Publications

A super enhancer controls expression and chromatin architecture within the MHC class II locus.
J Exp Med Volume: 217
02/03/2020 Authors: Majumder P; Lee JT; Rahmberg AR; Kumar G; Mi T; Scharer CD; Boss JM

Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells.
Nat Immunol
01/17/2020 Authors: Hayward SL; Scharer CD; Cartwright EK; Takamura S; Li Z-RT; Boss JM; Kohlmeier JE

PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis. Bally APR; Neeld DK; Lu P; Majumder P; Tang Y; Barwick BG; Wang Q; Boss JM. J Immunol Volume: 204 Page(s): 449 - 458. 01/15/2020

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
Immunity Volume: 52 Page(s): 203
01/14/2020 Authors: Jenks SA; Cashman KS; Zumaquero E; Marigorta UM; Patel AV; Wang X; Tomar D; Woodruff MC; Simon Z; Bugrovsky R

Signaling through the Inhibitory Fc Receptor FcRIIB Induces CD8+T Cell Apoptosis to Limit T Cell Immunity.
Immunity Volume: 52 Page(s): 136 - 150.e6
01/14/2020 Authors: Morris AB; Farley CR; Pinelli DF; Adams LE; Cragg MS; Boss JM; Scharer CD; Fribourg M; Cravedi P; Heeger PS
 

Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression.
Mol Cancer Res Volume: 17 Page(s): 2395 - 2409
12/01/2019 Authors: Chandrasekaran S; Sasaki M; Scharer CD; Kissick HT; Patterson DG; Magliocca KR; Seykora JT; Sapkota B; Gutman DA; Cooper LA
Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease.
Immunol Rev Volume: 292 Page(s): 76 - 89
11/01/2019 Authors: Cashman KS; Jenks SA; Woodruff MC; Tomar D; Tipton CM; Scharer CD; Eun-Hyung Lee F; Boss JM; Sanz I
IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes.
J Immunol Volume: 203 Page(s): 2121 - 2129
10/15/2019 Authors: Price MJ; Hicks SL; Bradley JE; Randall TD; Boss JM; Scharer CD
LSD1 Cooperates with Noncanonical NF-B Signaling to Regulate Marginal Zone B Cell Development.
J Immunol Volume: 203 Page(s): 1867 - 1881
10/01/2019 Authors: Haines RR; Scharer CD; Lobby JL; Boss JM
Antibody secreting cells require EZH2 for maximal metabolism, antibody production, and repression of the B cell transcriptional program
Volume: 49 Page(s): 320 - 320
10/01/2019 Authors: Guo M; Price MJ; Patterson DG; Barwick BG; Haines RR; Kania AK; Randall T; Boss JM; Scharer CD
Epigenetic programming underpins B cell dysfunction in human SLE.
Nat Immunol Volume: 20 Page(s): 1071 - 1082
08/01/2019 Authors: Scharer CD; Blalock EL; Mi T; Barwick BG; Jenks SA; Deguchi T; Cashman KS; Neary BE; Patterson DG; Hicks SL
PD-1 expression during acute infection is repressed through a LSD1- Blimp-1 axis

05/23/2019 Authors: Bally A; Neeld D; Lu P; Majumder P; Tang Y; Barwick B; Wang Q; Boss J
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN- on B Cells.
Immunity Volume: 50 Page(s): 1172 - 1187.e7
05/21/2019 Authors: Stone SL; Peel JN; Scharer CD; Risley CA; Chisolm DA; Schultz MD; Yu B; Ballesteros-Tato A; Wojciechowski W; Mousseau B
IFN induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation.
Elife Volume: 8
05/15/2019 Authors: Zumaquero E; Stone SL; Scharer CD; Jenks SA; Nellore A; Mousseau B; Rosal-Vela A; Botta D; Bradley JE; Wojciechowski W
Fc gamma RIIB is a Novel CD8+Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients.
Volume: 19 Page(s): 566 - 566
04/01/2019 Authors: Morris AB; Pinelli DF; Liu D; Boss JM; Scharer CD; Fribourg M; Cravedi P; Heeger PS; Ford ML

The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation.
J Immunol Volume: 201 Page(s): 2799 - 2811
11/01/2018 Authors: Haines RR; Barwick BG; Scharer CD; Majumder P; Randall TD; Boss JM

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
Immunity Volume: 49 Page(s): 725 - 739.e6
10/16/2018 Authors: Jenks SA; Cashman KS; Zumaquero E; Marigorta UM; Patel AV; Wang X; Tomar D; Woodruff MC; Simon Z; Bugrovsky R

Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen.
Cell Rep Volume: 23 Page(s): 3152 - 3159
06/12/2018 Authors: Price MJ; Patterson DG; Scharer CD; Boss JM

B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation.
Nat Commun Volume: 9 Page(s): 1900
05/15/2018 Authors: Barwick BG; Scharer CD; Martinez RJ; Price MJ; Wein AN; Haines RR; Bally APR; Kohlmeier JE; Boss JM

Cell cycle regulator Cyclin D1 is essential for dendritic cell differentiation
Volume: 48 Page(s): 174 - 174
05/01/2018 Authors: Scharer C; Ginwala R; Kawasawa Y; Madugula KK; Chigbu DG; Khan Z; Pestell R; Boss J; Jain P

Progressive upregulation of oxidative metabolism facilitates plasmablast differentiation to a T-independent antigen
Volume: 200
05/01/2018 Authors: Price MJ; Patterson D; Scharer CD; Boss JM

Cellular stress mediated by the local microenvironment regulates the homeostatic loss of tissue-resident memory CD8 T cells in different compartments of the lung
Volume: 200
05/01/2018 Authors: Hayward SL; Scharer CD; Takamura S; Kumar G; Boss JM; Kohlmeier JE

IRF4 regulates the rate of cell cycle during B cell differentiation
Volume: 200
05/01/2018 Authors: Patterson D; Scharer CD; Boss JM

The histone demethylase LSD1 regulates B cell proliferation and plasmablast differentiation
Volume: 200
05/01/2018 Authors: Haines RR; Barwick BG; Majumder P; Scharer CD; Boss JM

LSD1 regulates PD-1 expression through interactions with Blimp-1 during acute viral infection
Volume: 200
05/01/2018 Authors: Neeld DK; Bally A; Majumder P; Barwick B; Boss JM

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs.
Nat Commun Volume: 9 Page(s): 1698
04/27/2018 Authors: Scharer CD; Barwick BG; Guo M; Bally APR; Boss JM

EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production.
J Immunol Volume: 200 Page(s): 1039 - 1052
02/01/2018 Authors: Guo M; Price MJ; Patterson DG; Barwick BG; Haines RR; Kania AK; Bradley JE; Randall TD; Boss JM; Scharer CD

LSD1 protects against hippocampal and cortical neurodegeneration.
Nat Commun Volume: 8 Page(s): 805
10/09/2017 Authors: Christopher MA; Myrick DA; Barwick BG; Engstrom AK; Porter-Stransky KA; Boss JM; Weinshenker D; Levey AI; Katz DJ

The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns.
J Autoimmun Volume: 82 Page(s): 47 - 61
08/01/2017 Authors: Fortner KA; Bond JP; Austin JW; Boss JM; Budd RC

ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network.
Development Volume: 144 Page(s): 1948 - 1958
06/01/2017 Authors: Matsuda K; Mikami T; Oki S; Iida H; Andrabi M; Boss JM; Yamaguchi K; Shigenobu S; Kondoh H

Inhibition of H3K27me3-specific demethylases promotes plasma cell formation
Volume: 198
05/01/2017 Authors: Kania A; Scharer C; Boss JM

TULIPES: Tn5-mediated ltra low input parallel epigenetic sequencing
Volume: 198
05/01/2017 Authors: Patterson D; Scharer C; Boss JM

Pathogenic epigenetic programming of expanded B cell subsets in systemic lupus erythematosus
Volume: 198
05/01/2017 Authors: Scharer C; Blalock E; Barwick BG; Gandham B; Neary B; Sanz I; Boss JM

Ezh2 is required for the division -specific epigenetic programming of plasma cell differentiation
Volume: 198
05/01/2017 Authors: Scharer C; Guo M; Haines R; Kania A; Boss JM

Oxidative phosphorylation is progressively programmed during plasma cell differentiation
Volume: 198
05/01/2017 Authors: Price MJ; Barwick BG; Scharer CD; Boss JM

Role of Inflammation and Immune Responses in Age-Related Neurodegeneration
Volume: 26 Page(s): 727 - 728
05/01/2017 Authors: Tansey MG; Kannarkat GT; Cook DA; Eidson LN; Cintron AF; MacPherson KP; Carr C; Caudle WM; Factor SA; Boss J

Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory.
J Immunol Volume: 198 Page(s): 2238 - 2243
03/15/2017 Authors: Scharer CD; Bally APR; Gandham B; Boss JM

Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory.
J Immunol Volume: 198 Page(s): 205 - 217
01/01/2017 Authors: Bally APR; Tang Y; Lee JT; Barwick BG; Martinez R; Evavold BD; Boss JM

Role of Inflammation and Immune Responses in Age-Related Neurodegeneration
Volume: 26 Page(s): 727 - 728
01/01/2017 Authors: Tansey MG; Kannarkat GT; Cook DA; Eidson LN; Cintron AF; MacPherson KP; Carr C; Caudle WM; Factor SA; Boss J

LRRK2 levels in immune cells are increased in Parkinson's disease.
NPJ Parkinsons Dis Volume: 3 Page(s): 11
01/01/2017 Authors: Cook DA; Kannarkat GT; Cintron AF; Butkovich LM; Fraser KB; Chang J; Grigoryan N; Factor SA; West AB; Boss JM

LRRK2 levels in immune cells are increased in Parkinson's disease. Cook DA, Kannarkat GT, Cintron AF, Butkovich LM, Fraser KB, Chang J, Grigoryan N, Factor SA, West AB, Boss JM, Tansey MG. NPJ Parkinsons Dis. 2017 Mar 28;3:11. doi: 10.1038/s41531-017-0010-8. eCollection 2017. PMID: 28649611

The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns. Fortner KA, Bond JP, Austin JW, Boss JM, Budd RC. J Autoimmun. 2017 Aug;82:47-61. doi: 10.1016/j.jaut.2017.05.003. Epub 2017 May 24. PMID: 28551033

Quantum sensing with arbitrary frequency resolution. Boss JM, Cujia KS, Zopes J, Degen CL. Science. 2017 May 26;356(6340):837-840. doi: 10.1126/science.aam7009. PMID: 28546209

ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network. Matsuda K, Mikami T, Oki S, Iida H, Andrabi M, Boss JM, Yamaguchi K, Shigenobu S, Kondoh H. Development. 2017 Jun 1;144(11):1948-1958. doi: 10.1242/dev.143479. Epub 2017 Apr 28. PMID: 28455373

Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. Scharer CD, Bally AP, Gandham B, Boss JM. J Immunol. 2017 Mar 15;198(6):2238-2243. doi: 10.4049/jimmunol.1602086. Epub 2017 Feb 8. PMID: 28179496

Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. Bally AP, Tang Y, Lee JT, Barwick BG, Martinez R, Evavold BD, Boss JM. J Immunol. 2017 Jan 1;198(1):205-217. Epub 2016 Nov 28. PMID: 27895178