Pallavi Bhattaram
Academic Appointment
- Assistant Professor, Emory University
Education
Degrees
- PhD from Centre for Cellular and Molecular Biology
Research
Focus
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Inflammatory Joint Diseases
Fibroblast-like synoviocytes (FLS) are cells lining the joint capsule. They play a critical role in the pathogenesis of several autoimmune inflammatory joint diseases (IJD) including rheumatoid arthritis (RA), psoriatic arthritis and juvenile idiopathic arthritis. FLS retain their pathological properties even after removing them from the inflammatory environment of the arthritic joints, and can initiate joint degeneration when transplanted into a healthy joint. It is suggested that the reprogramming of the FLS chromatin landscape governs their persistently pathological properties and contributes to our current inability to attain sustained remission at the clinical and molecular levels. Hence, the key for achieving relapse-free cure to IJDs likely lies within the FLS. The research focus of our laboratory is to elucidate the molecular mechanisms underlying the pathological features of FLS and to develop FLS-targeted therapeutic strategies for the effective treatment of inflammation in arthritic diseases.
Publications
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The distinct transcriptomic signature of the resolution phase fibroblast-like synoviocytes supports endothelial cell dysfunction.
Commun Biol Volume: 8 Page(s): 837
05/30/2025 Authors: Gautam S; Whittaker JE; Vekariya R; Ramirez-Perez S; Gangishetti U; Drissi H; Bhattaram P -
MyD88 dimerization inhibitor ST2825 targets the aggressiveness of synovial fibroblasts in rheumatoid arthritis patients.
Arthritis Res Ther Volume: 25 Page(s): 180
09/25/2023 Authors: Ramirez-Perez S; Vekariya R; Gautam S; Reyes-Perez IV; Drissi H; Bhattaram P -
Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures.
Elife Volume: 12
01/30/2023 Authors: Khan NM; Diaz-Hernandez ME; Chihab S; Priyadarshani P; Bhattaram P; Mortensen LJ; Guzzo RM; Drissi H -
Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy.
iScience Volume: 25 Page(s): 105548
12/22/2022 Authors: Ramirez-Perez S; Reyes-Perez IV; Martinez-Fernandez DE; Hernandez-Palma LA; Bhattaram P -
SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes.
Front Immunol Volume: 13 Page(s): 789349
01/01/2022 Authors: Jones K; Ramirez-Perez S; Niu S; Gangishetti U; Drissi H; Bhattaram P -
Human Adult Fibroblast-like Synoviocytes and Articular Chondrocytes Exhibit Prominent Overlap in Their Transcriptomic Signatures.
ACR Open Rheumatol Volume: 3 Page(s): 359 - 370
06/01/2021 Authors: Jones K; Angelozzi M; Gangishetti U; Haseeb A; de Charleroy C; Lefebvre V; Bhattaram P -
JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling.
Bone Volume: 143 Page(s): 115657
02/01/2021 Authors: Kamalakar A; McKinney JM; Salinas Duron D; Amanso AM; Ballestas SA; Drissi H; Willett NJ; Bhattaram P; Garca AJ; Wood LB -
Targeting MyD88 Downregulates Inflammatory Mediators and Pathogenic Processes in PBMC From DMARDs-Nave Rheumatoid Arthritis Patients.
Front Pharmacol Volume: 12 Page(s): 800220
01/01/2021 Authors: Ramirez-Perez S; Oregon-Romero E; Reyes-Perez IV; Bhattaram P -
The Habc domain of syntaxin 3 is a ubiquitin binding domain.
Sci Rep Volume: 10 Page(s): 21350
12/07/2020 Authors: Giovannone AJ; Reales E; Bhattaram P; Nackeeran S; Monahan AB; Syed R; Weimbs T -
Chronic exposure to TNF reprograms cell signaling pathways in fibroblast-like synoviocytes by establishing long-term inflammatory memory.
Sci Rep Volume: 10 Page(s): 20297
11/20/2020 Authors: Gangishetti U; Ramirez-Perez S; Jones K; Arif A; Drissi H; Bhattaram P