Genetics Courses
HGC 715: Human Genetics
This course provides an overview of human genetics concepts including Mendelian and non-Mendelian inheritance, the molecular basis of human variation and disease susceptibility, and chromosome variation. Population and quantitative genetics are covered, including pedigree and risk assessment using Bayesian statistics.
Fall I – 3 credits
HGC 725: Developmental Biology and Human Malformation
Primary concepts covered in this course include principles of developmental genetics, human reproduction, and normal/abnormal embryological development. The relationship between human development and clinical topics such as congenital anomalies, human disease, teratogens, and infertility are presented, in addition to assistive reproductive technologies and fetal therapy. Development is covered by major organ systems, with emphasis on associated birth defects including etiology, ultrasound findings, and recurrence risks.
Fall I – 2 credits
HGC 745a&b: Medical Genetics I & II
This course introduces the student to the basic elements of a medical genetics evaluation including concepts involved in dysmorphology, physical assessment, and differential diagnosis. The clinical features, natural history, counseling issues and management strategies for major pediatric and adult genetic diagnoses/syndromes are reviewed including chromosome anomalies; bone dysplasias; hemoglobinopathies; metabolic conditions; trinucleotide repeat, connective tissue, neurogenetic, and ophthalmological disorders, as well as other single-gene disorders by organ system. The course also covers methods and procedures associated with newborn screening, carrier testing, and prenatal screening/diagnosis.
Fall I - 1 credit, Spring I – 2 credits
HGC 755: Current Topics in Clinical Genetic Testing
This course utilizes a case-based approach to clinical and laboratory aspects of cytogenetics, biochemical genetics, and molecular genetics testing. Testing methodologies, measures of analytic and clinical validity, and test interpretation are discussed. The course is designed to prepare the student to select appropriate genetic tests for clients and provide accurate counseling based on possible test results.
Spring I – 3 credits
HGC 760: Genetics of Common Diseases
Using cancer as a model, this course focuses on the genetic aspects of common diseases, including epidemiological concepts and levels of disease susceptibility. The clinical and molecular aspects of hereditary cancer syndromes are emphasized, and concepts related to cardiovascular genetics, psychiatric genetics, neuro/developmental genetics, and diseases such as diabetes, asthma, etc, are also addressed. The course provides a framework to address aspects unique to genetic counseling for common chronic diseases including risk assessment, genetic testing options, and screening/prevention strategies.
Spring I – 3 credits
HGC 805: Public Health Genomics
This course provides a basic overview of public health, societal and public policy issues, community-based interventions, and healthcare delivery systems. Public health genetics activities and perspectives at the local, state and federal level, as well as academia and industry, are illustrated using existing programs and projects as examples.
Online: 2 credits (Summer)
HGC 820: Hot Topics in Genomics
This course focuses on the analysis of new and evolving genetic/genomic technologies and their clinical application. Topics include microarray, NIPT, next-generation sequencing, gene panels, whole exome/genome testing, interpretation of genetic variants, pharmacogenomics, genomic profiling/direct-to-consumer genetic testing, carrier, and newborn screening advances, next-generation tumor sequencing, and return of research results. This is a literature-based course, utilizing recent publications to illustrate concepts and issues and stimulate in-class discussion. Application to genetic counseling practice is emphasized through role-play activities and student-led discussion.
Spring II – 3 credits