Emory University School of Medicine
Emory University School of Medicine
Department of Biochemistry

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Department of Biochemistry

Publications

 *Corresponding author 
^Equal contributions

2024 

  1. Sastre DE, Sultana N, V A S Navarro M, Huliciak M, Du J, Cifuente JO, Flowers M, Liu X, Lollar P, Trastoy B, Guerin ME, Sundberg EJ.Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate.Nat Commun. 2024 Jun 15;15(1):5123. doi: 10.1038/s41467-024-48802-3. 

2023

  1. Kapoor-Vazirani P, Rath SK, Liu X, Shu Z, Bowen NE, Chen Y, Haji-Seyed-Javadi R, Daddacha W, Minten EV, Danelia D, Farchi D, Duong DM, Seyfried NT, Deng X, Ortlund EA, Kim B, Yu DS.SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.Nat Commun. 2022 Nov 7;13(1):6707. doi: 10.1038/s41467-022-34578-x.
  1. Proffitt MR, Liu X, Ortlund EA, Smith GT.Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.Mol Cell Endocrinol. 2023 Dec 1;578:112068. doi: 10.1016/j.mce.2023.112068.
  1. Krumm CS, Landzberg RS, Ramos-Espiritu L, Adura C, Liu X, Acuna M, Xie Y, Xu X, Tillman MC, Li Y, Glickman JF, Ortlund EA, Ginn JD, Cohen DE. High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease.Mol Metab. 2023 Dec;78:101832. doi: 10.1016/j.molmet.2023.101832. 
  1. Head PE, Kapoor-Vazirani P, Nagaraju GP, Zhang H, Rath SK, Luong NC, Haji-Seyed-Javadi R, Sesay F, Wang SY, Duong DM, Daddacha W, Minten EV, Song B, Danelia D, Liu X, Li S, Ortlund EA, Seyfried NT, Smalley DM, Wang Y, Deng X, Dynan WS, El-Rayes B, Davis AJ, Yu DS.DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.Nucleic Acids Res.2023 Aug 25;51(15):7972-7987. doi: 10.1093/nar/gkad549

2022

  1. Frank F, Keen MM, Rao A, Bassit L, Liu X, Bowers HB, Patel AB, Cato ML, Sullivan JA, Greenleaf M, Piantadosi A, Lam WA, Hudson WH, Ortlund EA.Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.Cell. 2022 Sep 15;185(19):3603-3616.e13.
  1. Mays SG, D'Agostino EH, Flynn AR, Huang X, Wang G, Liu X, Millings EJ, Okafor CD, Patel A, Cato ML, Cornelison JL, Melchers D, Houtman R, Moore DD, Calvert JW, Jui NT, Ortlund EA.A phospholipid mimetic targeting LRH-1 ameliorates colitis.Cell Chem Biol. 2022 Jul 21;29(7):1174-1186.e7. doi: 10.1016/j.chembiol.2022.03.001

2021

  1. Frank F, Ortlund EA, Liu X*.Structural insights into glucocorticoid receptor function.Biochem Soc Trans. 2021 Nov 1;49(5):2333-2343. doi: 10.1042/BST20210419 (*correspondence author).  doi: 10.1042/BST20210419.
  1. Liu X, Weikum ER, Tilo D, Vinson C, Ortlund EA.Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element.Nucleic Acids Res. 2021 Sep 7;49(15):8923-8933. doi: 10.1093/nar/gkab605.
  1. Frank F, Liu X, Ortlund EA.Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation.Proc Natl Acad Sci U S A.2021 Jul 27;118(30).
  1. Bruno NE, Nwachukwu JC, Srinivasan S, Nettles CC, Izard T, Jin Z, Nowak J, Cameron MD, Boregowda SV, Phinney DG, Elemento O, Liu X, Ortlund EA, Houtman R, Stavreva DA, Hager GL, Kamenecka TM, Kojetin DJ, Nettles KW. Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling. Nat Chem Biol. 2021 Mar;17(3):307-316. doi: 10.1038/s41589-020-00719-w

2020 

  1. Liu X, Wang Y, Gutierrez JS, Damsker JM, Nagaraju K, Hoffman EP, Ortlund EA.Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24285-24293. doi: 10.1073/pnas.2006890117.
  1. Wolfarth AA, Liu X, Darby TM, Boyer DJ, Spizman JB, Owens JA, Chandrasekharan B, Naudin CR, Hanley KZ, Robinson BS, Ortlund EA, Jones RM, Neish AS.Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.Cell Mol Gastroenterol Hepatol. 2020;10(4):713-727. doi: 10.1016/j.jcmgh.2020.06.011. 
  1. Mays SG, Stec J, Liu X, D'Agostino EH, Whitby RJ, Ortlund EA.Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist.Sci Rep.2020 Dec 17;10(1):22279. doi: 10.1038/s41598-020-79251-9.

2019

  1. Liu X, Wang Y, Ortlund EA.First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids.Mol Pharmacol. 2019 Oct;96(4):408-417. doi: 10.1124/mol.119.116806. (Cover Story ; Highlighted Trainee Author ).

11.Liu X, Golden LC, Lopez JA, Shepherd TR, Yu L, Fuentes EJ. Conformational Dynamics and Cooperativity Drive the Specificity of a Protein-Ligand Interaction. Biophys J. 2019 Jun 18;116(12):2314-2330. doi: 10.1016/j.bpj.2019.05.008. 

  1. Liu X, Fuentes EJ.Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition.Int Rev Cell Mol Biol. 2019;343:129-218. doi: 10.1016/bs.ircmb.2018.05.013.  

2018

  1. Weikum ER^, Liu X^, Ortlund EA.The nuclear receptor superfamily: A structural perspective.Protein Sci. 2018 Nov;27(11):1876-1892. doi: 10.1002/pro.3496 (^equal contribution) (Top Downloaded paper 2018-2019, WILEY).
  1. Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X.Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.J Med Chem. 2018 Dec 13;61(23):10588-10601. doi: 10.1021/acs.jmedchem.8b01219.
  1. Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X.Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.J Med Chem. 2018 Apr 12;61(7):3193-3208. doi: 10.1021/acs.jmedchem.8b00261. 
  1. Chen G, Chen J, Qiao Y, Shi Y, Liu W, Zeng Q, Xie H, Shi X, Sun Y, Liu X, Li T, Zhou L, Wan J, Xie T, Wang H, Wang F.ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair.Nucleic Acids Res. 2018 Feb 16;46(3):1266-1279. doi: 10.1093/nar/gkx1258. 

2016

  1. Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ. Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.Structure. 2016 Dec 6;24(12):2053-2066. doi: 10.1016/j.str.2016.08.019. 
  1. Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JSK, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X.Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.Cell Chem Biol. 2016 Jul 21;23(7):769-781. doi: 10.1016/j.chembiol.2016.06.006.
  1. Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA, Vertino PM, Fu H, Cheng X.Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.J Biol Chem. 2016 Feb 5;291(6):2631-46. doi: 10.1074/jbc.M115.698449 (Highlighted in Science Daily News and Cell Press Crosstalk).

Before 2015

  1. Liu X, Shepherd TR, Murray AM, Xu Z, Fuentes EJ.The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.Structure. 2013 Mar 5;21(3):342-54. doi: 10.1016/j.str.2013.01.004. (Cover Story; Selected by Faculty of 1000).
  1. Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J Mol Biol. 2010 May 21;398(5):730-46. doi: 10.1016/j.jmb.2010.03.047.