Tobey MacDonald MD

SOM: Peds: Neuro-Oncology
Professor

(404) 727-1447
tobey.macdonald@emory.edu
MacDonald Laboratory
Children's Healthcare of Atlanta Provider Profile

Aflac Cancer and Blood Disorders Center
Pediatrics
1760 Haygood Drive

Academic Appointment

Professor of Pediatrics, Emory University
Program Medical Director of Neuro-Oncology, Children's Healthcare of Atlanta

Education

Degrees

BA from Cornell University
MD from Cornell University Medical College

Research

Focus

The primary research focus is on the mechanism and role of platelet-derived growth factor receptor (PDGFR) signaling in medulloblastoma progression, based on our findings that PDGFR is overexpressed by metastatic medulloblastomas (Nat Genet, 2001) and that PDGFR inhibition in blocks medulloblastoma cell migration (Molec Cancer Ther, 2009)

Publications

Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma.
Commun Mater Volume: 6 Page(s): 5
01/01/2025 Authors: Mokarram N; Case A; Hossainy NN; Lyon JG; MacDonald TJ; Bellamkonda R
Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity with High-Density Progenitor Cell Regions Correlating with High-Risk Disease.

06/28/2024 Authors: Chien F; Michaud ME; Bakhtiari M; Schroff C; Snuderl M; Velazquez Vega JE; MacDonald TJ; Bhasin MK
Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3 K27M-mutant glioma.
Neuro Oncol Volume: 26 Page(s): S155 - S164
05/03/2024 Authors: Odia Y; Koschmann C; Vitanza NA; de Blank P; Aguilera D; Allen J; Daghistani D; Hall M; Khatib Z; Kline C
ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma.
J Clin Oncol Volume: 42 Page(s): 1542 - 1552
05/01/2024 Authors: Arrillaga-Romany I; Gardner SL; Odia Y; Aguilera D; Allen JE; Batchelor T; Butowski N; Chen C; Cloughesy T; Cluster A
DNA Methylation Profiles Are Stable in H3 K27M-Mutant Diffuse Midline Glioma Neurosphere Cell Lines.
Children (Basel) Volume: 11
04/20/2024 Authors: Schniederjan MJ; Potnis C; Vasudevaraja V; Moser CD; Watson B; Snuderl M; MacDonald T; Rogers BB
Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial.
Neuro Oncol Volume: 26 Page(s): 348 - 361
02/02/2024 Authors: Johnson TS; MacDonald TJ; Pacholczyk R; Aguilera D; Al-Basheer A; Bajaj M; Bandopadhayay P; Berrong Z; Bouffet E; Castellino RC
BRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center's experience.
Front Oncol Volume: 14 Page(s): 1505951
01/01/2024 Authors: McThenia SS; Reddy KM; Damaraju E; Castellino E; He Z; Beers R; Chien F; Castellino RC; Goldman-Yassen AE; Fangusaro JR
Visual outcomes after bevacizumab-based therapy for optic pathway glioma.
Pediatr Blood Cancer Volume: 70 Page(s): e30668
12/01/2023 Authors: Siegel BI; Nelson D; Peragallo JH; MacDonald TJ; Wolf DS
The LIN28B-let-7-PBK pathway is essential for group 3 medulloblastoma tumor growth and survival.
Mol Oncol Volume: 17 Page(s): 1784 - 1802
09/01/2023 Authors: Shahab SW; Roggeveen CM; Sun J; Kunhiraman H; McSwain LF; Juraschka K; Kumar SA; Saulnier O; Taylor MD; Schniederjan M
Author Correction: YB1 modulates the DNA damage response in medulloblastoma.
Sci Rep Volume: 13 Page(s): 9717
06/15/2023 Authors: McSwain LF; Pillsbury CE; Haji-Seyed-Javadi R; Rath SK; Chen V; Huang T; Shahab SW; Kunhiraman H; Ross J; Price GA
YB1 modulates the DNA damage response in medulloblastoma.
Sci Rep Volume: 13 Page(s): 8087
05/19/2023 Authors: McSwain LF; Pillsbury CE; Haji-Seyed-Javadi R; Rath SK; Chen V; Huang T; Shahab SW; Kunhiraman H; Ross J; Price GA
IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma.
Acta Neuropathol Commun Volume: 11 Page(s): 62
04/08/2023 Authors: Kunhiraman H; McSwain L; Shahab SW; Gershon TR; MacDonald TJ; Kenney AM
Multi-institutional study of the frequency, genomic landscape, and outcome of IDH-mutant glioma in pediatrics.
Neuro Oncol Volume: 25 Page(s): 199 - 210
01/05/2023 Authors: Yeo KK; Alexandrescu S; Cotter JA; Vogelzang J; Bhave V; Li MM; Ji J; Benhamida JK; Rosenblum MK; Bale TA
Case report: ATIC-ALK fusion in infant-type hemispheric glioma and response to lorlatinib.
Front Oncol Volume: 13 Page(s): 1123378
01/01/2023 Authors: Shahab SW; Schniederjan M; Vega JV; Little S; Reisner A; MacDonald T; Aguilera D
Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.
Neuro Oncol Volume: 24 Page(s): 1964 - 1975
11/02/2022 Authors: Rosenberg T; Yeo KK; Mauguen A; Alexandrescu S; Prabhu SP; Tsai JW; Malinowski S; Joshirao M; Parikh K; Farouk Sait S
LIN28B-LET-7-PBK PATHWAY IS AN IMPORTANT REGULATOR OF GROUP 3 MEDULLOBLASTOMA PROLIFERATION
Volume: 24 Page(s): 46 - 46
11/01/2022 Authors: Shahab S; Sun J; Kunhiraman H; Schneiderjan M; Juraschka K; Kumar S; Taylor M; MacDonald T; Kenney A
FIRST-IN-CHILDREN PHASE 1 TRIAL OF INDOXIMOD-BASED CHEMO-IMMUNOTHERAPY FOR PATIENTS WITH PEDIATRIC BRAIN TUMORS: ANALYSIS OF SAFETY, TOLERABILITY, AND 5-YEAR OUTCOME
Volume: 24 Page(s): 68 - 68
11/01/2022 Authors: Johnson T; Pacholczyk R; Aguilera D; Al-Basheer A; Bajaj M; Bandopadhayay P; Berrong Z; Bouffet E; Castellino R; Dorris K
Developmentally Arrested Basket/Stellate Cells in Postnatal Human Brain as Potential Tumor Cells of Origin for Cerebellar Hemangioblastoma in von Hippel-Lindau Patients.
J Neuropathol Exp Neurol Volume: 81 Page(s): 885 - 899
01/01/2003 Authors: Shively SB; Edwards NA; MacDonald TJ; Johnson KR; Diaz-Rodriguez NM; Merrill MJ; Vortmeyer AO
Vorinostat and isotretinoin with chemotherapy in young children with embryonal brain tumors: A report from the Pediatric Brain Tumor Consortium (PBTC-026).
Neuro Oncol Volume: 24 Page(s): 1178 - 1190
07/01/2022 Authors: Leary SES; Kilburn L; Geyer JR; Kocak M; Huang J; Smith KS; Hadley J; Ermoian R; MacDonald TJ; Goldman S
UPFRONT MOLECULAR TARGETED THERAPY FOR THE TREATMENT OF BRAF-MUTANT PEDIATRIC HIGH-GRADE GLIOMA
Volume: 24 Page(s): 68 - 68
06/01/2022 Authors: Rosenberg T; Yeo KK; Mauguen A; Alexandrescu S; Prabhu SP; Tsai JW; Malinowski S; Joshirao M; Parikh K; Sait SF
DECIPHERING THE ROLE OF LIN28B IN GROUP 3 MEDULLOBLASTOMA
Volume: 24 Page(s): 121 - 121
06/01/2022 Authors: Shahab S; Sun J; Schnepp R; MacDonald T; Kenney A
A PHASE II STUDY OF PEGYLATED INTERFERON IN CHILDREN WITH RECURRENT OR REFRACTORY AND RADIOGRAPHICALLY OR CLINICALLY PROGRESSIVE JUVENILE PILOCYTIC ASTROCYTOMAS AND OPTIC PATHWAY GLIOMAS (NCT02343224)
Volume: 24 Page(s): 103 - 103
06/01/2022 Authors: Aguilera D; Mazewski C; Janss A; MAcDonald T; Goldman A; Leong T; Castellino RC
A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma.
CNS Oncol Volume: 11 Page(s): CNS87
06/01/2022 Authors: Groot JD; Ott M; Wei J; Kassab C; Fang D; Najem H; O'Brien B; Weathers S-P; Matsouka CK; Majd NK
Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has a Measurable Impact on Clinical Care.
JCO Precis Oncol Volume: 6 Page(s): e2100451
04/01/2022 Authors: Summers RJ; Castellino SM; Porter CC; MacDonald TJ; Basu GD; Szelinger S; Bhasin MK; Cash T; Carter AB; Castellino RC
MTHFR single nucleotide polymorphism associated with working memory in pediatric medulloblastoma survivors.
Child Neuropsychol Volume: 28 Page(s): 287 - 301
04/01/2022 Authors: Kautiainen RJ; Keeler C; Dwivedi B; MacDonald TJ; King TZ
STAT3 is required for Smo-dependent signaling and mediates Smo-targeted treatment resistance and tumorigenesis in Shh medulloblastoma.
Mol Oncol Volume: 16 Page(s): 1009 - 1025
02/01/2022 Authors: Yuan L; Zhang H; Liu J; Malhotra A; Dey A; Yu B; Jella KK; McSwain LF; Schniederjan MJ; MacDonald TJ
Phase I dose escalation and expansion trial of single agent ONC201 in pediatric diffuse midline gliomas following radiotherapy.
Neurooncol Adv Volume: 4 Page(s): vdac143
01/01/2022 Authors: Gardner SL; Tarapore RS; Allen J; McGovern SL; Zaky W; Odia Y; Daghistani D; Diaz Z; Hall MD; Khatib Z
Medulloblastoma and the DNA Damage Response.
Front Oncol Volume: 12 Page(s): 903830
01/01/2022 Authors: McSwain LF; Parwani KK; Shahab SW; Hambardzumyan D; MacDonald TJ; Spangle JM; Kenney AM
RETROSPECTIVE ANALYSIS OF VISUAL OUTCOMES AFTER BEVACIZUMAB-BASED THERAPY IN OPTIC PATHWAY GLIOMA
Volume: 23 Page(s): 156 - 156
11/01/2021 Authors: Siegel B; MacDonald T; Wolf D
Latent Profile Analysis to Describe Outcomes of Survivors of Pediatric Central Nervous System Tumors
Volume: 68 Page(s): S418 - S418
11/01/2021 Authors: Ingerski L; Lewis R; Macdonald T; Mertens A
Tumour immune landscape of paediatric high-grade gliomas.
Brain Volume: 144 Page(s): 2594 - 2609
10/22/2021 Authors: Ross JL; Velazquez Vega J; Plant A; MacDonald TJ; Becher OJ; Hambardzumyan D
Intellectual functioning among case-matched cohorts of children treated with proton or photon radiation for standard-risk medulloblastoma.
Cancer Volume: 127 Page(s): 3840 - 3846
10/15/2021 Authors: Eaton BR; Fong GW; Ingerski LM; Pulsifer MB; Goyal S; Zhang C; Weyman EA; Esiashvili N; Klosky JL; MacDonald TJ
UPFRONT TARGETED THERAPY FOR THE TREATMENT OF BRAFV600E-MUTANT PEDIATRIC HIGH-GRADE GLIOMA - A MULTI-INSTITUTIONAL EXPERIENCE
Volume: 23 Page(s): 25 - 25
06/01/2021 Authors: Rosenberg T; Yeo KK; Joshirao M; Michaiel G; Hung T; Dahiya S; Kachurak K; Friedman G; Huang M; Wright K
TARGETING THE RNA-BINDING PROTEIN LIN28B IN GROUP 3 MEDULLOBLASTOMA
Volume: 23 Page(s): 8 - 8
06/01/2021 Authors: Shahab S; Schnepp R; MacDonald T; Kenney A
Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles.
Sci Adv Volume: 7
04/01/2021 Authors: Guo Y; Lee H; Fang Z; Velalopoulou A; Kim J; Thomas MB; Liu J; Abramowitz RG; Kim Y; Coskun AF
Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo.
Cancers (Basel) Volume: 13
03/31/2021 Authors: MacDonald TJ; Liu J; Yu B; Malhotra A; Munson J; Park JC; Wang K; Fei B; Bellamkonda R; Arbiser J
Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma.
Brain Volume: 144 Page(s): 53 - 69
12/31/2009 Authors: Ross JL; Chen Z; Herting CJ; Grabovska Y; Szulzewsky F; Puigdelloses M; Monterroza L; Switchenko J; Wadhwani NR; Cimino PJ
RESPONSE ASSESSMENT IN PEDIATRIC HIGH-GRADE GLIOMA: RECOMMENDATIONS FROM THE RESPONSE ASSESSMENT IN PEDIATRIC NEURO-ONCOLOGY WORKING GROUP
Volume: 22 Page(s): 355 - 355
12/01/2020 Authors: Erker C; Tamrazi B; Poussaint TY; Mueller S; Mata-Mbemba D; Franceschi E; Brandes AA; Rao A; Haworth KB; Wen PY
USE OF PATIENT-REPORTED OUTCOMES TO IDENTIFY YOUTH AT RISK FOR IMPAIRED OVERALL HEALTH
Volume: 22 Page(s): 437 - 437
12/01/2020 Authors: Ingerski L; Lewis RW; Mertens A; MacDonald T
GENETIC SUSCEPTIBILITY AND OUTCOMES OF PEDIATRIC, ADOLESCENT AND YOUNG ADULT IDH-MUTANT ASTROCYTOMAS
Volume: 22 Page(s): 427 - 427
12/01/2020 Authors: Bornhorst M; Nobre L; Zapotocky M; Barseghyan H; Goecks J; Boue D; Tabori U; Hawkins C; Bouffet E; MacDonald T
PRECLINICAL EFFICACY OF THE IMIPRIDONE ONC-206 AGAINST MEDULLOBLASTOMA
Volume: 22 Page(s): 412 - 412
12/01/2020 Authors: Malhotra A; Liu J; Zhang H; Ma M; Vega JV; Schniederjan M; Prabhu V; Allen J; MacDonald T
BINIMETINIB IN CHILDREN WITH PROGRESSIVE OR RECURRENT LOW-GRADE GLIOMA NOT ASSOCIATED WITH NEUROFIBROMATOSIS TYPE 1: INITIAL RESULTS FROM A MULTI-INSTITUTIONAL PHASE II STUDY
Volume: 22 Page(s): 376 - 376
12/01/2020 Authors: Robison N; Pauly J; Malvar J; Gardner S; Allen J; MacDonald T; Aguilera D; Baxter P; Bendel A; Kilburn L
PHASE I CLINICAL TRIAL OF ONC201 IN PEDIATRIC H3 K27M-MUTANT GLIOMA OR NEWLY DIAGNOSED DIPG
Volume: 22 Page(s): 297 - 297
12/01/2020 Authors: Gardner S; Tarapore R; Allen J; Zaky W; Odia Y; Hall M; Daghistani D; Khatib Z; Koschmann C; Aguilera D
PRECLINICAL EFFICACY OF THE IMIPRIDONE ONC-206 AGAINST MEDULLOBLASTOMA
Volume: 22 Page(s): 101 - 101
11/01/2020 Authors: MacDonald T; Malhotra A; Liu J; Zhang H; Schneiderjan M; Vega JV; Prabhu V; Allen J
CLINICAL EFFICACY OF ONC201 IN NEWLY DIAGNOSED DIPG AND IN PREVIOUSLY IRRADIATED PEDIATRIC H3 K27M-MUTANT GLIOMAS
Volume: 22 Page(s): 45 - 45
11/01/2020 Authors: Gardner S; Koschmann C; Tarapore RS; Allen J; Zaky W; Odia Y; Hall M; Daghistani D; Khatib Z; Aguilera D
Integrated analysis of pediatric low-grade glioma: clinical implications and the path forward.
Neuro Oncol Volume: 22 Page(s): 1413 - 1414
10/14/2020 Authors: Packer RJ; MacDonald TJ
Lipidome signatures of metastasis in a transgenic mouse model of sonic hedgehog medulloblastoma.
Anal Bioanal Chem Volume: 412 Page(s): 7017 - 7027
10/01/2020 Authors: Huang D; Liu J; Eldridge RC; Gaul DA; Paine MRL; Uppal K; MacDonald TJ; Fernndez FM
Engineered biomimetic nanoparticle for dual targeting of the cancer stem-like cell population in sonic hedgehog medulloblastoma.
Proc Natl Acad Sci U S A Volume: 117 Page(s): 24205 - 24212
09/29/2020 Authors: Kim J; Dey A; Malhotra A; Liu J; Ahn SI; Sei YJ; Kenney AM; MacDonald TJ; Kim Y
Correction to: Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes.
Acta Neuropathol Volume: 140 Page(s): 247
08/01/2020 Authors: Saratsis AM; Kambhampati M; Snyder K; Yadavilli S; Devaney JM; Harmon B; Hall J; Raabe EH; An P; Weingart M
GSTP1 polymorphisms sex-specific association with verbal intelligence in survivors of pediatric medulloblastoma tumors.
Child Neuropsychol Volume: 26 Page(s): 739 - 753
08/01/2020 Authors: Kautiainen RJ; Dwivedi B; MacDonald TJ; King TZ
Subtype and grade-dependent spatial heterogeneity of T-cell infiltration in pediatric glioma.
J Immunother Cancer Volume: 8
08/01/2020 Authors: Robinson MH; Vasquez J; Kaushal A; MacDonald TJ; Velzquez Vega JE; Schniederjan M; Dhodapkar K
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.
Cancer Discov Volume: 10 Page(s): 942 - 963
07/01/2020 Authors: Clarke M; Mackay A; Ismer B; Pickles JC; Tatevossian RG; Newman S; Bale TA; Stoler I; Izquierdo E; Temelso S
Implications of new understandings of gliomas in children and adults with NF1: report of a consensus conference.
Neuro Oncol Volume: 22 Page(s): 773 - 784
01/09/2008 Authors: Packer RJ; Iavarone A; Jones DTW; Blakeley JO; Bouffet E; Fisher MJ; Hwang E; Hawkins C; Kilburn L; MacDonald T
Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group.
Lancet Oncol Volume: 21 Page(s): e317 - e329
06/01/2020 Authors: Erker C; Tamrazi B; Poussaint TY; Mueller S; Mata-Mbemba D; Franceschi E; Brandes AA; Rao A; Haworth KB; Wen PY
ONC201 in previously irradiated pediatric H3 K27M-mutant glioma or newly diagnosed DIPG.
Volume: 38
05/20/2020 Authors: Gardner SL; Koschmann CJ; Tarapore R; Allen JC; Zaky WT; Odia Y; Hall M; Daghistani D; Khatib Z; Aguilera D
A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.
Volume: 67 Page(s): e28134
04/01/2020 Authors: Qayed M; Cash T; Tighiouart M; MacDonald TJ; Goldsmith KC; Tanos R; Kean L; Watkins B; Suessmuth Y; Wetmore C
Microengineered human blood-brain barrier platform for understanding nanoparticle transport mechanisms.
Nat Commun Volume: 11 Page(s): 175
01/10/2020 Authors: Ahn SI; Sei YJ; Park H-J; Kim J; Ryu Y; Choi JJ; Sung H-J; MacDonald TJ; Levey AI; Kim Y
Phase 1 study of abemaciclib in children with recurrent and refractory solid tumors including malignant brain tumors
Volume: 18
12/01/2019 Authors: Cash T; Aguilera D; Macy ME; Hoffman L; Dorris K; McCracken C; Hanberry B; Castellino R; MacDonald T; Wetmore C
Results of the NLG2105 phase I trial using the IDO pathway inhibitor indoximod, in combination with radiation and chemotherapy, for children with newly diagnosed DIPG
Volume: 30 Page(s): 38 - 38
12/01/2019 Authors: Johnson TS; Aguilera D; Al-Basheer A; Berrong Z; Castellino RC; Eaton BR; Esiashvili N; Foreman N; Heger IM; Kennedy EP
ROLE OF ONC-206 IN REGULATING MEDULLOBLASTOMA TUMOR PROGRESSION
Volume: 21 Page(s): 196 - 197
11/01/2019 Authors: Malhotra A; Liu J; MacDonald T
GAINING INSIGHTS INTO THE INFLAMMATORY MICROENVIRONMENT OF PEDIATRIC HIGH-GRADE GLIOMAS USING GEMMs AND PATIENT SAMPLES
Volume: 21 Page(s): 189 - 189
11/01/2019 Authors: Ross J; Chen Z; Herting C; Szulzewsky F; Becher O; MacDonald T; Schniederjan M; Hambardzumyan D
PHASE I CLINICAL TRIAL OF ONC201 IN PEDIATRIC H3 K27M-MUTANT GLIOMA OR NEWLY DIAGNOSED DIPG
Volume: 21 Page(s): 185 - 185
11/01/2019 Authors: Gardner S; Tarapore R; Allen J; Zaky W; Odia Y; Hall M; Daghistani D; Khatib Z; Koschmann C; Aguilera D
Engineered HDL-mimetic nanoparticles synergize therapeutic effects on the cancer stem-like cell population in sonic hedgehog medulloblastoma
Volume: 258
08/25/2019 Authors: Kim J; Dey A; Malhotra A; Ahn SI; Liu J; Sei Y; Kenney A; MacDonald T; Kim Y
Host Genome Variation is Associated with Neurocognitive Outcome in Survivors of Pediatric Medulloblastoma.
Transl Oncol Volume: 12 Page(s): 908 - 916
07/01/2019 Authors: Siegel BI; King TZ; Rupji M; Dwivedi B; Carter AB; Kowalski J; MacDonald TJ
Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma.
Nat Commun Volume: 10 Page(s): 2410
06/03/2019 Authors: Maximov V; Chen Z; Wei Y; Robinson MH; Herting CJ; Shanmugam NS; Rudneva VA; Goldsmith KC; MacDonald TJ; Northcott PA
Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis.
Sci Rep Volume: 9 Page(s): 2205
02/18/2019 Authors: Paine MRL; Liu J; Huang D; Ellis SR; Trede D; Kobarg JH; Heeren RMA; Fernndez FM; MacDonald TJ
A PHASE II TRIAL OF POLY-ICLC IN THE MANAGEMENT OF RECURRENT OR PROGRESSIVE PEDIATRIC LOW GRADE GLIOMAS. RESULTS FOR THE NEUROFIBROMATOSIS 1 GROUP. (NCT01188096)
Volume: 20 Page(s): 201 - 201
11/01/2018 Authors: Aguilera D; MacDonald T; Castellino R; Janss A; Mazewski C; Kadom N; Pu M; Messer K; Crawford J; Connelly E
POSITIVE MODULATION OF NATIVE GABA A RECEPTORS IN MEDULLOBLASTOMA CANCER CELLS WITH BENZODIAZEPINES INDUCES RAPID MITOCHONDRIAL FRAGMENTATION AND TP53-DEPENDENT, CELL CYCLE-INDEPENDENT APOPTOSIS
Volume: 20 Page(s): 213 - 213
11/01/2018 Authors: Kallay L; Keskin H; Ross A; Moody O; Cottrill K; Nuckols A; Li G; Ahmed T; Rashid F; Stephen M
PEDIATRIC HIGH GRADE GLIOMAS: PATTERNS OF FAILURE AND OUTCOMES WITH LIMITED MARGIN RADIOTHERAPY
Volume: 20 Page(s): 229 - 229
11/01/2018 Authors: Morgan T; Chandora K; Switchenko J; Schreibmann E; Abugideiri M; Schniederjan M; MacDonald T; Esiashvili N; Eaton B
A NOVEL EX VIVO MODEL FOR HUMAN MEDULLOBLASTOMA: A NEW PERSONALIZED MEDICINE TOOL
Volume: 20 Page(s): 206 - 206
11/01/2018 Authors: Felker J; Dey A; Malhotra A; Liu J; Schniederjan M; Kenney A; MacDonald T
Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.
J Neurooncol Volume: 140 Page(s): 269 - 279
11/01/2018 Authors: Clark AR; Calligaris D; Regan MS; Pomeranz Krummel D; Agar JN; Kallay L; MacDonald T; Schniederjan M; Santagata S; Pomeroy SL
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma.
Neuro Oncol Volume: 20 Page(s): 1547 - 1555
10/09/2018 Authors: Gupta N; Goumnerova LC; Manley P; Chi SN; Neuberg D; Puligandla M; Fangusaro J; Goldman S; Tomita T; Alden T
BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.
Cancer Cell Volume: 33 Page(s): 1004 - 1016.e5
06/11/2018 Authors: Zhu D; Osuka S; Zhang Z; Reichert ZR; Yang L; Kanemura Y; Jiang Y; You S; Zhang H; Devi NS
REPRESSIVE CHROMATIN REMODELERS IN SHH-DRIVEN MEDULLOBLASTOMA
Volume: 20 Page(s): 141 - 141
06/01/2018 Authors: Tao R-H; Dobson T; Maegawa S; Swaminathan J; Shaik S; Taylor P; Kennis B; Qi L; Khatua S; Goldman S
RADIO-IMMUNOTHERAPY USING THE IDO PATHWAY INHIBITOR INDOXIMOD FOR CHILDREN WITH NEWLY-DIAGNOSED DIPG
Volume: 20 Page(s): 103 - 104
06/01/2018 Authors: Johnson TS; Aguilera D; Al-Basheer A; Castellino C; Eaton BR; Esiashvili N; Foreman N; Heger IM; Kennedy EP; Link CJ
SUCCESSFUL TREATMENT OF A SECONDARY PEDIATRIC HIGH GRADE GLIOMA WITH A NOVEL BEND4-NTRK2 FUSION WITH ENTRECTINIB, A TRK INHIBITOR
Volume: 20 Page(s): 67 - 67
06/01/2018 Authors: Felker J; Philbrook B; Schneiderjan M; Chern J; Mazewski C; Eaton B; Chow-Maneval E; MacDonald T; Aguilera D
A PHASE II TRIAL OF POLY-ICLC IN THE MANAGEMENT OF RECURRENT OR PROGRESSIVE PEDIATRIC LOW GRADE GLIOMAS (NCT01188096): PRELIMINARY ANALYSIS
Volume: 20 Page(s): 116 - 117
06/01/2018 Authors: Aguilera D; MacDonald T; Crawford J; Kadom N; Janss A; Mazewski C; Castellino RC; Gray R; Pu M; Connelly E
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.
Lancet Oncol Volume: 19 Page(s): 785 - 798
06/01/2018 Authors: Waszak SM; Northcott PA; Buchhalter I; Robinson GW; Sutter C; Groebner S; Grund KB; Brugires L; Jones DTW; Pajtler KW
Clinical responses of patients with diffuse leptomeningeal glioneuronal tumors to chemotherapy.
Childs Nerv Syst Volume: 34 Page(s): 329 - 334
02/01/2018 Authors: Aguilera D; Castellino RC; Janss A; Schniederjan M; McNall R; MacDonald T; Mazewski C
White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors.
Neuroimage Clin Volume: 20 Page(s): 485 - 497
01/01/2018 Authors: Na S; Li L; Crosson B; Dotson V; MacDonald TJ; Mao H; King TZ
UNDERSTANDING THE MECHANISM OF BENZODIAZEPINE MEDIATED CELL DEATH IN GABRA5 OVEREXPRESSING GROUP 3 MEDULLOBLASTOMAS
Volume: 19 Page(s): 182 - 182
11/01/2017 Authors: Kallay L; Ross A; Moody O; Li G; Cook J; MacDonald T; Jenkins A; Krummel DP; Sengupta S
RADIO-IMMUNOTHERAPY USING THE IDO-INHIBITOR INDOXIMOD IN COMBINATION WITH RE-IRRADIATION FOR CHILDREN WITH PROGRESSIVE BRAIN TUMORS IN THE PHASE 1 SETTING: AN UPDATED REPORT OF SAFETY AND TOLERABILITY (NCT02502708)
Volume: 19 Page(s): 185 - 185
11/01/2017 Authors: Johnson TS; Aguilera D; Al-Basheer A; Cooksey RM; Eaton BR; Esiashvili N; Firat S; Fiveash JB; Foreman N; Fridlyand D
A pediatric trial of radiation/cetuximab followed by irinotecan/cetuximab in newly diagnosed diffuse pontine gliomas and high-grade astrocytomas: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study.
Pediatr Blood Cancer Volume: 64
11/01/2017 Authors: Macy ME; Kieran MW; Chi SN; Cohen KJ; MacDonald TJ; Smith AA; Etzl MM; Kuei MC; Donson AM; Gore L
FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS
Volume: 19 Page(s): 188 - 188
11/01/2017 Authors: Gupta N; Goumnerova L; Ayyanar K; Gump W; Bendel A; Nagib M; Bowers D; Weprin B; Bredlau A-L; Gururangan S
A PHASE I DOSE ESCALATION TRIAL OF THE MEK1/2 INHIBITOR MEK162 (BINIMETINIB) IN CHILDREN WITH LOW-GRADE GLIOMAS AND OTHER RAS-RAF PATHWAY-ACTIVATED TUMORS: INITIAL REPORT
Volume: 19 Page(s): 189 - 189
11/01/2017 Authors: Robison N; Pauly J; Malvar J; Filbin M; de Mola RL; Dorris K; Bendel A; Bowers D; Bornhorst M; Gauvain K
Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma.
Neuro Oncol Volume: 19 Page(s): 1542 - 1552
10/19/2017 Authors: Kieran MW; Chisholm J; Casanova M; Brandes AA; Aerts I; Bouffet E; Bailey S; Leary S; MacDonald TJ; Mechinaud F
FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS
Volume: 19 Page(s): 56 - 56
06/01/2017 Authors: Gupta N; Goumnerova L; Ayyanar K; Gump W; Bendel A; Nagib M; Bowers D; Weprin B; Bredlau A-L; Gururangan S
Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles.
Colloids Surf B Biointerfaces Volume: 150 Page(s): 261 - 270
02/01/2017 Authors: Lin R; Li Y; MacDonald T; Wu H; Provenzale J; Peng X; Huang J; Wang L; Wang AY; Yang J
TARGETING MEDULLOBLASTOMA WITH BENZODIAZAPINES DELIVERED USING TUNABLE BIODEGRADABLE HYDROGELS
Volume: 18 Page(s): 156 - 156
11/01/2016 Authors: Kallay L; Krummel DP; Methuku KR; Zhang Z; Cook J; Olson J; Brat D; MacDonald T; Sydlik S; Sengupta S
MET FUSION, AMPLIFICATION, AND/OR OVEREXPRESSION DEFINES DIFFUSELY INVASIVE TUMOR CELLS IN PEDIATRIC AND ADULT GLIOBLASTOMA
Volume: 18 Page(s): 46 - 46
11/01/2016 Authors: Vigneswaran K; Read R; Olson JJ; MacDonald T; Neill S; Rossi M
ORGANOTYPIC TUMOR SLICE CULTURE FOR EVALUATING TREATMENT OF MEDULLOBLASTOMA
Volume: 18 Page(s): 151 - 151
11/01/2016 Authors: Felker J; Dey A; MacDonald T; Kenney A
Phase II Trial of Molecularly Determined Treatment of Children and Young Adults with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG): Feasibility and Safety Update
PEDIATRIC BLOOD & CANCER Volume: 63 Page(s): S32 - S32
11/01/2016 Authors: Wright KD; Bandopadhayay P; Goldman S; Rubin J; Leary SE; Gardner S; Elster JD; Wang ZJ; Bowers D; Robison NJ
REST ELEVATION UNRESTRAINS SHH SIGNALING IN MEDULLOBLASTOMA
Volume: 18 Page(s): 121 - 121
06/01/2016 Authors: Tao R-H; Dobson T; Shaik S; Taylor P; Hatcher R; Brugmann W; Busschers E; Kennis B; Khatua S; Zaky W
SAFETY AND FEASIBILITY OF A MULTI-INSTITUTIONAL PHASE II TRIAL INCOPORATING BIOPSY AND MOLECULARLY DETERMINED TREATMENT OF CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPG)
Volume: 18 Page(s): 65 - 65
06/01/2016 Authors: Wright KD; Bandopadhayay P; Gourmnerova L; Chi SN; Manley P; Marcus K; Kannan G; Banerjee A; Becher O; Bendel A
Endocrine outcomes with proton and photon radiotherapy for standard risk medulloblastoma.
Neuro Oncol Volume: 18 Page(s): 881 - 887
06/01/2016 Authors: Eaton BR; Esiashvili N; Kim S; Patterson B; Weyman EA; Thornton LT; Mazewski C; MacDonald TJ; Ebb D; MacDonald SM
Successful Retreatment of a Child with a Refractory Brainstem Ganglioglioma with Vemurafenib.
Pediatr Blood Cancer Volume: 63 Page(s): 541 - 543
03/01/2016 Authors: Aguilera D; Janss A; Mazewski C; Castellino RC; Schniederjan M; Hayes L; Brahma B; Fogelgren L; MacDonald TJ
Divergent clonal selection dominates medulloblastoma at recurrence.
Nature Volume: 529 Page(s): 351 - 357
01/21/2016 Authors: Morrissy AS; Garzia L; Shih DJH; Zuyderduyn S; Huang X; Skowron P; Remke M; Cavalli FMG; Ramaswamy V; Lindsay PE
Clinical Outcomes Among Children With Standard-Risk Medulloblastoma Treated With Proton and Photon Radiation Therapy: A Comparison of Disease Control and Overall Survival.
Int J Radiat Oncol Biol Phys Volume: 94 Page(s): 133 - 138
01/01/2016 Authors: Eaton BR; Esiashvili N; Kim S; Weyman EA; Thornton LT; Mazewski C; MacDonald T; Ebb D; MacDonald SM; Tarbell NJ
FEASIBILITY OF VORINOSTAT COMBINED WITH ISOTRETINOIN AND CHEMOTHERAPY FOR YOUNG CHILDREN WITH NEWLY DIAGNOSED EMBRYONAL BRAIN TUMORS: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY
Volume: 17 Page(s): 27 - 27
06/01/2015 Authors: Leary S; Kilburn L; Geyer JR; Olson JM; MacDonald T; Ellison D; Kocak M; Onar A; Ermoian R; Poussaint TY
DISSECTING THE ROLE OF EPIGENETIC MODULATORS IN SHH-DRIVEN MEDULLOBLASTOMA
Volume: 17 Page(s): 26 - 26
06/01/2015 Authors: Dobson T; Tao R-H; Shaik S; Taylor P; Hatcher R; Busschers E; Khatua S; Goldman S; Lulla R; Rajaram V
The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma.
Oncotarget Volume: 6 Page(s): 12141 - 12155
05/20/2015 Authors: Yadavilli S; Scafidi J; Becher OJ; Saratsis AM; Hiner RL; Kambhampati M; Mariarita S; MacDonald TJ; Codispoti K-E; Magge SN
PEG-b-AGE Polymer Coated Magnetic Nanoparticle Probes with Facile Functionalization and Anti-fouling Properties for Reducing Non-specific Uptake and Improving Biomarker Targeting.
J Mater Chem B Volume: 3 Page(s): 3591 - 3603
05/07/2015 Authors: Li Y; Lin R; Wang L; Huang J; Wu H; Cheng G; Zhou Z; MacDonald T; Yang L; Mao H
Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization.
Oncotarget Volume: 6 Page(s): 8929 - 8946
04/20/2015 Authors: Bhatia S; Baig NA; Timofeeva O; Pasquale EB; Hirsch K; MacDonald TJ; Dritschilo A; Lee YC; Henkemeyer M; Rood B
Medulloblastoma subgroups remain stable across primary and metastatic compartments.
Acta Neuropathol Volume: 129 Page(s): 449 - 457
03/01/2015 Authors: Wang X; Dubuc AM; Ramaswamy V; Mack S; Gendoo DMA; Remke M; Wu X; Garzia L; Luu B; Cavalli F
A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.
Clin Cancer Res Volume: 21 Page(s): 585 - 593
02/01/2015 Authors: Shou Y; Robinson DM; Amakye DD; Rose KL; Cho Y-J; Ligon KL; Sharp T; Haider AS; Bandaru R; Ando Y
EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma.
J Neurooncol Volume: 121 Page(s): 109 - 118
01/01/2015 Authors: McKinney N; Yuan L; Zhang H; Liu J; Cho Y-J; Rushing E; Schniederjan M; MacDonald TJ
CLINICAL OUTCOMES OF CHILDREN WITH STANDARD RISK MEDULLOBLASTOMA TREATED WITH PROTON AND PHOTON RADIOTHERAPY
PEDIATRIC BLOOD & CANCER Volume: 61 Page(s): S111 - S112
12/01/2014 Authors: Eaton B; Esiashvili N; Kim S; Weyman E; Thornton L; Kasper H; Mazewski C; MacDonald T; Ebb D; MacDonald S
DRASTIC GENOMIC DIVERGENCE OF RECURRENT MEDULLOBLASTOMA INVALIDATES TARGETED THERAPIES DISCOVERED AT DIAGNOSIS
NEURO-ONCOLOGY Volume: 16
11/01/2014 Authors: Morrissy S; Garzia L; Remke M; Ramaswamy V; Jorgensen F; Wu X; Shah S; Ma Y; Mungall K; Van Meter T
Dasatinib suppression of medulloblastoma survival and migration is markedly enhanced by combining treatment with the aurora kinase inhibitor AT9283.
Cancer Lett Volume: 354 Page(s): 68 - 76
11/01/2014 Authors: Petersen W; Liu J; Yuan L; Zhang H; Schneiderjan M; Cho Y-J; MacDonald TJ
Response of subependymal giant cell astrocytoma with spinal cord metastasis to everolimus.
J Pediatr Hematol Oncol Volume: 36 Page(s): e448 - e451
10/01/2014 Authors: Aguilera D; Flamini R; Mazewski C; Schniederjan M; Hayes L; Boydston W; Castellino RC; MacDonald TJ
Clinical Outcomes Among Children With Standard Risk Medulloblastoma in Proton and Photon Treated Cohorts
Volume: 90 Page(s): S113 - S113
09/01/2014 Authors: Eaton BR; Esiashvili N; Kim S; Patterson B; Weyman E; Thornton LT; Kasper H; Mazewski C; MacDonald T; Ebb D
Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors.
J Pediatr Hematol Oncol Volume: 36 Page(s): 451 - 457
08/01/2014 Authors: Hartman LLR; Crawford JR; Makale MT; Milburn M; Joshi S; Salazar AM; Hasenauer B; VandenBerg SR; MacDonald TJ; Durden DL
THE BATS DIPG STUDY: A NATIONAL CLINICAL TRIAL OF UPFRONT BIOPSY AND TREATMENT STRATIFICATION FOR NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DFCI # 10-321)
Volume: 16 Page(s): 56 - 57
06/01/2014 Authors: Kieran M; Fontebasso A; Papillon-Cavanagh S; Schwartzentruber J; Nikbakht H; Gerges N; Fiset P-O; Bechet D; Faury D; De Jay N
RECURRENT GANGLIOGLIOMA WITH BRAF V600E MUTATION RESPONSE TO VEMURAFENIB: CASE REPORT
Volume: 16 Page(s): 61 - 61
06/01/2014 Authors: Aguilera D; Mazewski C; Janss A; Castellino RC; Schniederjan M; Hayes L; Brahma B; MacDonald T
MAINTENANCE OF MOLECULAR SUBGROUP AFFILIATION IN METASTATIC MEDULLOBLASTOMA
Volume: 16 Page(s): 96 - 96
06/01/2014 Authors: Wang X; Dubuc A; Korshunov A; Ramaswamy V; Remke M; Mack S; Gendoo D; Peacock J; Luu B; Cho Y-J
Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres.
Nat Mater Volume: 13 Page(s): 308 - 316
03/01/2014 Authors: Jain A; Betancur M; Patel GD; Valmikinathan CM; Mukhatyar VJ; Vakharia A; Pai SB; Brahma B; MacDonald TJ; Bellamkonda RV
Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes.
Acta Neuropathol Volume: 127 Page(s): 881 - 895
01/01/2014 Authors: Saratsis AM; Kambhampati M; Snyder K; Yadavilli S; Devaney JM; Harmon B; Hall J; Raabe EH; An P; Weingart M
The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma.
J Immunother Cancer Volume: 2 Page(s): 21
01/01/2014 Authors: Li M; Bolduc AR; Hoda MN; Gamble DN; Dolisca S-B; Bolduc AK; Hoang K; Ashley C; McCall D; Rojiani AM
The rationale for targeted therapies in medulloblastoma.
Neuro Oncol Volume: 16 Page(s): 9 - 20
01/01/2014 Authors: MacDonald TJ; Aguilera D; Castellino RC
IDENTIFYING DIFFERENTIAL ROLES FOR COLLAPSIN RESPONSE MEDIATOR PROTEIN4 (CRMP4) VARIANTS IN MEDULLOBLASTOMA GROWTH AND METASTASIS
Volume: 15 Page(s): 176 - 176
11/01/2013 Authors: Sivasankaran B; Velayutham RP; Fraschilla IR; Morris KJ; MacDonald TJ; Read T-A
Strategies for Glycomics and Glycosaminoglycan Analysis as part of Analytical Services at the Complex Carbohydrate Research Center
Volume: 23 Page(s): 1350 - 1351
11/01/2013 Authors: Archer-Hartmann S; Ishihara M; Heiss C; Byrne G; McGregor C; Kittur F; Xie J; Saxena T; Bellamkonda R; MacDonald T
Phase II study of cilengitide in the treatment of refractory or relapsed high-grade gliomas in children: a report from the Children's Oncology Group.
Neuro Oncol Volume: 15 Page(s): 1438 - 1444
10/01/2013 Authors: MacDonald TJ; Vezina G; Stewart CF; Turner D; Pierson CR; Chen L; Pollack IF; Gajjar A; Kieran MW
A PROSPECTIVE MULTI-INSTITUTIONAL PHASE II STUDY OF EVEROLIMUS (RAD001), AN MTOR INHIBITOR, IN PEDIATRIC PATIENTS WITH RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA. A POETIC CONSORTIUM TRIAL
PEDIATRIC BLOOD & CANCER Volume: 60 Page(s): 19 - 20
09/01/2013 Authors: Kieran M; Yao X; Macy M; Geyer R; Cohen K; MacDonald T; Allen J; Boklan J; Smith A; Nazemi K
A phase II trial of radiation and cetuximab followed by irinotecan/cetuximab for children with newly diagnosed diffuse pontine tumors and high-grade astrocytomas
Volume: 31
05/20/2013 Authors: Macy M; Kieran MW; Chi SN; Cohen KJ; MacDonald T; Smith AA; Etzl MM; Narendran A; Gore L; DiRenzo J
NG2 upregulation and its defective asymmetric distribution in pediatric brainstem glioma and diffuse intrinsic pontine glioma
Volume: 73
04/15/2013 Authors: Yadavilli S; Kambhampati M; Becher OJ; MacDonald T; Bellamkonda R; Paker RJ; Nazarian J
Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience.
Childs Nerv Syst Volume: 29 Page(s): 589 - 596
04/01/2013 Authors: Aguilera D; Mazewski C; Fangusaro J; MacDonald TJ; McNall-Knapp RY; Hayes LL; Kim S; Castellino RC
NG2 UPREGULATION IN PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA AND ITS ROLE IN TUMORIGENECITY IN VIVO
Volume: 15 Page(s): 47 - 47
04/01/2013 Authors: Yadavilli S; Kambhampati M; Becher O; MacDonald T; Bellamkonds R; Packer R; Nazarian J
UNCOVERING CLONAL EVOLUTION PATTERNS IN MEDULLOBLASTOMA METASTASES USING WHOLE GENOME SEQUENCING
Volume: 15 Page(s): 34 - 35
04/01/2013 Authors: Morrissy AS; Mayoh C; Lo A; Thiessen N; Tse K; Moore R; Mungall A; Wu X; Van Meter TE; Cho Y-J
DEVELOPMENT OF A FIVE-GENE HEDGEHOG SIGNATURE AS A PATIENT PRESELECTION TOOL FOR HEDGEHOG PATHWAY-TARGETED THERAPY IN MEDULLOBLASTOMA
Volume: 15 Page(s): 33 - 34
04/01/2013 Authors: Amakye D; Robinson D; Rose K; Cho Y-J; Ligon KL; Sharp T; Ando Y; Geoerger B; Doz F; Ashley D
Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration.
Mol Cancer Volume: 12 Page(s): 18
03/05/2013 Authors: Yuan L; Zhang H; Liu J; Rubin JB; Cho Y-J; Shu HK; Schniederjan M; MacDonald TJ
A feasibility and efficacy study of rapamycin and erlotinib for recurrent pediatric low-grade glioma (LGG).
Pediatr Blood Cancer Volume: 60 Page(s): 71 - 76
01/01/2013 Authors: Yalon M; Rood B; MacDonald TJ; McCowage G; Kane R; Constantini S; Packer RJ
Prolonged survival after treatment of diffuse intrinsic pontine glioma with radiation, temozolamide, and bevacizumab: report of 2 cases.
J Pediatr Hematol Oncol Volume: 35 Page(s): e42 - e46
01/01/2013 Authors: Aguilera DG; Mazewski C; Hayes L; Jordan C; Esiashivilli N; Janns A; Macdonald TJ
UPDATED RESULTS FROM A PHASE I STUDY OF LDE225, A SMOOTHENED ANTAGONIST, IN PEDIATRIC PATIENTS WITH RECURRENT MEDULLOBLASTOMA OR OTHER SOLID TUMORS
PEDIATRIC BLOOD & CANCER Volume: 59 Page(s): 980 - 980
12/01/2012 Authors: Geoerger B; Aerts I; Casanova M; Chisholm J; Hargrave D; Leary SES; Ashley D; Bouffet E; MacDonald T; Di Giannatale A
Transient enlargement of craniopharyngioma after radiation therapy: pattern of magnetic resonance imaging response following radiation.
J Neurooncol Volume: 109 Page(s): 349 - 355
09/01/2012 Authors: Shi Z; Esiashvili N; Janss AJ; Mazewski CM; MacDonald TJ; Wrubel DM; Brahma B; Schwaibold FP; Marcus RB; Crocker IR
REST is a novel prognostic factor and therapeutic target for medulloblastoma.
Mol Cancer Ther Volume: 11 Page(s): 1713 - 1723
08/01/2012 Authors: Taylor P; Fangusaro J; Rajaram V; Goldman S; Helenowski IB; MacDonald T; Hasselblatt M; Riedemann L; Laureano A; Cooper L
THE APPLICATION OF NANOPARTICLE LIPOSOME-IMPRAMINE BLUE IN THE TREATMENT OF MEDULLOBLASTOMA IN THE SmoA1 TRANSGENIC MICE
Volume: 14 Page(s): 83 - 83
06/01/2012 Authors: MacDonald T; Liu J; Munson J; Park J; Wang K; Fei B; Bellamkonda R; Arbiser J
A PHASE II TRIAL OF RADIATION AND CETUXIMAB FOLLOWED BY IRINOTECAN/CETUXIMAB FOR CHILDREN WITH NEWLY DIAGNOSED DIFFUSE PONTINE TUMORS AND HIGH GRADE ASTROCYTOMAS: A PRELIMINARY REPORT FROM POETIC
Volume: 14 Page(s): 18 - 18
06/01/2012 Authors: Macy M; Kieran M; Chi S; Cohen K; MacDonald T; Smith A; Etzl M; Naranderan A; Gore L; DiRenzo J
RESPONSE TO BEVACIZUMAB, IRINOTECAN, AND TEMOZOLAMIDE IN RECURRENT EMBRYONAL TUMORS: A MULTI-INSTITUTIONAL EXPERIENCE
Volume: 14 Page(s): 20 - 20
06/01/2012 Authors: Aguilera D; Mazewski C; Fangusaro J; MacDonald T; McNall R; Hayes L; Liu Y; Castellino R
SUBEPENDYMAL GIANT CELL ASTROCYTOMA OF THE SPINAL CORD AND RESPONSE TO EVEROLIMUS
Volume: 14 Page(s): 155 - 156
06/01/2012 Authors: Aguilera D; Flamini R; Mazewski C; Schniederjan M; Hayes L; Boydston W; MacDonald T
A phase I/II study of LDE225, a smoothened (Smo) antagonist, in pediatric patients with recurrent medulloblastoma (MB) or other solid tumors.
Volume: 30
05/20/2012 Authors: Geoerger B; Aerts I; Casanova M; Chisholm JC; Hargrave DR; Leary S; Ashley DM; Bouffet E; MacDonald T; Hurh E
The predictive value of a 5-gene signature as a patient pre-selection tool in medulloblastoma for Hedgehog pathway inhibitor therapy
CANCER RESEARCH Volume: 72
04/15/2012 Authors: Amakye D; Robinson D; Rose K; Cho J; Ligon KL; Sharp T; Haider A; Bandaru R; Ando Y; Geoerger B
Combined Src and aurora kinase inhibition in medulloblastoma
CANCER RESEARCH Volume: 72
04/15/2012 Authors: Petersen WC; Liu J; MacDonald TJ
Diffuse intrinsic pontine glioma (DIPG): time to biopsy again?
Pediatr Blood Cancer Volume: 58 Page(s): 487 - 488
04/01/2012 Authors: MacDonald TJ
Clonal selection drives genetic divergence of metastatic medulloblastoma.
Nature Volume: 482 Page(s): 529 - 533
02/15/2012 Authors: Wu X; Northcott PA; Dubuc A; Dupuy AJ; Shih DJH; Witt H; Croul S; Bouffet E; Fults DW; Eberhart CG
Medulloblastoma and primitive neuroectodermal tumors.
Volume: 105 Page(s): 529 - 548
01/01/2012 Authors: Packer RJ; Macdonald T; Vezina G; Keating R; Santi M
Hedgehog Pathway in Pediatric Cancers: They're Not Just for Brain Tumors Anymore.
Am Soc Clin Oncol Educ Book Page(s): 605 - 609
01/01/2012 Authors: Macdonald TJ
VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.
Cancer Biol Ther Volume: 12 Page(s): 818 - 826
11/01/2011 Authors: Ringer L; Sirajuddin P; Heckler M; Ghosh A; Suprynowicz F; Yenugonda VM; Brown ML; Toretsky JA; Uren A; Lee Y
Treatment of high-grade glioma in children and adolescents.
Neuro Oncol Volume: 13 Page(s): 1049 - 1058
10/01/2011 Authors: MacDonald TJ; Aguilera D; Kramm CM
A MCP1 fusokine with CCR2-specific tumoricidal activity.
Mol Cancer Volume: 10 Page(s): 121
09/24/2011 Authors: Rafei M; Deng J; Boivin M-N; Williams P; Matulis SM; Yuan S; Birman E; Forner K; Yuan L; Castellino C
Phase I study of tandem high-dose chemotherapy with autologous peripheral blood stem cell rescue for children with recurrent brain tumors: a Pediatric Blood and MarrowTransplant Consortium study.
Pediatr Blood Cancer Volume: 57 Page(s): 506 - 513
09/01/2011 Authors: Gilman AL; Jacobsen C; Bunin N; Levine J; Goldman F; Bendel A; Joyce M; Anderson P; Rozans M; Wall DA
Identification of transcriptional regulatory networks specific to pilocytic astrocytoma.
BMC Med Genomics Volume: 4 Page(s): 57
07/11/2011 Authors: Deshmukh H; Yu J; Shaik J; MacDonald TJ; Perry A; Payton JE; Gutmann DH; Watson MA; Nagarajan R
Secretome signature of invasive glioblastoma multiforme.
J Proteome Res Volume: 10 Page(s): 3149 - 3159
07/01/2011 Authors: Formolo CA; Williams R; Gordish-Dressman H; MacDonald TJ; Lee NH; Hathout Y
Characterization of signaling function and expression of HLA class I molecules in medulloblastoma.
J Neurooncol Volume: 103 Page(s): 197 - 206
06/01/2011 Authors: Smith C; Santi M; Rushing EJ; Cornelison R; MacDonald TJ; Vukmanovic S
RESPONSES IN PATIENTS WITH NEW DIAGNOSIS OF DIFFUSE INTRINSIC PONTINE GLIOMA: REPORT ON TWO CASES TREATED WITH RADIATION, TEMOZOLAMIDE AND BEVACIZUMAB
PEDIATRIC BLOOD & CANCER Volume: 56 Page(s): 962 - 962
06/01/2011 Authors: Aguilera D; Mazewski C; Eshivilli N; Hayes L; Jordan C; Macdonald T
Neurofibromatosis-2 and spinal cord ependymomas: Report of two cases and review of the literature.
Childs Nerv Syst Volume: 27 Page(s): 757 - 764
05/01/2011 Authors: Aguilera DG; Mazewski C; Schniederjan MJ; Leong T; Boydston W; Macdonald TJ
RNA and microRNA analysis of diffused intrinsic pontine glioma specimens
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Sandza AE; Hill A; MacDonald T; Nazarian J
Aurora kinase inhibitor AT9283 potently inhibits the proliferation and migration of medulloblastoma cells
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Macdonald TJ; Liu J; Lyons J
RNA and microRNA analysis of diffused intrinsic pontine glioma specimens
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Sandza AE; Hill A; MacDonald T; Nazarian J
Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric brain tumor consortium study.
Proteomics Volume: 11 Page(s): 935 - 943
03/01/2011 Authors: Rajagopal MU; Hathout Y; MacDonald TJ; Kieran MW; Gururangan S; Blaney SM; Phillips P; Packer R; Gordish-Dressman H; Rood BR
Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018.
J Clin Oncol Volume: 29 Page(s): 324 - 329
01/20/2011 Authors: Warren KE; Goldman S; Pollack IF; Fangusaro J; Schaiquevich P; Stewart CF; Wallace D; Blaney SM; Packer R; Macdonald T
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.
J Clin Invest Volume: 121 Page(s): 148 - 160
01/01/2011 Authors: Beauchamp EM; Ringer L; Bulut G; Sajwan KP; Hall MD; Lee Y-C; Peaceman D; Ozdemirli M; Rodriguez O; Macdonald TJ
Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells.
J Neurooncol Volume: 101 Page(s): 215 - 226
01/01/2011 Authors: Abouantoun TJ; Castellino RC; MacDonald TJ
ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration.
Clin Exp Metastasis Volume: 27 Page(s): 481 - 491
10/01/2010 Authors: Yuan L; Santi M; Rushing EJ; Cornelison R; MacDonald TJ
LABEL FREE MASS SPECTROMETRIC ANALYSIS OF THE MEDULLOBLASTOMA CEREBROSPINAL FLUID PROTEOME
Volume: 12 Page(s): II55 - II55
06/01/2010 Authors: Rajagopal MU; Hathout Y; MacDonald TJ; Gordish-Dressman H; Rood BR
Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.
PLoS One Volume: 5 Page(s): e10849
05/26/2010 Authors: Castellino RC; Barwick BG; Schniederjan M; Buss MC; Becher O; Hambardzumyan D; Macdonald TJ; Brat DJ; Durden DL
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.
Cancer Res Volume: 70 Page(s): 2548 - 2557
03/15/2010 Authors: Becher OJ; Hambardzumyan D; Walker TR; Helmy K; Nazarian J; Albrecht S; Hiner RL; Gall S; Huse JT; Jabado N
Central nervous system tumors.
Hematol Oncol Clin North Am Volume: 24 Page(s): 87 - 108
02/01/2010 Authors: Packer RJ; Macdonald T; Vezina G
Detection of human herpesvirus-6 in adult central nervous system tumors: predominance of early and late viral antigens in glial tumors.
J Neurooncol Volume: 95 Page(s): 49 - 60
10/01/2009 Authors: Crawford JR; Santi MR; Cornelison R; Sallinen S-L; Haapasalo H; MacDonald TJ
Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low grade gliomas.
Volume: 46 Page(s): 37 - 42
09/01/2009 Authors: Crawford JR; Santi MR; Thorarinsdottir HK; Cornelison R; Rushing EJ; Zhang H; Yao K; Jacobson S; Macdonald TJ
A novel role of HLA class I in the pathology of medulloblastoma.
J Transl Med Volume: 7 Page(s): 59
07/12/2009 Authors: Smith C; Santi M; Rajan B; Rushing EJ; Choi MR; Rood BR; Cornelison R; MacDonald TJ; Vukmanovic S
Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan.
Pediatr Blood Cancer Volume: 52 Page(s): 791 - 795
07/01/2009 Authors: Packer RJ; Jakacki R; Horn M; Rood B; Vezina G; MacDonald T; Fisher MJ; Cohen B
Imatinib blocks migration and invasion of medulloblastoma cells by concurrently inhibiting activation of platelet-derived growth factor receptor and transactivation of epidermal growth factor receptor.
Mol Cancer Ther Volume: 8 Page(s): 1137 - 1147
05/01/2009 Authors: Abouantoun TJ; MacDonald TJ
Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors.
Pediatr Blood Cancer Volume: 52 Page(s): 169 - 176
02/01/2009 Authors: Kieran MW; Supko JG; Wallace D; Fruscio R; Poussaint TY; Phillips P; Pollack I; Packer R; Boyett JM; Blaney S
IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.
Volume: 23 Page(s): 1205 - 1213
10/01/2008 Authors: Becher OJ; Peterson KM; Khatua S; Santi MR; MacDonald TJ
Aggressive infantile embryonal tumors.
Volume: 23 Page(s): 1195 - 1204
10/01/2008 Authors: MacDonald TJ
Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival.
Pediatr Blood Cancer Volume: 51 Page(s): 349 - 355
09/01/2008 Authors: Chen K; Fallen S; Abaan HO; Hayran M; Gonzalez C; Wodajo F; MacDonald T; Toretsky JA; Uren A
The CSF proteome of medulloblastoma
Volume: 10 Page(s): 389 - 389
06/01/2008 Authors: Rajagopal M; Hathout Y; Macdonald T; Rood B
Detection of human herpesvirus 6 variants in pediatric brain tumors: Association of viral replication in low-grade gliomas
Volume: 10 Page(s): 377 - 377
06/01/2008 Authors: Crawford J; Santi M; Thorarinsdottir H; Cornelison R; Rushing E; Jacobson S; Macdonald T
Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas.
Clin Cancer Res Volume: 14 Page(s): 3386 - 3394
06/01/2008 Authors: Thorarinsdottir HK; Santi M; McCarter R; Rushing EJ; Cornelison R; Jales A; MacDonald TJ
Protein profiling of formalin fixed paraffin embedded tissue: Identification of potential biomarkers for pediatric brainstem glioma.
Proteomics Clin Appl Volume: 2 Page(s): 915 - 924
06/01/2008 Authors: Nazarian J; Santi M; Hathout Y; Macdonald TJ
PDGF and EGF stimulation induces rapid degradation of Akt in medulloblastoma cells
Volume: 10 Page(s): 486 - 486
06/01/2008 Authors: Yuan L; Macdonald T
Expression of the notch pathway effectors HES-1 and HES-5 is associated with favorable outcome in medulloblastoma
Volume: 10 Page(s): 381 - 381
06/01/2008 Authors: Choi MR; Rushing E; Santi MR; Cornelison R; Macdonald T
Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan
Volume: 10 Page(s): 449 - 449
06/01/2008 Authors: Packer R; Macdonald T; Horn M; Rood B; Jakacki R; Fisher M; Cohen B
PDGF-CC and medulloblastoma migration
Volume: 10 Page(s): 486 - 486
06/01/2008 Authors: Zhang H; Santi M; Macdonald T; Rood B
Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors.
Pediatr Blood Cancer Volume: 50 Page(s): 970 - 975
05/01/2008 Authors: Choi LMR; Rood B; Kamani N; La Fond D; Packer RJ; Santi MR; Macdonald TJ
Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012.
J Clin Oncol Volume: 26 Page(s): 919 - 924
02/20/2008 Authors: MacDonald TJ; Stewart CF; Kocak M; Goldman S; Ellenbogen RG; Phillips P; Lafond D; Poussaint TY; Kieran MW; Boyett JM
Central nervous system tumors.
Pediatr Clin North Am Volume: 55 Page(s): 121 - xi
02/01/2008 Authors: Packer RJ; MacDonald T; Vezina G
Recurrent childhood low-grade gliomas: Response to Bevacizumab and Irinotecan
Volume: 64 Page(s): S87 - S87
01/01/2008 Authors: Packer RJ; MacDonald TJ; Horn M; Rood BR; Vezina G; Jakacki R; Fisher M; Cohen B
Medulloblastoma in childhood: new biological advances.
Lancet Neurol Volume: 6 Page(s): 1073 - 1085
12/01/2007 Authors: Crawford JR; MacDonald TJ; Packer RJ
Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report.
Volume: 13 Page(s): 6712 - 6718
11/15/2007 Authors: Broniscer A; Gururangan S; MacDonald TJ; Goldman S; Packer RJ; Stewart CF; Wallace D; Danks MK; Friedman HS; Poussaint TY
The role of RAC signaling in PDGF-mediated cell motility in medulloblastoma
Volume: 9 Page(s): 552 - 552
10/01/2007 Authors: Yuan L; MacDonald T
Peptidomic analysis of cerebrospinal fluid from children with common brain tumors
Volume: 9 Page(s): 554 - 555
10/01/2007 Authors: Rajagopal M; Hathout Y; MacDonald T; Rood B
CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis.
Neurology Volume: 68 Page(s): 1668 - 1673
05/15/2007 Authors: Crawford JR; Santi MR; Vezina G; Myseros JS; Keating RF; LaFond DA; Rood BR; MacDonald TJ; Packer RJ
Phase I trial of pirfenidone in children with neurofibromatosis 1 and plexiform neurofibromas.
Pediatr Neurol Volume: 36 Page(s): 293 - 300
05/01/2007 Authors: Babovic-Vuksanovic D; Widemann BC; Dombi E; Gillespie A; Wolters PL; Toledo-Tamula MA; O'Neill BP; Fox E; MacDonald T; Beck H
Detection of human herpes virus 6 in childhood central nervous system gliomas
Volume: 9 Page(s): 185 - 185
04/01/2007 Authors: Crawford JR; Santi MR; MacDonald TJ
PDGF-C expression in medulloblastoma: Implications for autocrine signaling
Volume: 9 Page(s): 183 - 184
04/01/2007 Authors: Rood BR; Zhang H; MacDonald TJ; Santi M
Phase I trial of oral temozolomide and intravenous O-6-benzylguanine (O-6-BG), a methylguanine methyltransferase inhibitor, in pediatric patients with recurrent brain tumors
Volume: 9 Page(s): 189 - 189
04/01/2007 Authors: Broniscer A; Gururangan S; Goldman S; MacDonald T; Wallace D; Stewart CF; Jakacki R; Kieran MW; Chintagumpala M; Banerjee A
Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme.
J Neurooncol Volume: 82 Page(s): 95 - 101
03/01/2007 Authors: Turner CD; Chi S; Marcus KJ; MacDonald T; Packer RJ; Poussaint TY; Vajapeyam S; Ullrich N; Goumnerova LC; Scott RM
Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue.
Pediatr Blood Cancer Volume: 48 Page(s): 278 - 284
03/01/2007 Authors: Thorarinsdottir HK; Rood B; Kamani N; Lafond D; Perez-Albuerne E; Loechelt B; Packer RJ; MacDonald TJ
Medulloblastoma and Primitive Neuroectodermal Tumors
Page(s): 425 - 432
01/01/2007 Authors: Elshihabi S; Rutka JT
Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis.
Methods Mol Biol Volume: 377 Page(s): 203 - 222
01/01/2007 Authors: MacDonald TJ; Pollack IF; Okada H; Bhattacharya S; Lyons-Weiler J
The putative role of MHC class 1 downregulation in the reduced immune response to medulloblastoma
Volume: 8 Page(s): 469 - 469
10/01/2006 Authors: Smith C; Vollmer A; Rajan B; Rood B; MacDonald T; Vukmanovic S
An analysis of SEER data of increasing risk of secondary malignant neoplasms among long-term survivors of childhood brain tumors.
Pediatr Blood Cancer Volume: 47 Page(s): 83 - 88
07/01/2006 Authors: Peterson KM; Shao C; McCarter R; MacDonald TJ; Byrne J
Detection of CMV in pediatric central nervous system glioma and normal brain
Volume: 60 Page(s): S120 - S120
01/01/2006 Authors: Crawford JR; Sarti MR; Colberg-Poley A; MacDonald TJ
Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933.
Cancer Volume: 104 Page(s): 2862 - 2871
12/15/2005 Authors: MacDonald TJ; Arenson EB; Ater J; Sposto R; Bevan HE; Bruner J; Deutsch M; Kurczynski E; Luerssen T; McGuire-Cullen P
Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches.
J Neurooncol Volume: 75 Page(s): 267 - 272
12/01/2005 Authors: Rood BR; MacDonald TJ
Radial glia cells are candidate stem cells of ependymoma.
Cancer Cell Volume: 8 Page(s): 323 - 335
10/01/2005 Authors: Taylor MD; Poppleton H; Fuller C; Su X; Liu Y; Jensen P; Magdaleno S; Dalton J; Calabrese C; Board J
Outcome for children <= 3 years of age with malignant brain or spinal cord tumors treated with high dose chemotherapy with peripheral blood stem cell rescue.
Volume: 23 Page(s): 813S - 813S
06/01/2005 Authors: Thorarinsdottir HK; Rood B; Lafond D; Perez E; Loechelt B; Kamani N; Packer R; MacDonald T
An expression signature classifies chemotherapy-resistant pediatric osteosarcoma.
Cancer Res Volume: 65 Page(s): 1748 - 1754
03/01/2005 Authors: Mintz MB; Sowers R; Brown KM; Hilmer SC; Mazza B; Huvos AG; Meyers PA; Lafleur B; McDonough WS; Henry MM
PDGFR inhibition in medulloblastoma cells induces apoptosis and alters gene expression
Volume: 6 Page(s): 405 - 405
10/01/2004 Authors: Dzirlo M; Peterson KM; Kushner R; Abouantoun T; MacDonald T
Current treatment of medulloblastoma: recent advances and future challenges.
Semin Oncol Volume: 31 Page(s): 666 - 675
10/01/2004 Authors: Rood BR; Macdonald TJ; Packer RJ
Second malignant neoplasms in long-term survivors of pediatric brain cancer: An analysis of SEER data
Volume: 6 Page(s): 442 - 442
10/01/2004 Authors: Peterson KM; Shao C; MacDonald T; Byrne J
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease (vol 29, pg 143, 2001)
NATURE GENETICS Volume: 35 Page(s): 287 - 287
11/01/2003 Authors: MacDonald TJ; Brown KM; LaFleur B; Peterson K; Lawlor C; Chen Y; Packer RJ; Cogen P; Stephan DA
Medulloblastoma: present concepts of stratification into risk groups.
Pediatr Neurosurg Volume: 39 Page(s): 60 - 67
07/01/2003 Authors: Packer RJ; Rood BR; MacDonald TJ
The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma.
Pediatr Neurosurg Volume: 39 Page(s): 68 - 74
07/01/2003 Authors: Chopra A; Brown KM; Rood BR; Packer RJ; MacDonald TJ
Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling.
Cancer Res Volume: 63 Page(s): 1865 - 1870
04/15/2003 Authors: Khatua S; Peterson KM; Brown KM; Lawlor C; Santi MR; LaFleur B; Dressman D; Stephan DA; MacDonald TJ
Serial expression profiling of T98 glioblastoma cell line with and without exogenous recombinant IGFBP2 suggests its role in angiogenesis
Volume: 53 Page(s): 272A - 273A
04/01/2003 Authors: Becher OJ; Peterson KM; Brown KM; MacDonald TJ
Integrin alpha6 and laminin receptor1 as potential therapeutic targets in pediatric astrocytomas
Volume: 53 Page(s): 280A - 280A
04/01/2003 Authors: Khatua S; Peterson K; MacDonald TJ
Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors.
Oncologist Volume: 8 Page(s): 174 - 186
01/01/2003 Authors: MacDonald TJ; Rood BR; Santi MR; Vezina G; Bingaman K; Cogen PH; Packer RJ
High-dose preirradiation chemotherapy for children with newly diagnosed high-grade astrocytomas
Volume: 54 Page(s): S152 - S152
01/01/2003 Authors: MacDonald TJ; Arenson A; Sposto R; Yates A; Phillips P; Deutsch M; Vezina LG; Packer RJ
Growth factors and their receptors in pediatric gliomas using microarray gene chips
PEDIATRIC RESEARCH Volume: 51 Page(s): 248A - 248A
04/01/2002 Authors: Becher OJ; Khatua S; Lawlor C; Chopra A; Peterson K; MacDonald T
Profile of alpha4 chain containing laminins in different grades of pediatric astrocytomas as identified by gene microarray analysis
PEDIATRIC RESEARCH Volume: 51 Page(s): 248A - 248A
04/01/2002 Authors: Khatua S; Becker O; Lawlor C; Peterson K; Macdonald T
Expression profiling of medulloblastoma: identification of therapeutic targets for metastatic disease.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 69 Page(s): 273 - 273
10/01/2001 Authors: Brown KM; MacDonald TJ; LaFleur B; Peterson K; Lawlor C; Chen Y; Packer RJ; Cogen P; Stephan DA
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease.
Nat Genet Volume: 29 Page(s): 143 - 152
10/01/2001 Authors: MacDonald TJ; Brown KM; LaFleur B; Peterson K; Lawlor C; Chen Y; Packer RJ; Cogen P; Stephan DA
Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist.
Neurosurgery Volume: 48 Page(s): 151 - 157
01/01/2001 Authors: MacDonald TJ; Taga T; Shimada H; Tabrizi P; Zlokovic BV; Cheresh DA; Laug WE
Antisense to integrin alpha v inhibits growth and induces apoptosis in medulloblastoma cells.
Anticancer Res Volume: 21 Page(s): 3785 - 3791
01/01/2001 Authors: MacDonald TJ; Ladisch S
Identification of expression changes of prognostic and therapeutic value in metastasizing medulloblastoma.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 67 Page(s): 102 - 102
10/01/2000 Authors: MacDonald T; Brown KM; Cogen PH; Chen YW; Rood B; Packer RJ; Stephan DA
Peripheral blood stem cell (PBSC) harvests in pediatric brain tumor patients.
BLOOD Volume: 94 Page(s): 340B - 340B
11/15/1999 Authors: Lumadue J; Taylor B; Fritzel S; Logan J; Dinndorf P; MacDonald T
Antagonist to alpha v-integrin inhibits growth of orthotopically but not heterotopically transplanted brain tumors
THROMBOSIS AND HAEMOSTASIS Page(s): 205 - 206
08/01/1999 Authors: MacDonald TJ; Shimada H; Cheresh DA; Laug WE
Glioma and medulloblastoma growth inhibition by alpha V integrin antagonist
PEDIATRIC RESEARCH Volume: 45 Page(s): 774 - 774
05/01/1999 Authors: MacDonald TJ; Shimada H; Cheresh DA; Laug WE
Urokinase induces receptor mediated brain tumor cell migration and invasion.
J Neurooncol Volume: 40 Page(s): 215 - 226
12/01/1998 Authors: MacDonald TJ; DeClerck YA; Laug WE
Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein.
Neurosurgery Volume: 43 Page(s): 1437 - 1442
12/01/1998 Authors: MacDonald TJ; Tabrizi P; Shimada H; Zlokovic BV; Laug WE
The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide.
Cancer Res Volume: 58 Page(s): 2469 - 2476
06/01/1998 Authors: Lawlor ER; Lim JF; Tao W; Poremba C; Chow CJ; Kalousek IV; Kovar H; MacDonald TJ; Sorensen PH
Role of serine and matrix metalloproteinases in brain tumor cell invasion
THROMBOSIS AND HAEMOSTASIS Page(s): S1541 - S1541
06/01/1997 Authors: MacDonald T; DeClerck Y; Laug W
Prevalence of nonclassical steroid 21-hydroxylase deficiency based on a morning salivary 17-hydroxyprogesterone screening test: a small sample study.
J Clin Endocrinol Metab Volume: 70 Page(s): 1662 - 1667
06/01/1990 Authors: Zerah M; Ueshiba H; Wood E; Speiser PW; Crawford C; McDonald T; Pareira J; Gruen D; New MI