Principal Investigator
Mohamed Abdel Hakeem, PhD
Assistant Professor
Pathology Advanced Translational Research Unit
Department of Pathology & Laboratory Medicine
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Biography and Education
Mohamed obtained his B.Pharm. degree from Cairo University, then his M.Sc. and Ph.D. degrees from the University of Montreal. Following his graduate studies, he moved to the University of Pennsylvania, where he was a CRI Irvington, FRQS, and CanHepC Postdoctoral fellow.
Dr. Hakeem joined PATRU in September 2021.
Research Focus and Interests
During his M.Sc. graduate studies in the laboratory of Dr. Naglaa Shoukry, Mohamed investigated the effects of early versus late interferon treatment on the functional recovery of HCV-specific exhausted T lymphocytes (Tex). As a CIHR Banting and CanHepC Doctoral Fellow, he studied the cellular correlates of protective immunity against chronic viruses in HCV patients who cleared several episodes of infection, as well as the dynamics of the repertoire of T-cell receptor (TCR) associated with protective immunity upon reinfection.
In the laboratory of Dr. E. John Wherry at Penn Institute for Immunology, Mohamed investigated the transcriptional and epigenetic aspects of Tex recovery post cure form chronic disease, as well as factors affecting the recall capacity of Tex. Mohamed also collaborated with colleagues at UPenn to explore the subset dynamics of Tex and the roles of different microRNAs in the differentiation of Tex.
At PATRU, Dr. Hakeem continues to investigate T cells in the context of chronic viral infections and tumors. His current research interests at Emory include studying the different factors modulating the epigenetic landscapes of exhausted T cells (Tex), using both mouse models and human samples from patients. Concomitantly, he investigates factors that impact the recall and protective capacities of Tex.
Hakeem Lab Members
