Publications

• Use of the Microfluidic Impedance Red Cell Assay (MIRCA) in Sickle Cell Disease.
  Blood Adv
  05/01/2025 Authors: Patwardhan AA; Patel AP; Pasupuleti AK; Oshabaheebwa S; Delianides CA; Sekyonda Z; Yoo JJ; Wade JW; Evans EN; Suster MA
• Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.
  Nat Genet Volume: 57 Page(s): 548 - 562
  03/01/2025 Authors: Choi SH; Jurgens SJ; Xiao L; Hill MC; Haggerty CM; Sveinbjrnsson G; Morrill VN; Marston NA; Weng L-C; Pirruccello JP
• Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease.
  Nat Commun Volume: 16 Page(s): 1441
  02/07/2025 Authors: Kostamo Z; Ortega MA; Xu C; Feliciano PR; Budak E; Lam D; Winton V; Jenkins R; Venugopal A; Zhang M
• A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.
  Nat Comput Sci Volume: 5 Page(s): 125 - 143
  02/01/2025 Authors: Li X; Chen H; Selvaraj MS; Van Buren E; Zhou H; Wang Y; Sun R; McCaw ZR; Yu Z; Jiang M-Z
• Impact of hydroxycarbamide treatment on the whole-blood transcriptome in sickle cell disease.
  Br J Haematol Volume: 206 Page(s): 713 - 720
  02/01/2025 Authors: Bhat V; Potdar AA; Yu GK; Gibson G; Sheehan VA
• Dual -globin-truncated erythropoietin receptor knockin restores hemoglobin production in -thalassemia-derived erythroid cells.
  Cell Rep Volume: 44 Page(s): 115141
  01/28/2025 Authors: Chu SN; Soupene E; Sharma D; Sinha R; McCreary T; Hernandez B; Shen H; Wienert B; Bowman C; Yin H
• Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells.
  Nat Biomed Eng Volume: 8 Page(s): 1540 - 1552
  12/01/2024 Authors: Luna SE; Camarena J; Hampton JP; Majeti KR; Charlesworth CT; Soupene E; Selvaraj S; Jia K; Sheehan VA; Cromer MK
• Concerns With Statistical Analysis of 2016 CDC Opioid Guideline and Sickle Cell Outcomes.
  JAMA Intern Med Volume: 184 Page(s): 1133
  09/01/2024 Authors: Patel AP; McLemore M; Sheehan VA
• A miniaturized wash-free microfluidic assay for electrical impedance-based assessment of red blood cell-mediated microvascular occlusion.
  Biosens Bioelectron Volume: 258 Page(s): 116352
  08/15/2024 Authors: Oshabaheebwa S; Delianides CA; Patwardhan AA; Evans EN; Sekyonda Z; Bode A; Apio FM; Mutuluuza CK; Sheehan VA; Suster MA
• Can we use biomarkers to identify those at risk of acute pain from sickle cell disease?
  Expert Rev Hematol Volume: 17 Page(s): 411 - 418
  08/01/2024 Authors: Bhat V; Sheehan VA
• A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels.
  Blood Volume: 143 Page(s): 1845 - 1855
  05/02/2024 Authors: de Vries PS; Reventun P; Brown MR; Heath AS; Huffman JE; Le N-Q; Bebo A; Brody JA; Temprano-Sagrera G; Raffield LM
• Gene Therapies for Hemoglobinopathies: Promises and Challenges.
  Hemoglobin Volume: 48 Page(s): 139 - 140
  05/01/2024 Authors: Sheehan V
• Oxygen gradient ektacytometry-derived biomarkers are associated with acute complications in sickle cell disease.
  Blood Adv Volume: 8 Page(s): 276 - 286
  01/23/2024 Authors: Rab MAE; Kanne CK; Boisson C; Bos J; van Oirschot BA; Houwing ME; Renoux C; Bartels M; Rijneveld AW; Nur E
• Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma.
  EBioMedicine Volume: 95 Page(s): 104758
  09/01/2023 Authors: Recto K; Kachroo P; Huan T; Van Den Berg D; Lee GY; Bui H; Lee DH; Gereige J; Yao C; Hwang S-J
• iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays.
  Nat Commun Volume: 14 Page(s): 5022
  08/18/2023 Authors: Fay ME; Oshinowo O; Iffrig E; Fibben KS; Caruso C; Hansen S; Musick JO; Valdez JM; Azer SS; Mannino RG
• Author Correction: Clonal haematopoiesis and risk of chronic liver disease.
  Nature Volume: 619 Page(s): E47
  07/01/2023 Authors: Wong WJ; Emdin C; Bick AG; Zekavat SM; Niroula A; Pirruccello JP; Dichtel L; Griffin G; Uddin MM; Gibson CJ
• Increasing Erythropoietic Output from Genome-Edited Hematopoietic Stem and Progenitor Cells Using a Truncated EPO Receptor
  Volume: 31 Page(s): 538 - 539
  05/01/2023 Authors: Luna SE; Camarena J; Hampton JP; Majeti KR; Charlesworth CT; Soupene E; Sheehan V; Cromer K; Porteus MH
• Clonal haematopoiesis and risk of chronic liver disease.
  Nature Volume: 616 Page(s): 747 - 754
  04/01/2023 Authors: Wong WJ; Emdin C; Bick AG; Zekavat SM; Niroula A; Pirruccello JP; Dichtel L; Griffin G; Uddin MM; Gibson CJ
• Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
  Nature Volume: 616 Page(s): 755 - 763
  04/01/2023 Authors: Weinstock JS; Gopakumar J; Burugula BB; Uddin MM; Jahn N; Belk JA; Bouzid H; Daniel B; Miao Z; Ly N
• Genetic regulation of fetal hemoglobin across global populations.
  medRxiv
  03/28/2023 Authors: Cato LD; Li R; Lu HY; Yu F; Wissman M; Mkumbe BS; Ekwattanakit S; Deelen P; Mwita L; Sangeda R
• Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.
  Nat Genet Volume: 55 Page(s): 154 - 164
  01/01/2023 Authors: Li X; Quick C; Zhou H; Gaynor SM; Liu Y; Chen H; Selvaraj MS; Sun R; Dey R; Arnett DK
• Africa must participate in finding a gene therapy cure for sickle-cell disease.
  Nat Med Volume: 28 Page(s): 2451 - 2452
  12/01/2022 Authors: Moshi G; Sheehan VA; Makani J
• A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies.
  Nat Methods Volume: 19 Page(s): 1599 - 1611
  12/01/2022 Authors: Li Z; Li X; Zhou H; Gaynor SM; Selvaraj MS; Arapoglou T; Quick C; Liu Y; Chen H; Sun R
• Sickle Cell Disease Pathophysiology and Related Molecular and Biophysical Biomarkers.
  Hematol Oncol Clin North Am Volume: 36 Page(s): 1077 - 1095
  12/01/2022 Authors: Saah E; Fadaei P; Gurkan UA; Sheehan V
• Comprehensive analysis and accurate quantification of unintended large gene modifications induced by CRISPR-Cas9 gene editing.
  Sci Adv Volume: 8 Page(s): eabo7676
  10/21/2022 Authors: Park SH; Cao M; Pan Y; Davis TH; Saxena L; Deshmukh H; Fu Y; Treangen T; Sheehan VA; Bao G
• Whole genome sequence analysis of blood lipid levels in >66,000 individuals.
  Nat Commun Volume: 13 Page(s): 5995
  10/11/2022 Authors: Selvaraj MS; Li X; Li Z; Pampana A; Zhang DY; Park J; Aslibekyan S; Bis JC; Brody JA; Cade BE
• Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
  Nat Commun Volume: 13 Page(s): 4923
  08/22/2022 Authors: Tahir UA; Katz DH; Avila-Pachecho J; Bick AG; Pampana A; Robbins JM; Yu Z; Chen Z-Z; Benson MD; Cruz DE
• Validation of single-gene noninvasive prenatal testing for sickle cell disease.
  Am J Hematol Volume: 97 Page(s): E270 - E273
  07/01/2022 Authors: Westin ER; Tsao DS; Atay O; Landry BP; Ye PP; Chandler-Brown D; Alford B; Hoskovec J; Subramaniam A; Pawlik KM
• Clonal Hematopoiesis and the Risk of Hematologic Malignancies after Curative Therapies for Sickle Cell Disease.
  J Clin Med Volume: 11
  06/02/2022 Authors: Gondek LP; Sheehan VA; Fitzhugh CD
• Comment on: Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia.
  Br J Haematol Volume: 197 Page(s): e61 - e62
  06/01/2022 Authors: Sheehan VA; van Beers EJ; Connes P; van Wijk R; Rab MAE
• Burden of central nervous system complications in sickle cell disease: A systematic review and meta-analysis.
  Pediatr Blood Cancer Volume: 69 Page(s): e29493
  04/01/2022 Authors: Lee S; Lucas S; Proudman D; Nellesen D; Paulose J; Sheehan VA
• Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.
  Nat Genet Volume: 54 Page(s): 263 - 273
  03/01/2022 Authors: Wainschtein P; Jain D; Zheng Z; TOPMed Anthropometry Working Group; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Cupples LA; Shadyab AH; McKnight B; Shoemaker BM; Mitchell BD
• OcclusionChip: A functional microcapillary occlusion assay complementary to ektacytometry for detection of small-fraction red blood cells with abnormal deformability.
  Front Physiol Volume: 13 Page(s): 954106
  01/01/2022 Authors: Man Y; An R; Monchamp K; Sekyonda Z; Kucukal E; Federici C; Wulftange WJ; Goreke U; Bode A; Sheehan VA
• Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.
  Nat Genet Volume: 53 Page(s): 1722
  12/01/2021 Authors: Luo Y; Kanai M; Choi W; Li X; Sakaue S; Yamamoto K; Ogawa K; Gutierrez-Arcelus M; Gregersen PK; Stuart PE
• Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without -thalassaemia.
  Br J Haematol Volume: 195 Page(s): 629 - 633
  11/01/2021 Authors: Boisson C; Renoux C; Nader E; Gauthier A; Poutrel S; Rab M; Fort R; Bertrand Y; Stauffer E; Cannas G
• A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.
  Nat Genet Volume: 53 Page(s): 1504 - 1516
  10/01/2021 Authors: Luo Y; Kanai M; Choi W; Li X; Sakaue S; Yamamoto K; Ogawa K; Gutierrez-Arcelus M; Gregersen PK; Stuart PE
• Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.
  Genome Med Volume: 13 Page(s): 136
  08/26/2021 Authors: Cade BE; Lee J; Sofer T; Wang H; Zhang M; Chen H; Gharib SA; Gottlieb DJ; Guo X; Lane JM
• A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.
  Blood Adv Volume: 5 Page(s): 2839 - 2851
  07/27/2021 Authors: Rampersaud E; Kang G; Palmer LE; Rashkin SR; Wang S; Bi W; Alberts NM; Anghelescu D; Barton M; Birch K
• Genome sequencing unveils a regulatory landscape of platelet reactivity.
  Nat Commun Volume: 12 Page(s): 3626
  06/15/2021 Authors: Keramati AR; Chen M-H; Rodriguez BAT; Yanek LR; Bhan A; Gaynor BJ; Ryan K; Brody JA; Zhong X; Wei Q
• Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.
  Nat Commun Volume: 12 Page(s): 3506
  06/09/2021 Authors: Sofer T; Zheng X; Laurie CA; Gogarten SM; Brody JA; Conomos MP; Bis JC; Thornton TA; Szpiro A; O'Connell JR
• Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.
  Genome Med Volume: 13 Page(s): 66
  04/21/2021 Authors: Kasela S; Ortega VE; Martorella M; Garudadri S; Nguyen J; Ampleford E; Pasanen A; Nerella S; Buschur KL; Barjaktarevic IZ
• Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.
  Nat Commun Volume: 12 Page(s): 2182
  04/12/2021 Authors: Natarajan P; Pampana A; Graham SE; Ruotsalainen SE; Perry JA; de Vries PS; Broome JG; Pirruccello JP; Honigberg MC; Aragam K
• Effects of Genotypes and Treatment on Oxygenscan Parameters in Sickle Cell Disease.
  Cells Volume: 10
  04/05/2021 Authors: Boisson C; Rab MAE; Nader E; Renoux C; Kanne C; Bos J; van Oirschot BA; Joly P; Fort R; Gauthier A
• Gene replacement of -globin with -globin restores hemoglobin balance in -thalassemia-derived hematopoietic stem and progenitor cells.
  Nat Med Volume: 27 Page(s): 677 - 687
  04/01/2021 Authors: Cromer MK; Camarena J; Martin RM; Lesch BJ; Vakulskas CA; Bode NM; Kurgan G; Collingwood MA; Rettig GR; Behlke MA
• Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
  Nature Volume: 591 Page(s): E27
  03/01/2021 Authors: Bick AG; Weinstock JS; Nandakumar SK; Fulco CP; Bao EL; Zekavat SM; Szeto MD; Liao X; Leventhal MJ; Nasser J
• Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.
  Nature Volume: 590 Page(s): 290 - 299
  02/01/2021 Authors: Taliun D; Harris DN; Kessler MD; Carlson J; Szpiech ZA; Torres R; Taliun SAG; Corvelo A; Gogarten SM; Kang HM
• Concurrent Assessment of Deformability and Adhesiveness of Sickle Red Blood Cells by Measuring Perfusion of an Adhesive Artificial Microvascular Network.
  Front Physiol Volume: 12 Page(s): 633080
  01/01/2021 Authors: Lu M; Kanne CK; Reddington RC; Lezzar DL; Sheehan VA; Shevkoplyas SS
• Methodological aspects of oxygen gradient ektacytometry in sickle cell disease: Effects of sample storage on outcome parameters in distinct patient subgroups.
  Clin Hemorheol Microcirc Volume: 77 Page(s): 391 - 394
  01/01/2021 Authors: Boisson C; Rab MAE; Nader E; Renoux C; van Oirschot BA; Joly P; Fort R; Stauffer E; van Beers EJ; Sheehan VA
• Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model.
  Front Physiol Volume: 12 Page(s): 742784
  01/01/2021 Authors: Kanne CK; Nebor D; Pochron M; Oksenberg D; Sheehan VA
• Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease.
  Am J Hematol Volume: 96 Page(s): E29 - E32
  01/01/2021 Authors: Rab MAE; Kanne CK; Bos J; van Oirschot BA; Boisson C; Houwing ME; Gerritsma J; Teske E; Renoux C; Riedl J
• Concurrent assessment of deformability and adhesiveness of sickle red blood cells by measuring perfusion of an adhesive artificial microvascular network
  Volume: 58 Page(s): 140 - 140
  01/01/2021 Authors: Lu M; Kanne C; Reddington R; Lezzar D; Sheehan V; Shevkoplyas S
• Usefulness of oxygen gradient ektacytometry in sickle cell disease
  Volume: 58 Page(s): 140 - 141
  01/01/2021 Authors: Connes P; Boisson C; Rab M; Nader E; Renoux C; Joly P; Fort R; Gauthier A; Bertrand Y; van Wijk R
• Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
  Nat Commun Volume: 11 Page(s): 6417
  12/18/2020 Authors: Nielsen JB; Rom O; Surakka I; Graham SE; Zhou W; Roychowdhury T; Fritsche LG; Gagliano Taliun SA; Sidore C; Liu Y
• Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
  Nature Volume: 586 Page(s): 763 - 768
  10/01/2020 Authors: Bick AG; Weinstock JS; Nandakumar SK; Fulco CP; Bao EL; Zekavat SM; Szeto MD; Liao X; Leventhal MJ; Nasser J
• A novel algorithm comprehensively characterizes human RH genes using whole-genome sequencing data.
  Blood Adv Volume: 4 Page(s): 4347 - 4357
  09/22/2020 Authors: Chang T-C; Haupfear KM; Yu J; Rampersaud E; Sheehan VA; Flanagan JM; Hankins JS; Weiss MJ; Wu G; Vege S
• The vaso-occlusive pain crisis in sickle cell disease: Definition, pathophysiology, and management.
  Eur J Haematol Volume: 105 Page(s): 237 - 246
  09/01/2020 Authors: Darbari DS; Sheehan VA; Ballas SK
• Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.
  Nat Genet Volume: 52 Page(s): 969 - 983
  09/01/2020 Authors: Li X; Li Z; Zhou H; Gaynor SM; Liu Y; Chen H; Sun R; Dey R; Arnett DK; Aslibekyan S
• Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
  Nat Commun Volume: 11 Page(s): 1715
  04/01/2020 Authors: Zekavat SM; Ruotsalainen S; Handsaker RE; Alver M; Bloom J; Poterba T; Seed C; Ernst J; Chaffin M; Engreitz J
• Rheologic Assessments of Sickle Cell Patients Post Allogeneic Hematopoietic Cell Transplant
  Volume: 26 Page(s): S209 - S209
  03/01/2020 Authors: John T; Lu M; Kanne C; Rab MAE; van Wijk R; Shevkoplyas S; Sheehan V
• Pediatric to Adult Transition in Sickle Cell Disease: Survey Results from Young Adult Patients.
  Acta Haematol Volume: 143 Page(s): 163 - 175
  01/01/2020 Authors: Travis K; Wood A; Yeh P; Allahabadi S; Chien L-C; Curtis S; Hammond A; Kohn J; Ogugbuaja C; Rees M
• Blood rheology biomarkers in sickle cell disease.
  Exp Biol Med (Maywood) Volume: 245 Page(s): 155 - 165
  01/01/2020 Authors: Lu M; Rab MA; Shevkoplyas SS; Sheehan VA
• Methodological aspects of the oxygenscan in sickle cell disease: A need for standardization.
  Am J Hematol Volume: 95 Page(s): E5 - E8
  01/01/2020 Authors: Rab MAE; Kanne CK; Bos J; Boisson C; van Oirschot BA; Nader E; Renoux C; Joly P; Fort R; van Beers EJ
• End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain.
  Blood Adv Volume: 3 Page(s): 3982 - 4001
  12/10/2019 Authors: Farrell AT; Panepinto J; Carroll CP; Darbari DS; Desai AA; King AA; Adams RJ; Barber TD; Brandow AM; DeBaun MR
• Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.
  Chest Volume: 156 Page(s): 1068 - 1079
  12/01/2019 Authors: Kachroo P; Hecker J; Chawes BL; Ahluwalia TS; Cho MH; Qiao D; Kelly RS; Chu SH; Virkud YV; Huang M
• KLF4 Is Needed for Optimal Hydroxyurea Induction of Gamma-Globin in K562 Cells
  Volume: 134
  11/13/2019 Authors: Paikari A; Goyal A; Kanne CK; Sheehan VA
• Rheological Assessments of Sickle Cell Patients Post Allogeneic Hematopoietic Cell Transplant
  Volume: 134
  11/13/2019 Authors: John TD; Lu M; Kanne CK; Rab MAE; van Wijk R; Shevkoplyas SS; Sheehan VA
• Microglia-like Cells Derived from Hematopoietic Stem and Progenitor Cells Are a Model System to Investigate Chronic Pain in Sickle Cell Disease
  Volume: 134
  11/13/2019 Authors: Zhang Y; Kanne CK; Tran JN; Lacagnina MJ; Grace PM; Sheehan VA
• The Oxygenscan Provides Clinically Relevant Biomarkers for Treatment Efficacy That Are Associated with Frequency of Vaso-Occlusive Crisis in Sickle Cell Disease
  Volume: 134
  11/13/2019 Authors: Rab MAE; van Wijk R; Kanne CK; van Oirschot BA; Bos J; Boisson C; Houwing ME; Gerritsma JJ; Fijnvandraat K; Renoux C
• Regulation of Fetal Hemoglobin through the Insulin Signaling Pathway
  Volume: 134
  11/13/2019 Authors: Paikari A; Zhang Y; Chang A; Goyal A; Rampersaud E; Flanagan JM; Weiss MJ; Sheehan VA
• Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry.
  J Vis Exp
  11/05/2019 Authors: Rab MAE; van Oirschot BA; Bos J; Kanne CK; Sheehan VA; van Beers EJ; van Wijk R
• A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT.
  Sci Rep Volume: 9 Page(s): 14382
  10/07/2019 Authors: Tsao DS; Silas S; Landry BP; Itzep NP; Nguyen AB; Greenberg S; Kanne CK; Sheehan VA; Sharma R; Shukla R
• Highly efficient editing of the-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease.
  Nucleic Acids Res Volume: 47 Page(s): 7955 - 7972
  09/05/2019 Authors: Park SH; Lee CM; Dever DP; Davis TH; Camarena J; Srifa W; Zhang Y; Paikari A; Chang AK; Porteus MH
• Spontaneous healing of avascular necrosis of the femoral head in sickle cell disease.
  Am J Hematol Volume: 94 Page(s): E160 - E162
  06/01/2019 Authors: Itzep NP; Jadhav SP; Kanne CK; Sheehan VA
• Microglia-Like Cells Derived from Hematopoietic Stem and Progenitor Cells from Patients with Sickle Cell Disease as a Model System to Investigate Chronic Pain
  Volume: 20 Page(s): S29 - S29
  04/01/2019 Authors: Zhang Y; Ballas S; Sheehan V
• Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Induces Fetal Hemoglobin in Hematopoietic Stem and Progenitor Cells from Patients with Sickle Cell Anemia
  Volume: 132
  11/29/2018 Authors: Paikari A; Mi T; Zhang Y; Rampersaud E; Kang G; Wu G; Hankins JS; Estepp JH; Sumazin P; Weiss MJ
• Surgical Splenectomy Alters Red Cell Rheology in Patients with Sickle Cell Disease
  Volume: 132
  11/29/2018 Authors: Kanne CK; Sheehan VA
• Microglia-like Cells Derived from Hematopoietic Stem and Progenitor Cells Are a Model System to Investigate Chronic Pain in Sickle Cell Disease
  Volume: 132
  11/29/2018 Authors: Zhang Y; Ballas SK; Sheehan VA
• The Oxygenscan: A Rapid and Reproducible Test to Determine Patient-Specific, Clinically Relevant Biomarkers of Disease Severity in Sickle Cell Anemia
  Volume: 132
  11/29/2018 Authors: Minke AER; Kanne CK; van Oirschot BA; Bos JF; Houwing ME; Cnossen MH; Schutgens R; Pasterkamp G; van Wijk R; Sheehan VA
• Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.
  Nat Commun Volume: 9 Page(s): 3391
  08/23/2018 Authors: Natarajan P; Peloso GM; Zekavat SM; Montasser M; Ganna A; Chaffin M; Khera AV; Zhou W; Bloom JM; Engreitz JM
• Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
  Nat Commun Volume: 9 Page(s): 3493
  08/23/2018 Authors: Zekavat SM; Ruotsalainen S; Handsaker RE; Alver M; Bloom J; Poterba T; Seed C; Ernst J; Chaffin M; Engreitz J
• Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.
  Blood Volume: 132 Page(s): 321 - 333
  07/19/2018 Authors: Zhang Y; Paikari A; Sumazin P; Ginter Summarell CC; Crosby JR; Boerwinkle E; Weiss MJ; Sheehan VA
• Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
  Nat Commun Volume: 9 Page(s): 2606
  07/04/2018 Authors: Zekavat SM; Ruotsalainen S; Handsaker RE; Alver M; Bloom J; Poterba T; Seed C; Ernst J; Chaffin M; Engreitz J
• A Retrospective Analysis of Sociodemographic and Hematologic Characteristics Associated With Achieving Optimal Hydroxyurea Therapy in Children With Sickle Cell Disease.
  J Pediatr Hematol Oncol Volume: 40 Page(s): 341 - 347
  07/01/2018 Authors: George PE; Bazo-Alvarez JC; Sheehan VA
• Cell Models of Hemoglobinopathy for Screening Therapeutic Approaches
  Volume: 26 Page(s): 379 - 379
  05/01/2018 Authors: Lee CM; Park SH; Zhang Y; Chang AK; Paikari A; Deshmukh H; Khodakova A; Xia Y; Sheehan V; Bao G
• Whole-exome sequencing of sickle cell disease patients with hyperhemolysis syndrome suggests a role for rare variation in disease predisposition.
  Transfusion Volume: 58 Page(s): 726 - 735
  03/01/2018 Authors: Mwesigwa S; Moulds JM; Chen A; Flanagan J; Sheehan VA; George A; Hanchard NA
• Fetal haemoglobin induction in sickle cell disease.
  Br J Haematol Volume: 180 Page(s): 189 - 200
  01/01/2018 Authors: Paikari A; Sheehan VA
• Genetic modifiers of severity in sickle cell disease.
  Clin Hemorheol Microcirc Volume: 68 Page(s): 147 - 164
  01/01/2018 Authors: Chang AK; Ginter Summarell CC; Birdie PT; Sheehan VA
• Echocardiography Differentiates Lethally Irradiated Whole-Body From Partial-Body Exposed Rats.
  Front Cardiovasc Med Volume: 5 Page(s): 138
  01/01/2018 Authors: Inoue T; Zawaski JA; Sheehan V; Kanne C; Paikari A; Kaffes CC; Sarkar P; Sabek OM; Gaber MW
• p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy.
  Clin Cancer Res Volume: 23 Page(s): 6629 - 6639
  11/01/2017 Authors: Moreno-Smith M; Lakoma A; Chen Z; Tao L; Scorsone KA; Schild L; Aviles-Padilla K; Nikzad R; Zhang Y; Chakraborty R
• Genome Editing Based Reactivation of Fetal Hemoglobin Expression in HSPCs for Treating Sickle Cell Disease
  Volume: 25 Page(s): 305 - 305
  05/01/2017 Authors: Lee CM; Park SH; Zhang Y; Deshmukh H; Cradick TJ; Sheehan V; Bao G
• Gene Edited Hematopoietic Stem/Progenitor Cells for Treating Sickle Cell Disease
  Volume: 25 Page(s): 178 - 178
  05/01/2017 Authors: Park SH; Lee CM; Zhang Y; Sheehan V; Bao G
• Pre-Treatment Steady-State Rheology Predicts Response to Hydroxyurea in Patients with Sickle Cell Disease
  Volume: 128
  12/02/2016 Authors: Baldan A; Summerall CG; James L; Dinu BR; Flanagan JM; Sheehan VA
• Metformin Induces FOXO3-Dependent Fetal Hemoglobin Production in Primary Erythroid Cells
  Volume: 128
  12/02/2016 Authors: Zhang Y; Weiss M; Sumazin P; Sheehan VA
• The role of BCL11A and HMIP-2 polymorphisms on endogenous and hydroxyurea induced levels of fetal hemoglobin in sickle cell anemia patients from southern Brazil.
  Blood Cells Mol Dis Volume: 62 Page(s): 32 - 37
  11/01/2016 Authors: Friedrisch JR; Sheehan V; Flanagan JM; Baldan A; Summarell CCG; Bittar CM; Friedrisch BK; Wilke II; Ribeiro CB; Daudt LE
• Whole Exome Sequencing in Sickle Cell Disease Patients with Hyperhemolysis Syndrome
  Volume: 56 Page(s): 134A - 135A
  09/01/2016 Authors: Mwesigwa S; Moulds J; Chen A; Flannagan J; Sheehan V; George A; Belmont J; Hanchard N
• A SURVEY OF SICKLE CELL PATIENTS TRANSITIONED TO ADULT CARE FROM TEXAS CHILDREN'S HEMATOLOGY CENTER BETWEEN JANUARY 1999 AND JANUARY 2014
  Volume: 63 Page(s): S44 - S44
  06/01/2016 Authors: Sheehan V; Wood A; Allahabadi S; Curtis S; Hammond A; Chien L-C; Schupp J; Rees M; Yeh P; Travis K
• Original Research: Use of hydroxyurea and phlebotomy in pediatric patients with hemoglobin SC disease.
  Exp Biol Med (Maywood) Volume: 241 Page(s): 737 - 744
  04/01/2016 Authors: Summarell CCG; Sheehan VA
• Pharmacological Induction of FOXO3 Is a Potential Treatment for Sickle Cell Disease
  Volume: 126
  12/03/2015 Authors: Zhang Y; Crosby JR; Boerwinkle E; Pace B; Sheehan VA
• Hydroxyurea Improves Oxygen Transport Effectiveness in Sickle Cell Anemia Patients
  Volume: 124
  12/06/2014 Authors: Sheehan VA; Nelson S; Yappan C; Dinu BR; Guffey D; Minard CG; Ware RE
• Hepatitis C and neutropenia.
  Curr Opin Hematol Volume: 21 Page(s): 58 - 63
  01/01/2014 Authors: Sheehan VA; Weir A; Waters B
• Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia.
  PLoS One Volume: 9 Page(s): e110740
  01/01/2014 Authors: Sheehan VA; Crosby JR; Sabo A; Mortier NA; Howard TA; Muzny DM; Dugan-Perez S; Aygun B; Nottage KA; Boerwinkle E
• Transcranial Doppler velocity and brain MRI/MRA changes in children with sickle cell anemia on chronic transfusions to prevent primary stroke.
  Pediatr Blood Cancer Volume: 60 Page(s): 1499 - 1502
  09/01/2013 Authors: Sheehan VA; Hansbury EN; Smeltzer MP; Fortner G; McCarville MB; Aygun B
• Genetic modifiers of sickle cell anemia in the BABY HUG cohort: influence on laboratory and clinical phenotypes.
  Am J Hematol Volume: 88 Page(s): 571 - 576
  07/01/2013 Authors: Sheehan VA; Luo Z; Flanagan JM; Howard TA; Thompson BW; Wang WC; Kutlar A; Ware RE; BABY HUG Investigators
• EFFECTS OF HYDROXYUREA ON WHOLE BLOOD VISCOSITY IN CHILDREN WITH SICKLE CELL DISEASE
  Volume: 60 Page(s): S24 - S25
  06/01/2013 Authors: Sheehan V; Dinu B; Bergeron A; Cruz M; Ware R
• Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia.
  Blood Volume: 121 Page(s): 3237 - 3245
  04/18/2013 Authors: Flanagan JM; Sheehan V; Linder H; Howard TA; Wang Y-D; Hoppe CC; Aygun B; Adams RJ; Neale GA; Ware RE
• Severe neutropenia in patients with chronic hepatitis C: a benign condition.
  Acta Haematol Volume: 129 Page(s): 96 - 100
  01/01/2013 Authors: Sheehan V; Weir A; Waters B
• Dantrolene sodium for the treatment of aldesleukin-induced rigors in a melanoma patient.
  Ann Pharmacother Volume: 46 Page(s): e11
  05/01/2012 Authors: Azari LM; Sheehan VS; Sachdev JC; Jones TS
• TRANSCRANIAL DOPPLER MEASUREMENTS IN CHILDREN WITH SICKLE CELL ANEMIA ON CHRONIC TRANSFUSION THERAPY TO PREVENT PRIMARY STROKE
  Volume: 56 Page(s): 897 - 898
  06/01/2011 Authors: Sheehan V; Aygun B; Hansbury E; Fortner G; Smeltzer M