2022
February 2022, Press Release: Alzforum had a nice write-up of our recent research titled: “Proteomics Highlight Alzheimer’s Changes in Matrisome, MAPK Signaling”.
February, Paper Published. Erik, Kathleen and Eric’s paper titled “Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level” was accepted to Nature Neuroscience.
2021
November 2021, Thesis Defense: BCDB graduate student Sean Kundinger successfully defended his thesis. Congrats Dr. Kundinger!
October 2021, Paper Accepted. Sean’s paper titled “Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization” was accepted to J. Biol Chem.
April 2021, Paper Accepted. Measho’s paper titled “TBK1 interacts with tau and enhances neurodegeneration in tauopathy” was accepted to J. Biol Chem.
January 2021, Paper Accepted. Qi’s paper titled “Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer's Disease” was accepted to Front. Mol. Neurosci.
January 2021, Paper Accepted: Our collaborative paper with Thomas and Aliza Wingo titled ”Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis” was accepted for publication in Nat Genet.
January 2021, Paper Accepted: Our collaborative paper titled ” Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease” was accepted for publication in Alzheimers Dement.
2020
Oct 2020, Paper Accepted: Our collaborative paper with Thomas Kukar titled ” Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations” was accepted for publication in Acta Neuropathol Commun.
Oct 2020, Paper Accepted: Lenora’s paper titled “Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease” was accepted for publication in Sci Adv.
Sept 2020, Paper Accepted: Lingyan’s paper titled “Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer's disease” was accepted for publication in Sci Data.
Sept 2020, Graduation: Congratulations to Pritha who graduated from the Aspiring Leaders at Emory Program.
Sept 2020, Paper Accepted: Sruti and Lenora’s paper titled “Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau” was accepted for publication in Neuropsychopharmacology.
July 2020, Conference Presentation: Nick and Erick Johnson presented a talk titled “A Proteomic network approach for target and biomarker discovery in AD” at the NIA-AA Symposium Enabling Precision Medicine for Alzheimer’s Disease Through Open Science AAIC pre-meeting.
May 2020, Press Release: Alzforum had a nice write-up of our recent research titled: “Massive Proteomics Studies Peg Glial Metabolism, Myelination, to AD”.
May 2020, Paper Accepted: Maotian’s paper titled “Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer's disease” was accepted for publication in Clinical Proteomics.
May 2020, Grant News: Congratulations to Lenora who was awarded a BrightFocus Foundation granted titled, “Unraveling the Biological Overlap of Alzheimer's Disease and Dementia with Lewy Bodies Using Integrative Brain-CSF Proteomic Analysis”
April 2020, Paper Accepted: Sruti’s paper titled “Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease” was accepted to Molecular Neurodegeneration.
April 2020, Paper Accepted: Our collaborative paper with Thomas and Aliza Wingo titled ”Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain” was accepted for publication in Nature Neuroscience.
April 2020, Press Release: GenomeWeb has a nice write-up of our recent Nature Medicine paper titled “Alzheimer's Disease Proteomic Study Reveals Potential New Biomarkers, Drug Targets”
April 2020, Paper Accepted: Erik and Eric’s paper titled “Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation” was accepted in Nature Medicine. Congrats to all the AMP-AD partners who contributed to this work!
March 2020, Conference news: Both Nick and Erik were scheduled to present at US HUPO in Seattle, which was unfortunately cancelled due to the Covid-19 pandemic. Looking forward to next year!
March 2020, Publication News: Both Nick and Erik contribution at chapter of the “A biologist’s guide to mass spectrometry-based protein quantitation”
February, Press Release: Our paper with Anthony Fitzpatrick at Columbia on mapping tau PTMs was highlighted in Alzforum in an article titled: “CryoEM of CBD Tau Suggests Another Unique Protofibril”.
February 2020, Paper Accepted: Our collaborative paper with Anthony Fitzpatrick and Len Petrucelli titled “Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains” was recently accepted in Cell.
February 2020, Grant News: Congratulations to Lenora Higginbotham who was just awarded a Clinical Research Training Scholarship in Lewy Body Diseases funded by The Mary E. Groff Charitable Trust, the Alzheimer’s Association, and the American Brain Foundation, in collaboration with the American Academy of Neurology.
January 2020, Paper Accepted: Sean and Isaac’s paper titled “Middle-Down Proteomics Reveals Dense Sites of Methylation and Phosphorylation in Arginine-Rich RNA-Binding Proteins” was accepted at Journal of Proteome Research.
2019
December 2019, Presentation: Nick presented a talk tilted “A Proteomic Network Approach for Target Discovery in AD” Treat-AD kickoff meeting, Washington DC, December 2019.
October 2019 Conference Presentation: Nick presented a talk in the “Proteome Dysfunction in Aging, Neurodegenerative Disorders, and Alzheimer's Disease” symposium at the Society of Neuroscience meeting in Chicago Ill.
October 2019 Conference Presentation: Nick presented an update on the AMP-AD proteomics efforts at the M2OVE-AD and Resilience-AD Investigators Meeting in Bethesda MD
September 2019 Conference Presentations: Sean and Erica give talks at the Atlanta-Athens Mass Spectrometry Discussion Group (AAMSDG) meeting held at Emory School of Medicine
August 2019, Paper Accepted: Lenora’s paper titled “Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer's Disease.” was recently accepted for publication in Proteomes
August 2019 Press Release: Our recent findings presented at AAIC were highlighted in Alzforum in an article titled “Proteomics Uncovers Potential Markers, Subtypes of Alzheimer’s”
July 2019 Conference Presentation: Nick presented a talk, “Molecular and Cell Biology: Biomarkers and Proteomics” Session, July 2019, Alzheimer’s Association International Conference (AAIC), in Los Angeles CA
July 2019, Grant News: Congratulations to Sruti who had her F32 NRSA grant titled “Defining microglial and endothelial cell-type specific proteomic alterations of APOE risk in Alzheimer's disease” funded by the NIA.
June 2019, Invited Seminar: Nick presented a seminar title “Integrative Proteomics for Target and Biomarker Discovery in Alzheimer’s Disease: From Basic to Data Science” at Auburn University in AL.
June 2019, Conference Presentations: Seyfried lab members present their most recent and exciting research findings at the American Society for Mass Spectrometry (ASMS) meeting here in Atlanta GA.
May 2019, Presentation: Nick presented an update on the AMP-AD proteomics efforts at the Alzheimer’s Disease Center Director’s Meeting in Philadelphia PA
April 2019, Conference Presentation: Nick presented an update on the AMP-AD proteomics efforts at the Alzheimer’s Disease Sequencing Program (ADSP) Conference in Bethesda MD.
April 2019, Paper Accepted: Maotian’s paper titled “Mass Spectrometry-Based Quantification of Tau in Human Cerebrospinal Fluid Using a Complementary Tryptic Peptide Standard.” was recently accepted for publication in the Journal of Proteome Research
March 2019, Invited Seminar: Nick was invited by to his alma mater to present a seminar on integrative proteomics for biomarker discovery in AD in the Department of Biology at Boston College, MA
February 2019, Invited Seminar: Nick presented a seminar on integrative proteomics for biomarker discovery in AD in the Department of Pathology at the University of Pittsburgh School of Medicine
February 2019, Webinar.: Nick was invited by the The Scientist to present webinar tin he series “Omics Analysis for Brain Disorders”. Check it out.
2018
September 2018, Promotion: Dr. Nick Seyfried promoted to Associate Professor. Congratulations, Nick!
June 2018, New Publication: Dr. Srikant Rangaraju's paper titled, "Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins", is published in Molecular Neurodegeneration. Jun 28;13(1):34.
May 2018, Thesis Defense: BCDB graduate student Isaac Bishof successfully defended his thesis. Congrats Dr. Bishof!
May 2018, paper accepted: Isaac's paper titled "RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease" was recently accepted for publication by the Journal of Biological Chemistry.
March, 2018, conference presentation: Nick presented a talk titled "Integrative Proteomics for Novel Target and Biomarker Discovery in Alzheimer's Disease" at the National Institutes of Health (NIH) Alzheimer's Disease Research Summit in Bethesda Maryland. Click link above to see Nick's talk at the 4:21:00 mark.
March 2018, paper accepted: Lingyan's paper titled "Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease" was recently accepted for publication by the Scientific Data.
2017
November 2017, Paper Accepted: Mfon's paper titled, "A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain" was accepted for publication to the EMBO Molecular Medicine. This work was done in collaboration with Jonathan Glass (Emory Neurology), Director of the Emory ALS Clinic.
September 2017, Paper Accepted: Ian's paper titled, "Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain" was accepted for publication at Bioconjugate Chemistry. This work was done in collaboration with Lary Walker (Emory Neurology).
August 2017, Press Release: Excellent summary of our new GenPro software by Genomeweb, "Emory Team Develops New Software for Building Sample-Specific Mass Spec Reference Databases".
August 2017, Paper Review: GenPro is highlighted on Ben Orsburn's blog, "GenPro -- 1 step closer to personalized proteomics!".
July 2017, Press Release: Our research on Alzheimer's Disease protein networks was highlighted in an article on Alzforum titled, "Alzheimer's Proteomics Treasure Trove?"
July 2017, Conference Presentation: Nick co-chaired and presented a talk in the Protein-Protein Interactions Session at the Alzheimer's Association International Conference (AAIC) in London, England.
July 2017 Paper Accepted: Our paper titled, "Integrating Next-Generation Genomic Sequencing and Mass Spectrometry to Estimate Allele-Specific Protein Abundance in Human Brain," was accepted for publication to the Journal of Proteome Research. This work was done in collaboration with Thomas Wingo (Emory Neurology), who developed the GenPro software.
June 2017, Conference Presentation: Nick Presented a talk titled, "Protein co-expression network analysis of asymptomatic Alzheimer's disease" at the EMBO | EMBL Symposia on Mechanisms in Neurodegeneration in Heidelberg Germany.
March 2017, Conference Presentation: Nick Presented a talk titled, "A Multi-Network Approach to Define Pathways Altered in Alzheimer's Disease and Parkinson's Disease" at the US HUPO meeting in San Diego, CA.
March 2017, Travel Award: Congratulations to Isaac Bishof who was awarded a Travel Grant for his attendance at the 2017 RNA Society meeting in Prague to present a poster titled, "A Network Approach Reveals Novel Roles of Low Complexity Domains in Spliceosomal Proteins".
January 2017, Grant News: Nick, Dean Jones and Eric Ortlund were awarded a $13.5 grant from the NIH to serve as a site for the Molecular Transducers of Physical Activity in Humans Program. This work will also be conducted in collaboration with GaTech. Read the Emory News Center press release.
2016
December 2016, press release: "Alzheimer's Researchers Identify Protein Co-Expression Networks Linked to Disease" highlights the findings of our new Cell Systems Paper.
December 2016, press release: "Alzheimer's: Proteomics gives clues toward alternatives to amyloid" highlights the findings of our newCell Systems Paper.
December 2016, paper accepted: Our paper titled "A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease" was recently accepted for publication by Cell Systems
October 2016, paper accepted: Our paper titled "Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression" was recently accepted for publication by Proteomics.
September 2016, grant news: Our R01 proposal titled "Tau-Spliceosome Interactions in Alzheimer's Disease" was recently funded by the National Institute on Aging (NIA). This work is being done in collaboration with Dr. Josh Shulman at Baylor College of Medicine.
September 2016, Fellowship award: Congratulations to Srikant Rangaraju from being awarded a NIH K08 fellowship titled, "Microglial and macrophage potassium channels as regulators of neuroinflammation in Alzheimer's Disease". Nick is serving as co-mentor.
July, 2016, conference presentation: Nick presented a talk titled "Proteomic network analysis to find common mechanisms underlying Alzheimer's and Parkinson's Disease" at the Alzheimer's Association International Conference (AAIC) in Toronto, Canada.
June 2016, conference presentation: Isaac Bishof presented his poster titled "Identification of methylation and phosphorylation in arginine/serine rich domains by electron transfer dissociation" at the American Society for Mass Spectrometry (ASMS) meeting in San Antonio, Texas.
June 2016, conference presentation: Nick presented a poster titled "A Network Based Approach to Understand the Brain Proteome in Alzheimer's Disease" at the American Society for Mass Spectrometry (ASMS) meeting in San Antonio, Texas.
May 2016, Fellowship Award: Congratulations to Isaac Bishof (BCDB program) for being awarded a Ruth L. Kirschstein National Research Service Award (NRSA) F31 Fellowship titled "Defining Mechanisms of RNA-Binding Protein Assembly Linked to Alzheimer's Disease"
March 2016, Conference Presentation: Nick Presented at talk titled "Protein Co-Expression Network Analysis Reveals Cell Type Changes Linked to Alzheimer's Disease" at the US HUPO meeting in Boston, Massachusetts.
2015
November 2015, grant news: Our Biomarkers Across Neurodegenerative Diseases (BAND) proposal was funded by the Alzheimer's Association, Michael J. Fox Foundation, Weston Brain Institute and Alzheimer's Research UK.
March 2015, Travel Award: Congratulations to Isaac Bishof who was awarded a Travel Grant for his attendance at the 2015 ASBMB meeting to present a poster on his work on the intrinsically disordered low complexity domains in the RNA-binding protein U1-70K.
January 2015, Paper Accepted: Eric's paper on the quantitative phosphoproteome analysis of Alzheimer's Disease postmortem brain tissue was published in Proteomics.
2014
December 2014, Paper Accepted: Ian's paper on the aggregation properties of U1-70K was published in the Journal of Biological Chemistry.