Annette Kalifeh MD, MSc
Overview
Dr. Esper received her undergraduate degree at the University of Texas at Austin. She earned her medical degree in 2002 from the University of Texas Medical School at Houston. She completed an Internal Medicine residency program in 2005 and a Pulmonary/Critical Care fellowship in 2008 at Emory University. In 2008, after completing fellowship, she joined the faculty at Emory University as an Assistant Professor of Medicine in the Division of Pulmonary, Allergy, and Critical Care. During her first two years on faculty she earned her Masters of Science in Clinical Research from the Laney Graduate School at Emory University. Dr. Esper is clinically active in pulmonary and critical care at Grady Memorial Hospital and serves as the medical director of the stepdown Intensive Care Unit at Grady Memorial Hospital.
Dr. Espers research includes clinical and translational research in critically ill patients, with a specific interest in sepsis and the acute respiratory distress syndrome (ARDS). She has conducted research that evaluated disparities in sepsis and the impact of diabetes on ARDS development. Currently, her work focuses on translational research in sepsis-induced ARDS, where she is investigating the role of alveolar macrophage function and phenotype, and conducting biomarker and metabolomics studies in ARDS. In addition to her clinical and research work, she has the opportunity to teach medical students, residents and fellows in both the inpatient and outpatient settings.
Academic Appointment
- Distinguished Physician, Emory University School of Medicine
- Faculty Lecturer and Simulation Center Proctor, Emory University School of Medicine
- Assistant Professor of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine
Education
Degrees
- MA from Emory University
- MD from The University of Texas at Houston Medical School
- BA from The University of Texas at Austin
Research
Focus
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Clinical & translational research in ARDS
I continue to study factors that influence fluid balance in the acutely injured lung, particularly as it relates to hypo-oncotic acute lung injury patients. This spans a spectrum from observational and controlled clinical trials to comparative physiology to translational biochemistry of pharmaceutical therapies. I began working in this field in the 1990s, first demonstrating an independent association between protein osmotic pressure and physiologic fluid handling capabilities, the risk of developing ARDS, and clinically important outcomes. Our group subsequently completed three randomized, blinded, controlled clinical trials testing strategies to favorably influence lung fluid balance and lung function, each demonstrating the superiority of combination colloid and diuretic therapy over diuretic therapy alone for improving oxygenation and systemic hemodynamics.
Publications
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Rapid and Robust Identification of Sepsis Using SeptiCyte RAPID in a Heterogeneous Patient Population.
J Clin Med Volume: 13
10/10/2024 Authors: Balk R; Esper AM; Martin GS; Miller RR; Lopansri BK; Burke JP; Levy M; Rothman RE; D'Alessio FR; Sidhaye VK -
Executive Summary: Guidelines on Use of Corticosteroids in Critically Ill Patients With Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia Focused Update 2024.
Crit Care Med Volume: 52 Page(s): 833 - 836
05/01/2024 Authors: Chaudhuri D; Nei AM; Rochwerg B; Balk RA; Asehnoune K; Cadena RS; Carcillo JA; Correa R; Drover K; Esper AM -
2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia.
Crit Care Med Volume: 52 Page(s): e219 - e233
05/01/2024 Authors: Chaudhuri D; Nei AM; Rochwerg B; Balk RA; Asehnoune K; Cadena R; Carcillo JA; Correa R; Drover K; Esper AM -
Acute Respiratory Failure: Problems Solved and Unsolved.
Crit Care Clin Volume: 40 Page(s): xiii - xv
04/01/2024 Authors: Yang P; Esper AM -
Racial Differences in Accuracy of Predictive Models for High-Flow Nasal Cannula Failure in COVID-19.
Crit Care Explor Volume: 6 Page(s): e1059
03/01/2024 Authors: Yang P; Gregory IA; Robichaux C; Holder AL; Martin GS; Esper AM; Kamaleswaran R; Gichoya JW; Bhavani SV -
Validation of SeptiCyte RAPID to Discriminate Sepsis from Non-Infectious Systemic Inflammation.
J Clin Med Volume: 13
02/20/2024 Authors: Balk R; Esper AM; Martin GS; Miller RR; Lopansri BK; Burke JP; Levy M; Opal S; Rothman RE; D'Alessio FR -
HIRA: Heart Rate Interval based Rapid Alert score to characterize autonomic dysfunction among patients with sepsis-related acute respiratory failure (ARF).
Physiol Meas Volume: 44
10/13/2023 Authors: Krishnan P; Rad MG; Agarwal P; Marshall C; Yang P; Bhavani SV; Holder AL; Esper A; Kamaleswaran R -
Study on the relationship between selenium and cadmium in diseased human lungs.
Adv Redox Res Volume: 7
04/01/2023 Authors: Smith MR; Hu X; Jarrell ZR; He X; Orr M; Fernandes J; Chandler JD; Walker DI; Esper A; Marts L -
Systematized and efficient: organization of critical care in the future.
Crit Care Volume: 26 Page(s): 366
11/28/2022 Authors: Esper AM; Arabi YM; Cecconi M; Du B; Giamarellos-Bourboulis EJ; Juffermans N; Machado F; Peake S; Phua J; Rowan K -
Dysregulated naive B cells and de novo autoreactivity in severe COVID-19.
Nature Volume: 611 Page(s): 139 - 147
11/01/2022 Authors: Woodruff MC; Ramonell RP; Haddad NS; Anam FA; Rudolph ME; Walker TA; Truong AD; Dixit AN; Han JE; Cabrera-Mora M