The LaRock Lab is part of the Department of Microbiology and Immunology
Johnson A, Sands J, Trivedi K, Russell R, LaRock D, LaRock C. Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection. PLoS Pathogens(2023)
Everett M, Davies D, Leiris S, Sprynski N, Llanos A, Castandet J, Lozano C, LaRock C, LaRock D, Corsica G, Docquier J-D, Pallin D, Cridland A, Blench T, Zalacain M, Lemonnier M. Chemical optimization of selective Pseudomonas aeruginosa LasB elastase inhibitors and their impact on LasB-mediated activation of IL-1β in cellular and animal infection models. ACS Infectious Disease(2023)
Theus A, Ning L, Kabboul G, LaRock C, Bauser-Heaton H, Mahmoudi M, Serpooshan V. 3D bioprinting of nanoparticle-laden hydrogel scaffolds with enhanced antibacterial and imaging properties.iScience (2022)
LaRock D, Johnson A, Wilde S, Sands J, Monteiro M, LaRock C. Group A Streptococcus induces GSDMA-dependent pyroptosis of keratinocytes. Nature (2022)
Johnson A, LaRock C. Antibiotic treatment, mechanisms for failure, and adjunctive therapies for infections by group A Streptococcus. Frontiers in Microbiology (2021)
Johnson A, Sands J, Trivedi K, Russell R, LaRock D, LaRock C. Pro-IL-18 secreted by keratinocytes detects the group A streptococcal protease SpeB. BioRxiv(2021)
Atashgah R, Ghasemi A, Raoufi M, Abdollahifar M, Zanganeh S, Nejadnik H, Abdollahi A, Sharifi S, Lea B, Cuerva M, Akbarzadeh M, Alvarez-Lorenzo C, Ostad S, Theus A, LaRock D, LaRock C, Serpooshan V, Sarrafi R, Lee KB, Vali H, Schönherr H, Gould L, Taboada P, Mahmoudi M. Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing. Molecular Pharmaceutics (2021)
Shokoubimehr M, Theus A, Kamalakar A, Ning L, Cao C, Tomov M, Kaiser J, Goudy S, Willet N, Jang H, LaRock C, Hanna P, Lechtig A, Yousef M, Da Silva Martins J, Nazarian A, Harris M, Mahmoudi M, Serpooshan V. 3D bioprinted bacteriostatic hyperelastic bone scaffold aimed at damage-specific bone regeneration. Polymers (2021)
Wilde S, Olivares K, Hoffman H, Nizet V, Radhakrishna S, LaRock C. Effects of anti-interlekin-6 immunotherapy on opportunistic invasive infection by group A Streptococcus. The Journal of Infectious Diseases (2020)
LaRock D, Russell R, Johnson A, Wilde S, LaRock C. Group A Streptococcus infection of the nasopharynx requires proinflammatory signaling through the Interleukin-1 receptor. Infection and Immunity (2020)
Xia J, Lyons R, Lin M-Y, Khalifa Y, LaRock C. Combination of lidocaine gel and povidone-iodine to decrease acquired infections in procedures performed using topical anesthesia. Journal of Cataract and Refractive Surgery (2020)
Wierzbicki I, Cambeau A, Dehaini D, Holay M, Wei X, Greene T, Ying M, Sands J, Lamsa A, Zuniga E, Pogliano K, Fang R, LaRock C, Zhang L, Gonzalez D. Group A streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion. Cell Reports (2019)
LaRock D, Sands J, Ettouati E, Richard M, Bushway P, Adler E, Nizet V, LaRock C. Inflammasome inhibition protects against cardiac glycoside cellular toxicity. The Journal of Biological Chemistry (2019)
Dan J, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales S, Anderson E, LaRock C, Seumois G, Layfield D, Cutress R, Ottensmier C, Arlehamn C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Science Translational Medicine (2019)
Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PM, Beltrão-Braga PC, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Molecular Genetics (2018)
Valderrama J, Riestra A, Gao N, LaRock C, Ali S, Gupta N, Hoffman H, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nature Microbiology (2017)
Döhrmann S, LaRock C, Anderson E, Cole J, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones. Scientific Reports (2017)
LaRock C, Todd J, LaRock D, Olson J, O’Donoghue A, Robertson A, Cooper M, Hoffman H, Nizet V. IL-1β is an innate immune sensor of microbial proteolysis. Science Immunology (2017)
LaRock C & Cookson B. Burning down the house: cell actions during pyroptosis. PLoS Pathogens (2013)
LaRock C, Yu J, Horswill A, Parsek M, Minion F. Transcriptome analysis of acyl-homoserine lactone based quorum sensing regulation in Yersinia pestis. PLoS One (2013)
LaRock C & Cookson B. The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing. Cell Host & Microbe (2012)
Livny J, LaRock C, Friedman D. Identification and isolation of lysogens with induced prophage. Methods in Molecular Biology (2009)
Tchesnokova V, Aprikian P, Yakovenko O, LaRock C, Kidd B, Vogel V, Thomas W, Sokurenko E. Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli. The Journal of Biological Chemistry (2008)
Held K, LaRock C, D'Argenio D, Berg C, Collins C. A metalloprotease secreted by the insect pathogen Photorhabdus luminescens induces melanization. Applied & Environmental Microbiology (2007)