Complement is activated in patients with Acute Chest Syndrome caused by Sickle Cell Disease and represents a therapeutic target. Chonat S, Jones JA, Patel SR, Briones WM, Schoettler ML, Maarouf M, Jeffers LA, Adisa O, Tan F, Fields E, Sterling MS, Jajosky RP, Verkerke H, Graciaa SH, Foppiani EM, Fasano RM, Zerra PE, Qiu Y, Arthur CM, Lam WA, Ofori-Acquah SF, Koval M, Joiner CH, Archer DR, Stowell SR. Sci Transl Med. 2025 Jul 16;17(807). PMID: 40668893
Diagnosis and management of pyruvate kinase deficiency: international expert guidelines. Al-Samkari H, Shehata N, Lang-Robertson K, Bianchi P, Glenthøj A, Sheth S, Neufeld EJ, Rees DC, Chonat S, Kuo KHM, Rothman JA, Barcellini W, van Beers EJ, Pospíšilová D, Shah AJ, van Wijk R, Glader B, Mañú Pereira MDM, Andres O, Kalfa TA, Eber SW, Gallagher PG, Kwiatkowski JL, Galacteros F, Lander C, Watson A, Elbard R, Peereboom D, Grace RF. Lancet Haematol. 2024 Mar;11(3):e228-e239. doi: 10.1016/S2352-3026(23)00377-0. Epub 2024 Feb 5. PMID: 38330977
Factor H Autoantibodies Contribute to Complement Dysregulation in Multisystem Inflammatory Syndrome in Children (MIS-C). Am J Hematol. 2023 May;98(5):E98-E101. PMCID PMC10089943. Zerra PE, Stowell J, Verkerke H, McCoy J, Jones J, Graciaa S, Lu A, Hussaini L, Anderson EJ, Rostad CA, Stowell SR, Chonat S.
Clinical features and neurological outcomes in pediatric immune-mediated thrombotic thrombocytopenic purpura: A report from a large pediatric hematology center. Graciaa S, Adeagbo S, Fong G, Rollins M, McElfresh P, Zerra PE, Bennett C, Josephson CD, Briones M, Fasano RM, Chonat S. Pediatr Blood Cancer. 2022 Dec;69(12):e29992. doi: 10.1002/pbc.29992. Epub 2022 Sep 24.PMID: 36151977
Sickle cell disease is a risk factor for transplant-associated thrombotic microangiopathy in children. Blood Adv. 2022 Sep 8. PMID: 36075028. Schoettler M, Stenger EO, Spencer K, Lutterman D, Rumbika S, Jones JA, Haight AE, Parikh SH, Qayed M, Watkins B, Lakshmanan K, Williams KM, Chonat S.
Pyruvate kinase deficiency in children. Chonat S, Eber SW, Holzhauer S, Kollmar N, Morton DH, Glader B, Neufeld EJ, Yaish HM, Rothman JA, Sharma M, Ravindranath Y, Wang H, Breakey VR, Sheth S, Bradeen HA, Al-Sayegh H, London WB, Grace RF. Pediatr Blood Cancer. 2021 Sep;68(9):e29148. doi: 10.1002/pbc.29148. Epub 2021 Jun 14. PMID: 34125488
Complement Mediated Thrombotic Microangiopathy in Sickle Cell Disease. Haematologica. 2020 Dec 1;105(12):2887-2891. PMCID: PMC7716365. Chonat S, Graciaa S, Shin HS, Newton JG, Quarmyne MO, Boudreaux J, Tang A, Zerra PE, Rollins MR, Josephson CD, Brown C, Joiner CH, Fasano RM, Stowell SR.
The Spectrum of SPTA1-Associated Hereditary Spherocytosis. Front Physiol. 2019 Jul 3;10:815. PMCID: PMC6617536 Chonat S, Risinger M, Sakthivel H, Niss O, Rothman JA, Hsieh L, Chou ST, Kwiatkowski JL, Khandros E, Gorman MF, Wells DT, Maghathe T, Dagaonkar N, Seu KG, Zhang K, Zhang W, Kalfa TA.
Contribution of alternative complement pathway to delayed hemolytic transfusion reaction in sickle cell disease. Chonat S, Quarmyne MO, Bennett CM, Dean CL, Joiner CH, Fasano RM, Stowell SR. Haematologica. 2018 Oct;103(10):e483-e485.