David Archer PhD

Department of Pediatrics
Associate Professor

(404) 727-1378
darcher@emory.edu

Aflac Cancer and Blood Disorders Center
2015 Uppergate Drive

Academic Appointment

Associate Professor of Pediatrics, Emory University
Assistant Professor, Winship Cancer Institute, Emory University

Education

Degrees

PhD from University of Liverpool
BS from University of Dundee

Research

Focus

My research is focused on the use of stem cell therapy for inherited blood disorders, specifically sickle cell disease. Of particular interest is the pathogenesis of end organ damage, especially in the kidney, and the potential of therapy to prevent or reverse these processes.

Publications

Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice.
Cell Death Dis Volume: 15 Page(s): 907
12/18/2024 Authors: Tripathi AK; Dabeer S; Song J; Vikulina T; Roser-Page S; Alvarez JA; Archer DR; Weitzmann MN
Impact of arginine therapy on kyotorphin in children with sickle cell disease and vaso-occlusive pain.
Blood Adv Volume: 8 Page(s): 3267 - 3271
06/25/2024 Authors: Korman R; Hatabah D; Brown LA; Harris F; Wilkinson H; Rees CA; Bakshi N; Archer DR; Dampier C; Morris CR
Voxelotor improves red blood cell functionality in children with sickle cell anaemia: An ancillary study of the HOPE-KIDS 1 trial.
EJHaem Volume: 5 Page(s): 125 - 130
02/01/2024 Authors: Chonat S; Fields E; Baratz H; Watt A; Pochron M; Dixon S; Tonda M; Brown C; Archer D
Accelerated atherosclerosis in beta-thalassemia.
Am J Physiol Heart Circ Physiol Volume: 325 Page(s): H1133 - H1143
11/01/2023 Authors: Hurtado J; Sellak H; Joseph G; Lewis CV; Naudin CR; Garcia S; Wodicka JR; Archer DR; Taylor WR
Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis.
FASEB Bioadv Volume: 5 Page(s): 199 - 210
05/01/2023 Authors: Lewis CV; Sellak H; Sawan MA; Joseph G; Darby TM; VanInsberghe D; Naudin CR; Archer DR; Jones RM; Taylor WR
DEVELOPMENT OF A HUMANIZED MOUSE MODEL OF CHOLESTATIC SICKLE CELL DISEASE
Volume: 76 Page(s): S1025 - S1026
10/01/2022 Authors: Michael A; Dawson PA; Karpen SJ; Archer DR
Increasing nitric oxide bioavailability fails to improve collateral vessel formation in humanized sickle cell mice.
Lab Invest Volume: 102 Page(s): 805 - 813
08/01/2022 Authors: Lewis CV; Sellak H; Hansen L; Joseph G; Hurtado J; Archer DR; Jun H-W; Brown LA; Taylor WR
Sickle Cell Transplantation Evaluation of Long-term and Late Effects Registry (STELLAR) to Compare Long-term Outcomes After Hematopoietic Cell Transplantation to Those in Siblings Without Sickle Cell Disease and in Nontransplanted Individuals With Sickle Cell Disease: Design and Feasibility Study.
JMIR Res Protoc Volume: 11 Page(s): e36780
07/06/2022 Authors: Krishnamurti L; Arnold SD; Haight A; Abraham A; Guilcher GM; John T; Bakshi N; Shenoy S; Syrjala K; Martin PL
Adhesion molecules and cerebral microvascular hemodynamic abnormalities in sickle cell disease.
Front Neurol Volume: 13 Page(s): 976063
01/01/2022 Authors: Abi Rached NM; Gbotosho OT; Archer DR; Jones JA; Sterling MS; Hyacinth HI
CHRONIC INFLAMMATION PROMOTES HEPATIC FIBROSIS IN A HUMANIZED MICE MODEL OF SICKLE CELL DISEASE
Volume: 74 Page(s): 807A - 807A
10/01/2021 Authors: Michael AOA; Flowers-Steele J; Song H; Platt MO; Archer DR
PPAR increases HUWE1 to attenuate NF-B/p65 and sickle cell disease with pulmonary hypertension.
Blood Adv Volume: 5 Page(s): 399 - 413
01/26/2021 Authors: Jang AJ; Chang SS; Park C; Lee C-M; Benza RL; Passineau MJ; Ma J; Archer DR; Sutliff RL; Hart CM
Whole Blood Transcriptome Analysis in Children with Sickle Cell Anemia.
Front Genet Volume: 12 Page(s): 737741
01/01/2021 Authors: Gee BE; Pearson A; Buchanan-Perry I; Simon RP; Archer DR; Meller R
Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease.
Volume: 246 Page(s): 106 - 120
01/01/2021 Authors: Hardy RA; Rached NA; Jones JA; Archer DR; Hyacinth HI
VOXELOTOR IN CHILDREN WITH SICKLE CELL ANEMIA: EFFICACY AND IMPROVEMENT IN ERYTHROCYTE PHYSIOLOGY
Volume: 67 Page(s): S40 - S40
06/01/2020 Authors: Chonat S; Fields E; Baratz H; Watt A; Pochron M; Dixon S; Tonda M; Lehrer-Graiwer J; Brown C; Archer D
Generation of Multi Modal Lentiviral Vectors for High-Level Fetal Hemoglobin Expression
Volume: 28 Page(s): 350 - 351
04/28/2020 Authors: Bagchi A; McCarty D; Shields J; Fields E; Wandu S; Archer D; Velayudhan SR; Spencer HT; Srivastava A
Integrative Analysis of Long Non-Coding RNAs and mRNAs in Lungs of Sickle Cell Mice
Volume: 34
04/01/2020 Authors: Kang B-Y; Chang S; Park C; Archer D; Sutliff R; Hart C
Characterization of Donor Variability for T Cell ex vivo Expansion and Development of an Allogeneic T Cell Immunotherapy.
Front Med (Lausanne) Volume: 7 Page(s): 588453
01/01/2020 Authors: Burnham RE; Zoine JT; Story JY; Garimalla SN; Gibson G; Rae A; Williams E; Bixby L; Archer D; Doering CB
A pilot study of the effect of atorvastatin on endothelial function and albuminuria in sickle cell disease.
Am J Hematol Volume: 94 Page(s): E299 - E301
11/01/2019 Authors: Ataga KI; Wichlan D; Elsherif L; Derebail VK; Wogu AF; Maitra P; Cai J; Caughey MC; Pollock DM; Pollock JS
MODELING COMPLEMENT-MEDIATED ACUTE LUNG INJURY IN SICKLE CELL MICE
Volume: 114 Page(s): 496 - 496
10/01/2019 Authors: Chonat S; Patel S; Jeffers L; Koval M; Archer D; Joiner C; Stowell S
The role of age and neuroinflammation in the mechanism of cognitive and neurobehavioral deficits in sickle cell disease
Volume: 39 Page(s): 343 - 343
07/01/2019 Authors: Hardy RA; Rached NA; Jones J; Archer DR; Hyacinth HI
Plasma metabolomics analysis in sickle cell disease patients with albuminuria - an exploratory study.
Br J Haematol Volume: 185 Page(s): 620 - 623
05/01/2019 Authors: Elsherif L; Pathmasiri W; McRitchie S; Archer DR; Ataga KI
Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease.
J Cereb Blood Flow Metab Volume: 39 Page(s): 342 - 351
02/01/2019 Authors: Hyacinth HI; Sugihara CL; Spencer TL; Archer DR; Shih AY
The Role of Long Non-Coding RNA MALAT1/HMOX1 Axis in Sickle Cell Mouse Lungs and in Hemin-Treated Human Pulmonary Artery Endothelial Cells
Volume: 199
01/01/2019 Authors: Kang B; Chang SS; Archer DR; Sutliff RL; Hart C
Stressed Neutrophils Impede Vascular Repair
Volume: 138
11/06/2018 Authors: Okwan-Duodu D; Liu W; Xu K; Quintana R; Hansen L; Sellak H; Joseph G; Levit R; Archer D; Taylor WR
Impaired Collateral Vessel Formation in Sickle Cell Disease.
Arterioscler Thromb Vasc Biol Volume: 38 Page(s): 1125 - 1133
05/01/2018 Authors: Okwan-Duodu D; Hansen L; Joseph G; Lyle AN; Weiss D; Archer DR; Taylor WR
Lentiviral Vector Based Gene Therapy for Major Haemoglobin Disorders
Volume: 26 Page(s): 239 - 239
05/01/2018 Authors: Bagchi A; Velayudhan SR; Archer D; Shields JE; McCarty D; Spencer HT; Srivastava A
Does the Sickle Trait Portend Increased Cardiovascular Risks?
Volume: 38
05/01/2018 Authors: Okwan-Duodu D; Quintana RA; Joseph G; Hansen L; Liu W; Sellak H; Archer D; Taylor WR
Neutrophils Aged Under Oxidative Stress Impede Vascular Repair
Volume: 38
05/01/2018 Authors: Okwan-Duodu D; Liu W; Xu K; Shin E; Quintana RA; Joseph G; Hansen L; Sellak H; Levit R; Archer D
The Long Non-Coding RNA XIST Is Decreased in Lungs and Plasma Exosomes of Sickle Cell Mice and in Hemin-Treated Human Pulmonary Artery Endothelial Cells
Volume: 32
04/01/2018 Authors: Kang B-Y; Chang SS; Bedi B; Sutliff RL; Archer DR; Hart CM; Sadikot RT
Renal protection by atorvastatin in a murine model of sickle cell nephropathy.
Br J Haematol Volume: 181 Page(s): 111 - 121
04/01/2018 Authors: Zahr RS; Chappa P; Yin H; Brown LA; Ataga KI; Archer DR
Losartan therapy decreases albuminuria with stable glomerular filtration and permselectivity in sickle cell anemia.
Blood Cells Mol Dis Volume: 69 Page(s): 65 - 70
03/01/2018 Authors: Yee ME; Lane PA; Archer DR; Joiner CH; Eckman JR; Guasch A
Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment.
Stroke Volume: 48 Page(s): 3347 - 3355
12/01/2017 Authors: Sun Y-Y; Lee J; Huang H; Wagner MB; Joiner CH; Archer DR; Kuan C-Y
Estimation of glomerular filtration rate using serum cystatin C and creatinine in adults with sickle cell anemia.
Am J Hematol Volume: 92 Page(s): E598 - E599
10/01/2017 Authors: Yee MEM; Lane PA; Archer DR; Joiner CH; Eckman JR; Guasch A
Neutrophil-Mediated Inflammation Drives Sickle Cell Vasculopathy
Volume: 37
05/01/2017 Authors: Okwan D; Hansen L; Joseph G; Weiss D; Archer DR; Taylor WR
Characterizing spontaneous cerebral vasculopathy in a murine model of sickle cell disease
Volume: 37 Page(s): 248 - 249
04/01/2017 Authors: Hyacinth HI; Sugihara CL; Archer DR; Shih AY
Peroxisome Proliferator-Activated Receptor Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung.
Am J Respir Cell Mol Biol Volume: 56 Page(s): 131 - 144
01/01/2017 Authors: Kang B-Y; Park K; Kleinhenz JM; Murphy TC; Sutliff RL; Archer D; Hart CM
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
Br J Haematol Volume: 175 Page(s): 141 - 153
10/01/2016 Authors: Oksenberg D; Dufu K; Patel MP; Chuang C; Li Z; Xu Q; Silva-Garcia A; Zhou C; Hutchaleelaha A; Patskovska L
Hemolysis Reduces Huwe1 Through Ppar gamma Downregulation In Sickle Cell Disease-Pulmonary Hypertension
Volume: 193
01/01/2016 Authors: Kang B-Y; Kleinhenz JM; Murphy TC; Sutliff RL; Archer D; Hart CM
Albuminuria Is Associated with Endothelial Dysfunction and Elevated Plasma Endothelin-1 in Sickle Cell Anemia.
PLoS One Volume: 11 Page(s): e0162652
01/01/2016 Authors: Ataga KI; Derebail VK; Caughey M; Elsherif L; Shen JH; Jones SK; Maitra P; Pollock DM; Cai J; Archer DR
Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice.
JCI Insight Volume: 1
01/01/2016 Authors: Ghosh S; Ihunnah CA; Hazra R; Walker AL; Hansen JM; Archer DR; Owusu-Ansah AT; Ofori-Acquah SF
Endothelin-1 Is Associated with Albuminuria and Measures of Vascular Endothelial Dysfunction in Sickle Cell Anemia
Volume: 126
12/03/2015 Authors: Derebail VK; Jones SK; Shen J; Caughey M; Hinderliter AL; Pollock DM; Archer DR; Ataga KI
Albuminuria Is Associated with Endothelial Dysfunction in Sickle Cell Disease
Volume: 126
12/03/2015 Authors: Caughey M; Derebail VK; Jones SK; Shen J; Maitra P; Cai J; Hinderliter AL; Archer DR; Ataga KI
Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice
Volume: 126
12/03/2015 Authors: Ghosh S; Ihunnah CA; Hazra R; Owusu-Ansah AT; Hansen JM; Archer DR; Ofori-Acquah SF
Controlled delivery of -globin-targeting TALENs and CRISPR/Cas9 into mammalian cells for genome editing using microinjection.
Sci Rep Volume: 5 Page(s): 16031
11/12/2015 Authors: Cottle RN; Lee CM; Archer D; Bao G
Immune parameter analysis of children with sickle cell disease on hydroxycarbamide or chronic transfusion therapy.
Br J Haematol Volume: 169 Page(s): 574 - 583
05/01/2015 Authors: Nickel RS; Osunkwo I; Garrett A; Robertson J; Archer DR; Promislow DEL; Horan JT; Hendrickson JE; Kean LS
Identifying and characterizing spontaneous cerebrovascular disease in a murine model of human sickle cell disease
Volume: 169 Page(s): 23 - 24
04/01/2015 Authors: Hyacinth HI; Sugihara CL; Kindy MS; Greenberg CS; Fay ME; Lam W; Archer DR; Adams RJ; Shih AY
Body composition and grip strength are improved in transgenic sickle mice fed a high-protein diet.
J Nutr Sci Volume: 4 Page(s): e6
01/01/2015 Authors: Capers PL; Hyacinth HI; Cue S; Chappa P; Vikulina T; Roser-Page S; Weitzmann MN; Archer DR; Newman GW; Quarshie A
Targeted Disruption of Nrf2 in Non-Hematopoietic Tissues Exacerbates Hemolysis and Accelerates Chronic Lung Disease in Transgenic Sickle Cell Anemia Mice
Volume: 124
12/06/2014 Authors: Ghosh S; Hansen J; Hazra R; Archer DR; Ofori-Acquah SF
The glomerulopathy of sickle cell disease.
Am J Hematol Volume: 89 Page(s): 907 - 914
09/01/2014 Authors: Ataga KI; Derebail VK; Archer DR
High protein diet attenuates histopathologic organ damage and vascular leakage in transgenic murine model of sickle cell anemia.
Exp Biol Med (Maywood) Volume: 239 Page(s): 966 - 974
08/01/2014 Authors: Manci EA; Hyacinth HI; Capers PL; Archer DR; Pitts S; Ghosh S; Patrickson J; Titford ME; Ofori-Acquah SF; Hibbert JM
TNF-, IFN-, IL-10, and IL-4 levels were elevated in a murine model of human sickle cell anemia maintained on a high protein/calorie diet.
Exp Biol Med (Maywood) Volume: 239 Page(s): 65 - 70
01/01/2014 Authors: Hyacinth HI; Capers PL; Archer DR; Hibbert JM
Using microfluidics to investigate hematopoietic stem cell and microniche interactions at the single cell level.
Methods Mol Biol Volume: 1185 Page(s): 223 - 233
01/01/2014 Authors: Ahn B; Wang Z; Archer DR; Lam WA
Targeted Treatment Of Acute Chest Syndrome In Transgenic Sickle Mice
Volume: 122
11/15/2013 Authors: Ghosh S; Adisa O; Chappa P; Tan F; Jackson KA; Archer DR; Ofori-Acquah SF
Extracellular hemin crisis triggers acute chest syndrome in sickle mice.
J Clin Invest Volume: 123 Page(s): 4809 - 4820
11/01/2013 Authors: Ghosh S; Adisa OA; Chappa P; Tan F; Jackson KA; Archer DR; Ofori-Acquah SF
Platelet functions require correct protein O-glycosylation
Volume: 22 Page(s): 1632 - 1632
11/01/2012 Authors: Wang Y; Jobe SM; Ding X; Choo H; Archer D; Mi R; Ju T; Cummings RD
Platelet biogenesis and functions require correct protein O-glycosylation.
Proc Natl Acad Sci U S A Volume: 109 Page(s): 16143 - 16148
10/02/2012 Authors: Wang Y; Jobe SM; Ding X; Choo H; Archer DR; Mi R; Ju T; Cummings RD
Th1 and Th2 cytokine levels are increased in murine models of human sickle cell anaemia maintained on a high protein calories feed
Volume: 157 Page(s): 7 - 7
04/01/2012 Authors: Hyacinth HI; Capers PL; Chappa P; Quarshie A; Newman G; Weitzman N; Archer DR; Hibbert JM
Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease.
Transfusion Volume: 52 Page(s): 231 - 240
02/01/2012 Authors: Hendrickson JE; Hod EA; Perry JR; Ghosh S; Chappa P; Adisa O; Kean LS; Ofori-Acquah SF; Archer DR; Spitalnik SL
Hematopoietic stem cell function in a murine model of sickle cell disease.
Anemia Volume: 2012 Page(s): 387385
01/01/2012 Authors: Javazon EH; Radhi M; Gangadharan B; Perry J; Archer DR
Measuring the Direct Effects of Sickle Cell Vaso-Occlusion on Endothelial Cells Using Microfluidic Technology
Volume: 118 Page(s): 410 - 410
11/18/2011 Authors: Myers DR; Sakurai Y; Chappa P; Barabino G; Archer DR; Lam W
Stem cell survival and functional outcome after traumatic brain injury is dependent on transplant timing and location.
Restor Neurol Neurosci Volume: 29 Page(s): 215 - 225
01/01/2011 Authors: Shear DA; Tate CC; Tate MC; Archer DR; LaPlaca MC; Stein DG; Dunbar GL
Cosmc Is Essential for O-Glycosylation of Platelet Glycoproteins and Platelet Function
Volume: 116 Page(s): 172 - 173
11/19/2010 Authors: Wang Y; Jobe S; Ding X; Archer DR; Mi R; Ju T; Cummings R
Cosmc is Essential for O-Glycosylation of Platelet Glycoproteins and Several Key Platelet Functions
Volume: 20 Page(s): 1458 - 1458
11/01/2010 Authors: Wang Y; Jobe S; Ding X; Archer D; Mi R; Ju T; Cummings R
Delivery of nucleic acid therapeutics by genetically engineered hematopoietic stem cells.
Adv Drug Deliv Rev Volume: 62 Page(s): 1204 - 1212
09/30/2010 Authors: Doering CB; Archer D; Spencer HT
Effect of High Protein Diet on Transgenic Sickle Mice
Volume: 24
04/01/2010 Authors: Capers PL; Hyacinth H; Cue S; Chappa P; Archer D; Hibbert J
Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production.
Am J Physiol Heart Circ Physiol Volume: 297 Page(s): H1647 - H1654
11/01/2009 Authors: Kleinhenz JM; Kleinhenz DJ; You S; Ritzenthaler JD; Hansen JM; Archer DR; Sutliff RL; Hart CM
Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain.
J Tissue Eng Regen Med Volume: 3 Page(s): 208 - 217
03/01/2009 Authors: Tate CC; Shear DA; Tate MC; Archer DR; Stein DG; LaPlaca MC
Berkeley Mice with Sickle Cell Disease Are Not More Immunizable to Transfused HOD Red Blood Cells Than Sickle Trait Control Mice
Volume: 112 Page(s): 114 - 114
11/16/2008 Authors: Hendrickson J; Archer DR; Perry JR; Hillyer CD; Zimring JC
C-reactive protein and interleukin-6 are decreased in transgenic sickle cell mice fed a high protein diet.
J Nutr Volume: 138 Page(s): 1148 - 1152
06/01/2008 Authors: Archer DR; Stiles JK; Newman GW; Quarshie A; Hsu LL; Sayavongsa P; Perry J; Jackson EM; Hibbert JM
Berkeley sickle cell disease mice exhibit multifaceted immune hyper-activation, and avidly reject allogeneic bone marrow transplantation.
Volume: 110 Page(s): 667A - 668A
11/16/2007 Authors: Kean LS; Hamby K; Perry J; Archer DR
Effects of timing, location, and environment on neural stem cell transplant survival, migration, differentiation, and functional recovery following experimental traumatic brain injury
Volume: 24 Page(s): 1231 - 1231
07/01/2007 Authors: Shear D; Tate C; Tate M; Archer D; Dunbar G; LaPlaca M; Stein D
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.
J Immunol Volume: 178 Page(s): 4194 - 4213
04/01/2007 Authors: Niu L; Strahotin S; Hewes B; Zhang B; Zhang Y; Archer D; Spencer T; Dillehay D; Kwon B; Chen L
Effects of sickle cell disease on hematopoietic stem cell function and the bone marrow microenvironment.
Volume: 108 Page(s): 361A - 361A
11/16/2006 Authors: Javazon EH; Kean LS; Perry J; Butler J; Archer DR
Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy.
Hum Gene Ther Volume: 17 Page(s): 798 - 806
08/01/2006 Authors: McMillin DW; Hewes B; Gangadharan B; Archer DR; Mittler RS; Spencer HT
Enforced expression of cytosolic 5'-nucleotidase I confers resistance to nucleoside analogues in vitro but systemic chemotherapy toxicity precludes in vivo selection.
Cancer Chemother Pharmacol Volume: 58 Page(s): 117 - 128
07/01/2006 Authors: Gray T; Morrey EL; Gangadharan B; Sumter TF; Spychala J; Archer DR; Spencer HT
Neural stem cell transplantation for traumatic brain injury
Volume: 23 Page(s): 1032 - 1032
06/01/2006 Authors: Shear D; Tate C; Tate M; Archer D; Hoffman S; Hulce V; LaPlaca M; Dunbar G; Stein D
Laminin enhances survival of neural stem cells transplanted into the traumatically injured brain
Volume: 23 Page(s): 1041 - 1041
06/01/2006 Authors: Tate C; Shear D; Tate M; Archer D; Stein D; LaPlaca M
A high protein diet decreases inflammation in a transgenic mouse model of sickle cell disease
Volume: 26 Page(s): E101 - E101
05/01/2006 Authors: Sayavongsa S; Creary MS; Newman G; Archer DR; Jackson E; Hibbert JM
Vascular abnormalities and pulmonary hypertension in the Berkeley sickle mouse
Volume: 106 Page(s): 890A - 890A
11/16/2005 Authors: Archer DR; Elms S; Boutwell J; Perry J; Sutliff R
Highly efficient transduction of repopulating bone marrow cells using rapidly concentrated polymer-complexed retrovirus.
Biochem Biophys Res Commun Volume: 330 Page(s): 768 - 775
05/13/2005 Authors: McMillin DW; Landzuri N; Gangadharan B; Hewes B; Archer DR; Spencer HT; Le Doux JM
Donor marker infidelity in transgenic hematopoietic stem cells.
Stem Cells Volume: 23 Page(s): 638 - 643
05/01/2005 Authors: Anderson DA; Wu Y; Jiang S; Zhang X; Streeter PR; Spangrude GJ; Archer DR; Fleming WH
Transplantation of methylcellulose scaffolds seeded with neural stem cells to the traumatically injured mouse brain
Volume: 193 Page(s): 259 - 259
05/01/2005 Authors: Schumm MA; Stabenfeldt SE; Archer DR; LaPlaca MC
Degeneration of myelinated efferent fibers prompts mitosis in Remak Schwann cells of uninjured C-fiber afferents.
J Neurosci Volume: 25 Page(s): 1179 - 1187
02/02/2005 Authors: Murinson BB; Archer DR; Li Y; Griffin JW
Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantation.
Volume: 1054 Page(s): 423 - 428
01/01/2005 Authors: Roberts C; Kean L; Archer D; Balkan C; Hsu LL
Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury.
Brain Res Volume: 1026 Page(s): 11 - 22
11/05/2004 Authors: Shear DA; Tate MC; Archer DR; Hoffman SW; Hulce VD; Laplaca MC; Stein DG
Genetic modification of embryonic stems cells to ectopically express proendocrine factors
Volume: 15 Page(s): 219A - 219A
11/01/2004 Authors: Chilton JM; Le Doux JM; Archer DR
Specific beta1 integrins mediate adhesion, migration, and differentiation of neural progenitors derived from the embryonic striatum.
Mol Cell Neurosci Volume: 27 Page(s): 22 - 31
09/01/2004 Authors: Tate MC; Garca AJ; Keselowsky BG; Schumm MA; Archer DR; LaPlaca MC
Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth.
Clin Cancer Res Volume: 10 Page(s): 5187 - 5201
08/01/2004 Authors: Landen JW; Hau V; Wang M; Davis T; Ciliax B; Wainer BH; Van Meir EG; Glass JD; Joshi HC; Archer DR
Strategies using retroviral coexpression of indoleamine 2,3 dioxygenase and Fas ligand for allogeneic bone marrow transplantation
Volume: 9 Page(s): S348 - S349
05/01/2004 Authors: Gangadharan B; Ide L; Holtzclaw D; Archer D; Spencer HT
Development of neural progenitor cells derived from embryonic stem cells.
Volume: 187 Page(s): 218 - 218
05/01/2004 Authors: Schumm MA; LaPlaca MC; Archer DR
Transduction of hematopoietic stem cells using polymer-concentrated ecotropic retrovirus coupled with in vivo selection of gene-modified cells
Volume: 9 Page(s): S153 - S154
05/01/2004 Authors: McMillin DW; Landazuri N; Gangadharan B; Archer D; Le Doux J; Spencer HT
Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease.
Blood Volume: 102 Page(s): 4582 - 4593
12/15/2003 Authors: Kean LS; Manci EA; Perry J; Balkan C; Coley S; Holtzclaw D; Adams AB; Larsen CP; Hsu LL; Archer DR
High efficiency transduction of murine hematopoietic stem cells using transiently produced and concentrated ecotropic retroviral supernatant.
Volume: 102 Page(s): 500B - 500B
11/16/2003 Authors: McMillin D; Landazuri N; Archer D; Le Doux J; Spencer T
Evidence for heterologous immunity in sickle-mediated allograft rejection.
Volume: 102 Page(s): 112A - 112A
11/16/2003 Authors: Kean L; Hamby K; Perry J; Rees P; Pearson T; Larsen C; Archer D
Chimerism and cure: Benchmarks for hematologic and pathologic correction of murine sickle cell disease with mixed RBC chimerism after nonmyeloablative bone marrow transplantation.
Volume: 100 Page(s): 46A - 46A
11/16/2002 Authors: Kean L; Manci E; Perry J; Balkan C; Coley S; Hsu L; Archer D
Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma.
Cancer Res Volume: 62 Page(s): 4109 - 4114
07/15/2002 Authors: Landen JW; Lang R; McMahon SJ; Rusan NM; Yvon A-M; Adams AW; Sorcinelli MD; Campbell R; Bonaccorsi P; Ansel JC
Long term survival and functional efficacy of transplanted neural stem cells in a mouse model of traumatic brain surgery
EXPERIMENTAL NEUROLOGY Volume: 175 Page(s): 421 - 421
06/01/2002 Authors: Shear DA; Tate MC; Archer DR; Hoffman SW; Haik KL; Hulce VD; LaPlaca MC; Stein DG
Migration of neural stem cells is enhanced on laminin and fibronectin: Implications for novel treatment strategies for traumatic brain injury
EXPERIMENTAL NEUROLOGY Volume: 175 Page(s): 421 - 421
06/01/2002 Authors: Tate MC; Shear DA; Stein DG; Archer DR; LaPlaca MC
Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure.
Exp Hematol Volume: 30 Page(s): 394 - 402
05/01/2002 Authors: Kean LS; Brown LE; Nichols JW; Mohandas N; Archer DR; Hsu LL
A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation.
Blood Volume: 99 Page(s): 1840 - 1849
03/01/2002 Authors: Kean LS; Durham MM; Adams AB; Hsu LL; Perry JR; Dillehay D; Pearson TC; Waller EK; Larsen CP; Archer DR
Fibronectin promotes survival and migration of primary neural stem cells transplanted into the traumatically injured mouse brain.
Volume: 11 Page(s): 283 - 295
01/01/2002 Authors: Tate MC; Shear DA; Hoffman SW; Stein DG; Archer DR; LaPlaca MC
Progressive correction of murine Sickle cell disease with increasing levels of red cell chimerism after allogeneic bone marrow transplantation.
BLOOD Volume: 98 Page(s): 172A - 172A
11/16/2001 Authors: Kean L; Durham M; Adams A; Hsu LL; Pearson T; Larsen C; Archer DR
A cure for murine sickle cell disease (SCD) through stable mixed chimerism and tolerance induction after non-myeloablative conditioning and MHC-mismatched bone marrow transplantation.
BLOOD Volume: 98 Page(s): 736A - 736A
11/16/2001 Authors: Kean L; Durham M; Adams A; Hsu LL; Waller E; Dillehay D; Pearson T; Larsen C; Archer DR
Predicting partial mixed chimerism in hemoglobinopathy transplant: A proposed simple math model.
BLOOD Volume: 98 Page(s): 16B - 16B
11/16/2001 Authors: Hsu LL; West C; Kean L; Archer D
A cure for murine beta-thalassemia (beta-THAL) through stable mixed chimerism after nonmyeloablative bone marrow transplantation (BMT).
BLOOD Volume: 98 Page(s): 438A - 439A
11/16/2001 Authors: West C; Kean L; Archer D; Hsu L
The alkaloid noscapine is a low toxicity agent with significant antitumor effects in melanoma
JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 117 Page(s): 484 - 484
08/01/2001 Authors: Lang R; Landen J; McMahon S; Adams A; Campbell R; Bonaccorsi P; Archer D; Ansel J; Joshi H; Armstrong C
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
J Immunol Volume: 167 Page(s): 1103 - 1111
07/15/2001 Authors: Adams AB; Durham MM; Kean L; Shirasugi N; Ha J; Williams MA; Rees PA; Cheung MC; Mittelstaedt S; Bingaman AW
Reticulocytosis and apoptosis: Ineffective erythropoiesis (IE) occurs in beta-thalassemic but not in sickle mice.
BLOOD Volume: 96 Page(s): 598A - +
11/16/2000 Authors: Kean L; Brown LE; Nichols JW; Narla M; Archer DR; Hsu LL
Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses.
Cancer Immunol Immunother Volume: 49 Page(s): 217 - 225
07/01/2000 Authors: Ke Y; Ye K; Grossniklaus HE; Archer DR; Joshi HC; Kapp JA
Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection.
Immunity Volume: 13 Page(s): 129 - 141
07/01/2000 Authors: Balachandran S; Roberts PC; Brown LE; Truong H; Pattnaik AK; Archer DR; Barber GN
Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway.
J Virol Volume: 74 Page(s): 1513 - 1523
02/01/2000 Authors: Balachandran S; Roberts PC; Kipperman T; Bhalla KN; Compans RW; Archer DR; Barber GN
In utero transplantation of human fetal hematopoietic cells in NOD/SCID mice.
BLOOD Volume: 92 Page(s): 287B - 287B
11/15/1998 Authors: Fleming WH; Archer DR; Wong J; Yeager AM; Turner CW
The transplantation potential of adult and fetal murine stem cells is determined by the recipient hematopoietic microenvironment.
BLOOD Volume: 92 Page(s): 56A - 56A
11/15/1998 Authors: Archer DR; Hester LE; Mulcahy JM; Yeager AM; Fleming WH
Successful in utero engraftment of allogeneic hematopoietic cells in murine beta-thalassemia.
BLOOD Volume: 92 Page(s): 267A - 267A
11/15/1998 Authors: Archer DR; Hester LE; Gu Y; Fleming WH; Yeager AM; Hsu LL
In utero transplantation of human fetal haemopoietic cells in NOD/SCID mice.
Br J Haematol Volume: 103 Page(s): 326 - 334
11/01/1998 Authors: Turner CW; Archer DR; Wong J; Yeager AM; Fleming WH
In utero transplantation of CD34+ human hematopoietic progenitor cells into non-human primates.
BLOOD Volume: 90 Page(s): 4161 - 4161
11/15/1997 Authors: Fleming WH; Wong J; Strobert E; Swenson B; Feng T; Webb G; Archer D; Turner CW
Sustained multilineage engraftment of allogeneic hematopoietic stem cells in NOD/SCID mice after in utero transplantation.
Blood Volume: 90 Page(s): 3222 - 3229
10/15/1997 Authors: Archer DR; Turner CW; Yeager AM; Fleming WH
Myelination following transplantation of EGF-responsive neural stem cells into a myelin-deficient environment.
Exp Neurol Volume: 147 Page(s): 84 - 95
09/01/1997 Authors: Hammang JP; Archer DR; Duncan ID
Competitive engraftment of adult and fetal murine hematopoietic progenitor cells following in utero transplantation.
EXPERIMENTAL HEMATOLOGY Volume: 25 Page(s): 44 - 44
08/01/1997 Authors: Archer DR; Turner CW; Turner PL; Hester LE; Yeager AM; Fleming WH
Myelination of the canine central nervous system by glial cell transplantation: a model for repair of human myelin disease.
Nat Med Volume: 3 Page(s): 54 - 59
01/01/1997 Authors: Archer DR; Cuddon PA; Lipsitz D; Duncan ID
High levels of engraftment of allogeneic hematopoietic stem cells following in utero transplantation.
BLOOD Volume: 88 Page(s): 2374 - 2374
11/15/1996 Authors: Fleming WH; Turner CW; Turner PL; Yeager AM; Archer DR
MULTIPLE CONGENIC BONE-MARROW TRANSPLANTS WITHOUT MYELOABLATION DO NOT PROLONG SURVIVAL IN DEMYELINATING MURINE LYSOSOMAL STORAGE DISEASE (THE TWITCHER MOUSE)
EXPERIMENTAL HEMATOLOGY Volume: 23 Page(s): 809 - 809
08/01/1995 Authors: RATANAPRASATPORN S; CANNON D; ARCHER DR; YEAGER AM
Acute dispersion of glial cells following transplantation into the myelin-deficient rat spinal cord.
Glia Volume: 14 Page(s): 237 - 242
07/01/1995 Authors: Lipsitz D; Archer DR; Duncan ID
Transplantation of an oligodendrocyte cell line leading to extensive myelination.
Proc Natl Acad Sci U S A Volume: 91 Page(s): 11616 - 11620
11/22/1994 Authors: Tontsch U; Archer DR; Dubois-Dalcq M; Duncan ID
Phosphorylation-dependent immunoreactivity of neurofilaments and the rate of slow axonal transport in the central and peripheral axons of the rat dorsal root ganglion.
J Neurochem Volume: 62 Page(s): 1119 - 1125
03/01/1994 Authors: Archer DR; Watson DF; Griffin JW
Myelination by cryopreserved xenografts and allografts in the myelin-deficient rat.
Exp Neurol Volume: 125 Page(s): 268 - 277
02/01/1994 Authors: Archer DR; Levn S; Duncan ID
Transplantation of glial cells enhances action potential conduction of amyelinated spinal cord axons in the myelin-deficient rat.
Proc Natl Acad Sci U S A Volume: 91 Page(s): 53 - 57
01/04/1994 Authors: Utzschneider DA; Archer DR; Kocsis JD; Waxman SG; Duncan ID
TRANSPLANTATION OF MYELINATING CELLS INTO THE CENTRAL-NERVOUS-SYSTEM
Volume: 258 Page(s): 195 - 206
01/01/1994 Authors: DUNCAN ID; ARCHER DR
Changes in slow axonal transport of tubulin induced by local application of colchicine to rabbit vagus nerve.
Acta Physiol Scand Volume: 150 Page(s): 57 - 65
01/01/1994 Authors: Archer DR; Dahlin LB; McLean WG
MYELINATION OF MYELIN-DEFICIENT RAT AXONS BY TRANSPLANTED GLIA RESTORES CONDUCTION
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY Volume: 52 Page(s): 287 - 287
05/01/1993 Authors: DUNCAN ID; UTZSCHNEIDER DA; ARCHER DR; KOCSIS JD; WAXMAN SG
Axonal transport and morphological changes following nerve compression. An experimental study in the rabbit vagus nerve.
J Hand Surg Br Volume: 18 Page(s): 106 - 110
02/01/1993 Authors: Dahlin LB; Archer DR; McLean WG
Functional capacities of transplanted cell-sorted adult oligodendrocytes.
Dev Neurosci Volume: 14 Page(s): 114 - 122
01/01/1992 Authors: Duncan ID; Paino C; Archer DR; Wood PM
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Proc Natl Acad Sci U S A Volume: 87 Page(s): 1561 - 1565
02/01/1990 Authors: Koo EH; Sisodia SS; Archer DR; Martin LJ; Weidemann A; Beyreuther K; Fischer P; Masters CL; Price DL
Changes in fast axonally transported proteins in the regenerating rabbit vagus nerve.
Neurosci Lett Volume: 87 Page(s): 151 - 156
04/22/1988 Authors: Archer DR; McLean WG
Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat.
Diabetologia Volume: 30 Page(s): 414 - 418
06/01/1987 Authors: Dahlin LB; Archer DR; McLean WG
Monoamine oxidase activities in dissociated cell fractions from rat skeletal muscle.
J Pharm Pharmacol Volume: 38 Page(s): 288 - 293
04/01/1986 Authors: Lyles GA; Archer DR

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David Archer PhD

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