CALIBREX (CAndesartan vs. LIsinopril effects on the BRain and Endothelial function in eXecutive)
What is the purpose of this study?
- The purpose of this study is to compare the effect of two high blood pressure drugs, candesartan and Lisinopril, on thinking abilities and brain activities.
- This research may help us learn how to stop the damaging effects of hypertension on our brains and memory abilities. Information from the study might lead to new treatments in the future.
- This study involves 5-8 visits at our study site during the course of a year.
- One-year supply of blood pressure medications
- Volunteers will be compensated for time and travel
Who can participate?
- 55 years or older with high blood pressure with or without medications.
- We will invite you to come to Emory for an evaluation to check if you are eligible.
This study has fulfilled the enrollment goals and is closed to enrollment. Learn more about the CALIBREX study by visiting ClinicalTrials.gov.
VASCULAR (VAScular ContribUtors to prodromaL AlzheimeR’s disease)
What is the purpose of this study?
- The purpose of this study is to identify factors that are linked to memory and cognitive loss in both those without any memory difficulties and in those who are experiencing loss of memory. We are particularly studying the role of the vascular system, which includes the heart and the circulation, in memory loss. We will study 175 individuals with prodromal Alzheimer’s disease (AD) and 175 matched controls.
- Cardiovascular disease and Alzheimer’s disease (AD) share many risk factors including hypertension. Identifying the role of vascular dysfunction in AD will offer new therapeutic targets for AD prevention and treatment. This study will help to provide knowledge about the development of AD and will offer an explanation for the association between cardiovascular disease and AD.
- This is a 4 year long study that includes yearly visits to the study center.
- Volunteers will be compensated for time and travel.
Who can participate?
- All individuals age 50 and older are invited to come in for an evaluation to determine eligibility.
- Individuals with memory concerns such as Mild Cognitive Impairment (MCI) and individuals who do not have any memory concerns.
Learn more about the VASCULAR study.
REACTION (REActivity of the Cardiovascular System and Cognitive FuncTION)
What is about this study?
- This study investigates the way your heart reacts to stress, and whether it may be related to cognitive function.
- Participants will undergo a memory evaluation and have their heart response to mildly stressful conditions measured.
- This study involves a one-time visit to our study center.
- Volunteers will be compensated for time and travel
Who can participate?
- 25 years or older
- with and without memory problems
- African American or white participants
- A diagnosis of early-stage dementia is allowed
Learn more about REACTION study.
CEDAR (Candesartan's Effects on Alzheimer's Disease and Related Biomarkers)
What is the purpose of this study?
- This study tests if an FDA approved blood pressure medication might help cognitive function and thinking skills. It also aims to study the effect of this medication in reducing the build-up of proteins in the brain that causes Alzheimer’s disease.
- This study will last 1 year and will include between 8-11 visits to our Emory study site during the one-year period.
- Volunteers will be compensated for time and travel
Who can participate?
- All individuals 50 years or older with memory difficulties are invited to come in for a screening to determine eligibility
- Individuals without history of hypertension
- Willing to undergo a memory evaluation, lumbar puncture and take an FDA-approved blood pressure medication
- Not currently participating in other studies with brain assessments or medications
Learn more about CEDAR study.