Publications

• Local FK506 delivery induces osteogenesis in rat bone defect and rabbit spine fusion models.
  Bone Volume: 187 Page(s): 117195
  10/01/2024 Authors: Andraca Harrer J; Fulton TM; Sangadala S; Kaiser JM; Devereaux EJ; Oliver C; Presciutti SM; Boden SD; Willett NJ
• Local FK506 delivery induces osteogenesis in in vivo rat bone defect and rabbit spine fusion models.
  bioRxiv
  03/13/2024 Authors: Harrer JA; Fulton TM; Sangadala S; Kaiser J; Devereaux EJ; Oliver C; Presciutti SM; Boden SD; Willett NJ
• Sclerostin small-molecule inhibitors promote osteogenesis by activating canonical Wnt and BMP pathways.
  Elife Volume: 12
  08/10/2023 Authors: Sangadala S; Kim CH; Fernandes LM; Makkar P; Beck GR; Boden SD; Drissi H; Presciutti SM
• Multifocal heterotopic ossification in a man with germline variants of LIM Mineralization Protein-1 (LMP-1).
  Am J Med Genet A Volume: 191 Page(s): 2164 - 2174
  08/01/2023 Authors: Sangadala S; Shore EM; Xu M; Bergwitz C; Lozano-Calderon SA; Lin AE; Boden SD; Kaplan FS
• Correction: Sangadala, S. et al. FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis. Int. J. Mol. Sci. 2019, 20, 1900.
  Int J Mol Sci Volume: 21
  08/31/2020 Authors: Sangadala S; Devereaux EJ; Presciutti SM; Boden SD; Willett NJ
• Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia.
  J Clin Invest Volume: 130 Page(s): 4396 - 4410
  08/03/2020 Authors: Pinzon-Guzman C; Sangadala S; Riera KM; Popova EY; Manning E; Huh WJ; Alexander MS; Shelton JS; Boden SD; Goldenring JR
• FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis.
  Int J Mol Sci Volume: 20
  04/17/2019 Authors: Sangadala S; Devereaux EJ; Presciutti SM; Boden SD; Willet NJ
• Lim mineralization protein-1 knockout mice have reduced spine trabecular bone density on microcomputed tomography due to decreased bone morphogenetic protein responsiveness.
  Neurosurgery Volume: 61 Suppl 1 Page(s): 182 - 186
  08/01/2014 Authors: Gary MF; Viggeswarapu M; Oliver C; Teklemariam M; Sangadala S; Titus L; Boden SD
• Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1.
  Mol Cell Biochem Volume: 385 Page(s): 145 - 157
  01/01/2014 Authors: Sangadala S; Yoshioka K; Enyo Y; Liu Y; Titus L; Boden SD
• Link protein N-terminal peptide binds to bone morphogenetic protein (BMP) type II receptor and drives matrix protein expression in rabbit intervertebral disc cells.
  J Biol Chem Volume: 288 Page(s): 28243 - 28253
  09/27/2013 Authors: Wang Z; Weitzmann MN; Sangadala S; Hutton WC; Yoon ST
• LMP Knockout Mice Have Reduced Spine Trabecular Bone Density on Micro-Computed Tomography Due to Decreased BMP Responsiveness
  Volume: 60 Page(s): 186 - 186
  08/01/2013 Authors: Gary MF; Viggeswarapu M; Oliver C; Bargouti M; Teklemariam M; Sangadala S; Titus L; Boden S
• A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair.
  J Bone Joint Surg Am Volume: 95 Page(s): 454 - 461
  03/06/2013 Authors: Wong E; Sangadala S; Boden SD; Yoshioka K; Hutton WC; Oliver C; Titus L
• Pdlim7 (LMP) Knock-Out Mice Display a Significant Decrease in Trabecular Bone Volume
  Volume: 28
  02/01/2013 Authors: Viggeswarapu M; Gary M; Oliver C; Teklemariam M; Sangadala S; Titus FL; Boden SD
• A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype.
  Mol Cell Biochem Volume: 349 Page(s): 97 - 106
  03/01/2011 Authors: Kato S; Sangadala S; Tomita K; Titus L; Boden SD
• Osteoinductive LIM mineralization protein-1 suppresses activation of NF-kappaB and selectively regulates MAPK pathways in pre-osteoclasts.
  Bone Volume: 46 Page(s): 1328 - 1335
  05/01/2010 Authors: Liu H; Bargouti M; Zughaier S; Zheng Z; Liu Y; Sangadala S; Boden SD; Titus L
• Virtual screening and selection of drug-like compounds to block noggin interaction with bone morphogenetic proteins.
  J Mol Graph Model Volume: 28 Page(s): 670 - 682
  04/01/2010 Authors: Ahmed S; Metpally RPR; Sangadala S; Reddy BVB
• Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein-2 activity.
  Cell Biochem Funct Volume: 27 Page(s): 526 - 534
  12/01/2009 Authors: Okada M; Sangadala S; Liu Y; Yoshida M; Reddy BVB; Titus L; Boden SD
• Engineering, cloning, and functional characterization of recombinant LIM mineralization protein-1 containing an N-terminal HIV-derived membrane transduction domain.
  Protein Expr Purif Volume: 65 Page(s): 165 - 173
  06/01/2009 Authors: Sangadala S; Okada M; Liu Y; Viggeswarapu M; Titus L; Boden SD
• Modeling and analysis of MH1 domain of Smads and their interaction with promoter DNA sequence motif.
  J Mol Graph Model Volume: 27 Page(s): 803 - 812
  04/01/2009 Authors: Makkar P; Metpally RPR; Sangadala S; Reddy BVB
• Expression, purification and mass spectrometric analysis of LIM mineralization protein-1 in human lung epithelial cells.
  Acta Biochim Biophys Sin (Shanghai) Volume: 40 Page(s): 909 - 918
  11/01/2008 Authors: Sangadala S; Titus L; Boden SD
• Characterization of Jun Activation-Domain Binding Protein (Jab1)-Interacting Motif in LIM Mineralization Protein-1
  Volume: 23 Page(s): S139 - S139
  09/01/2008 Authors: Sangadala S; Liu Y; Viggeswarupu M; Titus L; Boden S
• Truncated human LMP-1 triggers differentiation of C2C12 cells to an osteoblastic phenotype in vitro.
  Acta Biochim Biophys Sin (Shanghai) Volume: 39 Page(s): 693 - 700
  09/01/2007 Authors: Fei Q; Boden SD; Sangadala S; Viggeswarapu M; Liu Y; Titus L
• Modeling and analysis of molecularinteraction between Smurf1-WW2 domain and various isoforms of LIM mineralization protein.
  Proteins Volume: 68 Page(s): 690 - 701
  08/15/2007 Authors: Sangadala S; Boden SD; Metpally RPR; Reddy BVB
• Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1, Smad5, and Smad6--modeling and analysis.
  J Biomol Struct Dyn Volume: 25 Page(s): 11 - 23
  08/01/2007 Authors: Sangadala S; Metpally RPR; Reddy BVB
• Molecular Interaction Between Smurfl WW2 Domain and PPXY Motifs of Smadl, Smad5, and Smad6-Modeling and Analysis.
  J Biomol Struct Dyn Volume: 25 Page(s): 11 - 23
  08/01/2007 Authors: Sangadala S; Rao Metpally RP; B Reddy BV
• Inhibition of Smurf1 potentiates BMP-2 activity.
  Volume: 21 Page(s): S34 - S34
  09/01/2006 Authors: Sangadala S; Boden SD; Viggeswarapu M; Liu Y; Titus L
• LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads.
  J Biol Chem Volume: 281 Page(s): 17212 - 17219
  06/23/2006 Authors: Sangadala S; Boden SD; Viggeswarapu M; Liu Y; Titus L
• LMP-1 interacts with Smurf1 and potentiates cellular responsiveness to BMP-2.
  Volume: 20 Page(s): S320 - S320
  09/01/2005 Authors: Sangadala S; Liu Y; Viggeswarapu M; Boden SD; Titus L
• Cloning, expression and properties of porcine trachea UDP-galnac: polypeptide N-acetylgalactosaminyl transferase.
  Mol Cell Biochem Volume: 266 Page(s): 117 - 126
  11/01/2004 Authors: Sangadala S; Swain JB; McNear A; Mendicino J
• Use of LMP-1 fusion protein to induce bone formation without risks of gene therapy.
  Volume: 18 Page(s): S185 - S185
  09/01/2003 Authors: Sangadala S; Titus L; Viggeswarapu M; Liu Y; Hair GA; Gibson E; Oliver C; Boden SD
• Denaturation of either Manduca sexta aminopeptidase N or Bacillus thuringiensis Cry1A toxins exposes binding epitopes hidden under nondenaturing conditions.
  Appl Environ Microbiol Volume: 68 Page(s): 2106 - 2112
  05/01/2002 Authors: Daniel A; Sangadala S; Dean DH; Adang MJ
• Polydispersity of Bacillus thuringiensis Cry1 toxins in solution and its effect on receptor binding kinetics.
  Biochim Biophys Acta Volume: 1594 Page(s): 266 - 275
  02/11/2002 Authors: Masson L; Mazza A; Sangadala S; Adang MJ; Brousseau R
• Carbohydrate analyses of Manduca sexta aminopeptidase N, co-purifying neutral lipids and their functional interactions with Bacillus thuringiensis Cry1Ac toxin.
  Insect Biochem Mol Biol Volume: 32 Page(s): 97 - 107
  12/01/2001 Authors: Sangadala S; Azadi P; Carlson R; Adang MJ
• Binding of Bacillus thuringiensis Cry1Ac toxin to Manduca sexta aminopeptidase-N receptor is not directly related to toxicity.
  FEBS Lett Volume: 462 Page(s): 373 - 376
  12/03/1999 Authors: Jenkins JL; Lee MK; Sangadala S; Adang MJ; Dean DH
• Synthesis of sulfated oligosaccharides by cystic fibrosis trachea epithelial cells.
  Mol Cell Biochem Volume: 201 Page(s): 141 - 149
  11/01/1999 Authors: Mendicino J; Sangadala S
• Domain III of the Bacillus thuringiensis delta-endotoxin Cry1Ac is involved in binding to Manduca sexta brush border membranes and to its purified aminopeptidase N.
  Mol Microbiol Volume: 31 Page(s): 463 - 471
  01/01/1999 Authors: de Maagd RA; Bakker PL; Masson L; Adang MJ; Sangadala S; Stiekema W; Bosch D
• Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase from swine trachea epithelium.
  Mol Cell Biochem Volume: 185 Page(s): 135 - 145
  08/01/1998 Authors: Mendicino J; Sangadala S
• The heliothis virescens 170 kDa aminopeptidase functions as "receptor A" by mediating specific Bacillus thuringiensis Cry1A delta-endotoxin binding and pore formation.
  Insect Biochem Mol Biol Volume: 27 Page(s): 735 - 743
  01/01/1997 Authors: Luo K; Sangadala S; Masson L; Mazza A; Brousseau R; Adang MJ
• PROPERTIES OF BACILLUS-THURINGIENSIS CRYIAC AND CRYIC DELTA-ENDOTOXIN BINDING IN SUSCEPTIBLE AND RESISTANT INSECTS
  Page(s): 191 - 191
  03/10/1995 Authors: ADANG M; LUO K; LU YJ; SANGADALA S; GARCZYNSKI S
• A mixture of Manduca sexta aminopeptidase and phosphatase enhances Bacillus thuringiensis insecticidal CryIA(c) toxin binding and 86Rb(+)-K+ efflux in vitro.
  J Biol Chem Volume: 269 Page(s): 10088 - 10092
  04/01/1994 Authors: Sangadala S; Walters FS; English LH; Adang MJ
• Structures of sulfated oligosaccharides in human trachea mucin glycoproteins.
  Mol Cell Biochem Volume: 126 Page(s): 37 - 47
  09/08/1993 Authors: Sangadala S; Bhat UR; Mendicino J
• Quantitation and structures of oligosaccharide chains in human trachea mucin glycoproteins.
  Mol Cell Biochem Volume: 118 Page(s): 75 - 90
  12/02/1992 Authors: Sangadala S; Bhat UR; Mendicino J
• Characterization of mucin glycoprotein-specific translation products from swine and human trachea, pancreas and colon.
  Mol Cell Biochem Volume: 106 Page(s): 1 - 14
  07/24/1991 Authors: Sangadala S; Wallace P; Mendicino J
• Immunological characterization of deglycosylated human and swine trachea and Cowper's gland mucin glycoproteins.
  Am J Physiol Volume: 260 Page(s): L326 - L339
  04/01/1991 Authors: Sangadala S; Brewer JM; Mendicino J
• IMMUNOLOGICAL CHARACTERIZATION OF DEGLYCOSYLATED HUMAN AND SWINE TRACHEA AND COWPER GLAND MUCIN GLYCOPROTEINS
  AMERICAN JOURNAL OF PHYSIOLOGY Volume: 260 Page(s): L326 - L339
  04/01/1991 Authors: SANGADALA S; BREWER JM; MENDICINO J
• Subunit structure of deglycosylated human and swine trachea and Cowper's gland mucin glycoproteins.
  Mol Cell Biochem Volume: 102 Page(s): 71 - 93
  03/27/1991 Authors: Sangadala S; Kim D; Brewer JM; Mendicino J
• UDP-GlcNAc: Gal beta 3GalNAc-mucin: (GlcNAc----GalNAc) beta 6-N-acetylglucosaminyltransferase and UDP-GlcNAc: Gal beta 3(GlcNAc beta 6) GalNAc-mucin (GlcNAc----Gal)beta 3-N-acetylglucosaminyltransferase from swine trachea epithelium.
  Mol Cell Biochem Volume: 101 Page(s): 125 - 143
  03/13/1991 Authors: Sangadala S; Sivakami S; Mendicino J