK; Gonzalez-Nieto L; Briney B; Sok D; Le K; Strubel A
Using infant animal models to advance pediatric HIV prevention, vaccines and cure
JOURNAL OF VIRUS ERADICATION Volume: 3 Page(s): 255 - 256
10/01/2017 Authors: Chahroudi A
Sexually Transmitted Infections in Youth With Controlled and Uncontrolled Human Immunodeficiency Virus Infection.
J Pediatric Infect Dis Soc Volume: 6 Page(s): e22 - e29
09/01/2017 Authors: Camacho-Gonzalez AF; Chernoff MC; Williams PL; Chahroudi A; Oleske JM; Traite S; Chakraborty R; Purswani MU; Abzug MJ; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1074 Study Team
Liver associated inflammation and macrophage infiltration during SIV infection is partly reversed during cART
Volume: 46 Page(s): 163 - 163
08/01/2017 Authors: Fisher B; Brown R; Silvestri G; Chahroudi A; Klatt N; Sodora D
Inhibiting memory CD4+T cell self-renewal to reduce HIV persistence
Volume: 20 Page(s): 51 - 51
07/01/2017 Authors: Mavigner M; Zanoni M; Habib J; Mattingly C; Demarest J; Kouji H; Lawson B; Vanderford T; Tharp G; Bosinger S
Correction for Mylvaganam et al., Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection.
Proc Natl Acad Sci U S A Volume: 114 Page(s): E3366
04/18/2017
Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection.
Proc Natl Acad Sci U S A Volume: 114 Page(s): 1976 - 1981
02/21/2017 Authors: Mylvaganam GH; Rios D; Abdelaal HM; Iyer S; Tharp G; Mavigner M; Hicks S; Chahroudi A; Ahmed R; Bosinger SE
Neurocognitive dysfunction in HIV-infected youth: investigating the relationship with immune activation.
Antivir Ther Volume: 22 Page(s): 669 - 680
01/01/2017 Authors: Eckard AR; Rosebush JC; O'Riordan MA; Graves CC; Alexander A; Grover AK; Lee ST; Habib JG; Ruff JH; Chahroudi A
Increased Immune Activation and Exhaustion in HIV-infected Youth.
Pediatr Infect Dis J Volume: 35 Page(s): e370 - e377
12/01/2016 Authors: Eckard AR; Rosebush JC; Lee ST; O'Riordan MA; Habib JG; Daniels JE; Labbato D; Uribe-Leitz M; Chahroudi A; McComsey GA
Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.
J Virus Erad Volume: 2 Page(s): 219 - 226
10/05/2016 Authors: Mavigner M; Lee ST; Habib J; Robinson C; Silvestri G; O'Doherty U; Chahroudi A
The latest science from the IAS Towards an HIV Cure Symposium: 16-17 July 2016, Durban, South Africa.
J Virus Erad Volume: 2 Page(s): 235 - 241
10/05/2016 Authors: Mann J; Pasternak AO; Chahroudi A; Singh JA; Ross AL
Induction of Unique Subset of Follicular Homing SIV-specific CD8 T Cells by Vaccination Is Associated with Enhanced Control of Pathogenic SIV
Volume: 32 Page(s): 85 - 85
10/01/2016 Authors: Mylvaganam G; Reddy P; Rios D; Mohammad H; Gangadhara S; Turner-Styles T; Iyer S; Hicks S; Tharp G; Mavigner M
What pediatric nonprogressors and natural SIV hosts teach us about HIV.
Sci Transl Med Volume: 8 Page(s): 358fs16
09/28/2016 Authors: Chahroudi A; Silvestri G
CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.
Immunity Volume: 45 Page(s): 656 - 668
09/20/2016 Authors: Cartwright EK; Spicer L; Smith SA; Lee D; Fast R; Paganini S; Lawson BO; Nega M; Easley K; Schmitz JE
Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis.
J Virol Volume: 90 Page(s): 7541 - 7551
08/15/2016 Authors: Calascibetta F; Micci L; Carnathan D; Lawson B; Vanderford TH; Bosinger SE; Easley K; Chahroudi A; Mackel J; Keele BF
Initiation of Antiretroviral Therapy Restores CD4+ T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques.
J Virol Volume: 90 Page(s): 6699 - 6708
08/01/2016 Authors: Cartwright EK; Palesch D; Mavigner M; Paiardini M; Chahroudi A; Silvestri G
Animal models to achieve an HIV cure.
Curr Opin HIV AIDS Volume: 11 Page(s): 432 - 441
07/01/2016 Authors: Kumar N; Chahroudi A; Silvestri G
HIV and Tfh Cells: Circulating New Ideas to Identify and Protect.
Immunity Volume: 44 Page(s): 16 - 18
01/19/2016 Authors: Chahroudi A; Silvestri G
Correction: Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (T(FH)) in Simian Immunodeficiency Virus-Infected Rhesus Macaques May Contribute to Accumulation of T(FH) in Chronic Infection.
J Immunol Volume: 195 Page(s): 5843
12/15/2015 Authors: Chowdhury A; Del Rio Estrada PM; Tharp GK; Trible RP; Amara RR; Chahroudi A; Reyes-Teran G; Bosinger SE; Silvestri G
Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.
J Clin Invest Volume: 125 Page(s): 4497 - 4513
12/01/2015 Authors: Micci L; Ryan ES; Fromentin R; Bosinger SE; Harper JL; He T; Paganini S; Easley KA; Chahroudi A; Benne C
Social Stress Impacts the Pathogenesis of SIV Infection and Treatment Response
Volume: 40 Page(s): S154 - S154
12/01/2015 Authors: Neigh G; Ethun K; Cartwright E; McGary C; Micci L; Paiardini M; Silvestri G; Chahroudi A
Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors.
J Virol Volume: 89 Page(s): 10136 - 10144
10/01/2015 Authors: Mir KD; Mavigner M; Wang C; Paiardini M; Sodora DL; Chahroudi AM; Bosinger SE; Silvestri G
Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus-Infected Rhesus Macaques May Contribute to Accumulation of TFH in Chronic Infection.
J Immunol Volume: 195 Page(s): 3237 - 3247
10/01/2015 Authors: Chowdhury A; Del Rio Estrada PM; Tharp GK; Trible RP; Amara RR; Chahroudi A; Reyes-Teran G; Bosinger SE; Silvestri G
IAS Towards an HIV Cure Symposium: people focused, science driven: 18-19 July 2015, Vancouver, Canada.
Volume: 1 Page(s): 276 - 281
10/01/2015 Authors: Fidler S; Thornhill J; Malatinkova E; Reinhard R; Lamplough R; Ananworanich J; Chahroudi A
Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques.
J Virol Volume: 89 Page(s): 8677 - 8686
09/01/2015 Authors: Chowdhury A; Hayes TL; Bosinger SE; Lawson BO; Vanderford T; Schmitz JE; Paiardini M; Betts M; Chahroudi A; Estes JD
Missed opportunities for prevention of mother-to-child transmission in the United States.
AIDS Volume: 29 Page(s): 1511 - 1515
07/31/2015 Authors: Camacho-Gonzalez AF; Kingbo M-H; Boylan A; Eckard AR; Chahroudi A; Chakraborty R
The association of uncontrolled HIV infection and other sexually transmitted infections in metropolitan Atlanta youth.
Pediatr Infect Dis J Volume: 34 Page(s): e119 - e124
05/01/2015 Authors: Brownstein PS; Gillespie SE; Leong T; Chahroudi A; Chakraborty R; Camacho-Gonzalez AF
T memory stem cells and HIV: a long-term relationship.
Curr HIV/AIDS Rep Volume: 12 Page(s): 33 - 40
03/01/2015 Authors: Chahroudi A; Silvestri G; Lichterfeld M
Transition of youth living with HIV from pediatric to adult-oriented healthcare: a review of the literature (vol 9, pg 921, 2014)
FUTURE VIROLOGY Volume: 10 Page(s): 463 - 463
01/01/2015 Authors: Hussen SA; Chahroudi A; Boylan A; Camacho-Gonzalez AF; Hackett S; Chakraborty R
Transition of youth living with HIV from pediatric to adult-oriented healthcare: a review of the literature.
Future Virol Volume: 9 Page(s): 921 - 929
01/01/2015 Authors: Hussen SA; Chahroudi A; Boylan A; Camacho-Gonzalez AF; Hackett S; Chakraborty R
TARGETING SIV RESERVOIRS THROUGH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANT IN RHESUS MACAQUES
JOURNAL OF MEDICAL PRIMATOLOGY Volume: 43 Page(s): 380 - 380
10/01/2014 Authors: Mavigner M; Watkins B; Lawson B; Chahroudi A; Kean L; Silvestri G
DIVERGENT CD4+T MEMORY STEM CELL DYNAMICS IN PATHOGENIC AND NONPATHOGENIC SIV INFECTIONS
JOURNAL OF MEDICAL PRIMATOLOGY Volume: 43 Page(s): 384 - 384
10/01/2014 Authors: Cartwright E; McGary C; Cervasi B; Lawson B; Bosinger SE; Paiardini M; Vanderford TH; Chahroudi A; Silvestri G
TARGET CELL AVAILABILITY, RATHER THAN BREAST MILK SPECIFIC FACTORS, DICTATES MOTHER-TO-INFANT TRANSMISSION OF SIV
JOURNAL OF MEDICAL PRIMATOLOGY Volume: 43 Page(s): 385 - 385
10/01/2014 Authors: Chahroudi A; Cartwright E; Carnathan DG; Lee ST; Lawson B; Carnathan PM; Hashempoor T; Murphy MK; Meeker T; Ehnert S
Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant.
PLoS Pathog Volume: 10 Page(s): e1004406
09/01/2014 Authors: Mavigner M; Watkins B; Lawson B; Lee ST; Chahroudi A; Kean L; Silvestri G
Divergent CD4+ T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections.
J Immunol Volume: 192 Page(s): 4666 - 4673
05/15/2014 Authors: Cartwright EK; McGary CS; Cervasi B; Micci L; Lawson B; Elliott STC; Collman RG; Bosinger SE; Paiardini M; Vanderford TH
Increased stability and limited proliferation of CD4+ central memory T cells differentiate nonprogressive simian immunodeficiency virus (SIV) infection of sooty mangabeys from progressive SIV infection of rhesus macaques.
J Virol Volume: 88 Page(s): 4533 - 4542
04/01/2014 Authors: McGary CS; Cervasi B; Chahroudi A; Micci L; Taaffe J; Meeker T; Silvestri G; Davenport MP; Paiardini M
Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques.
PLoS Pathog Volume: 10 Page(s): e1003958
03/01/2014 Authors: Chahroudi A; Cartwright E; Lee ST; Mavigner M; Carnathan DG; Lawson B; Carnathan PM; Hashempoor T; Murphy MK; Meeker T
The oral mucosa immune environment and oral transmission of HIV/SIV.
Immunol Rev Volume: 254 Page(s): 34 - 53
07/01/2013 Authors: Wood LF; Chahroudi A; Chen H-L; Jaspan HB; Sodora DL
Target cell restriction may limit mother-to-child transmission of SIV in sooty mangabeys
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY Volume: 15 Page(s): 26 - 26
10/01/2012 Authors: Chahroudi A; Carnathan D; Carnathan P; Silvestri G
Natural SIV hosts: Showing AIDS the door (vol 335, pg 1188, 2012)
SCIENCE Volume: 336 Page(s): 413 - 413
04/27/2012 Authors: Chahroudi A
IRIS: the unfortunate rainbow of HIV.
Blood Volume: 119 Page(s): 2971 - 2972
03/29/2012 Authors: Chahroudi A; Silvestri G
Natural SIV hosts: showing AIDS the door.
Science Volume: 335 Page(s): 1188 - 1193
03/09/2012 Authors: Chahroudi A; Bosinger SE; Vanderford TH; Paiardini M; Silvestri G
Reply to "Control of Simian Immunodeficiency Virus SIVmnd-1 RNA Plasma Viremia after Coinfection or Superinfection with SIVmnd-1 in SIVmnd-2-Infected Mandrills and Vice Versa".
J Virol Volume: 86 Page(s): 2387 - 2388
02/01/2012 Authors: Souquiere S; Apetrei C; Chahroudi A; Pandrea I; Silvestri G; Roques P
Immunovirological analyses of chronically simian immunodeficiency virus SIVmnd-1- and SIVmnd-2-infected mandrills (Mandrillus sphinx).
J Virol Volume: 85 Page(s): 13077 - 13087
12/01/2011 Authors: Apetrei C; Sumpter B; Souquiere S; Chahroudi A; Makuwa M; Reed P; Ribeiro RM; Pandrea I; Roques P; Silvestri G
Low levels of SIV infection in sooty mangabey central memory CD T cells are associated with limited CCR5 expression.
Nat Med Volume: 17 Page(s): 830 - 836
06/26/2011 Authors: Paiardini M; Cervasi B; Reyes-Aviles E; Micci L; Ortiz AM; Chahroudi A; Vinton C; Gordon SN; Bosinger SE; Francella N
Mother-to-infant transmission of simian immunodeficiency virus is rare in sooty mangabeys and is associated with low viremia.
J Virol Volume: 85 Page(s): 5757 - 5763
06/01/2011 Authors: Chahroudi A; Meeker T; Lawson B; Ratcliffe S; Else J; Silvestri G
Secondary complications and co-infections in the HIV-infected adolescent in the antiretroviral era.
Curr Opin Infect Dis Volume: 24 Page(s): 212 - 218
06/01/2011 Authors: Ross AC; Camacho-Gonzalez A; Chahroudi A; Chakraborty R
Interleukin-7 inHIV pathogenesis andtherapy.
Eur Cytokine Netw Volume: 21 Page(s): 202 - 207
09/01/2010 Authors: Chahroudi A; Silvestri G
Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.
Blood Volume: 116 Page(s): 748 - 758
08/05/2010 Authors: Engram JC; Cervasi B; Borghans JAM; Klatt NR; Gordon SN; Chahroudi A; Else JG; Mittler RS; Sodora DL; de Boer RJ
A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation.
J Virol Volume: 84 Page(s): 5476 - 5484
06/01/2010 Authors: Taaffe J; Chahroudi A; Engram J; Sumpter B; Meeker T; Ratcliffe S; Paiardini M; Else J; Silvestri G
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
J Immunol Volume: 180 Page(s): 6798 - 6807
05/15/2008 Authors: Estes JD; Gordon SN; Zeng M; Chahroudi AM; Dunham RM; Staprans SI; Reilly CS; Silvestri G; Haase AT
Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus.
J Virol Volume: 80 Page(s): 8469 - 8481
09/01/2006 Authors: Chahroudi A; Garber DA; Reeves P; Liu L; Kalman D; Feinberg MB
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases (vol 11, pg 731, 2005)
NATURE MEDICINE Volume: 11 Page(s): 1361 - 1361
12/01/2005 Authors: Reeves PM; Bommarius B; Lebeis S; McNulty S; Christensen J; Swimm A; Chahroudi A; Chavan R; Feinberg MB; Veach D
Measurement of HIV-1 CRF02_AG-specific T cell responses indicates the dominance of a p24gag epitope in blood donors in Abidjan, Cote d'Ivoire.
Volume: 192 Page(s): 1417 - 1421
10/15/2005 Authors: Chahroudi A; Sawadogo S; Ellenberger D; Pieniazek D; Borget-Alloue M-Y; Aidoo M; Koblavi-Deme S; Fernandez-Vina M; Maurice C; Chorba T
Vaccinia virus tropism for primary hematolymphoid cells is determined by restricted expression of a unique virus receptor.
J Virol Volume: 79 Page(s): 10397 - 10407
08/01/2005 Authors: Chahroudi A; Chavan R; Kozyr N; Waller EK; Silvestri G; Feinberg MB
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases.
Nat Med Volume: 11 Page(s): 731 - 739
07/01/2005 Authors: Reeves PM; Bommarius B; Lebeis S; McNulty S; Christensen J; Swimm A; Chahroudi A; Chavan R; Feinberg MB; Veach D
Measuring T cell-mediated cytotoxicity using fluorogenic caspase substrates.
Methods Volume: 31 Page(s): 120 - 126
10/01/2003 Authors: Chahroudi A; Silvestri G; Feinberg MB
Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates.
Nat Med Volume: 8 Page(s): 185 - 189
02/01/2002 Authors: Liu L; Chahroudi A; Silvestri G; Wernett ME; Kaiser WJ; Safrit JT; Komoriya A; Altman JD; Packard BZ; Feinberg MB
Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1.
J Exp Med Volume: 191 Page(s): 1649 - 1660
05/15/2000 Authors: Mnz C; Bickham KL; Subklewe M; Tsang ML; Chahroudi A; Kurilla MG; Zhang D; O'Donnell M; Steinman RM
Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion.
J Immunol Volume: 163 Page(s): 6762 - 6768
12/15/1999 Authors: Engelmayer J; Larsson M; Subklewe M; Chahroudi A; Cox WI; Steinman RM; Bhardwaj N
Presentation of epstein-barr virus latency antigens to CD8(+), interferon-gamma-secreting, T lymphocytes.
Eur J Immunol Volume: 29 Page(s): 3995 - 4001
12/01/1999 Authors: Subklewe M; Chahroudi A; Bickham K; Larsson M; Kurilla MG; Bhardwaj N; Steinman RM
Induction of Epstein-Barr virus-specific cytotoxic T-lymphocyte responses using dendritic cells pulsed with EBNA-3A peptides or UV-inactivated, recombinant EBNA-3A vaccinia virus.
Blood Volume: 94 Page(s): 1372 - 1381
08/15/1999 Authors: Subklewe M; Chahroudi A; Schmaljohn A; Kurilla MG; Bhardwaj N; Steinman RM
Elispot for the determination of the repertoire of EBV antigens recognized by human T-lymphocytes.
BLOOD Volume: 92 Page(s): 22A - 23A
11/15/1998 Authors: Subklewet M; Chahroudi A; Bickham K; Larsson M; Bhardwaj N; Steinmann RM
Induction of CTL responses with dendritic cells pulsed with EBNA-3A peptide or recombinant vaccinia-EBNA-3A.
BLOOD Volume: 92 Page(s): 411A - 411A
11/15/1998 Authors: Subklewe M; Chahroudi A; Bhardwaj N; Steinman RM
Vaccinia virus goes through an abortive replication cycle in dendritic cells and inhibits their maturation
JOURNAL OF LEUKOCYTE BIOLOGY Page(s): 37 - 37
01/01/1998 Authors: Engelmayer J; Larsson M; Subklewe M; Chahroudi A; Steinman R; Bhardwaj N
Strong, MHC I-restricted, cytolytic T lymphocyte responses to EBV antigen on dendritic cells.
BLOOD Volume: 90 Page(s): 2033 - 2033
11/15/1997 Authors: Subklewe M; Chahroudi A; Bhardwaj N; Steinman RM

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