LaRock Lab Publications Department of Microbiology and Immunology

Johnson A, Sands J, Trivedi K, Russell R, LaRock D, LaRock C. Pro-IL-18 secreted by keratinocytes detects the group A streptococcal protease SpeB. Preprint on bioRxiv

Wilde S, Johnson A, LaRock C. Playing With Fire: Proinflammatory Virulence Mechanisms of Group A Streptococcus. Frontiers in Cellular & Infection Microbiology (2021)

Atashgah R, Ghasemi A, Raoufi M, Abdollahifar M, Zanganeh S, Nejadnik H, Abdollahi A, Sharifi S, Lea B, Cuerva M, Akbarzadeh M, Alvarez-Lorenzo C, Ostad S, Theus A, LaRock D, LaRock C, Serpooshan V, Sarrafi R, Lee KB, Vali H, Schönherr H, Gould L, Taboada P, Mahmoudi M. Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing. Molecular Pharmaceutics (2021)

Shokoubimehr M, Theus A, Kamalakar A, Ning L, Cao C, Tomov M, Kaiser J, Goudy S, Willet N, Jang H, LaRock C, Hanna P, Lechtig A, Yousef M, Da Silva Martins J, Nazarian A, Harris M, Mahmoudi M, Serpooshan V. 3D bioprinted bacteriostatic hyperelastic bone scaffold aimed at damage-specific bone regeneration. Polymers (2021)

Wilde S, Olivares K, Hoffman H, Nizet V, Radhakrishna S, LaRock C. Effects of anti-interlekin-6 immunotherapy on opportunistic invasive infection by group A Streptococcus. The Journal of Infectious Diseases (2020)

anti-interlekin-6 immunotherapy on opportunistic invasive infection by group A Streptococcus

LaRock D, Russell R, Johnson A, Wilde S, LaRock C. Group A Streptococcus infection of the nasopharynx requires proinflammatory signaling through the Interleukin-1 receptor. Infection and Immunity (2020)

▪︎ bioRxiv "Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling Through the IL1R"▪︎ I&I Article of significant interest "Interleukin-1β Fuels Streptococcal Pharyngitis"

LaRock Publication image Infection and Immunity

Sun J, LaRock D, Skowronski E, Kimmey J, Olson J, Jiang Z, O’Donoghue A, Nizet V, LaRock C. The Pseudomonas aeruginosa Protease LasB Directly Activates IL-1β. EBioMedicine (2020)

▪︎ bioRxiv "Role of Inflammasome-independent Activation of IL-1β by the Pseudomonas aeruginosa Protease LasB"

Xia J, Lyons R, Lin M-Y, Khalifa Y, LaRock C. Combination of lidocaine gel and povidone-iodine to decrease acquired infections in procedures performed using topical anesthesia. Journal of Cataract and Refractive Surgery (2020)

Wierzbicki I, Cambeau A, Dehaini D, Holay M, Wei X, Greene T, Ying M, Sands J, Lamsa A, Zuniga E, Pogliano K, Fang R, LaRock C, Zhang L, Gonzalez D. Group A streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion. Cell Reports (2019)

▪︎ Smithsonian "Harmful Bacteria Masquerade as Red Blood Cells to Evade the Immune System"▪︎ Cell Press "How the strep bacterium hides from the immune system"

LaRock D, Sands J, Ettouati E, Richard M, Bushway P, Adler E, Nizet V, LaRock C. Inflammasome inhibition protects against cardiac glycoside cellular toxicity. The Journal of Biological Chemistry (2019)

Inflammasome inhibition protects against cardiac glycoside cellular toxicity

Dan J, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales S, Anderson E, LaRock C, Seumois G, Layfield D, Cutress R, Ottensmier C, Arlehamn C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Science Translational Medicine (2019)

▪︎ Science “Teasing apart tonsillitis”▪︎ Trends in Immunology “Recurrent Tonsillitis Tfh Cells Acquire a Killer Identity” by Andrew Baessler and J Scott Hale ▪︎ Newsweek “Some kids are more likely to get strep throat over and over again-here’s why”▪︎ Popular Science “We’re finally understanding why some kids get strep throat over and over again”▪︎ NIAID Now “Tonsillitis Again? Study Explains Why Some Children Get Recurrent Tonsil Infections”

Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PM, Beltrão-Braga PC, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Molecular Genetics (2018)

Valderrama J, Riestra A, Gao N, LaRock C, Ali S, Gupta N, Hoffman H, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nature Microbiology (2017)

Döhrmann S, LaRock C, Anderson E, Cole J, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones. Scientific Reports (2017)

Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones

LaRock C, Todd J, LaRock D, Olson J, O’Donoghue A, Robertson A, Cooper M, Hoffman H, Nizet V. IL-1β is an innate immune sensor of microbial proteolysis. Science Immunology (2017)

▪︎ Science Immunology "A one-protein signaling pathway in the innate immune system" by M Orzalli & J Kagan ▪︎ Nature Reviews Immunology “IL-1beta activation under scrutiny” ▪︎ Science “A new trick for IL-1beta” ▪︎ UCSD press “Flesh-eating infections in arthritis patients spur discovery” ▪︎ San Diego Union-Tribune “How flesh-eating bacteria evade immune response”

LaRock C & Nizet V. Inflammasome/IL-1β responses to streptococcal pathogens. Frontiers Immunology (2016)

LaRock C, Döhrmann S, Todd J, Corriden R, Johannssen T, Lepenies B, Gallo R, Ghosh P, Nizet V. Group A streptococcal M1 protein sequesters cathelicidin to evade innate immune killing. Cell Host & Microbe (2015)

▪︎ Cell Host & Microbe "Streptococcal M1 Strikes by Neutralizing Cathelicidins" by B Henriques-Normark & S Normark ▪︎ UCSD press "Deadly bacteria stiff-arm the immune system"

LaRock C & Nizet V. Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens. BBA Biomembranes (2015)

Barnett T, Liebl D, Seymour L, Gillen C, Lim J, LaRock C, Davies M, Schulz B, Nizet V, Teasdale R, Walker M. The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication. Cell Host & Microbe (2013)

▪︎ Cover▪︎ Cell Host & Microbe "S. pyogenes Escapes Autophagy" by I Nakagawa

LaRock C & Cookson B. Burning down the house: cell actions during pyroptosis. PLoS Pathogens (2013)

LaRock C, Yu J, Horswill A, Parsek M, Minion F. Transcriptome analysis of acyl-homoserine lactone based quorum sensing regulation in Yersinia pestis. PLoS One (2013)

Transcriptome analysis of acyl-homoserine lactone based quorum sensing regulation in Yersinia pestis

LaRock C & Cookson B. The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing. Cell Host & Microbe (2012)

▪︎ Cover▪︎ Cell Host & Microbe "YopM Puts Caspase-1 on Ice" by I Jørgensen & E Miao ▪︎ UW press "Dark Ages scourge enlightens modern struggle between man & microbe" ▪︎ Faculty of 1000: 3☆

Livny J, LaRock C, Friedman D. Identification and isolation of lysogens with induced prophage. Methods in Molecular Biology (2009)

Tchesnokova V, Aprikian P, Yakovenko O, LaRock C, Kidd B, Vogel V, Thomas W, Sokurenko E. Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli. The Journal of Biological Chemistry (2008)

Held K, LaRock C, D'Argenio D, Berg C, Collins C. A metalloprotease secreted by the insect pathogen Photorhabdus luminescens induces melanization. Applied & Environmental Microbiology (2007)

Wild-type fly pricked with 2.6 μg μl−1 rPrtS-E168A