Domains: ATD, amino terminal domain; CTD, carboxyl terminal domain; S1, S2, agonist binding domain; M1-M4, membrane domains; DM, de novo; trans, transmitted.
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Functional Data represent fold changes in receptor activity by gene variant. For example, -2.3 is a 2.3 fold decrease in variant receptor activity compared to wild-type (no mutation) control. A "1" means no change from wild-type; ‡ indicates variant receptor current too small, unable to measure endpoint activity; Glu, Glutamate; Gly, Glycine; Mg2+, magnesium; Zn2+, zinc.