Emory University School of Medicine
Emory University School of Medicine
Department of Neurosurgery

Residency & Education section navigation

Department of Neurosurgery

Reda M. Chalboub, MD, PhD

About me

Dr. Reda Chalhoub

Year 

  • PGY-1

Hometown 

  • Beirut, Lebanon

Professional Interests

  • Functional
  • Pediatrics

Future Plans

  • Academic neurosurgery

Awards/Honors

  • Best Neuroscience Graduate Student Retreat Poster, 2023
  • NIDA F30 Ruth L. Kirschstein National Research Service Award, 2020-25
  • NIDA T32 Institutional Training Grant Award, 2019-20

Memberships

  • American Medical Association
  • American Physician Scientists Association
  • Congress of Neurological Surgeons
  • Society for Neuroscience

Hobbies

  • Barbecue, grilling and smoking meats
  • Soccer
  • Chess



Education

  • BS, American University of Beirut
  • MD/PhD, Medical University of South Carolina, 2025


Publications

  • Chalhoub RM, Testen A, Hopkins J, Carthy C, Walterhouse S, Kalivas PW. “Neuronal Subpopulations in the Nucleus Accumbens Differentially Encode Drug and Natural Reward Seeking”. BioArxiv (2024) doi: 10.1101/2024.08.05.606522.
  • Aiyetigbo M, Korte A, Anderson E, Chalhoub R, Kalivas P, Luo F, Li N. “Unsupervised Microscopy Video Denoising” Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) Workshops (2024), pp. 6874-6883 
  • Ash L, Dimisko L, Chalhoub RM, […], Jonathan A Grossberg, Ali Alawieh;  “Comprehensive analysis of the impact of procedure time and the 'golden hour' in subpopulations of stroke thrombectomy patients”. Journal of Neurointerventional Surgery (2023). DOI: 10.1136/jnis-2023-020792. PMID: 37875342
  • Abecassis IJ, Almallouhi E, Chalhoub RM, […], Spiotta AM, Starke RM. “The effect of occlusion location and technique in mechanical thrombectomy for minor stroke”. Journal of Interventional Neuroradiology (2023). DOI: 10.1177/15910199231196451. PMID: 37593806
  • Ironside N, Chen CJ, Chalhoub RM, [...], et al. “Risk factors and predictors of intracranial hemorrhage after mechanical thrombectomy in acute ischemic stroke: insights from the Stroke Thrombectomy and Aneurysm Registry (STAR).” Journal of Neurointerventional Surgery (2023) DOI: 10.1136/jnis-2022-019513. PMID: 36725360
  • Lajthia O, Almallouhi E, Ali H, Essibayi MA, Bass E, Neyens R, Anadani M, Chalhoub R, Kicielinski K, Lena J, Porto G, Sattur M, Spiotta AM, Kasab SA. “Failed mechanical thrombectomy: prevalence, etiology, and predictors.” Journal of Neurosurgery (2023). DOI: 10.3171/2022.12.JNS222152 PMID: 36670537
  • Abecassis IJ, Almallouhi E, Chalhoub R, et al. “Outcomes after endovascular mechanical thrombectomy for low compared to high National Institutes of Health Stroke Scale (NIHSS): A multicenter study.” Clinical Neurology and Neurosurgery (2023) DOI: 10.1016/j.clineuro.2023.107592. PMID: 36657358 
  • Shaban A, Al Kasab S, Chalhoub RM, […], Spiotta AM, Samaniego EA. “Mechanical Thrombectomy for Large Vessel Occlusion Strokes Beyond 24 hours”. Journal of Neurointerventional Surgery (2023) DOI: 10.1136/jnis-2022-019372. PMID: 36593118
  • Grossberg JA, Chalhoub RM, […], Spiotta AM, Alawieh AM. “Multicenter investigation of technical and clinical outcomes after thrombectomy for Proximal Medium Vessel Occlusion (pMeVO) by frontline technique.” Journal of Interventional Neuroradiology (2022). DOI: 10.1177/15910199221138139. PMID: 36377352
  • Porto GBF, Chen CJ, Al Kasab S, Essibayi MA, Almallouhi E, Hubbard Z, Chalhoub R, […], Spiotta AM, Park MS. “Association of Noncontrast Computed Tomography and Perfusion Modalities with Outcomes in Patients Undergoing Late-Window Stroke Thrombectomy”.  JAMA Network (2022). DOI: 10.1001/jamanetworkopen.2022.41291. PMID: 36367728
  • Alawieh AM, Chalhoub RM, […], Grossberg JA, Spiotta AM. “Multicenter investigation of technical and clinical outcomes after thrombectomy for distal vessel occlusion by frontline technique.” Journal of Neurointerventional Surgery (2023). DOI: 10.1136/jnis-2022-019023. PMID: 35918129
  • Al Kasab S, Almallouhi E, […], Chalhoub RM, et al. “Impact of Increasing Aspiration Catheter Size and Refinement of Technique: Experience of Over 1000 Strokes Treated with ADAPT.” Journal of Neurosurgery (2022). PMID: 35411873
  • Nall RW, Chalhoub RM, Kalivas PW. “Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats”. Journal of Experimental Analysis of Behavior (2022). DOI: 10.1002/jeab.752. PMID: 35297047
  • Almallouhi E, Al Kasab S, Hubbard Z, Bass EC, Porto G, Alawieh A, Chalhoub R, et al. “Outcomes of Mechanical Thrombectomy for Patients With Stroke Presenting With Low Alberta Stroke Program Early Computed Tomography Score in the Early and Extended Window”. JAMA Network (2021) DOI: 10.1001/jamanetworkopen.2021.37708. PMID: 34878550
  • Kruyer A, Parilla-Carrero J, Powell C, Brandt L, Gutwinski S, Angelis A, Chalhoub RM, Jhou TC, Kalivas PW, Amato D. “Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity.” Molecular Psychiatry (2021) DOI: 10.1038/s41380-021-01235-6. PMID: 34349226
  • Anadani M, Alawieh A, Chalhoub R, et al. “Mechanical Thrombectomy for Distal Occlusions: Efficacy, Functional and Safety Outcomes: Insight from the STAR collaboration”. World Neurosurgery (2021) DOI: 10.1016/j.wneu.2021.04.136 PMID: 33974981
  • Chen CJ, Chalhoub R, et al. “Is a picture-perfect thrombectomy necessary in acute ischemic stroke?” Journal of Neurointerventional Surgery. (2021) doi: 10.1136/neurintsurg-2020-017193. PMID: 33593800
  • Alawieh A, Chalhoub RM, Mallah K, et al. “Complement Drives Synaptic Degeneration and Progressive Cognitive Decline in the Chronic Phase after Traumatic Brain Injury”. Journal of Neuroscience (2021). 41(8):1830-1843. doi: 10.1523/JNEUROSCI.1734-20.2020. PMID: 33446516
  • Bou-Gharios J, Assi S, Bahmad HF, Kharroubi H, Araji T, Chalhoub RM, et al. “The potential use of Tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells”. Pharmacological Reports (2021). 73(1):227-239. doi: 10.1007/s43440-020-00180-5. PMID: 33140310
  • Bahmad HF*, Chalhoub RM*, Harati H, Bou-Gharios J, Assi S, Ballout F et al. Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β. Pharmacological reports: PR. 2020. doi:10.1007/s43440-020-00162-7. PMID: 33030673 *Equal Contribution 
  • Alawieh A, Al Kasab S, Almallouhi E, Levitt MR, Jabbour PM, Sweid A, […], Chalhoub RM, […] et al. “Letter: An International Investigation Into the COVID-19 Pandemic and Workforce Depletion in Highly Specialized Neurointerventional Units - Insights From Stroke Thrombectomy and Aneurysm Registry and Endovascular Neurosurgery Research Group.” Journal of Neurosurgery (2020) doi:10.1093/neuros/nyaa415. PMID: 32893855
  • Bahmad HF, El-Ajami MK, Daouk R, Jalloul H, Darwish B, Chalhoub RM et al. “Stem Cells: In Sickness and in Health” Current Stem Cell Research & Therapy (2020). doi:10.2174/1574888x15999200831160710. PMID: 32867660
  • Asroui L, Mehanna CJ, Salloum A, Chalhoub RM, Roberts CJ, Awwad ST. Repeatability of Zone Averages Compared to Single Point Measurements of Maximal Curvature in Keratoconus. American Journal of Ophthalmology. (2020). doi: 10.1016/j.ajo.2020.08.011. PMID: 32800828
  • Chalhoub RM, Kalivas PW. Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date. Drugs (2020) ;80(15):1509-24. doi:10.1007/s40265-020-01373-1. PMID: 32776315
  • Heinsbroek JA, Bobadilla AC, Dereschewitz E, Assali A, Chalhoub RM, Cowan CW, Kalivas PW. “Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum.” Cell Reports (2020) 20(6):2018-2027. DOI: 10.1016/j.celrep.2020.01.023. PMID: 32049028 
  • Alawieh A*, Chalhoub R*, Korson CJ, Anadani M, Lena J, Spiotta A. “Impact of reperfusion pump power on technical and clinical outcomes after direct aspiration thrombectomy (ADAPT).” Journal of Neurointerventional Surgery. (2019) in press. DOI: 10.1136/neurintsurg-2019-015297. PMID: 31653754 *Equal Contribution 
  • Bahmad HF, Chamaa FO, Assi S, Chalhoub RM, Abou-Antoun T, Abou-Kheir W. “Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier.” Frontiers in Molecular Neuroscience (2019). 12:131. DOI: 10.3389/fnmol.2019.00131. PMID: 31191243
  • Bahmad HF*, Mouhieddine T*, Chalhoub RM*, Assi S, Araji T, Chamaa F, Itani M, Nokkari A, Kobeissy F, Daoud G, Abou-Kheir W. “The Akt/mTOR Pathway in Cancer Stem/Progenitor Cells is a Potential Therapeutic Target for Glioblastoma and Neuroblastoma.” Oncotarget (2018), 9, 33549-33561. PMID: 30323898.  *Equal Contribution
  • Bahmad HF*, Cheaito K*, Chalhoub RM*, Hadadeh O, Monzer A, El-Hajj A, Mukherji D, Liu YN, Daoud G, Abou-Kheir W. “Sphere-Formation Assay: Three-Dimensional in vitro Capturing of Prostate Cancer Stem/Progenitor Cells.” Frontiers in Oncology (2018) 8, 347. DOI: 10.3389/fonc.2018.00347. PMID: 30211124. *Equal Contribution
  • Chamaa FO, Bahmad, HF, Makkawi AK, Chalhoub RM, Al-Chaer, ED, Bikhazi, GB, Nahas Z and Abou-Kheir, W. “Nitrous Oxide Induces Prominent Cell Proliferation in Adult Rat Hippocampal Dentate Gyrus.” Frontiers in Cellular Neuroscience (2018), 12, 135. DOI: 10.3389/fncel.2018.00135. PMID: 29867368