Paul Dawson
- Department of Pediatrics
Professor
- (404) 727-7083
- paul.dawson@emory.edu
- Pediatric Research Alliance Faculty Page
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Emory University, Atlanta
Pediatrics
1760 Haygood Drive, Suite E220, #E206
Overview
Dr. Dawsons research is focused on elucidating the physiologic and molecular mechanisms controlling bile acid homeostasis and their relationship to the pathogenesis of disease. The major goals are to understand how dysfunction of the gut-liver axis contributes to hepatic, gastrointestinal, and metabolic diseases and to exploit those insights to develop new preventative measures and therapies. These efforts include investigating the gut microbiotas role and its untapped therapeutic potential. In 2014, Dr. Dawson moved with along his research group to Emory University to further pursue these goals. The scope of the health problems studied range from rare monogenic intestinal and liver disorders (Primary Bile Acid Malabsorption, Progressive Familial Intrahepatic Cholestasis) to Non-alcoholic Fatty Liver Disease (the most common liver abnormality in children). Toward that end, the Lab utilizes a wide variety of approaches including Genomics, Metabolomics, Gnotobiotics, and Novel Mouse Models.
Academic Appointment
- Professor, Pediatrics, Emory University
Education
Degrees
- PhD from Stony Brook University, Stony Brook
- BS from University of Florida, Gainesville
Research
Publications
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Erratum to: 'Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis' [J Hepatol (2024) 80:268-281].
J Hepatol
03/15/2025 Authors: Ghallab A; Gonzlez D; Strngberg E; Hofmann U; Myllys M; Hassan R; Hobloss Z; Brackhagen L; Begher-Tibbe B; Duda JC -
Hepatic bile acid accretion correlates with cholestatic liver injury and therapeutic response in Cyp2c70 knockout mice with a humanized bile acid composition.
Am J Physiol Gastrointest Liver Physiol Volume: 327 Page(s): G789 - G809
12/01/2024 Authors: Klindt C; Truong JK; Bennett AL; Pachura KJ; Herebian D; Mayatepek E; Luedde T; Ebert M; Karpen SJ; Dawson PA -
Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea.
Cell Host Microbe Volume: 32 Page(s): 1488 - 1501.e5
09/11/2024 Authors: Peiper AM; Morales Aparicio J; Hu Z; Phophi L; Helm EW; Rubinstein RJ; Phillips M; Williams CG; Subramanian S; Cross M -
BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images.
Am J Physiol Gastrointest Liver Physiol Volume: 327 Page(s): G1 - G15
07/01/2024 Authors: Hellen DJ; Fay ME; Lee DH; Klindt-Morgan C; Bennett A; Pachura KJ; Grakoui A; Huppert SS; Dawson PA; Lam WA -
Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis.
J Hepatol Volume: 80 Page(s): 268 - 281
02/01/2024 Authors: Ghallab A; Gonzlez D; Strngberg E; Hofmann U; Myllys M; Hassan R; Hobloss Z; Brackhagen L; Begher-Tibbe B; Duda JC -
Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice.
EXCLI J Volume: 23 Page(s): 1330 - 1352
01/01/2024 Authors: Ghallab A; Kunz S; Drossel C; Billo V; Friebel A; Georg M; Gttlich R; Hobloss Z; Hassan R; Myllys M -
Quantifying Forms and Functions of Enterohepatic Bile Acid Pools in Mice.
Cell Mol Gastroenterol Hepatol Volume: 18 Page(s): 101392
01/01/2024 Authors: Sudo K; Delmas-Eliason A; Soucy S; Barrack KE; Liu J; Balasubramanian A; Shu CJ; James MJ; Hegner CL; Dionne HD -
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2.
Am J Physiol Gastrointest Liver Physiol Volume: 325 Page(s): G446 - G452
11/01/2023 Authors: Smyth JS; Truong JK; Rao A; Lin R; Foulke-Abel J; Adorini L; Donowitz M; Dawson PA; Keely SJ -
The Concise Guide to PHARMACOLOGY 2023/24: Transporters.
Br J Pharmacol Volume: 180 Suppl 2 Page(s): S374 - S469
10/01/2023 Authors: Alexander SPH; Fabbro D; Kelly E; Mathie AA; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Davies JA -
Combination of Ileal bile acid transporter inhibitor and a nonsteroidal Farnesoid X receptor agonist for reversal of cholestatic liver injury in Cyp2c70 KO mice with a humanized bile acid composition
Volume: 78 Page(s): S415 - S416
06/01/2023 Authors: Klindt-Morgan C; Truong J; Bennett A; Pachura K; Herebian D; Mayatepek E; Karpen SJ; Dawson P