NIH/NCI/August University - 09/2019-08/2024
Chemo-radio immunotherapy for pediatric brain tumors
Goals: To conduct a Phase 2 trial of IDO-inhibitor drug indoximod in combination with chemotherapy and radiation in pediatric patients with relapsed/refractory brain tumors, and as front-line therapy for newly diagnosed DIPG
NIH/Georiga State University - 04/2022-06/2027
Optimizing Outcomes in AYA survivors of pediatric medulloblastoma
Goals: To examine contextual factors of socioeconomic status, neurological predictors, and targeted SNP arrays associated with cognitive impairment of adolescent and young adult survivors of pediatric medulloblastoma
NIH/NCI/University of California San Francisco - 07/2022-06/2027
Open label Phase 1 and Target Validation study of ONC206 in Children and Young Adults with Newly Diagnosed or Recurrent Diffuse Midline Glioma (DMG), and Other Recurrent Primary Malignant Brain Tumors
Goals: Phase I clinical trial of the drug ONC206 to determine its MTD and preliminary data of efficacy in pediatric patients with high-risk malignant brain tumors
V Foundation for Cancer Research - 11/2019-06/2025
Circulating Tumor Cell Clusters as a Novel Biomarker for Medulloblastoma Treatment
Goals: To molecularly characterize captured circulating tumor cell clusters (CTCCs) in blood and CSF and correlate CTCC detection with clinical outcomes in medulloblastoma patients
Ian's Friends Foundation - 07/2022-06/2024
Precision Medicine Treatment Approach Combining Molecular Diagnostics with High-Throughput Drug Screening Platforms Utilizing Tumor Cells Derived from Pediatric Malignant Brain Tumor Patient
Goals: To pave the way for a new paradigm for how we select the most effective drugs for the treatment of the most deadly brain cancers in children
CURE Childhood Cancer - 07/2022-06/2024
Clinical Investigation of Cluster-Wells in Pediatric Brain Tumors
Goals: To confirm the clinical utility of our Cluster-Wells technology as a novel biomarker assay for serially monitoring real-time minimal residual disease status in children with brain tumors