Emory University School of Medicine
Emory University School of Medicine
Department of Neurosurgery

Residency & Education section navigation

Department of Neurosurgery

Fadi Jacob, MD, PhD

About me

Year 

  • PGY-3

Hometown

  • Alpharetta, GA

Areas of Interest

  • Tumor
  • Skull base

Future Plans

  • Academic Neurosurgery

Awards/Honors

  • The Paul Ehrlich Young Investigator Award, 2020
  • New York Stem Cell Foundation Best Poster Prize, 2019

Hobbies

  • Sports
  • Biking
  • Foosball
  • Traveling
  • Gaming
  • Exploring new foods



Education

  • BS, Cornell University, 2014
  • PhD, The Johns Hopkins University School of Medicine, 2022
  • MD, The Johns Hopkins University School of Medicine, 2022


Publications

  • Jacob, F., Schnoll, J.G., Song, H., & Ming, G.L. (2021). Building the brain from scratch: Engineering region-specific brain organoids from human stem cells to study neural development and disease. Current Topics in Developmental Biology. doi: 10.1016/bs.ctdb.2020.12.011
  • Jacob, F.*, Ming, G. L., & Song, H. (2020). Generation and biobanking of patient-derived glioblastoma organoids and their application in CAR T cell testing. Nature Protocols, 15(12), 4000-4033. doi: 10.1038/s41596-020-0402-9** *Co-corresponding author **Featured on Dec. 2020 Issue Cover
  • Jacob, F., Pather, S. R., Huang, W. K., Zhang, F., Wong, S. Z. H., Zhou, H., Cubitt, B., Fan, W., Chen, C. Z., Xu, M., Pradhan, M., Zhang, D. Y., Zheng, W., Bang, A. G., Song, H., Carlos de la Torre, J., & Ming, G. L. (2020). Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium. Cell Stem Cell. doi: 10.1016/j.stem.2020.09.016* *Featured on Dec. 2020 Issue Cover
  • Qian, X., Su, Y., Adam, C. D., Deutschmann, A. U., Pather, S. R., Goldberg, E. M., Su, K., Li, S., Lu, L., Jacob, F., Nguyen, P. T. T., Huh, S., Hoke, A., Swinford-Jackson, S. E., Wen, Z., Gu, X., Pierce, R. C., Wu, H., Briand, L. A., Chen, H. I., Wolf, J. A., Song, H., & Ming, G.-l. (2020). Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. Cell Stem Cell, 26(5), 766-781.e769. doi: 10.1016/j.stem.2020.02.002
  • Jacob, F., & Bennett, M. L. (2020). Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains. Lab Animal (NY), 49(2), 49-51. doi: 10.1038/s41684-019-0465-9
  • Jacob, F., Salinas, R. D., Zhang, D. Y., Nguyen, P. T. T., Schnoll, J. G., Wong, S. Z. H., Thokala, R., Sheikh, S., Saxena, D., Prokop, S., Liu, D. A., Qian, X., Petrov, D., Lucas, T., Chen, H. I., Dorsey, J. F., Christian, K. M., Binder, Z. A., Nasrallah, M., Brem, S., O'Rourke, D. M., Ming, G. L., & Song, H. (2020). A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell, 180(1), 188-204 e122. doi: 10.1016/j.cell.2019.11.036* *Featured on Jan. 2020 Issue Cover
  • Makhlin, I., Salinas, R. D., Zhang, D., Jacob, F., Ming, G.-l., Song, H., Saxena, D., Dorsey, J. F., Nasrallah, M. P., Morrissette, J. J. D., Binder, Z. A., O'Rourke, D. M., Desai, A. S., Brem, S., & Bagley, S. J. (2019). Clinical activity of the EGFR tyrosine kinase inhibitor osimertinib in EGFR-mutant glioblastoma. CNS Oncology, 8(3), CNS43. doi: 10.2217/cns-2019-0014
  • Song, M., Yang, X., Ren, X., Maliskova, L., Li, B., Jones, I. R., Wang, C., Jacob, F., Wu, K., Traglia, M., Tam, T. W., Jamieson, K., Lu, S. Y., Ming, G. L., Li, Y., Yao, J., Weiss, L. A., Dixon, J. R., Judge, L. M., Conklin, B. R., Song, H., Gan, L., & Shen, Y. (2019). Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Nature Genetics, 51(8), 1252-1262. doi: 10.1038/s41588-019-0472-1
  • Qian, X., Jacob, F.*, Song, M. M., Nguyen, H. N., Song, H., & Ming, G. L. (2018). Generation of human brain region-specific organoids using a miniaturized spinning bioreactor. Nature Protocols, 13(3), 565-580. doi: 10.1038/nprot.2017.152** *Co-first author **Featured on Mar. 2018 Issue Cover
  • Ye, F., Kang, E., Yu, C., Qian, X., Jacob, F., Yu, C., Mao, M., Poon, R. Y. C., Kim, J., Song, H., Ming, G.-l., & Zhang, M. (2017). DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis. Neuron, 96(5), 1041-1054.e1045. doi: 10.1016/j.neuron.2017.10.010
  • Yoon, K.-J., Ringeling, F. R., Vissers, C., Jacob, F., Pokrass, M., Jimenez-Cyrus, D., Su, Y., Kim, N.-S., Zhu, Y., Zheng, L., Kim, S., Wang, X., Doré, L. C., Jin, P., Regot, S., Zhuang, X., Canzar, S., He, C., Ming, G.-l., & Song, H. (2017). Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Cell, 171(4), 877-889.e817. doi: 10.1016/j.cell.2017.09.003
  • Yoon, K.-J., Song, G., Qian, X., Pan, J., Xu, D., Rho, H.-S., Kim, N.-S., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E. M., Huang, W.-K., Ringeling, F. R., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C.-F., Wu, Q., Christian, K. M., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., & Ming, G.-l. (2017). Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins. Cell Stem Cell, 21(3), 349-358.e346. doi: 10.1016/j.stem.2017.07.014
  • Qian, X., Nguyen, H. N., Jacob, F., Song, H., & Ming, G.-l. (2017). Using brain organoids to understand Zika virus-induced microcephaly. Development, 144(6), 952-957. doi: 10.1242/dev.140707
  • Xu, M., Lee, E. M., Wen, Z., Cheng, Y., Huang, W. K., Qian, X., Tcw, J., Kouznetsova, J., Ogden, S. C., Hammack, C., Jacob, F., Nguyen, H. N., Itkin, M., Hanna, C., Shinn, P., Allen, C., Michael, S. G., Simeonov, A., Huang, W., Christian, K. M., Goate, A., Brennand, K. J., Huang, R., Xia, M., Ming, G. L., Zheng, W., Song, H., & Tang, H. (2016). Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nature Medicine, 22(10), 1101-1107. doi: 10.1038/nm.4184
  • Sada, A., Jacob, F., Leung, E., Wang, S., White, B. S., Shalloway, D., & Tumbar, T. (2016). Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin. Nature Cell Biology, 18(6), 619-631. doi: 10.1038/ncb3359
  • Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D., Ho, C. Y., Wen, Z., Christian, K. M., Shi, P. Y., Maher, B. J., Wu, H., Jin, P., Tang, H., Song, H., & Ming, G. L. (2016). Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell, 165(5), 1238-1254. doi: 10.1016/j.cell.2016.04.032

Meetings/Presentations

  • Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium [Oral presentation]. NYSCF 2020 Meeting, Virtual, Oct. 2020
  • A patient-derived glioblastoma organoid model and biobank recapitulates inter- and intra-tumoral heterogeneity [Oral Presentation]. IRM 2020 Retreat, Philadelphia, PA, Feb. 2020.
  • A patient-derived glioblastoma organoid model and biobank recapitulates inter- and intra-tumoral heterogeneity [Poster Presentation]. NYSCF 2019 Meeting, New York City, NY, Oct. 2019 *Winner of best poster award. 
  • Human dentate gyrus organoids derived from patient iPSCs. [Poster presentation]. ISSCR 2017 Meeting, Boston, MA, Jun. 2017
  • Understanding subcortical band heterotopia using patient-derived human forebrain organoids. [Poster presentation]. Keystone Symposium, Squaw Valley, CA, Jan. 2017
  • Towards understanding the role of hoxb7 in the skin. [Poster Presentation]. ISSCR 2013 Meeting, Boston, MA, Jun. 2013