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Profile

Harrison Hartzell Jr. Emeritus Profes

  • Department of Cell Biology
    Professor Emeritus
  • (404) 727-0444
  • criss.hartzell@emory.edu
  • Hartzell Lab Website
Head shot of Harrison Hartzell Jr.

Overview

The ionic composition inside cells and organelles is precisely controlled and is essential for their proper function. However, the lipid membranes that surround them are energy barriers that charged ions must cross to get from one side to the other. One way that ions traverse this greasy membrane is by diffusing through gated channels composed of proteins that essentially form aqueous pores across the membrane. Although we have interests in many kinds of ion channels, our main interest is devoted to channels that transport chloride ions. It is possible that more people have been killed by diseases that affect chloride channels than any other disease, because cholera, diarrheal diseases of infancy, and cystic fibrosis involve chloride channel function. Chloride channels are essential for fluid and salt secretion from epithelia, play roles in sensory transduction, regulate both cytosolic pH and the pH of intracellular organelles, control neuronal and cardiac excitability, and contribute to bone resorption by osteoclasts. One chloride channel family of ten genes called TMEM16 or ANO is particularly interesting to us because they are linked to a diverse spectrum of human diseases including at least two types of muscular dystrophy (LGMD2L and MMD3, ANO5), spinocerebellar ataxia (SCAR10, ANO10), dystonia and febrile seizures (ANO3), a bleeding disorder (Scotts Syndrome, ANO6), and cancer (ANO1, ANO7, ANO9). Although it was initially believed that all 10 ANO genes encoded chloride channels, we were recently surprised to find that the family is functionally diverse. Some ANOs are chloride channels, while others are thought to be channels that transport lipids between the leaflets of the membrane bilayer. We are interested in understanding how these proteins work on a molecular level: how are they activated and how do they conduct their substrates, ions and/or lipids? We are also interested in how mutations in these proteins produce human disease, particularly ANO5 muscular dystrophies. We are using stem cells from ANO5 patients as well as genetically engineered muscle cell lines to investigate how ANO5 mutations affect muscle cell biology.

Academic Appointment

  • Professor of Pharmacology, Emory University School of Medicine
  • Professor of Physiology, Emory University School of Medicine
  • Professor of Cell Biology, Emory University School of Medicine

Education

Degrees

  • Ph.D., with distinction from The Johns Hopkins University
  • A.B. from Lawrence University

Research

Publications

  • Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair.
    J Cell Biol Volume: 224
    07/07/2025 Authors: Williams JK; Ngo JM; Murugupandiyan A; Croall DE; Hartzell HC; Schekman R
  • Regenerative failure of sympathetic axons contributes to deficits in functional recovery after nerve injury.
    Neurobiol Dis Volume: 209 Page(s): 106893
    06/01/2025 Authors: Tian T; Kim D; Yu K; Hartzell HC; Ward PJ
  • Regenerative failure of sympathetic axons contributes to deficits in functional recovery after nerve injury.

    01/16/2025 Authors: Tian T; Kim D; Yu K; Hartzell HC; Ward PJ
  • Calpains Orchestrate Secretion of Annexin-containing Microvesicles during Membrane Repair.

    09/06/2024 Authors: Williams JK; Ngo JM; Murugupandiyan A; Croall DE; Hartzell HC; Schekman R
  • Niclosamide potentiates TMEM16A and induces vasoconstriction.
    J Gen Physiol Volume: 156
    07/01/2024 Authors: Liang P; Wan YCS; Yu K; Hartzell HC; Yang H
  • Niclosamide potentiates TMEM16A and induces vasoconstriction.
    bioRxiv
    08/02/2023 Authors: Liang P; Wan YCS; Yu K; Hartzell HC; Yang H
  • TMEM16E regulates endothelial cell procoagulant activity and thrombosis.
    J Clin Invest Volume: 133
    06/01/2023 Authors: Schmaier AA; Anderson PF; Chen SM; El-Darzi E; Aivasovsky I; Kaushik MP; Sack KD; Hartzell HC; Parikh SM; Flaumenhaft R
  • Phosphatidylserine exposure modulates adhesion GPCR BAI1 (ADGRB1) signaling activity.
    J Biol Chem Volume: 298 Page(s): 102685
    12/01/2022 Authors: Lala T; Doan JK; Takatsu H; Hartzell HC; Shin H-W; Hall RA
  • Sex differences in the involvement of skeletal and cardiac muscles in myopathic Ano5-/- mice.
    Am J Physiol Cell Physiol Volume: 322 Page(s): C283 - C295
    02/01/2022 Authors: Foltz S; Wu F; Ghazal N; Kwong JQ; Hartzell HC; Choo HJ
  • Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels.
    Channels (Austin) Volume: 15 Page(s): 569 - 603
    12/01/2021 Authors: Hawn MB; Akin E; Hartzell HC; Greenwood IA; Leblanc N
  • ANO5 ensures trafficking of annexins in wounded myofibers.
    J Cell Biol Volume: 220
    03/01/2021 Authors: Foltz SJ; Cui YY; Choo HJ; Hartzell HC
  • A Network of PIP2 Binding Sites Regulate Gating of the Calcium-Activated Chloride Channel TMEM16A
    Volume: 118 Page(s): 555A - 556A
    02/07/2020 Authors: Jiang T; Yu K; Cui Y; Hartzell HC; Tajkhorshid E
  • Effects of PIP2 Binding to its Different Binding Sites on ANO1 Function
    Volume: 118 Page(s): 419A - 419A
    02/07/2020 Authors: Yu K; Jiang T; Cui Y; Tajkhorshid E; Hartzell HC
  • Myosoft: An automated muscle histology analysis tool using machine learning algorithm utilizing FIJI/ImageJ software.
    PLoS One Volume: 15 Page(s): e0229041
    01/01/2020 Authors: Encarnacion-Rivera L; Foltz S; Hartzell HC; Choo H
  • Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate.
    Cell Calcium Volume: 84 Page(s): 102103
    12/01/2019 Authors: Arreola J; Hartzell HC
  • A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl- channel ANO1 (TMEM16A).
    Proc Natl Acad Sci U S A Volume: 116 Page(s): 19952 - 19962
    10/01/2019 Authors: Yu K; Jiang T; Cui Y; Tajkhorshid E; Hartzell HC
  • Elucidating Conformational Changes Underlying the Conversion of TMEM16A Mutants from Anion Channels to Scramblases
    Volume: 116 Page(s): 221A - 221A
    02/15/2019 Authors: Vasan AK; Jiang T; Hartzell HC; Tajkhorshid E
  • Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation.
    J Neurosci Volume: 38 Page(s): 10271 - 10285
    11/28/2018 Authors: Omotade OF; Rui Y; Lei W; Yu K; Hartzell HC; Fowler VM; Zheng JQ
  • Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion.
    J Gen Physiol Volume: 150 Page(s): 1498 - 1509
    11/05/2018 Authors: Whitlock JM; Yu K; Cui YY; Hartzell HC
  • Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1).
    Biochim Biophys Acta Mol Cell Biol Lipids Volume: 1863 Page(s): 299 - 312
    03/01/2018 Authors: De Jess-Prez JJ; Cruz-Rangel S; Espino-Saldaa E; Martnez-Torres A; Qu Z; Hartzell HC; Corral-Fernandez NE; Prez-Cornejo P; Arreola J
  • Lipids and Ions Traverse the Membrane by the Same Physical Pathway in the nhTMEM16 Scramblase
    Volume: 114 Page(s): 149A - 149A
    02/02/2018 Authors: Jiang T; Yu K; Hartzell HC; Tajkhorshid E
  • Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase.
    Elife Volume: 6
    09/16/2017 Authors: Jiang T; Yu K; Hartzell HC; Tajkhorshid E
  • Poring over furrows.
    Elife Volume: 6
    05/31/2017 Authors: Fisher SI; Hartzell HC
  • Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16A.
    J Physiol Volume: 595 Page(s): 1515 - 1531
    03/01/2017 Authors: Cruz-Rangel S; De Jess-Prez JJ; Archiga-Figueroa IA; Rodrguez-Menchaca AA; Prez-Cornejo P; Hartzell HC; Arreola J
  • Anoctamins/TMEM16 Proteins: Chloride Channels Flirting with Lipids and Extracellular Vesicles.
    Annu Rev Physiol Volume: 79 Page(s): 119 - 143
    02/10/2017 Authors: Whitlock JM; Hartzell HC
  • TMEM16 chloride channels are two-faced.
    J Gen Physiol Volume: 148 Page(s): 367 - 373
    11/01/2016 Authors: Hartzell HC; Whitlock JM
  • Limb-Girdle Muscular Dystrophy 2L Is Caused by a Defect in Phospholipid Scrambling Mediated by ANO5
    Volume: 148 Page(s): 35A - 35A
    08/01/2016 Authors: Whitlock JM; Yu K; Cui Y; Hartzell HC
  • Revealing the activation pathway for TMEM16A chloride channels from macroscopic currents and kinetic models.
    Pflugers Arch Volume: 468 Page(s): 1241 - 1257
    07/01/2016 Authors: Contreras-Vite JA; Cruz-Rangel S; De Jess-Prez JJ; Figueroa IAA; Rodrguez-Menchaca AA; Prez-Cornejo P; Hartzell HC; Arreola J
  • Defective membrane fusion and repair in Anoctamin5-deficient muscular dystrophy.
    Hum Mol Genet Volume: 25 Page(s): 1900 - 1911
    05/15/2016 Authors: Griffin DA; Johnson RW; Whitlock JM; Pozsgai ER; Heller KN; Grose WE; Arnold WD; Sahenk Z; Hartzell HC; Rodino-Klapac LR
  • A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid.
    Pflugers Arch Volume: 468 Page(s): 455 - 473
    03/01/2016 Authors: Whitlock JM; Hartzell HC
  • Limb-Girdle Muscular Dystrophy 2L Is Associated With a Defect in Phospholipid Scrambling Mediated by ANO5.
    Volume: 27
    01/01/2016 Authors: Whitlock JM; Yu K; Cui Y; Hartzell HC
  • Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.
    J Physiol Volume: 593 Page(s): 5283 - 5298
    12/15/2015 Authors: Cruz-Rangel S; De Jess-Prez JJ; Contreras-Vite JA; Prez-Cornejo P; Hartzell HC; Arreola J
  • Identification of a Lipid Scrambling Domain in ANO6/TMEM16F.
    Volume: 146 Page(s): 18A - 18A
    09/01/2015 Authors: Yu K; Whitlock JM; Cui YY; Hartzell HC
  • Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium.
    Pflugers Arch Volume: 467 Page(s): 1677 - 1687
    08/01/2015 Authors: Lee J; Jung J; Tak MH; Wee J; Lee B; Jang Y; Chun H; Yang D-J; Yang YD; Park SH
  • Identification of a lipid scrambling domain in ANO6/TMEM16F.
    Elife Volume: 4 Page(s): e06901
    06/09/2015 Authors: Yu K; Whitlock JM; Lee K; Ortlund EA; Cui YY; Hartzell HC
  • Characterization of Cardiac Anoctamin1 Ca-Activated Chloride Channels and Functional Role in Ischemia-Induced Arrhythmias.
    J Cell Physiol Volume: 230 Page(s): 337 - 346
    02/01/2015 Authors: Ye Z; Wu M-M; Wang C-Y; Li Y-C; Yu C-J; Gong Y-F; Zhang J; Wang Q-S; Song B-L; Yu K
  • Extracellular Chloride Regulates TMEM16A Gating
    Volume: 108 Page(s): 441A - 441A
    01/27/2015 Authors: Contreras-Vite JA; Cruz-Rangel S; Perez-Cornejo P; Hartzell HC; Arreola J
  • Hypoxia augments the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice.
    Br J Pharmacol Volume: 171 Page(s): 3680 - 3692
    08/01/2014 Authors: Wu M-M; Lou J; Song B-L; Gong Y-F; Li Y-C; Yu C-J; Wang Q-S; Ma T-X; Ma K; Hartzell HC
  • The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis.
    Mol Biol Cell Volume: 25 Page(s): 1793 - 1807
    06/01/2014 Authors: Ruppersburg CC; Hartzell HC
  • The Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis.
    Cancer Med Volume: 3 Page(s): 453 - 461
    06/01/2014 Authors: Qu Z; Yao W; Yao R; Liu X; Yu K; Hartzell C
  • Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin.
    J Gen Physiol Volume: 143 Page(s): 253 - 267
    02/01/2014 Authors: Yu K; Zhu J; Qu Z; Cui Y-Y; Hartzell HC
  • Differential effects of Best disease causing missense mutations on bestrophin-1 trafficking.
    Hum Mol Genet Volume: 22 Page(s): 4688 - 4697
    12/01/2013 Authors: Johnson AA; Lee Y-S; Stanton JB; Yu K; Hartzell CH; Marmorstein LY; Marmorstein AD
  • Functional reconstitution of a chloride channel bares its soul.
    Proc Natl Acad Sci U S A Volume: 110 Page(s): 19185 - 19186
    11/26/2013 Authors: Hartzell HC; Ruppersburg CC
  • MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1.
    Mol Pharmacol Volume: 84 Page(s): 726 - 735
    11/01/2013 Authors: Oh S-J; Hwang SJ; Jung J; Yu K; Kim J; Choi JY; Hartzell HC; Roh EJ; Lee CJ
  • A Novel Role for Chloride Channels in Ciliogenesis and Cell Polarization: The Ano1 Nimbus
    Volume: 142 Page(s): 4A - 4A
    08/01/2013 Authors: Ruppersburg CC; Cui Y; Hartzell HC
  • Drosophila bestrophin-1 currents are regulated by phosphorylation via a CaMKII dependent mechanism.
    PLoS One Volume: 8 Page(s): e58875
    01/01/2013 Authors: Duran C; Chien L-T; Hartzell HC
  • Activity-dependent regulation of dendritic growth and maintenance by glycogen synthase kinase 3.
    Nat Commun Volume: 4 Page(s): 2628
    01/01/2013 Authors: Rui Y; Myers KR; Yu K; Wise A; De Blas AL; Hartzell HC; Zheng JQ
  • A comprehensive strategy to identify stoichiometric membrane protein interactomes.
    Cell Logist Volume: 2 Page(s): 189 - 196
    10/01/2012 Authors: Gokhale A; Perez-Cornejo P; Duran C; Hartzell HC; Faundez V
  • Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network.
    Proc Natl Acad Sci U S A Volume: 109 Page(s): 10376 - 10381
    06/26/2012 Authors: Perez-Cornejo P; Gokhale A; Duran C; Cui Y; Xiao Q; Hartzell HC; Faundez V
  • Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology.
    Circ Res Volume: 110 Page(s): 990 - 999
    03/30/2012 Authors: Yu K; Duran C; Qu Z; Cui Y-Y; Hartzell HC
  • ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.
    Am J Physiol Cell Physiol Volume: 302 Page(s): C482 - C493
    02/01/2012 Authors: Duran C; Qu Z; Osunkoya AO; Cui Y; Hartzell HC
  • Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?
    Acta Pharmacol Sin Volume: 32 Page(s): 685 - 692
    06/01/2011 Authors: Duran C; Hartzell HC
  • Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop.
    Proc Natl Acad Sci U S A Volume: 108 Page(s): 8891 - 8896
    05/24/2011 Authors: Xiao Q; Yu K; Perez-Cornejo P; Cui Y; Arreola J; Hartzell HC
  • Interactive Calcium and Voltage Gating of TMEM16A/Anoctamin1 Chloride Channels
    Volume: 100 Page(s): 259 - 259
    02/02/2011 Authors: Xiao Q; Hartzell HC
  • Structure-Function Analysis of the Anion-Selective Pore of Anoctamin-1
    Volume: 100 Page(s): 266 - 266
    02/02/2011 Authors: Yu K; Cui Y; Hartzell HC
  • Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A.
    J Biol Chem Volume: 286 Page(s): 1381 - 1388
    01/14/2011 Authors: Sheridan JT; Worthington EN; Yu K; Gabriel SE; Hartzell HC; Tarran R
  • ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity.
    Nat Neurosci Volume: 13 Page(s): 1208 - 1215
    10/01/2010 Authors: Gu J; Lee CW; Fan Y; Komlos D; Tang X; Sun C; Yu K; Hartzell HC; Chen G; Bamburg JR
  • Bestrophins and retinopathies.
    Pflugers Arch Volume: 460 Page(s): 559 - 569
    07/01/2010 Authors: Xiao Q; Hartzell HC; Yu K
  • Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon.
    J Clin Invest Volume: 120 Page(s): 1722 - 1735
    05/01/2010 Authors: Yu K; Lujan R; Marmorstein A; Gabriel S; Hartzell HC
  • Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells.
    J Biol Chem Volume: 285 Page(s): 12990 - 13001
    04/23/2010 Authors: Romanenko VG; Cataln MA; Brown DA; Putzier I; Hartzell HC; Marmorstein AD; Gonzalez-Begne M; Rock JR; Harfe BD; Melvin JE
  • Inhibition of AMPA receptor trafficking at hippocampal synapses by beta-amyloid oligomers: the mitochondrial contribution.
    Mol Brain Volume: 3 Page(s): 10
    03/26/2010 Authors: Rui Y; Gu J; Yu K; Hartzell HC; Zheng JQ
  • Suppression of Ca2+ signaling in a mouse model of Best disease.
    Hum Mol Genet Volume: 19 Page(s): 1108 - 1118
    03/15/2010 Authors: Zhang Y; Stanton JB; Wu J; Yu K; Hartzell HC; Peachey NS; Marmorstein LY; Marmorstein AD
  • Chloride channels: often enigmatic, rarely predictable.
    Annu Rev Physiol Volume: 72 Page(s): 95 - 121
    01/01/2010 Authors: Duran C; Thompson CH; Xiao Q; Hartzell HC
  • Regulation and Gating of mAno1 by Voltage and Calcium
    BIOPHYSICAL JOURNAL Volume: 98 Page(s): 319A - 319A
    01/01/2010 Authors: Xiao Q; Yu K; Cui Y; Hartzell HC
  • THE ANO1/TMEM16A CHLORIDE CHANNEL IS A MULTIMER
    PEDIATRIC PULMONOLOGY Page(s): 254 - 254
    01/01/2010 Authors: Sheridan J; Worthington EN; Watson M; Gentzsch M; Yu K; Allen R; Gabriel S; Hartzell HC; Elston T; Tarran R
  • Dysregulation of human bestrophin-1 by ceramide-induced dephosphorylation.
    J Physiol Volume: 587 Page(s): 4379 - 4391
    09/15/2009 Authors: Xiao Q; Yu K; Cui Y-Y; Hartzell HC
  • Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.
    J Physiol Volume: 587 Page(s): 2127 - 2139
    05/15/2009 Authors: Hartzell HC; Yu K; Xiao Q; Chien L-T; Qu Z
  • Regulation of bestrophin Cl channels by calcium: role of the C terminus.
    J Gen Physiol Volume: 132 Page(s): 681 - 692
    12/01/2008 Authors: Xiao Q; Prussia A; Yu K; Cui Y-Y; Hartzell HC
  • Rescue of volume-regulated anion current by bestrophin mutants with altered charge selectivity.
    J Gen Physiol Volume: 132 Page(s): 537 - 546
    11/01/2008 Authors: Chien L-T; Hartzell HC
  • Physiology. CaCl-ing channels get the last laugh.
    Science Volume: 322 Page(s): 534 - 535
    10/24/2008 Authors: Hartzell HC
  • Bestrophin Cl- channels are highly permeable to HCO3-.
    Am J Physiol Cell Physiol Volume: 294 Page(s): C1371 - C1377
    06/01/2008 Authors: Qu Z; Hartzell HC
  • The best disease-linked Cl- channel hBest1 regulates Ca V 1 (L-type) Ca2+ channels via src-homology-binding domains.
    J Neurosci Volume: 28 Page(s): 5660 - 5670
    05/28/2008 Authors: Yu K; Xiao Q; Cui G; Lee A; Hartzell HC
  • Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies.
    Physiol Rev Volume: 88 Page(s): 639 - 672
    04/01/2008 Authors: Hartzell HC; Qu Z; Yu K; Xiao Q; Chien L-T
  • Bestrophin-2 is involved in the generation of intraocular pressure.
    Invest Ophthalmol Vis Sci Volume: 49 Page(s): 1563 - 1570
    04/01/2008 Authors: Bakall B; McLaughlin P; Stanton JB; Zhang Y; Hartzell HC; Marmorstein LY; Marmorstein AD
  • Drosophila bestrophin-1 chloride current is dually regulated by calcium and cell volume.
    J Gen Physiol Volume: 130 Page(s): 513 - 524
    11/01/2007 Authors: Chien L-T; Hartzell HC
  • Chloride channel activity of bestrophin mutants associated with mild or late-onset macular degeneration.
    Invest Ophthalmol Vis Sci Volume: 48 Page(s): 4694 - 4705
    10/01/2007 Authors: Yu K; Qu Z; Cui Y; Hartzell HC
  • Cell biology. The stress of relaxation.
    Science Volume: 317 Page(s): 1331 - 1332
    09/07/2007 Authors: Hartzell HC
  • Drosophila bestrophins are dually regulated by calcium and cell volume.
    Volume: 130 Page(s): 21A - 22A
    07/01/2007 Authors: Chien L-T; Hartzell HC
  • Activation of bestrophin Cl- channels is regulated by C-terminal domains.
    J Biol Chem Volume: 282 Page(s): 17460 - 17467
    06/15/2007 Authors: Qu ZQ; Yu K; Cui YY; Ying C; Hartzell C
  • New VMD2 gene mutations identified in patients affected by Best vitelliform macular dystrophy.
    J Med Genet Volume: 44 Page(s): e70
    03/01/2007 Authors: Marchant D; Yu K; Bigot K; Roche O; Germain A; Bonneau D; Drouin-Garraud V; Schorderet DF; Munier F; Schmidt D
  • The bestrophin mutation A243V, linked to adult-onset vitelliform macular dystrophy, impairs its chloride channel function.
    Invest Ophthalmol Vis Sci Volume: 47 Page(s): 4956 - 4961
    11/01/2006 Authors: Yu K; Cui Y; Hartzell HC
  • Single Cl- channels activated by Ca2+ in Drosophila S2 cells are mediated by bestrophins.
    J Gen Physiol Volume: 128 Page(s): 247 - 259
    09/01/2006 Authors: Chien L-T; Zhang Z-R; Hartzell HC
  • The anion-selective pore of the bestrophins, a family of chloride channels associated with retinal degeneration.
    J Neurosci Volume: 26 Page(s): 5411 - 5419
    05/17/2006 Authors: Qu Z; Chien L-T; Cui Y; Hartzell HC
  • A short motif in the C-terminus of mouse bestrophin 3 [corrected] inhibits its activation as a Cl channel.
    FEBS Lett Volume: 580 Page(s): 2141 - 2146
    04/03/2006 Authors: Qu Z; Cui Y; Hartzell C
  • Looking chloride channels straight in the eye: bestrophins, lipofuscinosis, and retinal degeneration.
    Physiology (Bethesda) Volume: 20 Page(s): 292 - 302
    10/01/2005 Authors: Hartzell C; Qu Z; Putzier I; Artinian L; Chien L-T; Cui Y
  • Volume-sensitivity of Ca-activated Cl channels in mouse IMCD-K2 cells
    Volume: 19 Page(s): A1181 - A1182
    03/07/2005 Authors: Fischmeister R; Hartzell HC
  • Volume sensitivity of the bestrophin family of chloride channels.
    J Physiol Volume: 562 Page(s): 477 - 491
    01/15/2005 Authors: Fischmeister R; Hartzell HC
  • Multiple TMDs of mouse bestrophin2 participate in anion permeation
    Volume: 88 Page(s): 613A - 613A
    01/01/2005 Authors: Qu ZQ; Cui YY; Chien LT; Hartzell HC
  • Calcium-activated chloride channels.
    Volume: 67 Page(s): 719 - 758
    01/01/2005 Authors: Hartzell C; Putzier I; Arreola J
  • Determinants of anion permeation in the second transmembrane domain of the mouse bestrophin-2 chloride channel.
    J Gen Physiol Volume: 124 Page(s): 371 - 382
    10/01/2004 Authors: Qu Z; Hartzell C
  • Teaching resources. Chloride concentration and pH along the endosomal pathway.
    Sci STKE Volume: 2004 Page(s): tr2
    05/18/2004 Authors: Faundez V; Hartzell HC; Adler EM
  • Intracellular chloride channels: determinants of function in the endosomal pathway.
    Sci STKE Volume: 2004 Page(s): re8
    05/11/2004 Authors: Faundez V; Hartzell HC
  • Mouse bestrophin-2 is a bona fide Cl(-) channel: identification of a residue important in anion binding and conduction.
    J Gen Physiol Volume: 123 Page(s): 327 - 340
    04/01/2004 Authors: Qu Z; Fischmeister R; Hartzell C
  • Is bestrophin A plasma membrane chloride channel?
    Volume: 86 Page(s): 331A - 331A
    01/01/2004 Authors: Hartzell HC; Fischmeister R; Qu ZQ
  • Two bestrophins cloned from Xenopus laevis oocytes express Ca(2+)-activated Cl(-) currents.
    J Biol Chem Volume: 278 Page(s): 49563 - 49572
    12/05/2003 Authors: Qu Z; Wei RW; Mann W; Hartzell HC
  • Characterization and regulation of T-type Ca2+ channels in embryonic stem cell-derived cardiomyocytes.
    Am J Physiol Heart Circ Physiol Volume: 285 Page(s): H2770 - H2779
    12/01/2003 Authors: Zhang YM; Shang L; Hartzell C; Narlow M; Cribbs L; Dudley SC
  • Characterization of Ca2+-activated Cl- currents in mouse kidney inner medullary collecting duct cells.
    Am J Physiol Renal Physiol Volume: 285 Page(s): F326 - F335
    08/01/2003 Authors: Qu Z; Wei RW; Hartzell HC
  • Molecular physiology of calcium-activated chloride channels
    Volume: 122 Page(s): 9A - 10A
    07/01/2003 Authors: Hartzell HC; Qu ZQ; Wei R; Mann W; Fischmeister R
  • Chloride currents in acutely isolated Xenopus retinal pigment epithelial cells.
    J Physiol Volume: 549 Page(s): 453 - 469
    06/01/2003 Authors: Hartzell HC; Qu Z
  • Stem cell-derived cardiomyocytes demonstrate arrhythmic potential.
    Circulation Volume: 106 Page(s): 1294 - 1299
    09/03/2002 Authors: Zhang YM; Hartzell C; Narlow M; Dudley SC
  • Functional geometry of the permeation pathway of Ca2+-activated Cl-channels inferred from analysis of voltage-dependent block.
    J Biol Chem Volume: 276 Page(s): 18423 - 18429
    05/25/2001 Authors: Qu Z; Hartzell HC
  • Anion permeation in Ca(2+)-activated Cl(-) channels.
    J Gen Physiol Volume: 116 Page(s): 825 - 844
    12/01/2000 Authors: Qu Z; Hartzell HC
  • A hyperpolarization- and acid-activated nonselective cation current in Xenopus oocytes.
    Am J Physiol Cell Physiol Volume: 279 Page(s): C1401 - C1413
    11/01/2000 Authors: Kuruma A; Hirayama Y; Hartzell HC
  • Voltage-dependent Ca2+sensitivity of Ca2+activated Cl- currents in Xenopus oocytes.
    BIOPHYSICAL JOURNAL Volume: 78 Page(s): 471A - 471A
    01/01/2000 Authors: Kuruma A; Hartzell HC
  • Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals.
    J Gen Physiol Volume: 115 Page(s): 59 - 80
    01/01/2000 Authors: Kuruma A; Hartzell HC
  • Bimodal control of a Ca2+-activated Cl- channel by different Ca2+signals.
    BIOPHYSICAL JOURNAL Volume: 78 Page(s): 470A - 470A
    01/01/2000 Authors: Kuruma A; Machaca K; Hartzell HC
  • Adenophostin A and inositol 1,4,5-trisphosphate differentially activate Cl- currents in Xenopus oocytes because of disparate Ca2+ release kinetics.
    J Biol Chem Volume: 274 Page(s): 4824 - 4831
    02/19/1999 Authors: Machaca K; Hartzell HC
  • Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents.
    J Gen Physiol Volume: 113 Page(s): 249 - 266
    02/01/1999 Authors: Machaca K; HC Hartzell
  • Dynamics of calcium regulation of chloride currents in Xenopus oocytes.
    Am J Physiol Volume: 276 Page(s): C161 - C175
    01/01/1999 Authors: Kuruma A; Hartzell HC
  • Acute regulation of norepinephrine transport: I. protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells.
    J Pharmacol Exp Ther Volume: 287 Page(s): 733 - 743
    11/01/1998 Authors: Apparsundaram S; Galli A; DeFelice LJ; Hartzell HC; Blakely RD
  • Asymmetrical distribution of Ca-activated Cl channels in Xenopus oocytes (vol 74, pg 1286, 1998)
    BIOPHYSICAL JOURNAL Volume: 74 Page(s): 3313 - 3313
    06/01/1998 Authors: Machaca K; Hartzell HC
  • Asymmetrical distribution of Ca-activated Cl channels in Xenopus oocytes.
    Biophys J Volume: 74 Page(s): 1286 - 1295
    03/01/1998 Authors: Machaca K; Hartzell HC
  • Effects of protein phosphatase and kinase inhibitors on Ca2+ and Cl- currents in guinea pig ventricular myocytes.
    Mol Pharmacol Volume: 52 Page(s): 725 - 734
    10/01/1997 Authors: Hirayama Y; Hartzell HC
  • Molecular cloning and characterization of an L-epinephrine transporter from sympathetic ganglia of the bullfrog, Rana catesbiana.
    J Neurosci Volume: 17 Page(s): 2691 - 2702
    04/15/1997 Authors: Apparsundaram S; Moore KR; Malone MD; Hartzell HC; Blakely RD
  • Effects of adenophostin-A and inositol-1,4,5-trisphosphate on Cl- currents in Xenopus laevis oocytes.
    Mol Pharmacol Volume: 51 Page(s): 683 - 692
    04/01/1997 Authors: Hartzell HC; Machaca K; Hirayama Y
  • Slow inward tail currents of frog cardiac myocytes studied with perforated patch clamp technique.
    BIOPHYSICAL JOURNAL Volume: 72 Page(s): TH141 - TH141
    02/01/1997 Authors: Parsons TD; Hartzell HC
  • Membrane topology of the TRP calcium channel family.
    BIOPHYSICAL JOURNAL Volume: 72 Page(s): THP53 - THP53
    02/01/1997 Authors: Machaca K; Hartzell HC
  • Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx.
    J Gen Physiol Volume: 108 Page(s): 157 - 175
    09/01/1996 Authors: Hartzell HC
  • Effect of arachidonic acid on the L-type calcium current in frog cardiac myocytes.
    J Physiol Volume: 493 ( Pt 1) Page(s): 67 - 81
    05/15/1996 Authors: Petit-Jacques J; Hartzell HC
  • Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels.
    Am J Physiol Volume: 270 Page(s): C1293 - C1299
    05/01/1996 Authors: Hartzell HC; Rinderknecht A
  • Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY Volume: 270 Page(s): C1293 - C1299
    05/01/1996 Authors: Hartzell HC; Rinderknecht A
  • Nitric oxide synthase does not participate in negative inotropic effect of acetylcholine in frog heart
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY Volume: 270 Page(s): H1178 - H1188
    04/01/1996 Authors: Mery PF; HoveMadsen L; Chesnais JM; Hartzell HC; Fischmeister R
  • Nitric oxide synthase does not participate in negative inotropic effect of acetylcholine in frog heart.
    Am J Physiol Volume: 270 Page(s): H1178 - H1188
    04/01/1996 Authors: Mry PF; Hove-Madsen L; Chesnais JM; Hartzell HC; Fischmeister R
  • Effects of microcystin and isoproterenol on L-type Ca2+ current and cAMP-regulated Cl- current in guinea pig ventricular myocytes.
    BIOPHYSICAL JOURNAL Volume: 70 Page(s): TU357 - TU357
    02/01/1996 Authors: Hirayama Y; Hartzell HC
  • Early loss of passive measles antibody in infants of mothers with vaccine-induced immunity.
    Pediatrics Volume: 96 Page(s): 447 - 450
    09/01/1995 Authors: Maldonado YA; Lawrence EC; DeHovitz R; Hartzell H; Albrecht P
  • Effects of protein phosphatase and kinase inhibitors on the cardiac L-type Ca current suggest two sites are phosphorylated by protein kinase A and another protein kinase.
    J Gen Physiol Volume: 106 Page(s): 393 - 414
    09/01/1995 Authors: Hartzell HC; Hirayama Y; Petit-Jacques J
  • Postnatal changes in the G-proteins, cyclic nucleotides and adenylyl cyclase activity in rabbit heart cells.
    J Mol Cell Cardiol Volume: 26 Page(s): 1537 - 1550
    12/01/1994 Authors: Kumar R; Joyner RW; Hartzell HC; Ellingsen D; Rishi F; Eaton DC; Lu C; Akita T
  • Molecular physiology of norepinephrine and serotonin transporters.
    J Exp Biol Volume: 196 Page(s): 263 - 281
    11/01/1994 Authors: Blakely RD; De Felice LJ; Hartzell HC
  • Dissection of eukaryotic transmembrane signalling using Chlamydomonas.
    Trends Pharmacol Sci Volume: 15 Page(s): 343 - 349
    09/01/1994 Authors: Quarmby LM; Hartzell HC
  • Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
    Circulation Volume: 90 Page(s): 469 - 478
    07/01/1994 Authors: Akita T; Joyner RW; Lu C; Kumar R; Hartzell HC
  • Two distinct, calcium-mediated, signal transduction pathways can trigger deflagellation in Chlamydomonas reinhardtii.
    J Cell Biol Volume: 124 Page(s): 807 - 815
    03/01/1994 Authors: Quarmby LM; Hartzell HC
  • 2 DIFFERENT CALCIUM SIGNALING PATHWAYS INDUCE DEFLAGELLATION IN CHLAMYDOMONAS-REINHARDTII
    BIOPHYSICAL JOURNAL Volume: 66 Page(s): A171 - A171
    02/01/1994 Authors: QUARMBY LM; HARTZELL HC
  • Opposite effects of phosphatase inhibitors on L-type calcium and delayed rectifier currents in frog cardiac myocytes.
    J Physiol Volume: 472 Page(s): 305 - 326
    12/01/1993 Authors: Frace AM; Hartzell HC
  • AN ENDOTHELIAL-DERIVED FACTOR OPENS A CALCIUM-SENSITIVE POTASSIUM CHANNEL IN PATCH CLAMPED VASCULAR SMOOTH-MUSCLE CELLS
    CIRCULATION Volume: 88 Page(s): 330 - 330
    10/01/1993 Authors: STEIN MA; HARRISON DG; HARTZELL HC
  • Filling the gaps in Ca2+ channel regulation.
    Biophys J Volume: 65 Page(s): 1358 - 1359
    10/01/1993 Authors: Hartzell HC
  • Regulation of Ca2+ current in frog ventricular cardiomyocytes by guanosine 5'-triphosphate analogues and isoproterenol.
    J Gen Physiol Volume: 102 Page(s): 525 - 549
    09/01/1993 Authors: Parsons TD; Hartzell HC
  • Mechanisms of flagellar excision. I. The role of intracellular acidification.
    Exp Cell Res Volume: 208 Page(s): 148 - 153
    09/01/1993 Authors: Hartzell LB; Hartzell HC; Quarmby LM
  • A comparative analysis of the time course of cardiac Ca2+ current response to rapid applications of beta-adrenergic and dihydropyridine agonists.
    Naunyn Schmiedebergs Arch Pharmacol Volume: 348 Page(s): 197 - 206
    08/01/1993 Authors: Mry PF; Frace AM; Hartzell HC; Fischmeister R
  • Regulation of the cardiac delayed rectifier K current by neurotransmitters and magnesium.
    Cardiovasc Drugs Ther Volume: 7 Suppl 3 Page(s): 547 - 554
    08/01/1993 Authors: Hartzell HC; Duchatelle-Gourdon I
  • MECHANISMS OF ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION
    CLINICAL RESEARCH Volume: 41 Page(s): A349 - A349
    04/01/1993 Authors: STEIN MA; HARTZELL HC; HARRISON DG
  • Rate-limiting steps in the beta-adrenergic stimulation of cardiac calcium current.
    J Gen Physiol Volume: 101 Page(s): 337 - 353
    03/01/1993 Authors: Frace AM; Mry PF; Fischmeister R; Hartzell HC
  • POSTNATAL DEVELOPMENTAL DIFFERENCES IN CYCLIC-NUCLEOTIDES AND MUSCARINIC RECEPTORS
    FASEB JOURNAL Volume: 7 Page(s): A106 - A106
    02/19/1993 Authors: KUMAR R; HARTZELL HC; JOYNER RW
  • Direct regulation of cardiac Ca2+ channels by G proteins: neither proven nor necessary?
    Trends Pharmacol Sci Volume: 13 Page(s): 380 - 385
    10/01/1992 Authors: Hartzell HC; Fischmeister R
  • Differences in effects of forskolin and an analog on calcium currents in cardiac myocytes suggest intra- and extracellular sites of action.
    Mol Pharmacol Volume: 41 Page(s): 880 - 888
    05/01/1992 Authors: Hartzell HC; Budnitz D
  • DOES FORSKOLIN ACT ON ADENYLYL CYCLASE FROM THE EXTRACELLULAR OR INTRACELLULAR FACE OF THE MEMBRANE
    FASEB JOURNAL Volume: 6 Page(s): A79 - A79
    01/01/1992 Authors: HARTZELL HC; BUDNITZ D
  • CHARACTERIZATION OF PERSISTENT ICA IN FROG VENTRICULAR MYOCYTES INDUCED BY GTP-GAMMA-S
    FASEB JOURNAL Volume: 6 Page(s): A283 - A283
    01/01/1992 Authors: PARSONS TD; HARTZELL HC
  • CHANNEL CONTROL - REPLY
    NATURE Volume: 354 Page(s): 364 - 364
    12/05/1991 Authors: HARTZELL HC; MERY PF; FISCHMEISTER R; SZABO G
  • Channel control.
    Nature Volume: 354 Page(s): 363 - 364
    12/05/1991
  • Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation.
    Nature Volume: 351 Page(s): 573 - 576
    06/13/1991 Authors: Hartzell HC; Mry PF; Fischmeister R; Szabo G
  • Alterations in Ca2+ sensitive tension due to partial extraction of C-protein from rat skinned cardiac myocytes and rabbit skeletal muscle fibers.
    J Gen Physiol Volume: 97 Page(s): 1141 - 1163
    06/01/1991 Authors: Hofmann PA; Hartzell HC; Moss RL
  • Effects of Mg2+ on basal and beta-adrenergic-stimulated delayed rectifier potassium current in frog atrial myocytes.
    J Physiol Volume: 435 Page(s): 333 - 347
    04/01/1991 Authors: Duchatelle-Gourdon I; Lagrutta AA; Hartzell HC
  • Cyclic AMP phosphodiesterases and Ca2+ current regulation in cardiac cells.
    Life Sci Volume: 48 Page(s): 2365 - 2376
    01/01/1991 Authors: Fischmeister R; Hartzell HC
  • Regulation of Ca2+ current in frog ventricular cardiomyocytes by 5'-guanylylimidodiphosphate and acetylcholine.
    J Physiol Volume: 432 Page(s): 593 - 620
    01/01/1991 Authors: Parsons TD; Lagrutta A; White RE; Hartzell HC
  • Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells.
    Mol Pharmacol Volume: 38 Page(s): 426 - 433
    09/01/1990 Authors: Fischmeister R; Hartzell HC
  • Single delayed rectifier channels in frog atrial cells. Effects of beta-adrenergic stimulation.
    Biophys J Volume: 57 Page(s): 903 - 909
    04/01/1990 Authors: Duchatelle-Gourdon I; Hartzell HC
  • AFFINITY OF ADENYLYL CYCLASE FOR SUB-UNIT(S) OF IRREVERSIBLY ACTIVATED G-PROTEIN, GI, DEPENDS ON GS
    BIOPHYSICAL JOURNAL Volume: 57 Page(s): A290 - A290
    02/01/1990 Authors: PARSONS TD; LAGRUTTA A; WHITE RE; HARTZELL HC
  • EFFECTS OF C-PROTEIN EXTRACTION ON CA-2+ ACTIVATED TENSION IN SINGLE SKINNED CARDIAC AND SKELETAL-MUSCLE FIBERS
    BIOPHYSICAL JOURNAL Volume: 57 Page(s): A146 - A146
    02/01/1990 Authors: HOFMANN PA; HARTZELL HC; MOSS RL
  • G-PROTEINS, GS AND GI, ACT AT SEPARATE SITES ON ADENYLYL CYCLASE TO REGULATE VOLTAGE-GATED CA-2+-CURRENTS IN CARDIOMYOCYTES
    BIOPHYSICAL JOURNAL Volume: 57 Page(s): A217 - A217
    02/01/1990 Authors: WHITE RE; LAGRUTTA A; PARSONS TD; HARTZELL HC
  • THE MODULATION OF SINGLE DELAYED RECTIFIER CHANNELS BY ISOPROTERENOL AND CAMP IN FROG ATRIAL CELLS
    BIOPHYSICAL JOURNAL Volume: 57 Page(s): A313 - A313
    02/01/1990 Authors: DUCHATELLEGOURDON I; HARTZELL HC
  • Effects of magnesium on inactivation of the voltage-gated calcium current in cardiac myocytes.
    J Gen Physiol Volume: 94 Page(s): 745 - 767
    10/01/1989 Authors: Hartzell HC; White RE
  • Modulation of the delayed rectifier potassium current in frog cardiomyocytes by beta-adrenergic agonists and magnesium.
    J Physiol Volume: 415 Page(s): 251 - 274
    08/01/1989 Authors: Duchatelle-Gourdon I; Hartzell HC; Lagrutta AA
  • Magnesium ions in cardiac function. Regulator of ion channels and second messengers.
    Biochem Pharmacol Volume: 38 Page(s): 859 - 867
    03/15/1989 Authors: White RE; Hartzell HC
  • SPHINGOSINE EFFECTS ON THE CA CURRENT IN FROG CARDIAC MYOCYTES
    JOURNAL OF PHYSIOLOGY-LONDON Volume: 406 Page(s): P82 - P82
    12/01/1988 Authors: HARTZELL HC; MONGO KG; SCAMPS F; VASSORT G
  • Inactivation, reactivation and pacing dependence of calcium current in frog cardiocytes: correlation with current density.
    J Physiol Volume: 401 Page(s): 201 - 226
    07/01/1988 Authors: Argibay JA; Fischmeister R; Hartzell HC
  • Role of phosphodiesterase in regulation of calcium current in isolated cardiac myocytes.
    Mol Pharmacol Volume: 33 Page(s): 664 - 671
    06/01/1988 Authors: Simmons MA; Hartzell HC
  • Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes.
    Science Volume: 239 Page(s): 778 - 780
    02/12/1988 Authors: White RE; Hartzell HC
  • EFFECTS OF INTRACELLULAR FREE MAGNESIUM ON CALCIUM CURRENT IN ISOLATED CARDIAC MYOCYTES
    BIOPHYSICAL JOURNAL Volume: 53 Page(s): A558 - A558
    02/01/1988 Authors: WHITE RE; HARTZELL HC
  • Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems.
    Prog Biophys Mol Biol Volume: 52 Page(s): 165 - 247
    01/01/1988 Authors: Hartzell HC
  • Effect of forskolin and acetylcholine on calcium current in single isolated cardiac myocytes.
    Mol Pharmacol Volume: 32 Page(s): 639 - 645
    11/01/1987 Authors: Hartzell HC; Fischmeister R
  • Comparison of effects of acetylcholine on calcium and potassium currents in frog atrium and ventricle.
    J Physiol Volume: 389 Page(s): 411 - 422
    08/01/1987 Authors: Hartzell HC; Simmons MA
  • A quantitative analysis of the acetylcholine-activated potassium current in single cells from frog atrium.
    Pflugers Arch Volume: 409 Page(s): 454 - 461
    08/01/1987 Authors: Simmons MA; Hartzell HC
  • Cyclic guanosine 3',5'-monophosphate regulates the calcium current in single cells from frog ventricle.
    J Physiol Volume: 387 Page(s): 453 - 472
    06/01/1987 Authors: Fischmeister R; Hartzell HC
  • MODIFICATIONS OF CARDIAC CALCIUM CURRENT IN CELLS WITH INHERENT DIFFERENCES IN CURRENT-DENSITY
    BIOPHYSICAL JOURNAL Volume: 51 Page(s): A29 - A29
    02/01/1987 Authors: FISCHMEISTER R; ARGIBAY JA; HARTZELL HC
  • EFFECTS OF ACETYLCHOLINE AND CYCLIC-GMP ON THE CALCIUM CURRENT IN VENTRICULAR AND ATRIAL MYOCYTES
    BIOPHYSICAL JOURNAL Volume: 51 Page(s): A426 - A426
    02/01/1987 Authors: HARTZELL HC; FISCHMEISTER R; SIMMONS MA
  • A time-dependent and voltage-sensitive K+ current in single cells from frog atrium.
    J Gen Physiol Volume: 88 Page(s): 739 - 755
    12/01/1986 Authors: Simmons MA; Creazzo T; Hartzell HC
  • Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells.
    Nature Volume: 323 Page(s): 273 - 275
    09/18/1986 Authors: Hartzell HC; Fischmeister R
  • Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.
    J Physiol Volume: 376 Page(s): 183 - 202
    07/01/1986 Authors: Fischmeister R; Hartzell HC
  • Effects of phosphorylated and unphosphorylated C-protein on cardiac actomyosin ATPase.
    J Mol Biol Volume: 186 Page(s): 185 - 195
    11/05/1985 Authors: Hartzell HC
  • Reduction of muscarinic acetylcholine receptor number and affinity by an endogenous substance.
    J Neurochem Volume: 45 Page(s): 710 - 718
    09/01/1985 Authors: Creazzo TL; Hartzell HC
  • Phosphoproteins: protein phosphorylation in the nervous system.
    Science Volume: 228 Page(s): 866 - 867
    05/17/1985 Authors: Hartzell HC
  • Structure of C protein purified from cardiac muscle.
    J Cell Biol Volume: 100 Page(s): 208 - 215
    01/01/1985 Authors: Hartzell HC; Sale WS
  • EFFECT OF C-PROTEIN ON CARDIAC-MUSCLE ACTOMYOSIN ATPASE
    BIOPHYSICAL JOURNAL Volume: 47 Page(s): A28 - A28
    01/01/1985 Authors: HARTZELL HC
  • Phosphorylation of purified cardiac muscle C-protein by purified cAMP-dependent and endogenous Ca2+-calmodulin-dependent protein kinases.
    J Biol Chem Volume: 259 Page(s): 15587 - 15596
    12/25/1984 Authors: Hartzell HC; Glass DB
  • Phosphorylation of C-protein in intact amphibian cardiac muscle. Correlation between 32P incorporation and twitch relaxation.
    J Gen Physiol Volume: 83 Page(s): 563 - 588
    04/01/1984 Authors: Hartzell HC
  • REGULATION OF MUSCARINIC ACETYLCHOLINE-RECEPTORS IN THE HEART BY AN ENDOGENOUS SOLUBLE FACTOR
    ANATOMICAL RECORD Volume: 208 Page(s): A38 - A38
    01/01/1984 Authors: CREAZZO TL; HARTZELL HC
  • STRUCTURE OF C-PROTEIN PURIFIED FROM CARDIAC MYOFIBRILS
    JOURNAL OF CELL BIOLOGY Volume: 99 Page(s): A438 - A438
    01/01/1984 Authors: HARTZELL HC; SALE WS
  • INVITRO DEPHOSPHORYLATION OF CARDIAC-MUSCLE C-PROTEIN
    JOURNAL OF CELL BIOLOGY Volume: 99 Page(s): A270 - A270
    01/01/1984 Authors: TITUS L; HARTZELL HC
  • CYCLIC-AMP DEPENDENT PHOSPHORYLATION IN HEART HOMOGENATES CAUSES A REDUCTION IN THE NUMBER OF MUSCARINIC ACETYLCHOLINE-RECEPTORS
    ANATOMICAL RECORD Volume: 205 Page(s): A40 - A40
    01/01/1983 Authors: CREAZZO TL; HARTZELL HC
  • Effects of cholinergic and adrenergic agonists on phosphorylation of a 165,000-dalton myofibrillar protein in intact cardiac muscle.
    J Biol Chem Volume: 257 Page(s): 2111 - 2120
    02/25/1982 Authors: Hartzell HC; Titus L
  • PHYSIOLOGICAL CONSEQUENCES OF MUSCARINIC RECEPTOR ACTIVATION
    TRENDS IN PHARMACOLOGICAL SCIENCES Volume: 3 Page(s): 213 - 214
    01/01/1982 Authors: HARTZELL HC
  • Mechanisms of slow postsynaptic potentials.
    Nature Volume: 291 Page(s): 539 - 544
    06/18/1981 Authors: Hartzell HC
  • Distribution of muscarinic acetylcholine receptors and presynaptic nerve terminals in amphibian heart.
    J Cell Biol Volume: 86 Page(s): 6 - 20
    07/01/1980 Authors: Hartzell HC
  • Adenosine receptors in frog sinus venosus: slow inhibitory potentials produced by adenine compounds and acetylcholine.
    J Physiol Volume: 293 Page(s): 23 - 49
    08/01/1979 Authors: Hartzell HC
  • Distribution of muscarinic acetylcholine receptors in amphibian cardiac muscle.
    Nature Volume: 278 Page(s): 569 - 571
    04/05/1979 Authors: Hartzell HC
  • ADENOSINE RECEPTORS IN FROG SINUS VENOSUS MYOCYTES
    BIOPHYSICAL JOURNAL Volume: 25 Page(s): A293 - A293
    01/01/1979 Authors: HARTZELL HC
  • Synaptic excitation and inhibition resulting from direct action of acetylcholine on two types of chemoreceptors on individual amphibian parasympathetic neurones.
    J Physiol Volume: 271 Page(s): 817 - 846
    10/01/1977 Authors: Hartzell HC; Kuffler SW; Stickgold R; Yoshikami D
  • The number of acetylcholine molecules in a quantum and the interaction between quanta at the subsynaptic membrane of the skeletal neuromuscular synapse.
    Cold Spring Harb Symp Quant Biol Volume: 40 Page(s): 175 - 186
    01/01/1976 Authors: Hartzell HC; Kuffler SW; Yoshikami D
  • Post-synaptic potentiation: interaction between quanta of acetylcholine at the skeletal neuromuscular synapse.
    J Physiol Volume: 251 Page(s): 427 - 463
    10/01/1975 Authors: Hartzell HC; Kuffler SW; Yoshikami D
  • Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins.
    Proc Natl Acad Sci U S A Volume: 72 Page(s): 3245 - 3249
    08/01/1975 Authors: Burden SJ; Hartzell HC; Yoshikami D
  • Trophic functions of the neuron. I. Development of neural connections. Receptor properties of developing muscle.
    Ann N Y Acad Sci Volume: 228 Page(s): 47 - 62
    03/22/1974 Authors: Fambrough D; Hartzell HC; Rash JE; Ritchie AK
  • Acetycholine receptor production and incorporation into membranes of developing muscle fibers.
    Dev Biol Volume: 30 Page(s): 153 - 165
    01/01/1973 Authors: Hartzell HC; Fambrough DM
  • Acetylcholine receptors. Distribution and extrajunctional density in rat diaphragm after denervation correlated with acetylcholine sensitivity.
    J Gen Physiol Volume: 60 Page(s): 248 - 262
    09/01/1972 Authors: Hartzell HC; Fambrough DM
  • Acetylcholine receptors: number and distribution at neuromuscular junctions in rat diaphragm.
    Science Volume: 176 Page(s): 189 - 191
    04/14/1972 Authors: Fambrough DM; Hartzell HC
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