Jay Patel

Department of Orthopaedics
Assistant Professor

Overview

My research is focused on the repair and regeneration of musculoskeletal soft tissues. Specifically, we study and enhance cellular activity in these micro-environments, with the goal of taking novel biomaterial and therapeutic approaches from conceptualization to the clinic. We leverage principles of mechano-biology and cell-biomaterial interactions to guide macro-scale tissue engineering and functional outcomes in large animal models. By using engineering and biological principles, along with novel mechanical and imaging modalities, we strive to restore the structure, biology, and function of cartilage and meniscus tissues.

Academic Appointment

Assistant Professor (Program Faculty, Biomedical Engineering, Georgia Institute of Technology/Emory University
Health Science Specialist, Atlanta VA Medical Center
Assistant Professor, Orthopaedics, Emory University

Education

Degrees

Postdoctoral Fellowship from University of Pennsylvania
PhD from Rutgers - Robert Wood Johnson Medical School
BS Bioengineering from Rice University

Research

Publications

Generating New Meniscus Therapies via Recent Breakthroughs in Development, Model Systems, and Clinical Diagnostics.
J Orthop Res
03/11/2025 Authors: Irwin RM; Brown M; Koff MF; Lee CH; Lemmon E; Jeong HJ; Simmonds SP; Robinson JL; Seitz AM; Tanska P
The Interplay Between Early Chondrocyte Spreading and Inflammatory Responsivity.
Cytoskeleton (Hoboken)
03/05/2025 Authors: Pepper TI; Pucha SA; Foster L; Liu AY; Alexander M; Patel JM
Automated quantitative assessment of bone contusions and overlying articular cartilage following anterior cruciate ligament injury.
J Orthop Res Volume: 42 Page(s): 2495 - 2506
11/01/2024 Authors: Champagne AA; Zuleger TM; Warren SM; Smith DR; Lamplot JD; Xerogeanes JW; Slutsky-Ganesh AB; Jayaram P; Patel JM; Myer GD
Revealing Early Spatial Patterns of Cellular Responsivity in Fiber-Reinforced Microenvironments.
Tissue Eng Part A Volume: 30 Page(s): 614 - 626
10/01/2024 Authors: Pucha SA; Hasson M; Solomon H; McColgan GE; Robinson JL; Vega SL; Patel JM
Considering the Cellular Landscape in Marrow Stimulation Techniques for Cartilage Repair.
Cells Tissues Organs Volume: 213 Page(s): 523 - 537
01/01/2024 Authors: Hasson M; Fernandes LM; Solomon H; Pepper T; Huffman NL; Pucha SA; Bariteau JT; Kaiser JM; Patel JM
Transient inhibition of meniscus cell migration following acute inflammatory challenge.
J Orthop Res Volume: 41 Page(s): 2055 - 2064
09/01/2023 Authors: Lemmon EA; Bonnevie ED; Patel JM; Miller LM; Mauck RL
Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel.
Bioengineering (Basel) Volume: 10
08/27/2023 Authors: Brackin RB; McColgan GE; Pucha SA; Kowalski MA; Drissi H; Doan TN; Patel JM
Exogenous All-Trans Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice.
Invest Ophthalmol Vis Sci Volume: 64 Page(s): 22
05/01/2023 Authors: Brown DM; Yu J; Kumar P; Paulus QM; Kowalski MA; Patel JM; Kane MA; Ethier CR; Pardue MT
Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia.
Invest Ophthalmol Vis Sci Volume: 63 Page(s): 13
12/01/2022 Authors: Brown DM; Kowalski MA; Paulus QM; Yu J; Kumar P; Kane MA; Patel JM; Ethier CR; Pardue MT
Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism.
J Tissue Eng Regen Med Volume: 16 Page(s): 1138 - 1148
12/01/2022 Authors: Kowalski MA; Fernandes LM; Hammond KE; Labib S; Drissi H; Patel JM
Plant Tissue Parenchyma and Vascular Bundles Selectively Regulate Stem Cell Mechanosensing and Differentiation.
Cell Mol Bioeng Volume: 15 Page(s): 439 - 450
10/01/2022 Authors: Driscoll K; Butani MS; Gultian KA; McSweeny A; Patel JM; Vega SL
Stable human cartilage progenitor cell line stimulates healing of meniscal tears and attenuates post-traumatic osteoarthritis.
Front Bioeng Biotechnol Volume: 10 Page(s): 970235
01/01/2022 Authors: Desai S; Dooner M; Newberry J; Twomey-Kozak J; Molino J; Trivedi J; Patel JM; Owens BD; Jayasuriya CT
In Situ Assessment of Porcine Osteochondral Repair Tissue in the Visible-Near Infrared Spectral Region.
Front Bioeng Biotechnol Volume: 10 Page(s): 885369
01/01/2022 Authors: Kandel S; Querido W; Falcon JM; Zlotnick HM; Locke RC; Stoeckl B; Patel JM; Patil CA; Mauck RL; Pleshko N
Editorial: Post-Traumatic Osteoarthritis After Meniscus Injury.
Front Bioeng Biotechnol Volume: 10 Page(s): 893800
01/01/2022 Authors: Patel JM; Haut Donahue TL; Galbusera F; Drews BH; Seitz AM
Impediments to Meniscal Repair: Factors at Play Beyond Vascularity.
Front Bioeng Biotechnol Volume: 10 Page(s): 843166
01/01/2022 Authors: Patel JM
Resorbable Pins to Enhance Scaffold Retention in a Porcine Chondral Defect Model.
Cartilage Volume: 13 Page(s): 1676S - 1687S
12/01/2021 Authors: Patel JM; Sennett ML; Martin AR; Saleh KS; Eby MR; Ashley BS; Miller LM; Dodge GR; Burdick JA; Carey JL
Six-Month Outcomes of Clinically Relevant Meniscal Injury in a Large-Animal Model.
Orthop J Sports Med Volume: 9 Page(s): 23259671211035444
11/01/2021 Authors: Bansal S; Meadows KD; Miller LM; Saleh KS; Patel JM; Stoeckl BD; Lemmon EA; Hast MW; Zgonis MH; Scanzello CR
Meniscal repair: The current state and recent advances in augmentation.
J Orthop Res Volume: 39 Page(s): 1368 - 1382
07/01/2021 Authors: Bansal S; Floyd ER; A Kowalski M; Aikman E; Elrod P; Burkey K; Chahla J; LaPrade RF; Maher SA; Robinson JL
Marked differences in local bone remodelling in response to different marrow stimulation techniques in a large animal.
Eur Cell Mater Volume: 41 Page(s): 546 - 557
05/19/2021 Authors: Zlotnick HM; Locke RC; Stoeckl BD; Patel JM; Gupta S; Browne KD; Koh J; Carey JL; Mauck RL
Stabilization of Damaged Articular Cartilage with Hydrogel-Mediated Reinforcement and Sealing.
Adv Healthc Mater Volume: 10 Page(s): e2100315
05/01/2021 Authors: Patel JM; Loebel C; Saleh KS; Wise BC; Bonnevie ED; Miller LM; Carey JL; Burdick JA; Mauck RL
Nanofibrous hyaluronic acid scaffolds delivering TGF-3 and SDF-1 for articular cartilage repair in a large animal model.
Acta Biomater Volume: 126 Page(s): 170 - 182
05/01/2021 Authors: Martin AR; Patel JM; Locke RC; Eby MR; Saleh KS; Davidson MD; Sennett ML; Zlotnick HM; Chang AH; Carey JL
Targeting cartilage EGFR pathway for osteoarthritis treatment.
Sci Transl Med Volume: 13
01/13/2021 Authors: Wei Y; Luo L; Gui T; Yu F; Yan L; Yao L; Zhong L; Yu W; Han B; Patel JM
Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
Eur Cell Mater Volume: 41 Page(s): 40 - 51
01/07/2021 Authors: Sennett ML; Friedman JM; Ashley BS; Stoeckl BD; Patel JM; Alini M; Cucchiarini M; Eglin D; Madry H; Mata A
Transection of the medial meniscus anterior horn results in cartilage degeneration and meniscus remodeling in a large animal model.
J Orthop Res Volume: 38 Page(s): 2696 - 2708
12/01/2020 Authors: Bansal S; Miller LM; Patel JM; Meadows KD; Eby MR; Saleh KS; Martin AR; Stoeckl BD; Hast MW; Elliott DM
Personalized Fiber-Reinforcement Networks for Meniscus Reconstruction.
J Biomech Eng Volume: 142
05/01/2020 Authors: Patel JM; Brzezinski A; Ghodbane SA; Tarapore R; Lu TM; Gatt CJ; Dunn MG
Biomechanical characterization of a novel collagen-hyaluronan infused 3D-printed polymeric device for partial meniscus replacement.
J Biomed Mater Res B Appl Biomater Volume: 107 Page(s): 2457 - 2465
11/01/2019 Authors: Ghodbane SA; Patel JM; Brzezinski A; Lu TM; Gatt CJ; Dunn MG
A Systematic Review and Guide to Mechanical Testing for Articular Cartilage Tissue Engineering.
Tissue Eng Part C Methods Volume: 25 Page(s): 593 - 608
10/01/2019 Authors: Patel JM; Wise BC; Bonnevie ED; Mauck RL
Bioactive factors for cartilage repair and regeneration: Improving delivery, retention, and activity.
Acta Biomater Volume: 93 Page(s): 222 - 238
07/15/2019 Authors: Patel JM; Saleh KS; Burdick JA; Mauck RL
Partial Meniscus Replacement with a Collagen-Hyaluronan Infused Three-Dimensional Printed Polymeric Scaffold.
Tissue Eng Part A Volume: 25 Page(s): 379 - 389
03/01/2019 Authors: Ghodbane SA; Brzezinski A; Patel JM; Plaff WH; Marzano KN; Gatt CJ; Dunn MG
Emerging therapies for cartilage regeneration in currently excluded 'red knee' populations.
NPJ Regen Med Volume: 4 Page(s): 12
01/01/2019 Authors: Martn AR; Patel JM; Zlotnick HM; Carey JL; Mauck RL
Interference Screw Versus Suture Endobutton Fixation of a Fiber-Reinforced Meniscus Replacement Device in a Human Cadaveric Knee Model.
Am J Sports Med Volume: 46 Page(s): 2133 - 2141
07/01/2018 Authors: Patel JM; Brzezinski A; Raole DA; Dunn MG; Gatt CJ
Tissue-Engineered Total Meniscus Replacement With a Fiber-Reinforced Scaffold in a 2-Year Ovine Model.
Am J Sports Med Volume: 46 Page(s): 1844 - 1856
07/01/2018 Authors: Patel JM; Ghodbane SA; Brzezinski A; Gatt CJ; Dunn MG
Carbodiimide cross-linking counteracts the detrimental effects of gamma irradiation on the physical properties of collagen-hyaluronan sponges.
J Mater Sci Mater Med Volume: 29 Page(s): 75
05/28/2018 Authors: Patel JM; Jackson RC; Schneider GL; Ghodbane SA; Dunn MG
* The Ovine Model for Meniscus Tissue Engineering: Considerations of Anatomy, Function, Implantation, and Evaluation.
Tissue Eng Part C Methods Volume: 23 Page(s): 829 - 841
12/01/2017 Authors: Brzezinski A; Ghodbane SA; Patel JM; Perry BA; Gatt CJ; Dunn MG
Negative Outcomes of Poly(l-Lactic Acid) Fiber-Reinforced Scaffolds in an Ovine Total Meniscus Replacement Model.
Tissue Eng Part A Volume: 22 Page(s): 1116 - 1125
09/01/2016 Authors: Patel JM; Merriam AR; Kohn J; Gatt CJ; Dunn MG
One-Year Outcomes of Total Meniscus Reconstruction Using a Novel Fiber-Reinforced Scaffold in an Ovine Model.
Am J Sports Med Volume: 44 Page(s): 898 - 907
04/01/2016 Authors: Patel JM; Merriam AR; Culp BM; Gatt CJ; Dunn MG
Successful Total Meniscus Reconstruction Using a Novel Fiber-Reinforced Scaffold: A 16- and 32-Week Study in an Ovine Model.
Am J Sports Med Volume: 43 Page(s): 2528 - 2537
10/01/2015 Authors: Merriam AR; Patel JM; Culp BM; Gatt CJ; Dunn MG
Mechanical activation of a multimeric adhesive protein through domain conformational change.
Phys Rev Lett Volume: 110 Page(s): 108102
03/08/2013 Authors: Wijeratne SS; Botello E; Yeh H-C; Zhou Z; Bergeron AL; Frey EW; Patel JM; Nolasco L; Turner NA; Moake JL

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