Jonathan Sevransky MD,MHS
Overview
Dr. Sevransky completed his undergraduate education at Dartmouth College and his medical education and the George Washington University of Medicine. He did his internship and residency at the Presbyterian Hospital of New York (Columbia University) and then a fellowship in Critical Care at the National Institutes of Health and in pulmonary medicine at Johns Hopkins. He joined the faculty at Johns Hopkins in 1999, and served as the director of the MICU at the Johns Hopkins Bayview Medical Center from 1999-2011. While at Johns Hopkins, he completed a masters in clinical investigation at the Johns Hopkins Bloomberg School of Public Health.
Dr. Sevransky was recruited to Emory in 2011, where he currently serves as professor of medicine, the director of the Medical ICU at Emory University Hospital, and as the site director for Emory University Hospital, Emory Critical Care Center. He also serves as the founding director for the Emory Critical Illness Research Center ( E-CIRC), a clinical research collaboration between Emergency Medicine, the Emory Critical Care Center, and the division of Pulmonary, Allergy, Critical Care and Sleep. In 2024 He assumed the Editor in Chief position for the journal, Critical Care Medicine
Jons clinical, educational and research center on the treatment of patients with life-threatening illness. He is a clinical investigator with a primary interest in the treatment of patients with sepsis and complications of sepsis such as acute respiratory distress syndrome (ARDS) and septic shock. An additional focus of investigation is the identification of patient and hospital related factors that may modify treatment effects of novel agents in clinical trials.
Current research projects include studies looking at early markers of sepsis in patients presenting to the emergency room, attempts to improve the treatment patients with sepsis, including potential prehospital markers, a large cohort trial examining the role of ICU organization and structure on in patient mortality, and is working with a team on ways to decrease the cost and efficiency of sepsis clinical trials using novel trial designs while leveraging the electronic medical record.
Dr Sevransky is past chair of the SCCM Discovery Research Network, , and served as an associate editor for the journal Critical Care Medicine. He was also a founding member of the US Critical Illness and Injury Trials Group, He sees patients at Emory University Hospital, and mentors fellows, residents and medical students in clinical investigation in critical care.
Academic Appointment
- Professor Of Medicine, Medicine, Emory University School of Medicine
- Eminent Physician, Emory University School of Medicine
Education
Degrees
- MHS from Johns Hopkins Bloomberg School of Public Health
- MD from George Washington University
- BA from Dartmouth College
Research
Focus
- My first interest relates to complications of sepsis including septic shock and severe sepsis induced acute lung injury. My second interest involves research into patient, treatment, and organizational factors that can modify the effects of interventions in critically ill patients. These factors can range from genetic polymorphisms to intensive care unit staffing and structural components
Publications
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Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients.
Clin Sci (Lond) Volume: 139 Page(s): 43 - 53
01/15/2025 Authors: Chappell MC; Schaich CL; Busse LW; Clark Files D; Martin GS; Sevransky JE; Hinson JS; Rothman RE; Khanna AK; Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Investigators -
Knowledge Transfer in the 21st Century: The Continuing Evolution of Critical Care Medicine.
Crit Care Med Volume: 53 Page(s): e1 - e3
01/01/2025 Authors: Sevransky JE; Barreto EF; Bleck TP; Chen J-T; Dellinger RP; Deutschman CS; Lyons PG; Mariscalo MM; Marshall JC; Maslove DM -
Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post-hoc analysis from the VICTAS trial.
Crit Care Volume: 28 Page(s): 333
10/14/2024 Authors: Chappell MC; Schaich CL; Busse LW; Martin GS; Sevransky JE; Hinson JK; Khanna AK; Vitamin C, Thiamine, Steroids in Sepsis (VICTAS) Investigators -
COVID-19 Across Pandemic Variant Periods: The Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study.
Crit Care Explor Volume: 6 Page(s): e1122
07/01/2024 Authors: Mukherjee V; Postelnicu R; Parker C; Rivers PS; Anesi GL; Andrews A; Ables E; Morrell ED; Brett-Major DM; Broadhurst MJ -
Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial.
Crit Care Med Volume: 52 Page(s): 441 - 451
03/01/2024 Authors: Busse LW; Schaich CL; Chappell MC; McCurdy MT; Staples EM; Ten Lohuis CC; Hinson JS; Sevransky JE; Rothman RE; Wright DW -
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.
Nat Commun Volume: 15 Page(s): 404
01/09/2024 Authors: Haslund-Gourley BS; Woloszczuk K; Hou J; Connors J; Cusimano G; Bell M; Taramangalam B; Fourati S; Mege N; Bernui M -
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
Nat Commun Volume: 15 Page(s): 216
01/03/2024 Authors: Ozonoff A; Jayavelu ND; Liu S; Melamed E; Milliren CE; Qi J; Geng LN; McComsey GA; Cairns CB; Baden LR -
Is It Time to Reconsider the Concept of "Salvage Therapy" in Refractory Shock?
Crit Care Med Volume: 51 Page(s): 1821 - 1824
12/01/2023 Authors: Wieruszewski PM; Sevransky JE; Roberts RJ -
Relationship of Heterologous Virus Responses and Outcomes in Hospitalized COVID-19 Patients.
J Immunol Volume: 211 Page(s): 1224 - 1231
10/15/2023 Authors: Rosenberg-Hasson Y; Holmes TH; Diray-Arce J; Chen J; Kellogg R; Snyder M; Becker PM; Ozonoff A; Rouphael N; Reed EF -
How Electronic Medical Record Integration Can Support More Efficient Critical Care Clinical Trials.
Crit Care Clin Volume: 39 Page(s): 733 - 749
10/01/2023 Authors: Agarwal A; Marion J; Nagy P; Robinson M; Walkey A; Sevransky J