Jeremy Boss PhD
- Department of Microbiology and Immunology
Professor
- (404) 727-5973
- jeremy.boss@emory.edu
- Pubmed
-
Emory University School of Medicine
Microbiology & Immunology
1510 Clifton Rd, Room 3001 RRC
Academic Appointment
- Emory Chair in Basic Sciences Research, Emory University School of Medicine
- Associate Dean for Basic Research, Emory University, School of Medicine
- Professor and Chair, Microbiology & Immunology, Emory University
Education
Degrees
- PhD from State University of New York at Albany
Research
Focus
- Molecular and epigenetic mechanisms of immune system gene regulation Regulation of human major histocompatibility complex class II genes Role of PARK18 in Parkinsons Disease Regulation of PD-1 during chronic viral infection
Publications
-
EZH2 coordinates memory B-cell programming and recall responses.
J Immunol Volume: 214 Page(s): 947 - 957
05/01/2025 Authors: Wiggins KJ; Williams ME; Hicks SL; Padilla-Quirarte HO; Akther J; Randall TD; Boss JM; Scharer CD -
MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation.
Sci Rep Volume: 15 Page(s): 13705
04/21/2025 Authors: Kline EM; Jernigan JE; Scharer CD; Maurer J; Hicks SL; Herrick MK; Wallings RL; Kelly SD; Chang J; Menees KB -
MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation.
bioRxiv
03/04/2025 Authors: Kline EM; Jernigan JE; Scharer CD; Maurer J; Hicks Sl S; Herrick M MK; Wallings RL; Kelly SD; Chang J; Menees KB -
Human immune organoids to decode B cell response in healthy donors and patients with lymphoma.
Nat Mater Volume: 24 Page(s): 297 - 311
02/01/2025 Authors: Zhong Z; Quiones-Prez M; Dai Z; Juarez VM; Bhatia E; Carlson CR; Shah SB; Patel A; Fang Z; Hu T -
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control.
Nat Immunol Volume: 25 Page(s): 1871 - 1883
10/01/2024 Authors: Weiss SA; Huang AY; Fung ME; Martinez D; Chen ACY; LaSalle TJ; Miller BC; Scharer CD; Hegde M; Nguyen TH -
Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8+ Tcells.
Cell Rep Volume: 43 Page(s): 114547
08/27/2024 Authors: Sacristn C; Youngblood BA; Lu P; Bally APR; Xu JX; McGary K; Hewitt SL; Boss JM; Skok JA; Ahmed R -
Factors associated with immune responses to SARS-CoV-2 vaccination in individuals with autoimmune diseases.
JCI Insight Volume: 9
06/04/2024 Authors: Anderson E; Powell M; Yang E; Kar A; Leung TM; Sison C; Steinberg R; Mims R; Choudhury A; Espinosa C -
Exploration of potential immune mechanisms in cervical dystonia.
Parkinsonism Relat Disord Volume: 122 Page(s): 106036
05/01/2024 Authors: Scorr LM; Kilic-Berkmen G; Sutcliffe DJ; Dinasarapu AR; McKay JL; Bagchi P; Powell MD; Boss JM; Cereb N; Little M -
Prevention of respiratory virus transmission by resident memory CD8+ T cells.
Nature Volume: 626 Page(s): 392 - 400
02/01/2024 Authors: Uddbck I; Michalets SE; Saha A; Mattingly C; Kost KN; Williams ME; Lawrence LA; Hicks SL; Lowen AC; Ahmed H -
CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation.
Heliyon Volume: 9 Page(s): e17527
06/01/2023 Authors: Zuo Z; Kania AK; Patterson DG; Hicks SL; Maurer J; Gupta M; Boss JM; Scharer CD -
The 'omics of obesity in B-cell acute lymphoblastic leukemia.
J Natl Cancer Inst Monogr Volume: 2023 Page(s): 12 - 29
05/04/2023 Authors: Geitgey DK; Lee M; Cottrill KA; Jaffe M; Pilcher W; Bhasin S; Randall J; Ross AJ; Salemi M; Castillo-Castrejon M -
A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans.
Immunity Volume: 56 Page(s): 847 - 863.e8
04/11/2023 Authors: Nellore A; Zumaquero E; Scharer CD; Fucile CF; Tipton CM; King RG; Mi T; Mousseau B; Bradley JE; Zhou F -
Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential.
Commun Biol Volume: 6 Page(s): 363
04/03/2023 Authors: Rose JR; Akdogan-Ozdilek B; Rahmberg AR; Powell MD; Hicks SL; Scharer CD; Boss JM -
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nat Commun Volume: 14 Page(s): 1652
03/24/2023 Authors: Read KA; Jones DM; Pokhrel S; Hales EDS; Varkey A; Tuazon JA; Eisele CD; Abdouni O; Saadey A; Leonard MR -
Deletion of histone demethylase Lsd1 (Kdm1a) during retinal development leads to defects in retinal function and structure.
Front Cell Neurosci Volume: 17 Page(s): 1104592
01/01/2023 Authors: Ferdous S; Shelton DA; Getz TE; Chrenek MA; L'Hernault N; Sellers JT; Summers VR; Iuvone PM; Boss JM; Boatright JH -
IL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells.
Immunohorizons Volume: 6 Page(s): 872 - 882
12/01/2022 Authors: Powell MD; Lu P; Neeld DK; Kania AK; George-Alexander L-EMM; Bally APR; Scharer CD; Boss JM -
Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8+ T Cells.
J Immunol Volume: 209 Page(s): 1778 - 1787
11/01/2022 Authors: Lobby JL; Uddbck I; Scharer CD; Mi T; Boss JM; Thomsen AR; Christensen JP; Kohlmeier JE -
The Regulation of Immunity.
J Immunol Volume: 208 Page(s): 2450 - 2455
06/01/2022 Authors: Boss JM -
Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis.
J Immunol Volume: 208 Page(s): 2141 - 2153
05/01/2022 Authors: Dale GA; Wilkins DJ; Rowley J; Scharer CD; Tipton CM; Hom J; Boss JM; Corces V; Sanz I; Jacob J -
H3K27me3 Demethylase UTX Restrains Plasma Cell Formation.
J Immunol Volume: 208 Page(s): 1873 - 1885
04/15/2022 Authors: Kania AK; Price MJ; George-Alexander L-E; Patterson DG; Hicks SL; Scharer CD; Boss JM -
Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.
Nat Commun Volume: 13 Page(s): 1157
03/03/2022 Authors: Lee M; Hamilton JAG; Talekar GR; Ross AJ; Michael L; Rupji M; Dwivedi B; Raikar SS; Boss J; Scharer CD -
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting.
Life Sci Alliance Volume: 5
03/01/2022 Authors: Joyner CJ; Ley AM; Nguyen DC; Ali M; Corrado A; Tipton C; Scharer CD; Mi T; Woodruff MC; Hom J -
Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs.
Front Cell Dev Biol Volume: 10 Page(s): 909557
01/01/2022 Authors: Lee M; Geitgey DK; Hamilton JAG; Boss JM; Scharer CD; Spangle JM; Haynes KA; Henry CJ -
Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors.
Exp Hematol Volume: 112-113 Page(s): 24 - 34
01/01/2022 Authors: Zhou C; Uluisik R; Rowley JW; David C; Jones CL; Scharer CD; Noetzli L; Fisher MH; Kirkpatrick GD; Bark K -
Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation.
Immunohorizons Volume: 5 Page(s): 918 - 930
12/08/2021 Authors: Kania AK; Guo M; Scharer CD; Boss JM -
An IRF4-MYC-mTORC1 Integrated Pathway Controls Cell Growth and the Proliferative Capacity of Activated B Cells during B Cell Differentiation In Vivo.
J Immunol Volume: 207 Page(s): 1798 - 1811
10/01/2021 Authors: Patterson DG; Kania AK; Price MJ; Rose JR; Scharer CD; Boss JM -
Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa.
Mucosal Immunol Volume: 14 Page(s): 1144 - 1159
09/01/2021 Authors: Corrado A; Ramonell RP; Woodruff MC; Tipton C; Wise S; Levy J; DelGaudio J; Kuruvilla ME; Magliocca KR; Tomar D -
Epigenetic gene regulation in plasma cells.
Immunol Rev Volume: 303 Page(s): 8 - 22
09/01/2021 Authors: Patterson DG; Kania AK; Zuo Z; Scharer CD; Boss JM -
Identifying mechanisms that enhance the longevity of tissue-resident memory CD8+T cells in the lung
Volume: 206
05/01/2021 Authors: Lobby JL; Uddback IEM; Scharer CD; Mi T; Boss JM; Thomsen AR; Christensen JP; Kohlmeier JE -
T-bet expression marks a transcriptionally and functionally distinct population of memory B cells
Volume: 206
05/01/2021 Authors: Risley CA; Scharer CD; Boss JM; Lund FE -
Unique abilities of human memory T cell subsets are associated with both specialized gene expression modules and epigenetic priming
Volume: 206
05/01/2021 Authors: Rose JR; Rahmberg A; Scharer C; Boss JM -
H3K27me3 demethylases restrict the magnitude of PC formation
Volume: 206
05/01/2021 Authors: Kania A; Price M; Scharer C; Boss JM -
H3K9 dimethyltransferase G9a deficiency modulates B-cell response to LPS
Volume: 206
05/01/2021 Authors: George-Alexander L-E; Kania A; Mi T; Scharer CD; Boss JM -
Genomic Screening of B cell differentiation by using CRIPSR/Cas9
Volume: 206
05/01/2021 Authors: Zuo Z; Kania AK; Patterson DG; Scharer CD; Boss JM -
IRF4 regulates the proliferative capacity of activated B cells during B cell differentiation
Volume: 206
05/01/2021 Authors: Patterson D; Scharer C; Kania A; Mi T; Hicks SL; Boss JM -
Exploring Mechanisms of Human PD-1 Gene Regulation in T Follicular Helper Cells
Volume: 206
05/01/2021 Authors: Powell MD; Neeld DK; Rose J; Scharer C; Boss JM -
Cell-intrinsic MAVS promotes antigen specific CD8+T cell proliferation and mitochondrial metabolism
Volume: 206
05/01/2021 Authors: Vanderheiden A; Valenzuela RA; Verkerke H; Jin F; Price M; Boss JM; Grakoui A; Suthar MS -
The Murine MHC Class II Super Enhancer IA/IE-SE Contains a Functionally Redundant CTCF-Binding Component and a Novel Element Critical for Maximal Expression.
J Immunol Volume: 206 Page(s): 2221 - 2232
05/01/2021 Authors: Majumder P; Lee JT; Barwick BG; Patterson DG; Bally APR; Scharer CD; Boss JM -
Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation.
J Immunol Volume: 206 Page(s): 1493 - 1504
04/01/2021 Authors: Price MJ; Scharer CD; Kania AK; Randall TD; Boss JM -
Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes.
Front Immunol Volume: 12 Page(s): 688493
01/01/2021 Authors: Rivas MA; Durmaz C; Kloetgen A; Chin CR; Chen Z; Bhinder B; Koren A; Viny AD; Scharer CD; Boss JM -
Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice.
Immunohorizons Volume: 4 Page(s): 679 - 687
10/23/2020 Authors: Scharer CD; Fortner KA; Dragon JA; Tighe S; Boss JM; Budd RC -
Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.
Hum Mol Genet Volume: 29 Page(s): 2579 - 2595
08/29/2020 Authors: Inglis GAS; Zhou Y; Patterson DG; Scharer CD; Han Y; Boss JM; Wen Z; Escayg A -
Antibody-secreting cell destiny emerges during the initial stages of B-cell activation.
Nat Commun Volume: 11 Page(s): 3989
08/10/2020 Authors: Scharer CD; Patterson DG; Mi T; Price MJ; Hicks SL; Boss JM -
IRF4 regulates the proliferative capacity of activated B cells during B cell differentiation
Volume: 204
05/01/2020 Authors: Patterson D; Scharer CD; Mi T; Hicks SL; Zhang Q; Boss JM -
CD8+T cell intrinsic MAVS promotes antigen-specific responses and mitochondrial metabolism during West Nile Virus neuroinvasive disease
Volume: 204
05/01/2020 Authors: Vanderheiden A; Aguilar-Valenzuela R; Verkerke H; Price M; Boss JM; Grakoui A; Suthar MS -
Templated mutagenesis in B cell non-Ig genes
Volume: 204
05/01/2020 Authors: Navarrete K; Dale GA; Woodruff MC; Scharer CD; Boss JM; Sanz I; Jacob J -
Defining altered regulome structured in response to antigen co-receptors, toll-like receptors, and cytokine receptors stimuli to predispose early developing B cells for pathogenic fate in Systemic lupus erythematosus
Volume: 204
05/01/2020 Authors: Saini A; Duan M; Mi T; Hicks S; Lee E-H; Scharer CD; Boss JM; Gibson G; Sanz I -
Single cell transcriptomics of in vivo differentiating antibody-secreting cells reveals a divergent activated B cell program dependent on IRF4
Volume: 204
05/01/2020 Authors: Scharer C; Patterson D; Mi T; Price M; Hicks SL; Boss JM -
H3K27me3 demethylases are important epigenetic regulators of B cell differentiation
Volume: 204
05/01/2020 Authors: Kania A; Price M; Scharer CD; Boss JM -
H3K9 dimethyltransferase G9a is an important epigenetic modulator of B cell differentiation
Volume: 204
05/01/2020 Authors: George-Alexander L-E; Kania A; Hicks S; Mi T; Scharer CD; Boss J -
Interferon gamma signaling regulates the generation of influenza-specific memory B cells
Volume: 204
05/01/2020 Authors: Risley CA; Stone SL; Scharer CD; Boss JM; Lund FE -
Murine gammaherpesvirus infection is skewed toward Ig+ B cells expressing a specific heavy chain V-segment.
PLoS Pathog Volume: 16 Page(s): e1008438
04/01/2020 Authors: Collins CM; Scharer CD; Murphy TJ; Boss JM; Speck SH -
Loss of L-selectin distinguishes activated B cells destined to differentiate to plasma cells.
Volume: 8 Page(s): 68 - 68
03/01/2020 Authors: Patterson DG; Scharer CD; Mi T; Price MJ; Hicks SL; Boss JM -
Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells.
Nat Immunol Volume: 21 Page(s): 309 - 320
03/01/2020 Authors: Hayward SL; Scharer CD; Cartwright EK; Takamura S; Li Z-RT; Boss JM; Kohlmeier JE -
A super enhancer controls expression and chromatin architecture within the MHC class II locus.
J Exp Med Volume: 217
02/03/2020 Authors: Majumder P; Lee JT; Rahmberg AR; Kumar G; Mi T; Scharer CD; Boss JM -
PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis.
J Immunol Volume: 204 Page(s): 449 - 458
01/15/2020 Authors: Bally APR; Neeld DK; Lu P; Majumder P; Tang Y; Barwick BG; Wang Q; Boss JM -
Signaling through the Inhibitory Fc Receptor FcRIIB Induces CD8+T Cell Apoptosis to Limit T Cell Immunity.
Immunity Volume: 52 Page(s): 136 - 150.e6
01/14/2020 Authors: Morris AB; Farley CR; Pinelli DF; Adams LE; Cragg MS; Boss JM; Scharer CD; Fribourg M; Cravedi P; Heeger PS -
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
Immunity Volume: 52 Page(s): 203
01/14/2020 Authors: Jenks SA; Cashman KS; Zumaquero E; Marigorta UM; Patel AV; Wang X; Tomar D; Woodruff MC; Simon Z; Bugrovsky R -
Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression.
Mol Cancer Res Volume: 17 Page(s): 2395 - 2409
12/01/2019 Authors: Chandrasekaran S; Sasaki M; Scharer CD; Kissick HT; Patterson DG; Magliocca KR; Seykora JT; Sapkota B; Gutman DA; Cooper LA -
Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease.
Immunol Rev Volume: 292 Page(s): 76 - 89
11/01/2019 Authors: Cashman KS; Jenks SA; Woodruff MC; Tomar D; Tipton CM; Scharer CD; Eun-Hyung Lee F; Boss JM; Sanz I -
IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes.
J Immunol Volume: 203 Page(s): 2121 - 2129
10/15/2019 Authors: Price MJ; Hicks SL; Bradley JE; Randall TD; Boss JM; Scharer CD -
Antibody secreting cells require EZH2 for maximal metabolism, antibody production, and repression of the B cell transcriptional program
Volume: 49 Page(s): 320 - 320
10/01/2019 Authors: Guo M; Price MJ; Patterson DG; Barwick BG; Haines RR; Kania AK; Randall T; Boss JM; Scharer CD -
LSD1 Cooperates with Noncanonical NF-B Signaling to Regulate Marginal Zone B Cell Development.
J Immunol Volume: 203 Page(s): 1867 - 1881
10/01/2019 Authors: Haines RR; Scharer CD; Lobby JL; Boss JM -
Epigenetic programming underpins B cell dysfunction in human SLE.
Nat Immunol Volume: 20 Page(s): 1071 - 1082
08/01/2019 Authors: Scharer CD; Blalock EL; Mi T; Barwick BG; Jenks SA; Deguchi T; Cashman KS; Neary BE; Patterson DG; Hicks SL -
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN- on B Cells.
Immunity Volume: 50 Page(s): 1172 - 1187.e7
05/21/2019 Authors: Stone SL; Peel JN; Scharer CD; Risley CA; Chisolm DA; Schultz MD; Yu B; Ballesteros-Tato A; Wojciechowski W; Mousseau B -
IFN induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation.
Elife Volume: 8
05/15/2019 Authors: Zumaquero E; Stone SL; Scharer CD; Jenks SA; Nellore A; Mousseau B; Rosal-Vela A; Botta D; Bradley JE; Wojciechowski W -
PD-1 is negatively regulated by LSD1 through interactions with Blimp-1 during acute viral infection
Volume: 202
05/01/2019 Authors: Neeld DK; Bally A; Lu P; Majumder P; Barwick B; Boss JM -
LSD1 epigenetically represses NF-kappa B target genes to regulate marginal zone B cell development
Volume: 202
05/01/2019 Authors: Haines RR; Scharer CD; Boss J -
Epigenetic priming underpins enhanced memory B cell differentiation
Volume: 202
05/01/2019 Authors: Price MJ; Scharer CD; Kania AK; Mi T; Hicks SL; Randall TD; Boss J -
H3K27me3-specific demethylases modulate B cell development and differentiation
Volume: 202
05/01/2019 Authors: Kania A; Scharer CD; Price MJ; Haines RR; -George L-EA; Boss J -
Epigenetic programming underpins B cell dysfunction in human SLE
Volume: 202
05/01/2019 Authors: Scharer C; Blalock E; Mi T; Barwick B; Jenks S; Neary B; Patterson D; Deguchi T; Lee E-H; Wei C -
IRF4 regulates the proliferative response during B cell differentiation in vivo
Volume: 202
05/01/2019 Authors: Patterson D; Scharer C; Mi T; Hicks SL; Zhang Q; Boss JM -
Fc gamma RIIB is a Novel CD8+Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients.
Volume: 19 Page(s): 566 - 566
04/01/2019 Authors: Morris AB; Pinelli DF; Liu D; Boss JM; Scharer CD; Fribourg M; Cravedi P; Heeger PS; Ford ML -
The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation.
J Immunol Volume: 201 Page(s): 2799 - 2811
11/01/2018 Authors: Haines RR; Barwick BG; Scharer CD; Majumder P; Randall TD; Boss JM -
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
Immunity Volume: 49 Page(s): 725 - 739.e6
10/16/2018 Authors: Jenks SA; Cashman KS; Zumaquero E; Marigorta UM; Patel AV; Wang X; Tomar D; Woodruff MC; Simon Z; Bugrovsky R -
Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen.
Cell Rep Volume: 23 Page(s): 3152 - 3159
06/12/2018 Authors: Price MJ; Patterson DG; Scharer CD; Boss JM -
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation.
Nat Commun Volume: 9 Page(s): 1900
05/15/2018 Authors: Barwick BG; Scharer CD; Martinez RJ; Price MJ; Wein AN; Haines RR; Bally APR; Kohlmeier JE; Boss JM -
LSD1 regulates PD-1 expression through interactions with Blimp-1 during acute viral infection
Volume: 200
05/01/2018 Authors: Neeld DK; Bally A; Majumder P; Barwick B; Boss JM -
The histone demethylase LSD1 regulates B cell proliferation and plasmablast differentiation
Volume: 200
05/01/2018 Authors: Haines RR; Barwick BG; Majumder P; Scharer CD; Boss JM -
IRF4 regulates the rate of cell cycle during B cell differentiation
Volume: 200
05/01/2018 Authors: Patterson D; Scharer CD; Boss JM -
Cellular stress mediated by the local microenvironment regulates the homeostatic loss of tissue-resident memory CD8 T cells in different compartments of the lung
Volume: 200
05/01/2018 Authors: Hayward SL; Scharer CD; Takamura S; Kumar G; Boss JM; Kohlmeier JE -
Progressive upregulation of oxidative metabolism facilitates plasmablast differentiation to a T-independent antigen
Volume: 200
05/01/2018 Authors: Price MJ; Patterson D; Scharer CD; Boss JM -
Cell cycle regulator Cyclin D1 is essential for dendritic cell differentiation
Volume: 48 Page(s): 174 - 174
05/01/2018 Authors: Scharer C; Ginwala R; Kawasawa Y; Madugula KK; Chigbu DG; Khan Z; Pestell R; Boss J; Jain P -
Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs.
Nat Commun Volume: 9 Page(s): 1698
04/27/2018 Authors: Scharer CD; Barwick BG; Guo M; Bally APR; Boss JM -
EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production.
J Immunol Volume: 200 Page(s): 1039 - 1052
02/01/2018 Authors: Guo M; Price MJ; Patterson DG; Barwick BG; Haines RR; Kania AK; Bradley JE; Randall TD; Boss JM; Scharer CD -
LSD1 protects against hippocampal and cortical neurodegeneration.
Nat Commun Volume: 8 Page(s): 805
10/09/2017 Authors: Christopher MA; Myrick DA; Barwick BG; Engstrom AK; Porter-Stransky KA; Boss JM; Weinshenker D; Levey AI; Katz DJ -
The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns.
J Autoimmun Volume: 82 Page(s): 47 - 61
08/01/2017 Authors: Fortner KA; Bond JP; Austin JW; Boss JM; Budd RC -
ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network.
Development Volume: 144 Page(s): 1948 - 1958
06/01/2017 Authors: Matsuda K; Mikami T; Oki S; Iida H; Andrabi M; Boss JM; Yamaguchi K; Shigenobu S; Kondoh H -
Inhibition of H3K27me3-specific demethylases promotes plasma cell formation
Volume: 198
05/01/2017 Authors: Kania A; Scharer C; Boss JM -
TULIPES: Tn5-mediated ltra low input parallel epigenetic sequencing
Volume: 198
05/01/2017 Authors: Patterson D; Scharer C; Boss JM -
Pathogenic epigenetic programming of expanded B cell subsets in systemic lupus erythematosus
Volume: 198
05/01/2017 Authors: Scharer C; Blalock E; Barwick BG; Gandham B; Neary B; Sanz I; Boss JM -
Ezh2 is required for the division -specific epigenetic programming of plasma cell differentiation
Volume: 198
05/01/2017 Authors: Scharer C; Guo M; Haines R; Kania A; Boss JM -
Oxidative phosphorylation is progressively programmed during plasma cell differentiation
Volume: 198
05/01/2017 Authors: Price MJ; Barwick BG; Scharer CD; Boss JM -
Role of Inflammation and Immune Responses in Age-Related Neurodegeneration
Volume: 26 Page(s): 727 - 728
05/01/2017 Authors: Tansey MG; Kannarkat GT; Cook DA; Eidson LN; Cintron AF; MacPherson KP; Carr C; Caudle WM; Factor SA; Boss J -
Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory.
J Immunol Volume: 198 Page(s): 2238 - 2243
03/15/2017 Authors: Scharer CD; Bally APR; Gandham B; Boss JM -
Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory.
J Immunol Volume: 198 Page(s): 205 - 217
01/01/2017 Authors: Bally APR; Tang Y; Lee JT; Barwick BG; Martinez R; Evavold BD; Boss JM -
Role of Inflammation and Immune Responses in Age-Related Neurodegeneration
Volume: 26 Page(s): 727 - 728
01/01/2017 Authors: Tansey MG; Kannarkat GT; Cook DA; Eidson LN; Cintron AF; MacPherson KP; Carr C; Caudle WM; Factor SA; Boss J -
LRRK2 levels in immune cells are increased in Parkinson's disease.
NPJ Parkinsons Dis Volume: 3 Page(s): 11
01/01/2017 Authors: Cook DA; Kannarkat GT; Cintron AF; Butkovich LM; Fraser KB; Chang J; Grigoryan N; Factor SA; West AB; Boss JM -
Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation.
Nat Immunol Volume: 17 Page(s): 1216 - 1225
10/01/2016 Authors: Barwick BG; Scharer CD; Bally APR; Boss JM -
ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.
J Immunol Volume: 197 Page(s): 1159 - 1168
08/15/2016 Authors: Jash A; Wang Y; Weisel FJ; Scharer CD; Boss JM; Shlomchik MJ; Bhattacharya D -
ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in nave SLE B cells.
Sci Rep Volume: 6 Page(s): 27030
06/01/2016 Authors: Scharer CD; Blalock EL; Barwick BG; Haines RR; Wei C; Sanz I; Boss JM -
The histone demethylase LSD1 inhibits PD-1 expression in acute viral infections
Volume: 196
05/01/2016 Authors: Bally A; Austin JW; Lu P; Boss J -
Role of Wnt-4 signaling in dendritic cells lineage and differentiation
Volume: 196
05/01/2016 Authors: Jain P; Scharer C; Kawasawa Y; Sreedhar S; Khan Z; Boss J -
Epigenetic regulation of histone H3 lysine 27 (H3K27) controls the division-specific timing of gene expression during B cell differentiation
Volume: 196
05/01/2016 Authors: Scharer C; Barwick B; Bally A; Boss JM -
Genetic and Epigenetic Regulation of PD-1 Expression.
J Immunol Volume: 196 Page(s): 2431 - 2437
03/15/2016 Authors: Bally APR; Austin JW; Boss JM -
The molecular signature of T cells undergoing recurrent homeostatic proliferation.
Volume: 194
05/01/2015 Authors: Fortner K; Bond J; Austin J; Boss J; Budd R -
NF-B regulates PD-1 expression in macrophages.
J Immunol Volume: 194 Page(s): 4545 - 4554
05/01/2015 Authors: Bally APR; Lu P; Tang Y; Austin JW; Scharer CD; Ahmed R; Boss JM -
Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment.
Nucleic Acids Res Volume: 43 Page(s): 3128 - 3142
03/31/2015 Authors: Scharer CD; Choi NM; Barwick BG; Majumder P; Lohsen S; Boss JM -
Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study.
NPJ Parkinsons Dis Volume: 1 Page(s): 15002-
01/01/2015 Authors: Kannarkat GT; Cook DA; Lee J-K; Chang J; Chung J; Sandy E; Paul KC; Ritz B; Bronstein J; Factor SA -
Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types.
Genes Immun Volume: 15 Page(s): 543 - 555
12/01/2014 Authors: Lohsen S; Majumder P; Scharer CD; Barwick BG; Austin JW; Zinzow-Kramer WM; Boss JM -
STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells.
J Immunol Volume: 192 Page(s): 4876 - 4886
05/15/2014 Authors: Austin JW; Lu P; Majumder P; Ahmed R; Boss JM -
B cell differentiation is associated with reprogramming the CCCTC binding factor-dependent chromatin architecture of the murine MHC class II locus.
J Immunol Volume: 192 Page(s): 3925 - 3935
04/15/2014 Authors: Majumder P; Scharer CD; Choi NM; Boss JM -
Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection.
J Exp Med Volume: 211 Page(s): 515 - 527
03/10/2014 Authors: Lu P; Youngblood BA; Austin JW; Mohammed AUR; Butler R; Ahmed R; Boss JM -
Transcriptional regulation of YWHAZ, the gene encoding 14-3-3.
PLoS One Volume: 9 Page(s): e93480
01/01/2014 Authors: Kasinski A; Dong X; Khuri FR; Boss J; Fu H -
Understanding The Stimulatory Pathways Responsible For Naive B Cell Activation In Systemic Lupus Erythematosus
Volume: 65 Page(s): S13 - S13
10/01/2013 Authors: Blalock E; Scharer C; Jenks S; Boss J; Sanz I -
Global DNA methylation remodeling accompanies CD8 T cell effector function.
J Immunol Volume: 191 Page(s): 3419 - 3429
09/15/2013 Authors: Scharer CD; Barwick BG; Youngblood BA; Ahmed R; Boss JM -
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.
J Immunol Volume: 191 Page(s): 540 - 544
07/15/2013 Authors: Youngblood B; Noto A; Porichis F; Akondy RS; Ndhlovu ZM; Austin JW; Bordi R; Procopio FA; Miura T; Allen TM -
Viral infection alters subnuclear localization of PD-1 and CD62L loci in LCMV-specific CD8 T-cells (P6369)
Volume: 190
05/01/2013 Authors: Sacristan C; Youngblood B; Xu J; Lu P; McGary K; Hewitt S; Skok J; Boss J; Ahmed R; Dustin M -
Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence.
PLoS Genet Volume: 9 Page(s): e1003404
04/01/2013 Authors: Gokcumen O; Zhu Q; Mulder LCF; Iskow RC; Austermann C; Scharer CD; Raj T; Boss JM; Sunyaev S; Price A -
The role of innate and adaptive immunity in Parkinson's disease.
J Parkinsons Dis Volume: 3 Page(s): 493 - 514
01/01/2013 Authors: Kannarkat GT; Boss JM; Tansey MG -
The PARK18 SNP is associated with altered expression and regulation of major histocompatibility complex II genes in Parkinson's disease patients
Volume: 253 Page(s): 155 - 155
12/15/2012 Authors: Kannarkat G; Choi N; Lee J-K; Boss J; Tansey M -
ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.
J Immunol Volume: 189 Page(s): 2393 - 2403
09/01/2012 Authors: Yoon HS; Scharer CD; Majumder P; Davis CW; Butler R; Zinzow-Kramer W; Skountzou I; Koutsonanos DG; Ahmed R; Boss JM -
CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments.
Genes Immun Volume: 13 Page(s): 299 - 310
06/01/2012 Authors: Zinzow-Kramer WM; Long AB; Youngblood BA; Rosenthal KM; Butler R; Mohammed A-U-R; Skountzou I; Ahmed R; Evavold BD; Boss JM -
Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene.
PLoS One Volume: 7 Page(s): e37554
01/01/2012 Authors: Choi NM; Boss JM -
Cohesin regulates MHC class II genes through interactions with MHC class II insulators.
J Immunol Volume: 187 Page(s): 4236 - 4244
10/15/2011 Authors: Majumder P; Boss JM -
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.
Immunity Volume: 35 Page(s): 400 - 412
09/23/2011 Authors: Youngblood B; Oestreich KJ; Ha S-J; Duraiswamy J; Akondy RS; West EE; Wei Z; Lu P; Austin JW; Riley JL -
DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture.
Genes Immun Volume: 12 Page(s): 291 - 299
06/01/2011 Authors: Majumder P; Boss JM -
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.
Nat Immunol Volume: 12 Page(s): 663 - 671
05/29/2011 Authors: Kao C; Oestreich KJ; Paley MA; Crawford A; Angelosanto JM; Ali M-AA; Intlekofer AM; Boss JM; Reiner SL; Weinmann AS -
Coordinated regulation of PD-1 gene expression and nuclear localization during virus-specific memory CD8+T cell differentiation
JOURNAL OF IMMUNOLOGY Volume: 186
04/01/2011 Authors: Sacristan C; Youngblood B; Xu J; Shipper K; Skok J; Boss J; Ahmed R; Dustin M -
Viral infection duration mediates locus specific de novo DNA methylation in antigen-specific CD8 T cells
JOURNAL OF IMMUNOLOGY Volume: 186
04/01/2011 Authors: Youngblood B; Oestreich K; Ha S-J; Duraiswamy J; Akondy R; Wei Z; Austin J; Riley J; Boss J; Ahmed R -
Discovery and characterization of novel distal regulatory elements involved in the regulation of CIITA promoter three.
JOURNAL OF IMMUNOLOGY Volume: 186
04/01/2011 Authors: Lohsen S; Boss J -
Regulation of major histocompatibility complex class II genes.
Curr Opin Immunol Volume: 23 Page(s): 81 - 87
02/01/2011 Authors: Choi NM; Majumder P; Boss JM -
Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.
J Mol Biol Volume: 403 Page(s): 40 - 51
10/15/2010 Authors: Laird KM; Briggs LL; Boss JM; Summers MF; Garvie CW -
CTCF controls expression and chromatin architecture of the human major histocompatibility complex class II locus.
Mol Cell Biol Volume: 30 Page(s): 4211 - 4223
09/01/2010 Authors: Majumder P; Boss JM -
PU.1 binds to a distal regulatory element that is necessary for B cell-specific expression of CIITA.
J Immunol Volume: 184 Page(s): 5018 - 5028
05/01/2010 Authors: Yoon H; Boss JM -
Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP.
Proteins Volume: 76 Page(s): 655 - 664
08/15/2009 Authors: Briggs L; Laird K; Boss JM; Garvie CW -
Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein.
J Virol Volume: 83 Page(s): 6484 - 6493
07/01/2009 Authors: Collins CM; Boss JM; Speck SH -
Aberrant DNA demethylation of PD-1 during chronic viral infection
JOURNAL OF IMMUNOLOGY Volume: 182
04/01/2009 Authors: Ben Y; Oestreich KJ; Ha S-JJ; Duraiswamy J; Akondy R; Boss JM; Ahmed R -
A novel zinc finger protein represses the MHC-II transactivator (CIITA) during B cell differentiation and interacts with the polycomb complex factor EZH2
JOURNAL OF IMMUNOLOGY Volume: 182
04/01/2009 Authors: Yoon H; Boss JM -
Yin yang 1 regulates the expression of snail through a distal enhancer.
Mol Cancer Res Volume: 7 Page(s): 221 - 229
02/01/2009 Authors: Palmer MB; Majumder P; Cooper JC; Yoon H; Wade PA; Boss JM -
Ultraviolet radiation-induced transcription is associated with gene-specific histone acetylation.
Photochem Photobiol Volume: 85 Page(s): 652 - 662
01/01/2009 Authors: Pollack BP; Sapkota B; Boss JM -
Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5.
Biochim Biophys Acta Volume: 1779 Page(s): 797 - 804
12/01/2008 Authors: Garvie CW; Boss JM -
NFATc1 regulates PD-1 expression upon T cell activation.
J Immunol Volume: 181 Page(s): 4832 - 4839
10/01/2008 Authors: Oestreich KJ; Yoon H; Ahmed R; Boss JM -
New dimensions of CIITA.
Nat Immunol Volume: 9 Page(s): 713 - 714
07/01/2008 Authors: Reith W; Boss JM -
Tomorrow's JI Today.
J Immunol Volume: 181 Page(s): 1 - 2
07/01/2008 Authors: Boss JM -
The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions.
J Exp Med Volume: 205 Page(s): 785 - 798
04/14/2008 Authors: Majumder P; Gomez JA; Chadwick BP; Boss JM -
Sustained trimethylation of histone H3 lysine 4 in the MKP-1 promoter region occurs after a single exposure to UVB
Volume: 128 Page(s): S210 - S210
04/01/2008 Authors: Pollack BP; Sapkota B; Boss JM -
The NLR gene family: a standard nomenclature.
Immunity Volume: 28 Page(s): 285 - 287
03/01/2008 Authors: Ting JP-Y; Lovering RC; Alnemri ES; Bertin J; Boss JM; Davis BK; Flavell RA; Girardin SE; Godzik A; Harton JA -
ATF3 is expressed in inflammatory skin diseases and its regulation involves histone acetylation
JOURNAL OF CUTANEOUS PATHOLOGY Volume: 35 Page(s): 137 - 137
01/01/2008 Authors: Pollack B; Sapkota B; Haun P; Boss J -
Mentoring and networking: how to make it work.
Nat Immunol Volume: 9 Page(s): 3 - 5
01/01/2008 Authors: Haynes L; Adams SL; Boss JM -
A 3' enhancer controls snail expression in melanoma cells.
Cancer Res Volume: 67 Page(s): 6113 - 6120
07/01/2007 Authors: Palmer MB; Majumder P; Green MR; Wade PA; Boss JM -
Controlling the Ir genes.
J Immunol Volume: 178 Page(s): 6675 - 6676
06/01/2007 Authors: Boss JM -
Identification of a novel distal hyperacetylated region within the ATF3 gene
Volume: 127 Page(s): S93 - S93
04/01/2007 Authors: Pollack BP; Sapkota B; Boss JM -
Characterization of the RFX complex and the RFX5(L66A) mutant: implications for the regulation of MHC class II gene expression.
Biochemistry Volume: 46 Page(s): 1597 - 1611
02/13/2007 Authors: Garvie CW; Stagno JR; Reid S; Singh A; Harrington E; Boss JM -
CREB and phospho-CREB interact with RFX5 and CIITA to regulate MHC class II genes.
Mol Immunol Volume: 44 Page(s): 837 - 847
02/01/2007 Authors: Lochamy J; Rogers EM; Boss JM -
Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.
J Immunol Volume: 178 Page(s): 961 - 969
01/15/2007 Authors: Venkataraman GM; Suciu D; Groh V; Boss JM; Spies T -
C/EBPbeta regulates TNF induced MnSOD expression and protection against apoptosis.
Apoptosis Volume: 11 Page(s): 1837 - 1849
10/01/2006 Authors: Ranjan P; Boss JM -
Epigenetic regulation during B cell differentiation controls CIITA promoter accessibility.
J Immunol Volume: 177 Page(s): 3865 - 3873
09/15/2006 Authors: Green MR; Yoon H; Boss JM -
Lab management: insights for the new investigator.
Nat Immunol Volume: 7 Page(s): 895 - 897
09/01/2006 Authors: Haynes L; Pfeffer S; Boss JM; Kavathas P; Kuchroo V -
Mechanism of action of a distal NF-kappaB-dependent enhancer.
Mol Cell Biol Volume: 26 Page(s): 5759 - 5770
08/01/2006 Authors: Teferedegne B; Green MR; Guo Z; Boss JM -
The human major histocompatibility complex class II HLA-DRB1 and HLA-DQA1 genes are separated by a CTCF-binding enhancer-blocking element.
J Biol Chem Volume: 281 Page(s): 18435 - 18443
07/07/2006 Authors: Majumder P; Gomez JA; Boss JM -
Changes in chromatin structure induced by Ultraviolet Radiation
Volume: 126 Page(s): 143 - 143
04/01/2006 Authors: Pollack BP; Boss JM -
Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.
J Immunol Volume: 176 Page(s): 4083 - 4093
04/01/2006 Authors: Kersh EN; Fitzpatrick DR; Murali-Krishna K; Shires J; Speck SH; Boss JM; Ahmed R -
Conserved residues of the bare lymphocyte syndrome transcription factor RFXAP determine coordinate MHC class II expression.
Mol Immunol Volume: 43 Page(s): 395 - 409
02/01/2006 Authors: Long AB; Ferguson AM; Majumder P; Nagarajan UM; Boss JM -
A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 gene.
J Immunol Volume: 175 Page(s): 7407 - 7418
12/01/2005 Authors: Guo Z; Garg S; Hill KM; Jayashankar L; Mooney MR; Hoelscher M; Katz JM; Boss JM; Sambhara S -
Activation of a methylated promoter mediated by a sequence-specific DNA-binding protein, RFX.
J Biol Chem Volume: 280 Page(s): 38914 - 38922
11/25/2005 Authors: Niesen MI; Osborne AR; Yang H; Rastogi S; Chellappan S; Cheng JQ; Boss JM; Blanck G -
A cytokine promoter/yellow fluorescent protein reporter transgene serves as an early activation marker of lymphocyte subsets.
Cell Immunol Volume: 237 Page(s): 131 - 140
10/01/2005 Authors: Kumar S; Skeen MJ; Adiri Y; Yoon H; Vezys VD; Lukacher AE; Evavold BD; Ziegler HK; Boss JM -
Regulation of snail transcription: A chromatin structure approach.
Volume: 283 Page(s): 609 - 610
07/15/2005 Authors: Palmer MB; Boss JM; Wade PA -
X box-like sequences in the MHC class II region maintain regulatory function.
J Immunol Volume: 175 Page(s): 1030 - 1040
07/15/2005 Authors: Gomez JA; Majumder P; Nagarajan UM; Boss JM -
Evolutionary conservation and characterization of the bare lymphocyte syndrome transcription factor RFX-B and its paralogue ANKRA2.
Immunogenetics Volume: 56 Page(s): 788 - 797
02/01/2005 Authors: Long AB; Boss JM -
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions.
Cell Volume: 119 Page(s): 1041 - 1054
12/29/2004 Authors: Impey S; McCorkle SR; Cha-Molstad H; Dwyer JM; Yochum GS; Boss JM; McWeeney S; Dunn JJ; Mandel G; Goodman RH -
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.
Cell Volume: 119 Page(s): 75 - 86
10/01/2004 Authors: Fujita N; Jaye DL; Geigerman C; Akyildiz A; Mooney MR; Boss JM; Wade PA -
A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression.
J Immunol Volume: 173 Page(s): 410 - 419
07/01/2004 Authors: Nagarajan UM; Long AB; Harreman MT; Corbett AH; Boss JM -
The functional domains of the MHC class II bare lymphocyte syndrome transcription factors RFX and CIITA are evolutionarily conserved in animals with adaptive immune responses
Volume: 18 Page(s): A40 - A40
03/23/2004 Authors: Long AB; Boss JM -
DNA methylation and expression of major histocompatibility complex class I and class II transactivator genes in human developmental tumor cells and in T cell malignancies.
Clin Immunol Volume: 109 Page(s): 46 - 52
10/01/2003 Authors: van den Elsen PJ; Holling TM; van der Stoep N; Boss JM -
Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor.
J Immunol Volume: 171 Page(s): 2374 - 2383
09/01/2003 Authors: Hornell TMC; Beresford GW; Bushey A; Boss JM; Mellins ED -
Role of the intronic enhancer in tumor necrosis factor-mediated induction of manganous superoxide dismutase.
J Biol Chem Volume: 278 Page(s): 23570 - 23578
06/27/2003 Authors: Guo Z; Boekhoudt GH; Boss JM -
Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene.
J Immunol Volume: 170 Page(s): 4139 - 4147
04/15/2003 Authors: Boekhoudt GH; Guo Z; Beresford GW; Boss JM -
Transcriptional regulation of the MHC class II antigen presentation pathway.
Curr Opin Immunol Volume: 15 Page(s): 105 - 111
02/01/2003 Authors: Boss JM; Jensen PE -
The adenovirus e3 promoter is sensitive to activation signals in human T cells.
J Virol Volume: 77 Page(s): 1112 - 1119
01/01/2003 Authors: Mahr JA; Boss JM; Gooding LR -
Modulation of gene expression by the MHC class II transactivator.
J Immunol Volume: 169 Page(s): 5078 - 5088
11/01/2002 Authors: Nagarajan UM; Bushey A; Boss JM -
CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
J Immunol Volume: 169 Page(s): 693 - 701
07/15/2002 Authors: Miller JD; Peters M; Oran AE; Beresford GW; Harrington L; Boss JM; Altman JD -
Kinetics of a gamma interferon response: expression and assembly of CIITA promoter IV and inhibition by methylation.
Mol Cell Biol Volume: 22 Page(s): 4781 - 4791
07/01/2002 Authors: Morris AC; Beresford GW; Mooney MR; Boss JM -
GM-CSF mediated upregulation of the class II MHC pathway in human monocytes
FASEB JOURNAL Volume: 16 Page(s): A1232 - A1232
03/22/2002 Authors: Hornell TMC; Bushey A; Boss J; Mellins ED -
Activation of the adenovirus E3 promoter in T lymphocytes
FASEB JOURNAL Volume: 16 Page(s): A303 - A303
03/20/2002 Authors: Mahr JA; Boss JM; Gooding L -
Class II transactivator is required for maximal expression of HLA-DOB in B cells.
J Immunol Volume: 168 Page(s): 1780 - 1786
02/15/2002 Authors: Nagarajan UM; Lochamy J; Chen X; Beresford GW; Nilsen R; Jensen PE; Boss JM -
The MHC-specific enhanceosome and its role in MHC class I and beta(2)-microglobulin gene transactivation.
J Immunol Volume: 167 Page(s): 5175 - 5184
11/01/2001 Authors: Gobin SJ; van Zutphen M; Westerheide SD; Boss JM; van den Elsen PJ -
CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter.
Nat Immunol Volume: 2 Page(s): 652 - 657
07/01/2001 Authors: Beresford GW; Boss JM -
Varying functions of specific major histocompatibility class II transactivator promoter III and IV elements in melanoma cell lines.
Cell Growth Differ Volume: 12 Page(s): 327 - 335
06/01/2001 Authors: Goodwin BL; Xi H; Tejiram R; Eason DD; Ghosh N; Wright KL; Nagarajan U; Boss JM; Blanck G -
Varying functions of specific MHC class II transactivator (CIITA) promoter III and IV elements in melanoma cell lines
FASEB JOURNAL Volume: 15 Page(s): A658 - A658
03/07/2001 Authors: Goodwin BL; Xi HK; Eason DD; Ghosh N; Wright KL; Nagarajan U; Boss JM; Blanck G -
CIITA is required for maximal expression at HLA-DOB
FASEB JOURNAL Volume: 15 Page(s): A694 - A694
03/07/2001 Authors: Nagarajan UM; Nilsen R; Lochamy J; Rudy C; Chen XJ; Jensen P; Boss J -
Associations and interactions between bare lymphocyte syndrome factors.
Mol Cell Biol Volume: 20 Page(s): 6587 - 6599
09/01/2000 Authors: DeSandro AM; Nagarajan UM; Boss JM -
Site A of the MCP-1 distal regulatory region functions as a transcriptional modulator through the transcription factor NF1.
Mol Immunol Volume: 37 Page(s): 623 - 632
08/01/2000 Authors: Kumar SN; Boss JM -
Methylation of class II trans-activator promoter IV: a novel mechanism of MHC class II gene control.
J Immunol Volume: 164 Page(s): 4143 - 4149
04/15/2000 Authors: Morris AC; Spangler WE; Boss JM -
Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells.
J Immunol Volume: 164 Page(s): 3666 - 3674
04/01/2000 Authors: Nagarajan UM; Peijnenburg A; Gobin SJ; Boss JM; van den elsen PJ -
Sp1 binding is critical for promoter assembly and activation of the MCP-1 gene by tumor necrosis factor.
J Biol Chem Volume: 275 Page(s): 1708 - 1714
01/21/2000 Authors: Ping D; Boekhoudt G; Zhang F; Morris A; Philipsen S; Warren ST; Boss JM -
trans-Retinoic acid blocks platelet-derived growth factor-BB-induced expression of the murine monocyte chemoattractant-1 gene by blocking the assembly of a promoter proximal Sp1 binding site.
J Biol Chem Volume: 274 Page(s): 31909 - 31916
11/05/1999 Authors: Ping D; Boekhoudt G; Boss JM -
A common set of factors control the expression of the MHC class II, invariant chain, and HLA-DM genes.
Microbes Infect Volume: 1 Page(s): 847 - 853
09/01/1999 Authors: Boss JM -
The bare lymphocyte syndrome: molecular clues to the transcriptional regulation of major histocompatibility complex class II genes.
Am J Hum Genet Volume: 65 Page(s): 279 - 286
08/01/1999 Authors: DeSandro A; Nagarajan UM; Boss JM -
Orientation and positional mapping of the subunits of the multicomponent transcription factors RFX and X2BP to the major histocompatibility complex class II transcriptional enhancer.
Nucleic Acids Res Volume: 27 Page(s): 1635 - 1641
04/01/1999 Authors: Westerheide SD; Boss JM -
RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency.
Immunity Volume: 10 Page(s): 153 - 162
02/01/1999 Authors: Nagarajan UM; Louis-Plence P; DeSandro A; Nilsen R; Bushey A; Boss JM -
CREB regulates MHC class II expression in a CIITA-dependent manner.
Immunity Volume: 10 Page(s): 143 - 151
02/01/1999 Authors: Moreno CS; Beresford GW; Louis-Plence P; Morris AC; Boss JM -
Nuclear factor-kappa B p65 mediates the assembly and activation of the TNF-responsive element of the murine monocyte chemoattractant-1 gene.
J Immunol Volume: 162 Page(s): 727 - 734
01/15/1999 Authors: Ping D; Boekhoudt GH; Rogers EM; Boss JM -
Infection with virulent Mycobacterium. tuberculosis inhibits IFN-gamma-induced MHC class II expression in macrophages.
JOURNAL OF LEUKOCYTE BIOLOGY Page(s): 30 - 30
01/01/1999 Authors: Vasquez GM; Patino E; Rojas M; Boss J; Garcia LF; Barrera LF -
MHC class II gene silencing in trophoblast cells is caused by inhibition of CIITA expression.
Am J Reprod Immunol Volume: 40 Page(s): 385 - 394
12/01/1998 Authors: Morris AC; Riley JL; Fleming WH; Boss JM -
The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element.
Nucleic Acids Res Volume: 26 Page(s): 4128 - 4136
09/15/1998 Authors: Brown JA; Rogers EM; Boss JM -
CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo.
Proc Natl Acad Sci U S A Volume: 95 Page(s): 6267 - 6272
05/26/1998 Authors: Wright KL; Chin KC; Linhoff M; Skinner C; Brown JA; Boss JM; Stark GR; Ting JP -
IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: functional interaction between an IFN-gamma-activated site and a GC-rich element.
J Immunol Volume: 160 Page(s): 3908 - 3916
04/15/1998 Authors: Zhou ZH; Chaturvedi P; Han YL; Aras S; Li YS; Kolattukudy PE; Ping D; Boss JM; Ransohoff RM -
Identification of immediate early TNF alpha responsive genes in human dermal microvascular endothelial cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 110 Page(s): 648 - 648
04/01/1998 Authors: Cannon G; Boss JM; Caughman SW -
Human cytomegalovirus inhibits MHC class II expression by disruption of the Jak/Stat pathway.
FASEB JOURNAL Volume: 12 Page(s): A473 - A473
03/17/1998 Authors: Miller DM; Rahill BM; Boss JM; Waldman WJ; Durbin JE; Laimore MD; Sedmak DD -
Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway.
J Exp Med Volume: 187 Page(s): 675 - 683
03/02/1998 Authors: Miller DM; Rahill BM; Boss JM; Lairmore MD; Durbin JE; Waldman JW; Sedmak DD -
Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB.
Mol Cell Biol Volume: 17 Page(s): 6970 - 6981
12/01/1997 Authors: Jones PL; Ping D; Boss JM -
Formation of a regulatory factor X/X2 box-binding protein/nuclear factor-Y multiprotein complex on the conserved regulatory regions of HLA class II genes.
J Immunol Volume: 159 Page(s): 3899 - 3909
10/15/1997 Authors: Louis-Plence P; Moreno CS; Boss JM -
Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex.
J Immunol Volume: 158 Page(s): 5841 - 5848
06/15/1997 Authors: Moreno CS; Rogers EM; Brown JA; Boss JM -
HLA-DMA and HLA-DMB gene expression functions through the conserved S-X-Y region.
J Immunol Volume: 158 Page(s): 4812 - 4821
05/15/1997 Authors: Westerheide SD; Louis-Plence P; Ping D; He XF; Boss JM -
TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.
J Immunol Volume: 158 Page(s): 2065 - 2075
03/01/1997 Authors: Lee YJ; Han Y; Lu HT; Nguyen V; Qin H; Howe PH; Hocevar BA; Boss JM; Ransohoff RM; Benveniste EN -
Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases.
J Biol Chem Volume: 272 Page(s): 5640 - 5646
02/28/1997 Authors: Smith ER; Jones PL; Boss JM; Merrill AH -
Regulation of transcription of MHC class II genes.
Curr Opin Immunol Volume: 9 Page(s): 107 - 113
02/01/1997 Authors: Boss JM -
Complex architecture of major histocompatibility complex class II promoters: reiterated motifs and conserved protein-protein interactions.
Mol Cell Biol Volume: 16 Page(s): 4683 - 4690
09/01/1996 Authors: Jabrane-Ferrat N; Fontes JD; Boss JM; Peterlin BM -
TNF regulates the in vivo occupancy of both distal and proximal regulatory regions of the MCP-1/JE gene.
Immunity Volume: 4 Page(s): 455 - 469
05/01/1996 Authors: Ping D; Jones PL; Boss JM -
Apoptosis independent, retinoblastoma protein rescue of HLA class II mRNA IFN-gamma inducibility in non-small cell lung carcinoma cells: Lack of surface class II expression associated with a specific defect in HLA-DR induction.
FASEB JOURNAL Volume: 10 Page(s): 2684 - 2684
04/30/1996 Authors: Lu YM; Boss JM; ShiXue; Xu HJ; Blanck G -
Retinoblastoma protein rescue of HLA class II mRNA IFN-gamma inducibility in non-small cell lung carcinoma (NSCLC) cells
HUMAN IMMUNOLOGY Volume: 47 Page(s): P66 - P66
04/15/1996 Authors: Lu YM; Boss JM; Hu SX; Xu HJ; Blanck G -
Apoptosis-independent retinoblastoma protein rescue of HLA class II messenger RNA IFN-gamma inducibility in non-small cell lung carcinoma cells. Lack of surface class II expression associated with a specific defect in HLA-DRA induction.
J Immunol Volume: 156 Page(s): 2495 - 2502
04/01/1996 Authors: Lu Y; Boss JM; Hu SX; Xu HJ; Blanck G -
Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5.
Immunogenetics Volume: 43 Page(s): 88 - 91
01/01/1996 Authors: Brown JA; He XF; Westerheide SD; Boss JM -
Purified X2 binding protein (X2BP) cooperatively binds the class II MHC X box region in the presence of purified RFX, the X box factor deficient in the bare lymphocyte syndrome.
J Immunol Volume: 155 Page(s): 4313 - 4321
11/01/1995 Authors: Moreno CS; Emery P; West JE; Durand B; Reith W; Mach B; Boss JM -
Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma.
J Exp Med Volume: 182 Page(s): 1517 - 1525
11/01/1995 Authors: Lu HT; Riley JL; Babcock GT; Huston M; Stark GR; Boss JM; Ransohoff RM -
Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA).
Immunity Volume: 2 Page(s): 533 - 543
05/01/1995 Authors: Riley JL; Westerheide SD; Price JA; Brown JA; Boss JM -
DNA AFFINITY-PURIFIED X2 BINDING-PROTEIN (X2BP) FORMS A STABILIZED COMPLEX WITH PURIFIED RFX ON MHC CLASS-II PROMOTERS
FASEB JOURNAL Volume: 9 Page(s): A239 - A239
03/09/1995 Authors: MORENO CS; WEST JE; BOSS JM -
CLONING, CHARACTERIZATION, AND REGULATION OF THE, MURINE MNSOD GENE
FASEB JOURNAL Volume: 9 Page(s): A488 - A488
03/09/1995 Authors: JONES PL; PING D; BOSS JM -
Cloning and characterization of the murine manganous superoxide dismutase-encoding gene.
Gene Volume: 153 Page(s): 155 - 161
02/14/1995 Authors: Jones PL; Kucera G; Gordon H; Boss JM -
Retinoblastoma protein regulation of surface CD74 (invariant chain) expression in breast carcinoma cells.
Mol Immunol Volume: 31 Page(s): 1365 - 1368
12/01/1994 Authors: Lu Y; Ussery GD; Jacim M; Tschickardt M; Boss JM; Blanck G -
Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction.
Immunity Volume: 1 Page(s): 687 - 697
11/01/1994 Authors: Chin KC; Mao C; Skinner C; Riley JL; Wright KL; Moreno CS; Stark GR; Boss JM; Ting JP -
ACTIVATION OF CLASS-II MHC GENES
JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 52 - 52
02/13/1994 Authors: RILEY JL; BOSS JM -
Class II MHC transcriptional mutants are defective in higher order complex formation.
J Immunol Volume: 151 Page(s): 6942 - 6953
12/15/1993 Authors: Riley JL; Boss JM -
Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells.
J Immunol Volume: 150 Page(s): 1781 - 1793
03/01/1993 Authors: Hasegawa SL; Riley JL; Sloan JH; Boss JM -
Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts.
J Immunol Volume: 148 Page(s): 4021 - 4027
06/15/1992 Authors: Gordon HM; Kucera G; Salvo R; Boss JM -
Single base pair substitutions within the HLA-DRA gene promoter separate the functions of the X1 and X2 boxes.
J Immunol Volume: 148 Page(s): 2591 - 2599
04/15/1992 Authors: Sloan JH; Hasegawa SL; Boss JM -
Two B cell factors bind the HLA-DRA X box region and recognize different subsets of HLA class II promoters.
Nucleic Acids Res Volume: 19 Page(s): 6269 - 6276
11/25/1991 Authors: Hasegawa SL; Boss JM -
DNA binding properties of YB-1 and dbpA: binding to double-stranded, single-stranded, and abasic site containing DNAs.
Nucleic Acids Res Volume: 19 Page(s): 4915 - 4920
09/25/1991 Authors: Hasegawa SL; Doetsch PW; Hamilton KK; Martin AM; Okenquist SA; Lenz J; Boss JM -
Sensitivity to tumour necrosis factor-mediated cytolysis is unrelated to manganous superoxide dismutase messenger RNA levels among transformed mouse fibroblasts.
Immunology Volume: 73 Page(s): 309 - 315
07/01/1991 Authors: Boss JM; Laster SM; Gooding LR -
Regulatory factor-X binding to mutant HLA-DRA promoter sequences.
Nucleic Acids Res Volume: 19 Page(s): 1243 - 1249
03/25/1991 Authors: Hasegawa SL; Sloan JH; Reith W; Mach B; Boss JM -
ANALYSIS OF MUTATIONS IN THE HLA-DRA GENE PROMOTER
FASEB JOURNAL Volume: 5 Page(s): A617 - A617
03/11/1991 Authors: BOSS JM; SLOAN JH; HASEGAWA SL; RILEY J; MACH B; REITH W -
The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.
Science Volume: 246 Page(s): 670 - 673
11/03/1989 Authors: Wilkinson KD; Lee KM; Deshpande S; Duerksen-Hughes P; Boss JM; Pohl J -
Conserved upstream sequences of human class II major histocompatibility genes enhance expression of class II genes in wild-type but not mutant B-cell lines.
Proc Natl Acad Sci U S A Volume: 85 Page(s): 8186 - 8190
11/01/1988 Authors: Sloan JH; Boss JM -
Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.
Immunogenetics Volume: 26 Page(s): 63 - 73
01/01/1987 Authors: Auffray C; Lillie JW; Korman AJ; Boss JM; Frchin N; Guillemot F; Cooper J; Mulligan RC; Strominger JL -
A highly diverged beta 1 exon in the DR region of the human MHC: sequence and evolutionary implications.
Immunogenetics Volume: 25 Page(s): 15 - 20
01/01/1987 Authors: Haas DA; Boss JM; Strominger JL; Spies T -
Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts.
Proc Natl Acad Sci U S A Volume: 83 Page(s): 9139 - 9143
12/01/1986 Authors: Boss JM; Strominger JL -
Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain.
Proc Natl Acad Sci U S A Volume: 83 Page(s): 2619 - 2623
04/01/1986 Authors: Dialynas DP; Murre C; Quertermous T; Boss JM; Leiden JM; Seidman JG; Strominger JL -
Major histocompatibility complex class II antigens: genes and proteins.
Mt Sinai J Med Volume: 53 Page(s): 202 - 209
03/01/1986 Authors: Sorrentino R; Auffray C; Boss J; Grossberger D; Kappes D; Levy D; Lillie J; Mengler R; Okada K; Prentice H -
Sequence analysis of the human major histocompatibility gene SX alpha.
Mol Cell Biol Volume: 5 Page(s): 2677 - 2683
10/01/1985 Authors: Boss JM; Mengler R; Okada K; Auffray C; Strominger JL -
Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis.
Nature Volume: 316 Page(s): 748 - 750
08/22/1985 Authors: Collins T; Ginsburg D; Boss JM; Orkin SH; Pober JS -
Structural organization of the DR subregion of the human major histocompatibility complex.
Proc Natl Acad Sci U S A Volume: 82 Page(s): 5165 - 5169
08/01/1985 Authors: Spies T; Sorrentino R; Boss JM; Okada K; Strominger JL -
Genetic complexity and expression of human class II histocompatibility antigens.
Immunol Rev Volume: 85 Page(s): 45 - 86
07/01/1985 Authors: Korman AJ; Boss JM; Spies T; Sorrentino R; Okada K; Strominger JL -
Gene organization of DC and DX subregions of the human major histocompatibility complex.
Proc Natl Acad Sci U S A Volume: 82 Page(s): 3410 - 3414
05/01/1985 Authors: Okada K; Boss JM; Prentice H; Spies T; Mengler R; Auffray C; Lillie J; Grossberger D; Strominger JL -
SB subregion of the human major histocompatibility complex: gene organization, allelic polymorphism and expression in transformed cells.
EMBO J Volume: 4 Page(s): 739 - 748
03/01/1985 Authors: Okada K; Prentice HL; Boss JM; Levy DJ; Kappes D; Spies T; Raghupathy R; Mengler RA; Auffray C; Strominger JL -
CULTURED HUMAN-ENDOTHELIAL CELLS TRANSCRIBE PLATELET DERIVED GROWTH-FACTOR CHAIN-2 - CDNA CLONING AND STRUCTURAL-ANALYSIS
FEDERATION PROCEEDINGS Volume: 44 Page(s): 1843 - 1843
01/01/1985 Authors: COLLINS T; GINSBERG D; BOSS J; ORKIN SH; POBER JS -
Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.
Proc Natl Acad Sci U S A Volume: 81 Page(s): 4917 - 4921
08/01/1984 Authors: Collins T; Korman AJ; Wake CT; Boss JM; Kappes DJ; Fiers W; Ault KA; Gimbrone MA; Strominger JL; Pober JS -
Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta.
Proc Natl Acad Sci U S A Volume: 81 Page(s): 5199 - 5203
08/01/1984 Authors: Boss JM; Strominger JL -
Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex.
Proc Natl Acad Sci U S A Volume: 80 Page(s): 6036 - 6040
10/01/1983 Authors: Roux-Dosseto M; Auffray C; Lillie JW; Boss JM; Cohen D; DeMars R; Mawas C; Seidman JG; Strominger JL -
DNA insertions which affect the expression of the yeast iso-2-cytochrome c gene.
Curr Genet Volume: 7 Page(s): 117 - 122
04/01/1983 Authors: Wright CF; Walthall DA; Boss JM; Zitomer RS -
The molecular characterization of three transcriptional mutations in the yeast iso-2-cytochrome c gene.
J Biol Chem Volume: 257 Page(s): 7756 - 7761
07/10/1982 Authors: Montgomery DL; Boss JM; McAndrew SJ; Marr L; Walthall DA; Zitomer RS -
Sequence of the yeast iso-1-cytochrome c mRNA.
J Biol Chem Volume: 256 Page(s): 12958 - 12961
12/25/1981 Authors: Boss JM; Gillam S; Zitomer RS; Smith M -
Characterization of yeast iso-1-cytochrome c mRNA.
J Biol Chem Volume: 255 Page(s): 8623 - 8628
09/25/1980 Authors: Boss JM; Darrow MD; Zitomer RS