Kristin Deeb

Department of Pathology and Laboratory Medicine
Assistant Professor

kristin.deeb@emory.edu

Emory University School of Medicine
Department of Pathology and Laboratory Medicine
531 Asbury Circle, Suite N252F

Overview

Studying the phenotypic and genotypic characteristics of hematologic neoplasms and solid tumors by utilizing multidisciplinary high-throughput analyses aiming to characterize the therapeutic, diagnostic and prognostic features of clinically relevant entities.

Investigating practical solutions and evidence-based diagnostic algorithms to optimize laboratory services, quality, and control cost.

Continuous diligent search for innovative methods of teaching medical professionals.

Academic Appointment

Assistant Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine

Education

Degrees

PhD Molecular Pharmacology and Cancer Therapeutics from University at Buffalo, State University of New York, Roswell Park Division
BS, BA Biochemistry and Cell Biology, Psychology from University of California, San Diego

Research

Focus

Utilizing multidisciplinary high-throughput genomic analyses to characterize hematologic neoplasms and solid tumors
Studying the phenotypic and genotypic characteristics of hematologic neoplasms and solid tumors by utilizing multidisciplinary high-throughput analyses aiming to characterize the therapeutic, diagnostic and prognostic features of clinically relevant entities. Improving efficiency, accuracy, and cost-effectiveness in laboratory testing and services by designing testing algorithms based on scientific evidence that will guide the diagnostic process, ensuring accurate and efficient identification of diseases. Continuous exploring creative ways to educate healthcare providers.

Publications

High-Grade Sarcomatous Transformation of Hybrid Hemosiderotic Fibrolipomatous Tumor-Myxoinflammatory Fibroblastic Sarcoma with Novel ADAMTS12::TERT Gene Fusion.
Int J Surg Pathol Page(s): 10668969241300492
01/07/2025 Authors: Gandhi JS; Deeb KK; Chen EY; Bandhlish A
Trans-differentiation of plasma cell neoplasm to acute myeloid leukemia with monocytic features: Case report of divergent phenotype with identical genotype.
Leuk Res Rep Volume: 23 Page(s): 100504
01/01/2025 Authors: Asakrah S; Deeb KK; Papadantonakis N; Deeb G
Measurable (Minimal) Residual Disease in Myelodysplastic Neoplasms (MDS): Current State and Perspectives.
Cancers (Basel) Volume: 16
04/15/2024 Authors: Zhang L; Deeb G; Deeb KK; Vale C; Peker Barclift D; Papadantonakis N
Section E6.7-6.12 of the American College of Medical Genetics and Genomics (ACMG) Technical Laboratory Standards: Cytogenomic studies of acquired chromosomal abnormalities in solid tumors.
Genet Med Volume: 26 Page(s): 101070
04/01/2024 Authors: Church AJ; Akkari Y; Deeb K; Kolhe R; Lin F; Spiteri E; Wolff DJ; Shao L; ACMG Laboratory Quality Assurance Committee. Electronic address: documents@acmg.net
Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study.
Arch Pathol Lab Med Volume: 148 Page(s): 310 - 317
03/01/2024 Authors: Bidot S; Yin J; Zhou P; Zhang L; Deeb KK; Smith G; Hill CE; Xiu J; Bilen MA; Case KB
Superficial dedifferentiated liposarcoma: A clinicopathologic study.
Hum Pathol Volume: 145 Page(s): 63 - 70
03/01/2024 Authors: Bourgeau M; Gandhi JS; Deeb KK; Bahrami A
Clinical Validation of a Rapid Myeloid Mutation Panel
Volume: 25 Page(s): S35 - S36
11/01/2023 Authors: Ma Y; Schneider T; Verma T; Saade R; Broadfoot B; Drumheller B; Rajack F; Ojo A; Deeb K; Zhang L
Clinicopathologic and Molecular Analysis of Gastric Carcinoma with Homologous Recombination Deficiency
Volume: 103 Page(s): S636 - S636
03/01/2023 Authors: Sohn A; Yin F; Teng Y; Zhang L; Deeb K; Saxena R; Krasinskas A; Zheng W
Loss of heterozygosity leading to incorrect HLA typing for platelet-transfusion refractory patient.
Volume: 63 Page(s): 263 - 268
01/01/2023 Authors: Horwath M; Tvrdik T; Saxe D; Deeb KK; Roback JD; Gebel HM; Bray RA; Sullivan HC
Clinical Validation and Diagnostic Utility of Optical Genome Mapping for Enhanced Cytogenomic Analysis of Hematological Neoplasms.
J Mol Diagn Volume: 24 Page(s): 1279 - 1291
12/01/2022 Authors: Sahajpal NS; Mondal AK; Tvrdik T; Hauenstein J; Shi H; Deeb KK; Saxe D; Hastie AR; Chaubey A; Savage NM
Comment on "A Novel COL1A1-CAMTA1 Rearrangement in Cranial Fasciitis".
Int J Surg Pathol Volume: 30 Page(s): 839 - 840
10/01/2022 Authors: Deeb KK; Li S; Zhang L
Revealing molecular architecture of FLT3 internal tandem duplication: Development and clinical validation of a web-based application to generate accurate nomenclature.
Int J Lab Hematol Volume: 44 Page(s): 918 - 927
10/01/2022 Authors: Ding Y; Smith GH; Deeb K; Schneider T; Campbell A; Zhang L
Erythropoietic properties of human induced pluripotent stem cells-derived red blood cells in immunodeficient mice.
Am J Hematol Volume: 97 Page(s): 194 - 202
02/01/2022 Authors: Deng J; Lancelot M; Jajosky R; Deng Q; Deeb K; Saakadze N; Gao Y; Jaye D; Liu S; Stowell SR
Cytologic features of hepatic YAP1-TFE3 rearranged epithelioid hemangioendothelioma.
Diagn Cytopathol Volume: 49 Page(s): E447 - E452
12/01/2021 Authors: Bourgeau M; Martinez A; Deeb KK; Reid MD; Lewis M; Point du Jour KS; Lai J; Shi Q
Expert Curation of Somatic FLT3 Variants By the Clingen Somatic Hematologic Cancer Taskforce (ClinGen HCT)
Volume: 138
11/23/2021 Authors: Shao X; Rao S; Mani C; Saliba J; He R; Kesserwan C; Danos A; Sheta L; Terraf P; Raca G
Hereditary Cancer Syndromes and Inherited Cancer Risks.
Practical Oncologic Molecular Pathology Frequently Asked Questions
07/10/2021 Authors: Deeb K; Kekis M; Tvrdik T
Clinicopathologic and Molecular Analysis of Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma: A Case Report and Review of Literature.
Turk Patoloji Derg Volume: 37 Page(s): 266 - 272
01/01/2021 Authors: Morales-Vargas B; Deeb K; Peker D
Expert Curation of Somatic Variants in Hematological Malignancies By the Clingen Somatic Hematological Cancer Taskforce (ClinGen HCT)
Volume: 136
11/05/2020 Authors: Kanagal-Shamanna R; Rao S; Terraf P; Raca G; Saliba J; Danos A; Mani C; Williams H; Jiang N; Vavra KC
Copy Number Variant Detection by Targeted Gene Next-Generation Sequencing
Volume: 21 Page(s): 1150 - 1151
11/01/2019 Authors: Myers CE; Nguyen HL; Hauenstein J; Saxe DF; Smith GH; Hill CE; Zhang L; Deeb KK
The Value of Comprehensive Thyroid Function Testing and Family History for Early Diagnosis of MCT8 Deficiency.
Clin Pediatr (Phila) Volume: 55 Page(s): 286 - 289
03/01/2016 Authors: Bedoyan JK; Tim-Aroon T; Deeb KK; Ganganna ST; Bass NE
Novel SMC1A frameshift mutations in children with developmental delay and epilepsy.
Eur J Med Genet Volume: 58 Page(s): 562 - 568
10/01/2015 Authors: Goldstein JHR; Tim-Aroon T; Shieh J; Merrill M; Deeb KK; Zhang S; Bass NE; Bedoyan JK
Routine Clinical Mutation Profiling of Non-Small Cell Lung Cancer Using Next-Generation Sequencing.
Arch Pathol Lab Med Volume: 139 Page(s): 913 - 921
07/01/2015 Authors: Deeb KK; Hohman CM; Risch NF; Metzger DJ; Starostik P
The c.1364C>A (p.A455E) Mutation in the CFTR Pseudogene Results in an Incorrectly Assigned Carrier Status by a Commonly Used Screening Platform.
J Mol Diagn Volume: 17 Page(s): 360 - 365
07/01/2015 Authors: Deeb KK; Metcalf JD; Sesock KM; Shen J; Wensel CA; Rippel LI; Smith M; Chapman MS; Zhang S
SOMATIC MOSAICISM FORA NOVEL PDHA1 MUTATION IN A MALE WITH SEVERE PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY: CASE REPORT AND LITERATURE REVIEW.
Volume: 111 Page(s): 245 - 245
03/01/2014 Authors: Deeb KK; Bedoyan JK; Wang R; Sremba L; Schroeder MC; Grahame GJ; Boyer M; Kerr DS; Zhang S
Deletion and deletion/insertion mutations in the juxtamembrane domain of the FLT3 gene in adult acute myeloid leukemia.
Leuk Res Rep Volume: 3 Page(s): 86 - 89
01/01/2014 Authors: Deeb KK; Smonskey MT; DeFedericis H; Deeb G; Sait SNJ; Wetzler M; Wang ES; Starostik P
Somatic mosaicism for a novel PDHA1 mutation in a male with severe pyruvate dehydrogenase complex deficiency.
Mol Genet Metab Rep Volume: 1 Page(s): 362 - 367
01/01/2014 Authors: Deeb KK; Bedoyan JK; Wang R; Sremba L; Schroeder MC; Grahame GJ; Boyer M; McCandless SE; Kerr DS; Zhang S
Routine Clinical Mutation Profiling of Non-Small Cell Lung Cancer (NSCLC) Using 454 Next-Generation Sequencing Technology
Volume: 15 Page(s): 932 - 933
11/01/2013 Authors: Starostik P; Deeb KK; Hohman CM; Risch NF; Metzger DJ
Multigene assays in metastatic colorectal cancer.
J Natl Compr Canc Netw Volume: 11 Suppl 4 Page(s): S9 - 17
09/01/2013 Authors: Deeb KK; Sram JP; Gao H; Fakih MG
Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue.
Oncotarget Volume: 4 Page(s): 1472 - 1483
09/01/2013 Authors: Luo W; Hu Q; Wang D; Deeb KK; Ma Y; Morrison CD; Liu S; Johnson CS; Trump DL
Genome-wide expression and methylation analysis in CD31+cells from African American and Caucasian American benign and malignant prostate tissue
Volume: 72
04/15/2012 Authors: Luo W; Deeb KK; Liu S; Ma Y; Morrison CD; Trump DL; Johnson CS
Dexamethasone enhances 1alpha,25-dihydroxyvitamin D3 effects by increasing vitamin D receptor transcription.
J Biol Chem Volume: 286 Page(s): 36228 - 36237
10/21/2011 Authors: Hidalgo AA; Deeb KK; Pike JW; Johnson CS; Trump DL
Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate.
Epigenetics Volume: 6 Page(s): 994 - 1000
08/01/2011 Authors: Deeb KK; Luo W; Karpf AR; Omilian AR; Bshara W; Tian L; Tangrea MA; Morrison CD; Johnson CS; Trump DL
Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer.
Cancer Res Volume: 70 Page(s): 5953 - 5962
07/15/2010 Authors: Luo W; Karpf AR; Deeb KK; Muindi JR; Morrison CD; Johnson CS; Trump DL
Regulation of vitamin D 24-hydroxylase gene expression in human prostate cancer by epigenetic mechanisms
Volume: 70
04/01/2010 Authors: Luo W; Karpf AR; Deeb KK; Muindi JR; Morrison CD; Trump DL; Johnson CS
Vitamin D: considerations in the continued development as an agent for cancer prevention and therapy.
Cancer J Volume: 16 Page(s): 1 - 9
01/01/2010 Authors: Trump DL; Deeb KK; Johnson CS
Erratum: Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis (Cancer Research (2007) 67, (8065-8080))
Cancer Research Volume: 67 Page(s): 10097
10/15/2007 Authors: Deeb KK; Michalowska AM; Yoon CY; Krummey SM; Hoenerhoff MJ; Kavanaugh C; Li MC; Demayo FJ; Linnoila I; Deng CX
Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis.
Cancer Res Volume: 67 Page(s): 8065 - 8080
09/01/2007 Authors: Deeb KK; Michalowska AM; Yoon C-Y; Krummey SM; Hoenerhoff MJ; Kavanaugh C; Li M-C; Demayo FJ; Linnoila I; Deng C-X
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics.
Nat Rev Cancer Volume: 7 Page(s): 684 - 700
09/01/2007 Authors: Deeb KK; Trump DL; Johnson CS
Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA.
J Biol Chem Volume: 282 Page(s): 8404 - 8413
03/16/2007 Authors: Jell J; Merali S; Hensen ML; Mazurchuk R; Spernyak JA; Diegelman P; Kisiel ND; Barrero C; Deeb KK; Alhonen L
Molecular profiling in breast cancer: genomic approaches toward tailored cancer therapies
Cancer Drug Resistance Page(s): 559 - 576
03/09/2006 Authors: Kee K; Green JE
Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines
JOURNAL OF VIROLOGY Volume: 80 Page(s): 1762 - 1772
02/01/2006 Authors: Stone GW; Barzee S; Snarsky V; Kee K; Spina CA; Yu XF; Kornbluth RS
Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice
JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 279 Page(s): 40076 - 40083
09/17/2004 Authors: Kee K; Foster BA; Merali S; Kramer DL; Hensen ML; Diegelman P; Kisiel N; Vujcic S; Mazurchuk RV; Porter CW
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells
JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 279 Page(s): 27050 - 27058
06/25/2004 Authors: Kee K; Vujcic S; Merali S; Diegelman P; Kisiel N; Powell CT; Kramer DL; Porter CW
The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells
CANCER RESEARCH Volume: 63 Page(s): 3619 - 3625
07/01/2003 Authors: Chen Y; Alm K; Vujcic S; Kramer DL; Kee K; Diegelman P; Porter CW
Multimeric forms of CD40L, RANKL, and other TNFSF ligands
Volume: 17 Page(s): C146 - C147
04/14/2003 Authors: Kornbluth RS; Kee K; Truong NH; Snarsky V
Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE Volume: 93 Page(s): 1234 - 1245
08/15/2001 Authors: Vredenburg MR; Ojima I; Veith J; Pera P; Kee K; Cabral F; Sharma A; Kanter P; Greco WR; Bernacki RJ
CD40L (CD154) fusion protein with pulmonary surfactant protein D as a prototype for soluble multimeric TNF superfamily ligand molecules.
Volume: 14 Page(s): A1162 - A1162
04/20/2000 Authors: Kornbluth RS; Kee K; Truong NH
Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy
JOURNAL OF VIROLOGY Volume: 73 Page(s): 9404 - 9412
11/01/1999 Authors: Gunthard HF; Frost SDW; Leigh-Brown AJ; Ignacio CC; Kee K; Perelson AS; Spina CA; Havlir DV; Hezareh M; Looney DJ
CD40L effects on mycobacterial growth in vitro and in vivo
Page(s): 33 - 33
01/01/1999 Authors: Kornbluth RS; Hayashi T; Rao SP; Kee K; Catanzaro A
CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive -chemokines
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Volume: 95 Page(s): 5205 - 5210
04/28/1998 Authors: Kornbluth RS; Kee K; Richman DD
CD40 ligand (CD154) stimulates macrophages to produce HIV-suppressive beta-chemokines.
Volume: 12 Page(s): A925 - A925
03/20/1998 Authors: Kornbluth RS; Kee K; Richman DD
Soluble CD40 receptor is produced by malignant cells in culture.
Page(s): 28 - 28
01/01/1998 Authors: Kornbluth RS; Sarkar U; Kee K; Hobson D
Cytokine modulation of CD40 ligand (CD40L)-induced beta-chemokine production by human macrophages.
Page(s): 50 - 50
01/01/1997 Authors: Kornbluth RS; Kee K
CD40L stimulates human macrophages to express pro-Th1 factors (IL-12, IL-18, B7) and HIV-suppressive beta-chemokines.
Volume: 99 Page(s): 1545 - 1545
01/01/1997 Authors: Kornbluth RS; Kee K; Richman DD

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