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Publications

The LaRock Lab is part of the Department of Microbiology and Immunology

LaRock Lab Research Description Word Art

Shokoubimehr M, Theus A, Kamalakar A, Ning L, Cao C, Tomov M, Kaiser J, Goudy S, Willet N, Jang H, LaRock C, Hanna P, Lechtig A, Yousef M, Da Silva Martins J, Nazarian A, Harris M, Mahmoudi M, Serpooshan V.  3D bioprinted bacteriostatic hyperelastic bone scaffold aimed at damage-specific bone regeneration. Polymers (2021)

Polymers 2020 publication figure

Wilde S, Olivares K, Hoffman H, Nizet V, Radhakrishna S, LaRock C. Effects of anti-interlekin-6 immunotherapy on opportunistic invasive infection by group A Streptococcus. The Journal of Infectious Diseases (2020)

anti-interlekin-6 immunotherapy on opportunistic invasive infection by group A Streptococcus

LaRock D, Russell R, Johnson A, Wilde S, LaRock C. Group A Streptococcus infection of the nasopharynx requires proinflammatory signaling through the Interleukin-1 receptor. Infection and Immunity (2020)

LaRock Publication image Infection and Immunity

Sun J, LaRock D, Skowronski E, Kimmey J, Olson J, Jiang Z, O’Donoghue A, Nizet V, LaRock C. The Pseudomonas aeruginosa Protease LasB Directly Activates IL-1β. EBioMedicine (2020)

Role of Inflammasome-independent Activation of IL-1β by the Pseudomonas aeruginosa Protease LasB

Xia J, Lyons R, Lin M-Y, Khalifa Y, LaRock C. Combination of lidocaine gel and povidone-iodine to decrease acquired infections in procedures performed using topical anesthesia. Journal of Cataract and Refractive Surgery (2020)

lidocaine gel and povidone-iodine

Wierzbicki I, Cambeau A, Dehaini D, Holay M, Wei X, Greene T, Ying M, Sands J, Lamsa A, Zuniga E, Pogliano K, Fang R, LaRock C, Zhang L, Gonzalez D. Group A streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion. Cell Reports (2019)

Harmful Bacteria Masquerade as Red Blood Cells to Evade the Immune System

LaRock D, Sands J, Ettouati E, Richard M, Bushway P, Adler E, Nizet V, LaRock C. Inflammasome inhibition protects against cardiac glycoside cellular toxicity. The Journal of Biological Chemistry (2019)

Inflammasome inhibition protects against cardiac glycoside cellular toxicity

Dan J, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales S, Anderson E, LaRock C, Seumois G, Layfield D, Cutress R, Ottensmier C, Arlehamn C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Science Translational Medicine (2019)

Teasing apart tonsillitis

Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PM, Beltrão-Braga PC, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Molecular Genetics (2018)

Zika virus infection

Valderrama J, Riestra A, Gao N, LaRock C, Ali S, Gupta N, Hoffman H, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nature Microbiology (2017)

Group A streptococcal M protein activates the NLRP3 inflammasome

Döhrmann S, LaRock C, Anderson E, Cole J, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones. Scientific Reports (2017)

Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones

LaRock C, Todd J, LaRock D, Olson J, O’Donoghue A, Robertson A, Cooper M, Hoffman H, Nizet V. IL-1β is an innate immune sensor of microbial proteolysis. Science Immunology (2017)

A one-protein signaling pathway in the innate immune system

LaRock C & Nizet V. Inflammasome/IL-1β responses to streptococcal pathogens. Frontiers Immunology (2016)

Inflammasome/IL-1β responses to streptococcal pathogens

LaRock C, Döhrmann S, Todd J, Corriden R, Johannssen T, Lepenies B, Gallo R, Ghosh P, Nizet V. Group A streptococcal M1 protein sequesters cathelicidin to evade innate immune killing. Cell Host & Microbe (2015)

Streptococcal M1 Strikes by Neutralizing Cathelicidins

LaRock C & Nizet V. Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens. BBA Biomembranes (2015)

Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens

Barnett T, Liebl D, Seymour L, Gillen C, Lim J, LaRock C, Davies M, Schulz B, Nizet V, Teasdale R, Walker M. The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication. Cell Host & Microbe (2013)

S. pyogenes Escapes Autophagy

LaRock C & Cookson B. Burning down the house: cell actions during pyroptosis. PLoS Pathogens (2013)

cell actions during pyroptosis

LaRock C, Yu J, Horswill A, Parsek M, Minion F. Transcriptome analysis of acyl-homoserine lactone based quorum sensing regulation in Yersinia pestis. PLoS One (2013)

Transcriptome analysis of acyl-homoserine lactone based quorum sensing regulation in Yersinia pestis

LaRock C & Cookson B. The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing. Cell Host & Microbe (2012)

YopM Puts Caspase-1 on Ice

Livny J, LaRock C, Friedman D. Identification and isolation of lysogens with induced prophage. Methods in Molecular Biology (2009)

Identification and isolation of lysogens with induced prophage

Tchesnokova V, Aprikian P, Yakovenko O, LaRock C, Kidd B, Vogel V, Thomas W, Sokurenko E. Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli. The Journal of Biological Chemistry (2008)

Held K, LaRock C, D'Argenio D, Berg C, Collins C. A metalloprotease secreted by the insect pathogen Photorhabdus luminescens induces melanization. Applied & Environmental Microbiology (2007)

Wild-type fly pricked with 2.6 μg μl−1 rPrtS-E168A