Publications

• Considerations for capsid-targeting antiretrovirals in pre-exposure prophylaxis.
  Trends Mol Med
  02/27/2025 Authors: McFadden WM; Faerch M; Kirby KA; Dick RA; Torbett BE; Sarafianos SG
• Adapting a Trapped Ion Mobility Spectrometry-Q-TOF for High m/z Native Mass Spectrometry and Surface-Induced Dissociation.
  Anal Chem Volume: 97 Page(s): 3827 - 3835
  02/25/2025 Authors: Lin Y-F; Jones BJ; Ridgeway ME; Panczyk EM; Somogyi A; Kaplan DA; Marathe I; Yun S; Kirby KA; Sarafianos SG
• Dimming the corona: studying SARS-coronavirus-2 at reduced biocontainment level using replicons and virus-like particles.
  mBio Volume: 15 Page(s): e0336823
  12/11/2024 Authors: Neilsen G; Mathew AM; Castro JM; McFadden WM; Wen X; Ong YT; Tedbury PR; Lan S; Sarafianos SG
• Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome.
  bioRxiv
  12/06/2024 Authors: Tedbury PR; Mahboubi D; Puray-Chavez M; Shah R; Ukah OB; Wahoski CC; Fadel HJ; Poeschla EM; Gao X; McFadden WM
• Quinazolinone-based Subchemotypes for Targeting HIV-1 Capsid Protein: Design and Synthesis.
  Med Chem Res Volume: 33 Page(s): 2431 - 2447
  12/01/2024 Authors: Akther T; McFadden WM; Zhang H; Kirby KA; Sarafianos SG; Wang Z
• HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration.
  Nucleic Acids Res Volume: 52 Page(s): 11060 - 11082
  10/14/2024 Authors: Jang S; Bedwell GJ; Singh SP; Yu HJ; Arnarson B; Singh PK; Radhakrishnan R; Douglas AW; Ingram ZM; Freniere C
• Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries.
  Antimicrob Agents Chemother Volume: 68 Page(s): e0090924
  10/08/2024 Authors: Akaberi D; Pourghasemi Lati M; Krambrich J; Berger J; Neilsen G; Strandback E; Turunen SP; Wannberg J; Gullberg H; Moche M
• Myrtus communis L. Essential Oil Exhibits Antiviral Activity against Coronaviruses.
  Pharmaceuticals (Basel) Volume: 17
  09/10/2024 Authors: Li D-Y; Donadu MG; Shue T; Dangas G; Athanasiadis A; Lan S; Wen X; Battah B; Zanetti S; Mazzarello V
• A Tag-Free Platform for Synthesis and Screening of Cyclic Peptide Libraries.
  Angew Chem Int Ed Engl Volume: 63 Page(s): e202320045
  05/21/2024 Authors: Bruce A; Adebomi V; Czabala P; Palmer J; McFadden WM; Lorson ZC; Slack RL; Bhardwaj G; Sarafianos SG; Raj M
• Design and Synthesis of New GS-6207 Subtypes for Targeting HIV-1 Capsid Protein.
  Int J Mol Sci Volume: 25
  03/27/2024 Authors: Akther T; McFadden WM; Zhang H; Kirby KA; Sarafianos SG; Wang Z
• Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition.
  Cell Chem Biol Volume: 31 Page(s): 477 - 486.e7
  03/21/2024 Authors: McFadden WM; Casey-Moore MC; Bare GAL; Kirby KA; Wen X; Li G; Wang H; Slack RL; Snyder AA; Lorson ZC
• Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
  Eur J Med Chem Volume: 268 Page(s): 116263
  03/15/2024 Authors: Amblard F; LeCher JC; De R; Zhou S; Liu P; Goh SL; Tao S; Patel D; Downs-Bowen J; Zandi K
• HIV-2 inhibits HIV-1 gene expression via two independent mechanisms during cellular co-infection.
  J Virol Volume: 97 Page(s): e0187022
  12/21/2023 Authors: Yapo V; Majumder K; Tedbury PR; Wen X; Ong YT; Johnson MC; Sarafianos SG
• Use of TSAR, Thermal Shift Analysis in R, to identify Folic Acid as a Molecule that Interacts with HIV-1 Capsid.
  bioRxiv
  11/29/2023 Authors: Gao X; McFadden WM; Wen X; Emanuelli A; Lorson ZC; Zheng H; Kirby KA; Sarafianos SG
• Discovery of Nirmatrelvir Resistance Mutations in SARS-CoV-2 3CLpro: A Computational-Experimental Approach.
  J Chem Inf Model Volume: 63 Page(s): 7180 - 7188
  11/27/2023 Authors: Havranek B; Demissie R; Lee H; Lan S; Zhang H; Sarafianos S; Ayitou AJ-L; Islam SM
• Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.
  FASEB J Volume: 37 Page(s): e23220
  11/01/2023 Authors: Tedbury PR; Manfredi C; Degenhardt F; Conway J; Horwath MC; McCracken C; Sorscher AJ; Moreau S; Wright C; Edwards C
• HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes.
  Viruses Volume: 15
  09/25/2023 Authors: Cilento ME; Wen X; Reeve AB; Ukah OB; Snyder AA; Carrillo CM; Smith CP; Edwards K; Wahoski CC; Kitzler DR
• Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
  Nat Commun Volume: 14 Page(s): 5614
  09/12/2023 Authors: Gres AT; Kirby KA; McFadden WM; Du H; Liu D; Xu C; Bryer AJ; Perilla JR; Shi J; Aiken C
• Biology of the hepatitis B virus (HBV) core and capsid assembly modulators (CAMs) for chronic hepatitis B (CHB) cure.
  Glob Health Med Volume: 5 Page(s): 199 - 207
  08/31/2023 Authors: McFadden WM; Sarafianos SG
• TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS.
  J Mol Cell Biol Volume: 15
  08/03/2023 Authors: Cicka D; Niu Q; Qui M; Qian K; Miller E; Fan D; Mo X; Ivanov AA; Sarafianos SG; Du Y
• The HIV-1 capsid core is an opportunistic nuclear import receptor.
  Nat Commun Volume: 14 Page(s): 3782
  06/24/2023 Authors: Xue G; Yu HJ; Buffone C; Huang S-W; Lee K; Goh SL; Gres AT; Guney MH; Sarafianos SG; Luban J
• Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus.
  Viruses Volume: 15
  04/17/2023 Authors: Liu D; Ndongwe TP; Ji J; Huber AD; Michailidis E; Rice CM; Ralston R; Tedbury PR; Sarafianos SG
• Targeting the HIV-1 and HBV Capsids, an EnCore.
  Viruses Volume: 15
  03/31/2023 Authors: McFadden WM; Sarafianos SG
• SARS-CoV-2 Induces Epithelial-Enteric Neuronal Crosstalk Stimulating VIP Release.
  Biomolecules Volume: 13
  01/20/2023 Authors: Balasubramaniam A; Tedbury PR; Mwangi SM; Liu Y; Li G; Merlin D; Gracz AD; He P; Sarafianos SG; Srinivasan S
• Nirmatrelvir Resistance in SARS-CoV-2 Omicron_BA.1 and WA1 Replicons and Escape Strategies.
  bioRxiv
  01/03/2023 Authors: Lan S; Neilsen G; Slack RL; Cantara WA; Castaner AE; Lorson ZC; Lulkin N; Zhang H; Lee J; Cilento ME
• Activation of HIV-1 proviruses increases downstream chromatin accessibility.
  iScience Volume: 25 Page(s): 105490
  12/22/2022 Authors: Shah R; Gallardo CM; Jung YH; Clock B; Dixon JR; McFadden WM; Majumder K; Pintel DJ; Corces VG; Torbett BE
• Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro.
  Sci Adv Volume: 8 Page(s): eadd2191
  12/09/2022 Authors: Yadav R; Courouble VV; Dey SK; Harrison JJEK; Timm J; Hopkins JB; Slack RL; Sarafianos SG; Ruiz FX; Griffin PR
• Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication.
  mBio Volume: 13 Page(s): e0222022
  10/26/2022 Authors: Rawson JMO; Nikolaitchik OA; Yoo JA; Somoulay X; Brown MA; Mbuntcha Bogni FS; Pathak VK; Soheilian F; Slack RL; Sarafianos SG
• Drug Interactions in Lenacapavir-Based Long-Acting Antiviral Combinations.
  Viruses Volume: 14
  05/31/2022 Authors: Cilento ME; Ong YT; Tedbury PR; Sarafianos SG
• ENTERIC NEURONAL VASOACTIVE INTESTINAL PEPTIDE MEDIATES SARS-COV-2 ASSOCIATED DIARRHEA
  Volume: 162 Page(s): S364 - S364
  05/01/2022 Authors: Balasubramaniam A; Tedbury P; Gracz AD; Mwangi SM; Li G; Merlin D; Sarafianos SG; He P; Srinivasan S
• Marine Natural Products as Leads against SARS-CoV-2 Infection.
  J Nat Prod Volume: 85 Page(s): 657 - 665
  03/25/2022 Authors: Chhetri BK; Tedbury PR; Sweeney-Jones AM; Mani L; Soapi K; Manfredi C; Sorscher E; Sarafianos SG; Kubanek J
• Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid.
  J Comput Aided Mol Des Volume: 36 Page(s): 193 - 203
  03/01/2022 Authors: Sun Q; Biswas A; Vijayan RSK; Craveur P; Forli S; Olson AJ; Castaner AE; Kirby KA; Sarafianos SG; Deng N
• Specific mutations in the HIV-1 G-tract of the 3'-polypurine tract cause resistance to integrase strand transfer inhibitors.
  J Antimicrob Chemother Volume: 77 Page(s): 574 - 577
  02/23/2022 Authors: Hachiya A; Kubota M; Shigemi U; Ode H; Yokomaku Y; Kirby KA; Sarafianos SG; Iwatani Y
• Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication.
  Nucleic Acids Res Volume: 50 Page(s): 1701 - 1717
  02/22/2022 Authors: Gruenke PR; Aneja R; Welbourn S; Ukah OB; Sarafianos SG; Burke DH; Lange MJ
• TRIM5 Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection.
  Viruses Volume: 14
  02/10/2022 Authors: Selyutina A; Simons LM; Kirby KA; Bulnes-Ramos A; Hu P; Sarafianos SG; Hultquist JF; Diaz-Griffero F
• Rotten to the core: antivirals targeting the HIV-1 capsid core.
  Retrovirology Volume: 18 Page(s): 41
  12/22/2021 Authors: McFadden WM; Snyder AA; Kirby KA; Tedbury PR; Raj M; Wang Z; Sarafianos SG
• Potency and metabolic stability: a molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein.
  RSC Med Chem Volume: 12 Page(s): 2031 - 2044
  12/15/2021 Authors: Sahani RL; Akther T; Cilento ME; Castaner AE; Zhang H; Kirby KA; Xie J; Sarafianos SG; Wang Z
• Development of Human Immunodeficiency Virus Type 1 Resistance to 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine Starting with Wild-Type or Nucleoside Reverse Transcriptase Inhibitor-Resistant Strains.
  Antimicrob Agents Chemother Volume: 65 Page(s): e0116721
  11/17/2021 Authors: Cilento ME; Reeve AB; Michailidis E; Ilina TV; Nagy E; Mitsuya H; Parniak MA; Tedbury PR; Sarafianos SG
• SARS-CoV-2 induces enteric neuronal production of vasoactive intestinal peptide as a potential mechanism of COVID-19-associated diarrhea
  Volume: 33
  08/01/2021 Authors: He P; Tedbury PR; Gracz A; Mwangi SM; Li G; Merlin D; Sarafianos SG; Srinivasan S
• Molecular Dynamics Free Energy Simulations Reveal the Mechanism for the Antiviral Resistance of the M66I HIV-1 Capsid Mutation.
  Viruses Volume: 13
  05/15/2021 Authors: Sun Q; Levy RM; Kirby KA; Wang Z; Sarafianos SG; Deng N
• The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr.
  Cell Host Microbe Volume: 29 Page(s): 792 - 805.e6
  05/12/2021 Authors: Dupont L; Bloor S; Williamson JC; Cuesta SM; Shah R; Teixeira-Silva A; Naamati A; Greenwood EJD; Sarafianos SG; Matheson NJ
• SARS-COV-2 INDUCES EPITHYELIAL-NEURONAL CROSSTALK STIMULATING VASOACTIVE INTESTINAL PEPTIDE RELEASE AS A POTENTIAL MECHANISM OF COVID-19-ASSOCIATED DIARRHEA
  Volume: 160 Page(s): S233 - S234
  05/01/2021 Authors: He P; Tedbury P; Gracz AD; Mwangi SM; Li G; Merlin D; Sarafianos SG; Srinivasan S
• Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches.
  Viruses Volume: 13
  04/27/2021 Authors: Senaweera S; Du H; Zhang H; Kirby KA; Tedbury PR; Xie J; Sarafianos SG; Wang Z
• Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase.
  Microorganisms Volume: 9
  04/22/2021 Authors: Zandi K; Musall K; Oo A; Cao D; Liang B; Hassandarvish P; Lan S; Slack RL; Kirby KA; Bassit L
• Avoiding Drug Resistance in HIV Reverse Transcriptase.
  Chem Rev Volume: 121 Page(s): 3271 - 3296
  03/24/2021 Authors: Cilento ME; Kirby KA; Sarafianos SG
• Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74.
  Viruses Volume: 13
  03/15/2021 Authors: Sahani RL; Diana-Rivero R; Vernekar SKV; Wang L; Du H; Zhang H; Castaner AE; Casey MC; Kirby KA; Tedbury PR
• Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability.
  Acta Pharm Sin B Volume: 11 Page(s): 810 - 822
  03/01/2021 Authors: Wang L; Casey MC; Vernekar SKV; Sahani RL; Kirby KA; Du H; Zhang H; Tedbury PR; Xie J; Sarafianos SG
• Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
  Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
  01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ
• Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
  Nat Commun Volume: 11 Page(s): 6165
  11/26/2020 Authors: Francis AC; Marin M; Singh PK; Achuthan V; Prellberg MJ; Palermino-Rowland K; Lan S; Tedbury PR; Sarafianos SG; Engelman AN
• Single-cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection.
  J Vis Exp
  10/29/2020 Authors: Shah R; Lan S; Puray-Chavez MN; Liu D; Tedbury PR; Sarafianos SG
• Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.
  Eur J Med Chem Volume: 204 Page(s): 112626
  10/15/2020 Authors: Wang L; Casey MC; Vernekar SKV; Sahani RL; Kankanala J; Kirby KA; Du H; Hachiya A; Zhang H; Tedbury PR
• Chemical profiling of HIV-1 capsid-targeting antiviral PF74.
  Eur J Med Chem Volume: 200 Page(s): 112427
  08/15/2020 Authors: Wang L; Casey MC; Vernekar SKV; Do HT; Sahani RL; Kirby KA; Du H; Hachiya A; Zhang H; Tedbury PR
• HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
  Nat Commun Volume: 11 Page(s): 3505
  07/14/2020 Authors: Francis AC; Marin M; Singh PK; Achuthan V; Prellberg MJ; Palermino-Rowland K; Lan S; Tedbury PR; Sarafianos SG; Engelman AN
• Effect of P-body component Mov10 on HCV virus production and infectivity.
  FASEB J Volume: 34 Page(s): 9433 - 9449
  07/01/2020 Authors: Liu D; Ndongwe TP; Puray-Chavez M; Casey MC; Izumi T; Pathak VK; Tedbury PR; Sarafianos SG
• Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs.
  Pathogens Volume: 9
  04/26/2020 Authors: Neogi U; Hill KJ; Ambikan AT; Heng X; Quinn TP; Byrareddy SN; Snnerborg A; Sarafianos SG; Singh K
• Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules.
  Viruses Volume: 12
  04/16/2020 Authors: Vernekar SKV; Sahani RL; Casey MC; Kankanala J; Wang L; Kirby KA; Du H; Zhang H; Tedbury PR; Xie J
• 7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety.
  Antiviral Res Volume: 176 Page(s): 104744
  04/01/2020 Authors: Hayashi S; Higashi-Kuwata N; Das D; Tomaya K; Yamada K; Murakami S; Venzon DJ; Hattori S-I; Isogawa M; Sarafianos SG
• Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.
  Acc Chem Res Volume: 53 Page(s): 218 - 230
  01/21/2020 Authors: Wang L; Sarafianos SG; Wang Z
• Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus.
  Viruses Volume: 11
  11/08/2019 Authors: Liu D; Tedbury PR; Lan S; Huber AD; Puray-Chavez MN; Ji J; Michailidis E; Saeed M; Ndongwe TP; Bassit LC
• Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H.
  ACS Infect Dis Volume: 5 Page(s): 1963 - 1974
  11/08/2019 Authors: Xi Z; Wang Z; Sarafianos SG; Myshakina NS; Ishima R
• Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation.
  Structure Volume: 27 Page(s): 1581 - 1593.e3
  10/01/2019 Authors: Slack RL; Ilina TV; Xi Z; Giacobbi NS; Kawai G; Parniak MA; Sarafianos SG; Sluis Cremer N; Ishima R
• Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus.
  EBioMedicine Volume: 47 Page(s): 269 - 283
  09/01/2019 Authors: Martinez-Lopez A; Persaud M; Chavez MP; Zhang H; Rong L; Liu S; Wang TT; Sarafianos SG; Diaz-Griffero F
• Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication.
  Viruses Volume: 11
  07/17/2019 Authors: Puray-Chavez MN; Farghali MH; Yapo V; Huber AD; Liu D; Ndongwe TP; Casey MC; Laughlin TG; Hannink M; Tedbury PR
• Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores.
  ACS Infect Dis Volume: 5 Page(s): 750 - 758
  05/10/2019 Authors: Huber AD; Pineda DL; Liu D; Boschert KN; Gres AT; Wolf JJ; Coonrod EM; Tang J; Laughlin TG; Yang Q
• Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase.
  Pharmaceuticals (Basel) Volume: 12
  04/20/2019 Authors: Singh K; Sarafianos SG; Snnerborg A
• CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.
  Antimicrob Agents Chemother Volume: 63
  04/01/2019 Authors: Higashi-Kuwata N; Hayashi S; Das D; Kohgo S; Murakami S; Hattori S-I; Imoto S; Venzon DJ; Singh K; Sarafianos SG
• Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.
  Eur J Med Chem Volume: 166 Page(s): 390 - 399
  03/15/2019 Authors: Tang J; Do HT; Huber AD; Casey MC; Kirby KA; Wilson DJ; Kankanala J; Parniak MA; Sarafianos SG; Wang Z
• Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket.
  mBio Volume: 10
  03/12/2019 Authors: Craveur P; Gres AT; Kirby KA; Liu D; Hammond JA; Deng Y; Forli S; Goodsell DS; Williamson JR; Sarafianos SG
• Strain-specific effect on biphasic DNA binding by HIV-1 integrase.
  AIDS Volume: 33 Page(s): 588 - 592
  03/01/2019 Authors: Hill KJ; Rogers LC; Njenda DT; Burke DH; Sarafianos SG; Snnerborg A; Neogi U; Singh K
• 5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors.
  Eur J Med Chem Volume: 164 Page(s): 179 - 192
  02/15/2019 Authors: Tang J; Huber AD; Pineda DL; Boschert KN; Wolf JJ; Kankanala J; Xie J; Sarafianos SG; Wang Z
• Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.
  J Med Chem Volume: 62 Page(s): 1125 - 1137
  02/14/2019 Authors: Wu X; Xu G; Li X; Xu W; Li Q; Liu W; Kirby KA; Loh ML; Li J; Sarafianos SG
• The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase.
  Cell Chem Biol Volume: 25 Page(s): 1268 - 1278.e3
  10/18/2018 Authors: Takamatsu Y; Das D; Kohgo S; Hayashi H; Delino NS; Sarafianos SG; Mitsuya H; Maeda K
• Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation.
  mBio Volume: 9
  10/16/2018 Authors: Novikova M; Adams LJ; Fontana J; Gres AT; Balasubramaniam M; Winkler DC; Kudchodkar SB; Soheilian F; Sarafianos SG; Steven AC
• Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.
  J Virol Volume: 92
  10/15/2018 Authors: de la Higuera I; Ferrer-Orta C; Moreno E; de vila AI; Soria ME; Singh K; Caridi F; Sobrino F; Sarafianos SG; Perales C
• Antiretroviral potency of 4'-ethnyl-2'-fluoro-2'-deoxyadenosine, tenofovir alafenamide and second-generation NNRTIs across diverse HIV-1 subtypes.
  J Antimicrob Chemother Volume: 73 Page(s): 2721 - 2728
  10/01/2018 Authors: Njenda DT; Aralaguppe SG; Singh K; Rao R; Snnerborg A; Sarafianos SG; Neogi U
• Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells.
  Viruses Volume: 10
  09/30/2018 Authors: Ukah OB; Puray-Chavez M; Tedbury PR; Herschhorn A; Sodroski JG; Sarafianos SG
• Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.
  Cell Host Microbe Volume: 24 Page(s): 392 - 404.e8
  09/12/2018 Authors: Achuthan V; Perreira JM; Sowd GA; Puray-Chavez M; McDougall WM; Paulucci-Holthauzen A; Wu X; Fadel HJ; Poeschla EM; Multani AS
• 6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.
  Eur J Med Chem Volume: 156 Page(s): 680 - 691
  08/05/2018 Authors: Wang L; Tang J; Huber AD; Casey MC; Kirby KA; Wilson DJ; Kankanala J; Parniak MA; Sarafianos SG; Wang Z
• 6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.
  Eur J Med Chem Volume: 156 Page(s): 652 - 665
  08/05/2018 Authors: Wang L; Tang J; Huber AD; Casey MC; Kirby KA; Wilson DJ; Kankanala J; Xie J; Parniak MA; Sarafianos SG
• 4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a novel HIV-1 reverse transcriptase translocation inhibitor.
  Curr Opin HIV AIDS Volume: 13 Page(s): 294 - 299
  07/01/2018 Authors: Markowitz M; Sarafianos SG
• Effect of tRNA on the Maturation of HIV-1 Reverse Transcriptase.
  J Mol Biol Volume: 430 Page(s): 1891 - 1900
  06/22/2018 Authors: Ilina TV; Slack RL; Elder JH; Sarafianos SG; Parniak MA; Ishima R
• The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells.
  mSphere Volume: 3
  04/25/2018 Authors: Huber AD; Wolf JJ; Liu D; Gres AT; Tang J; Boschert KN; Puray-Chavez MN; Pineda DL; Laughlin TG; Coonrod EM
• Ex-vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV type 1 non-B subtypes.
  AIDS Volume: 32 Page(s): 469 - 476
  02/20/2018 Authors: Neogi U; Singh K; Aralaguppe SG; Rogers LC; Njenda DT; Sarafianos SG; Hejdeman B; Snnerborg A
• Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes.
  Front Microbiol Volume: 9 Page(s): 1754
  01/01/2018 Authors: Rogers L; Obasa AE; Jacobs GB; Sarafianos SG; Snnerborg A; Neogi U; Singh K
• Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
  Eur J Med Chem Volume: 141 Page(s): 149 - 161
  12/01/2017 Authors: Kankanala J; Kirby KA; Huber AD; Casey MC; Wilson DJ; Sarafianos SG; Wang Z
• Multiplex single-cell visualization of nucleic acids and protein during HIV infection.
  Nat Commun Volume: 8 Page(s): 1882
  12/01/2017 Authors: Puray-Chavez M; Tedbury PR; Huber AD; Ukah OB; Yapo V; Liu D; Ji J; Wolf JJ; Engelman AN; Sarafianos SG
• A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase.
  Antimicrob Agents Chemother Volume: 61
  10/01/2017 Authors: Kirby KA; Myshakina NA; Christen MT; Chen Y-L; Schmidt HA; Huber AD; Xi Z; Kim S; Rao RK; Kramer ST
• Impact of HIV-1 Integrase L74F and V75I Mutations in a Clinical Isolate on Resistance to Second-Generation Integrase Strand Transfer Inhibitors.
  Antimicrob Agents Chemother Volume: 61
  08/01/2017 Authors: Hachiya A; Kirby KA; Ido Y; Shigemi U; Matsuda M; Okazaki R; Imamura J; Sarafianos SG; Yokomaku Y; Iwatani Y
• Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.
  J Med Chem Volume: 60 Page(s): 5045 - 5056
  06/22/2017 Authors: Vernekar SKV; Tang J; Wu B; Huber AD; Casey MC; Myshakina N; Wilson DJ; Kankanala J; Kirby KA; Parniak MA
• Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.
  Eur J Med Chem Volume: 133 Page(s): 85 - 96
  06/16/2017 Authors: Tang J; Vernekar SKV; Chen Y-L; Miller L; Huber AD; Myshakina N; Sarafianos SG; Parniak MA; Wang Z
• 3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H.
  Antimicrob Agents Chemother Volume: 61
  06/01/2017 Authors: Huber AD; Michailidis E; Tang J; Puray-Chavez MN; Boftsi M; Wolf JJ; Boschert KN; Sheridan MA; Leslie MD; Kirby KA
• Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.
  Genome Biol Evol Volume: 9 Page(s): 1212 - 1228
  05/01/2017 Authors: de la Higuera I; Ferrer-Orta C; de vila AI; Perales C; Sierra M; Singh K; Sarafianos SG; Dehouck Y; Bastolla U; Verdaguer N
• Exposing HIV's weaknesses.
  J Biol Chem Volume: 292 Page(s): 6027 - 6028
  04/07/2017 Authors: Tedbury PR; Sarafianos SG
• Molecular simulation of EFdA and related analogs to determine the structural basis of HIV-1 drug resistance
  Volume: 253
  04/02/2017 Authors: Das D; Takamatsu Y; Kohgo S; Hattori S; Hayashi H; Matsuda K; Sarafianos S; Mitsuya H; Maeda K
• 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
  Eur J Med Chem Volume: 128 Page(s): 168 - 179
  03/10/2017 Authors: Tang J; Kirby KA; Huber AD; Casey MC; Ji J; Wilson DJ; Sarafianos SG; Wang Z
• Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity.
  Sci Rep Volume: 7 Page(s): 43908
  03/08/2017 Authors: Kimani SG; Kumar S; Bansal N; Singh K; Kholodovych V; Comollo T; Peng Y; Kotenko SV; Sarafianos SG; Bertino JR
• Structural Basis of Inhibition and Resistance Mechanism to EFdA, a highly potent NRTI
  Volume: 74 Page(s): 45 - 45
  03/01/2017 Authors: Sarafianos S
• Soluble host factors CPSF6 and CypA determine the HIV-1 nuclear import pathway.
  Volume: 28
  01/01/2017 Authors: Xue G; Yu H; Goh S; Gres A; Sarafianos S; Luban J; KewalRamani VN
• Increased replication capacity following evolution of PYxE insertion in Gag-p6 is associated with enhanced virulence in HIV-1 subtype C from East Africa.
  J Med Virol Volume: 89 Page(s): 106 - 111
  01/01/2017 Authors: Aralaguppe SG; Winner D; Singh K; Sarafianos SG; Quiones-Mateu ME; Snnerborg A; Neogi U
• Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
  Proc Natl Acad Sci U S A Volume: 113 Page(s): 9274 - 9279
  08/16/2016 Authors: Salie ZL; Kirby KA; Michailidis E; Marchand B; Singh K; Rohan LC; Kodama EN; Mitsuya H; Parniak MA; Sarafianos SG
• 3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.
  J Med Chem Volume: 59 Page(s): 6136 - 6148
  07/14/2016 Authors: Wu B; Tang J; Wilson DJ; Huber AD; Casey MC; Ji J; Kankanala J; Xie J; Sarafianos SG; Wang Z
• Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.
  J Med Chem Volume: 59 Page(s): 5051 - 5062
  05/26/2016 Authors: Kankanala J; Kirby KA; Liu F; Miller L; Nagy E; Wilson DJ; Parniak MA; Sarafianos SG; Wang Z
• 3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.
  J Med Chem Volume: 59 Page(s): 2648 - 2659
  03/24/2016 Authors: Tang J; Liu F; Nagy E; Miller L; Kirby KA; Wilson DJ; Wu B; Sarafianos SG; Parniak MA; Wang Z
• Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries.
  J Antimicrob Chemother Volume: 71 Page(s): 367 - 371
  02/01/2016 Authors: Neogi U; Hggblom A; Singh K; Rogers LC; Rao SD; Amogne W; Schlter E; Zazzi M; Arnold E; Sarafianos SG
• 4'-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.
  Hepatology Volume: 62 Page(s): 1024 - 1036
  10/01/2015 Authors: Takamatsu Y; Tanaka Y; Kohgo S; Murakami S; Singh K; Das D; Venzon DJ; Amano M; Higashi-Kuwata N; Aoki M
• Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission.
  Pharm Res Volume: 32 Page(s): 2960 - 2972
  09/01/2015 Authors: Zhang W; Hu M; Shi Y; Gong T; Dezzutti CS; Moncla B; Sarafianos SG; Parniak MA; Rohan LC
• STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
  Science Volume: 349 Page(s): 99 - 103
  07/03/2015 Authors: Gres AT; Kirby KA; KewalRamani VN; Tanner JJ; Pornillos O; Sarafianos SG
• Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
  J Virol Volume: 89 Page(s): 6848 - 6859
  07/01/2015 Authors: Ferrer-Orta C; de la Higuera I; Caridi F; Snchez-Aparicio MT; Moreno E; Perales C; Singh K; Sarafianos SG; Sobrino F; Domingo E
• Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque.
  Antimicrob Agents Chemother Volume: 59 Page(s): 4190 - 4198
  07/01/2015 Authors: Stoddart CA; Galkina SA; Joshi P; Kosikova G; Moreno ME; Rivera JM; Sloan B; Reeve AB; Sarafianos SG; Murphey-Corb M
• Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
  J Med Chem Volume: 58 Page(s): 651 - 664
  01/22/2015 Authors: Vernekar SKV; Liu Z; Nagy E; Miller L; Kirby KA; Wilson DJ; Kankanala J; Sarafianos SG; Parniak MA; Wang Z
• CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease.
  Am J Hum Genet Volume: 96 Page(s): 121 - 135
  01/08/2015 Authors: Strauss KA; Jinks RN; Puffenberger EG; Venkatesh S; Singh K; Cheng I; Mikita N; Thilagavathi J; Lee J; Sarafianos S
• Fast hepatitis C virus RNA elimination and NS5A redistribution by NS5A inhibitors studied by a multiplex assay approach.
  Antimicrob Agents Chemother Volume: 59 Page(s): 3482 - 3492
  01/01/2015 Authors: Liu D; Ji J; Ndongwe TP; Michailidis E; Rice CM; Ralston R; Sarafianos SG
• Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.
  FASEB J Volume: 29 Page(s): 70 - 80
  01/01/2015 Authors: Kirby KA; Ong YT; Hachiya A; Laughlin TG; Chiang LA; Pan Y; Moran JL; Marchand B; Singh K; Gallazzi F
• Remembering Professor Walter A. Scott.
  Viruses Volume: 6 Page(s): 3873 - 3874
  10/20/2014 Authors: Sarafianos SG
• Antiviral drugs specific for coronaviruses in preclinical development.
  Curr Opin Virol Volume: 8 Page(s): 45 - 53
  10/01/2014 Authors: Adedeji AO; Sarafianos SG
• Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors.
  Viruses Volume: 6 Page(s): 3535 - 3562
  09/24/2014 Authors: Singh K; Flores JA; Kirby KA; Neogi U; Sonnerborg A; Hachiya A; Das K; Arnold E; McArthur C; Parniak M
• 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms.
  J Biol Chem Volume: 289 Page(s): 24533 - 24548
  08/29/2014 Authors: Michailidis E; Huber AD; Ryan EM; Ong YT; Leslie MD; Matzek KB; Singh K; Marchand B; Hagedorn AN; Kirby KA
• Native Hexameric Full-Length HIV-1 Capsid: Crystal Structure and Drug Targeting
  Volume: 70 Page(s): C696 - C696
  08/01/2014 Authors: Gres A; Kirby K; Hachiya A; Michailidis E; Pornillos O; Sugiura W; Lee K; KewalRamani V; Tanner J; Sarafianos S
• SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.
  Antimicrob Agents Chemother Volume: 58 Page(s): 4915 - 4919
  08/01/2014 Authors: Huber AD; Michailidis E; Schultz ML; Ong YT; Bloch N; Puray-Chavez MN; Leslie MD; Ji J; Lucas AD; Kirby KA
• Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention.
  Drug Dev Ind Pharm Volume: 40 Page(s): 1101 - 1111
  08/01/2014 Authors: Zhang W; Parniak MA; Mitsuya H; Sarafianos SG; Graebing PW; Rohan LC
• Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
  Antimicrob Agents Chemother Volume: 58 Page(s): 4894 - 4898
  08/01/2014 Authors: Adedeji AO; Singh K; Kassim A; Coleman CM; Elliott R; Weiss SR; Frieman MB; Sarafianos SG
• In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers.
  Eur J Pharmacol Volume: 732 Page(s): 86 - 95
  06/05/2014 Authors: Zhang W; Parniak MA; Sarafianos SG; Empey PE; Rohan LC
• Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics.
  Antiviral Res Volume: 106 Page(s): 1 - 4
  06/01/2014 Authors: Muftuoglu Y; Sohl CD; Mislak AC; Mitsuya H; Sarafianos SG; Anderson KS
• Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse transcriptase inhibitor.
  Int J Pharm Volume: 461 Page(s): 203 - 213
  01/30/2014 Authors: Zhang W; Parniak MA; Sarafianos SG; Cost MR; Rohan LC
• Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
  Antimicrob Agents Chemother Volume: 57 Page(s): 6254 - 6264
  12/01/2013 Authors: Kirby KA; Michailidis E; Fetterly TL; Steinbach MA; Singh K; Marchand B; Leslie MD; Hagedorn AN; Kodama EN; Marquez VE
• Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection.
  Future Med Chem Volume: 5 Page(s): 2119 - 2122
  12/01/2013 Authors: Adedeji AO; Sarafianos SG
• Structural requirements for RNA degradation by HIV-1 reverse transcriptase.
  Nat Struct Mol Biol Volume: 20 Page(s): 1341 - 1342
  12/01/2013 Authors: Das K; Sarafianos SG; Arnold E
• Evaluation of Combinations of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Clinically Used Antiretroviral Drugs.
  Antimicrob Agents Chemother Volume: 57 Page(s): 4554 - 4558
  09/01/2013 Authors: Hachiya A; Reeve AB; Marchand B; Michailidis E; Ong YT; Kirby KA; Leslie MD; Oka S; Kodama EN; Rohan LC
• HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains.
  Antimicrob Agents Chemother Volume: 57 Page(s): 4035 - 4038
  08/01/2013 Authors: Shimane K; Kawaji K; Miyamoto F; Oishi S; Watanabe K; Sakagami Y; Fujii N; Shimura K; Matsuoka M; Kaku M
• Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine.
  Antimicrob Agents Chemother Volume: 57 Page(s): 3100 - 3109
  07/01/2013 Authors: Xu H-T; Colby-Germinario SP; Asahchop EL; Oliveira M; McCallum M; Schader SM; Han Y; Quan Y; Sarafianos SG; Wainberg MA
• Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms.
  J Virol Volume: 87 Page(s): 8017 - 8028
  07/01/2013 Authors: Adedeji AO; Severson W; Jonsson C; Singh K; Weiss SR; Sarafianos SG
• Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.
  Retrovirology Volume: 10 Page(s): 65
  06/24/2013 Authors: Michailidis E; Ryan EM; Hachiya A; Kirby KA; Marchand B; Leslie MD; Huber AD; Ong YT; Jackson JC; Singh K
• Restriction fragment mass polymorphism (RFMP) analysis based on MALDI-TOF mass spectrometry for detecting antiretroviral resistance in HIV-1 infected patients.
  Clin Microbiol Infect Volume: 19 Page(s): E263 - E270
  06/01/2013 Authors: Lee J-H; Hachiya A; Shin S-K; Lee J; Gatanaga H; Oka S; Kirby KA; Ong YT; Sarafianos SG; Folk WR
• Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.
  Antiviral Res Volume: 98 Page(s): 380 - 385
  06/01/2013 Authors: Rai DK; Schafer EA; Singh K; McIntosh MA; Sarafianos SG; Rieder E
• Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design.
  Int J Biochem Cell Biol Volume: 45 Page(s): 908 - 915
  04/01/2013 Authors: Izumi K; Kawaji K; Miyamoto F; Shimane K; Shimura K; Sakagami Y; Hattori T; Watanabe K; Oishi S; Fujii N
• The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.
  PLoS Pathog Volume: 9 Page(s): e1003125
  01/01/2013 Authors: Tavis JE; Cheng X; Hu Y; Totten M; Cao F; Michailidis E; Aurora R; Meyers MJ; Jacobsen EJ; Parniak MA
• Preparation of biologically active single-chain variable antibody fragments that target the HIV-1 gp120 V3 loop.
  Cell Mol Biol (Noisy-le-grand) Volume: 58 Page(s): 71 - 79
  12/22/2012 Authors: Ong YT; Kirby KA; Hachiya A; Chiang LA; Marchand B; Yoshimura K; Murakami T; Singh K; Matsushita S; Sarafianos SG
• Structural and biochemical basis for the difference in the helicase activity of two different constructs of SARS-CoV helicase.
  Cell Mol Biol (Noisy-le-grand) Volume: 58 Page(s): 114 - 121
  12/22/2012 Authors: Adedeji AO; Singh K; Sarafianos SG
• Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant.
  Cell Mol Biol (Noisy-le-grand) Volume: 58 Page(s): 187 - 195
  12/22/2012 Authors: Michailidis E; Singh K; Ryan EM; Hachiya A; Ong YT; Kirby KA; Marchand B; Kodama EN; Mitsuya H; Parniak MA
• Biochemical mechanism of HIV-1 resistance to rilpivirine.
  J Biol Chem Volume: 287 Page(s): 38110 - 38123
  11/02/2012 Authors: Singh K; Marchand B; Rai DK; Sharma B; Michailidis E; Ryan EM; Matzek KB; Leslie MD; Hagedorn AN; Li Z
• Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.
  Biology (Basel) Volume: 1 Page(s): 521 - 541
  10/19/2012 Authors: Ilina T; Labarge K; Sarafianos SG; Ishima R; Parniak MA
• Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase.
  Antimicrob Agents Chemother Volume: 56 Page(s): 4718 - 4728
  09/01/2012 Authors: Adedeji AO; Singh K; Calcaterra NE; DeDiego ML; Enjuanes L; Weiss S; Sarafianos SG
• Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo.
  Antimicrob Agents Chemother Volume: 56 Page(s): 4707 - 4712
  09/01/2012 Authors: Murphey-Corb M; Rajakumar P; Michael H; Nyaundi J; Didier PJ; Reeve AB; Mitsuya H; Sarafianos SG; Parniak MA
• HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors.
  J Biol Chem Volume: 287 Page(s): 29988 - 29999
  08/24/2012 Authors: Hachiya A; Marchand B; Kirby KA; Michailidis E; Tu X; Palczewski K; Ong YT; Li Z; Griffin DT; Schuckmann MM
• Antiviral therapies: focus on hepatitis B reverse transcriptase.
  Int J Biochem Cell Biol Volume: 44 Page(s): 1060 - 1071
  07/01/2012 Authors: Michailidis E; Kirby KA; Hachiya A; Yoo W; Hong SP; Kim S-O; Folk WR; Sarafianos SG
• Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.
  Antimicrob Agents Chemother Volume: 56 Page(s): 2048 - 2061
  04/01/2012 Authors: Kirby KA; Marchand B; Ong YT; Ndongwe TP; Hachiya A; Michailidis E; Leslie MD; Sietsema DV; Fetterly TL; Dorst CA
• Mechanism of interaction of human mitochondrial DNA polymerase with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.
  Antimicrob Agents Chemother Volume: 56 Page(s): 1630 - 1634
  03/01/2012 Authors: Sohl CD; Singh K; Kasiviswanathan R; Copeland WC; Mitsuya H; Sarafianos SG; Anderson KS
• Mechanism of nucleic acid unwinding by SARS-CoV helicase.
  PLoS One Volume: 7 Page(s): e36521
  01/01/2012 Authors: Adedeji AO; Marchand B; Te Velthuis AJW; Snijder EJ; Weiss S; Eoff RL; Singh K; Sarafianos SG
• Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
  Nucleic Acids Res Volume: 40 Page(s): 345 - 359
  01/01/2012 Authors: Ndongwe TP; Adedeji AO; Michailidis E; Ong YT; Hachiya A; Marchand B; Ryan EM; Rai DK; Kirby KA; Whatley AS
• Hepatitis B Virus genotypic differences map structurally close to NRTI resistance hot spots.
  Int J Curr Chem Volume: 2 Page(s): 253 - 260
  10/01/2011 Authors: Michailidis E; Singh K; Kirby KA; Hachiya A; Yoo W; Hong SP; Kim S-O; Folk WR; Sarafianos SG
• Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates.
  Nucleic Acids Res Volume: 39 Page(s): 8237 - 8247
  10/01/2011 Authors: Ditzler MA; Bose D; Shkriabai N; Marchand B; Sarafianos SG; Kvaratskhelia M; Burke DH
• Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effects on T-20.
  Antivir Chem Chemother Volume: 22 Page(s): 51 - 55
  08/23/2011 Authors: Izumi K; Watanabe K; Oishi S; Fujii N; Matsuoka M; Sarafianos SG; Kodama EN
• The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase.
  Cell Mol Biol (Noisy-le-grand) Volume: 57 Page(s): 40 - 46
  02/12/2011 Authors: Kirby KA; Singh K; Michailidis E; Marchand B; Kodama EN; Ashida N; Mitsuya H; Parniak MA; Sarafianos SG
• K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism.
  PLoS One Volume: 6 Page(s): e16242
  01/13/2011 Authors: Hachiya A; Kodama EN; Schuckmann MM; Kirby KA; Michailidis E; Sakagami Y; Oka S; Singh K; Sarafianos SG
• Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.
  PLoS One Volume: 5 Page(s): e15049
  12/21/2010 Authors: Durk RC; Singh K; Cornelison CA; Rai DK; Matzek KB; Leslie MD; Schafer E; Marchand B; Adedeji A; Michailidis E
• Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors.
  J Biol Chem Volume: 285 Page(s): 39471 - 39480
  12/10/2010 Authors: Shimura K; Nameki D; Kajiwara K; Watanabe K; Sakagami Y; Oishi S; Fujii N; Matsuoka M; Sarafianos SG; Kodama EN
• The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.
  J Biol Chem Volume: 285 Page(s): 38700 - 38709
  12/03/2010 Authors: Schuckmann MM; Marchand B; Hachiya A; Kodama EN; Kirby KA; Singh K; Sarafianos SG
• Structural basis of HIV-1 resistance to AZT by excision.
  Nat Struct Mol Biol Volume: 17 Page(s): 1202 - 1209
  10/01/2010 Authors: Tu X; Das K; Han Q; Bauman JD; Clark AD; Hou X; Frenkel YV; Gaffney BL; Jones RA; Boyer PL
• Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors.
  J Virol Volume: 84 Page(s): 9817 - 9830
  10/01/2010 Authors: Tebit DM; Lobritz M; Lalonde M; Immonen T; Singh K; Sarafianos S; Herchenrder O; Krusslich H-G; Arts EJ
• Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.
  Int J Biochem Cell Biol Volume: 42 Page(s): 1482 - 1488
  09/01/2010 Authors: Shimane K; Kodama EN; Nakase I; Futaki S; Sakurai Y; Sakagami Y; Li X; Hattori T; Sarafianos SG; Matsuoka M
• Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.
  Biochim Biophys Acta Volume: 1804 Page(s): 1202 - 1212
  05/01/2010 Authors: Gtte M; Rausch JW; Marchand B; Sarafianos S; Le Grice SFJ
• Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.
  Viruses Volume: 2 Page(s): 606 - 638
  02/11/2010 Authors: Singh K; Marchand B; Kirby KA; Michailidis E; Sarafianos SG
• The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site.
  Retrovirology Volume: 7 Page(s): 6
  02/01/2010 Authors: Abram ME; Sarafianos SG; Parniak MA
• The crystal structure of EFdA-resistant HIV-1 reverse transcriptase reveals structural changes in the polymerase active site
  Volume: 15 Page(s): A10 - A10
  01/01/2010 Authors: Marchand B; Kirby KA; Sietsema D; Kodama EN; Mitsuya H; Parniak MA; Sarafianos SG
• The crystal structure of EFdA-resistant HIV-1 reverse transcriptase reveals structural changes in the polymerase active site
  Volume: 15 Page(s): A10 - A10
  01/01/2010 Authors: Marchand B; Kirby KA; Sietsema D; Kodama EN; Mitsuya H; Parmak MA; Sarafianos SG
• Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.
  J Biol Chem Volume: 284 Page(s): 35681 - 35691
  12/18/2009 Authors: Michailidis E; Marchand B; Kodama EN; Singh K; Matsuoka M; Kirby KA; Ryan EM; Sawani AM; Nagy E; Ashida N
• Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
  J Biol Chem Volume: 284 Page(s): 35092 - 35100
  12/11/2009 Authors: Das K; Bandwar RP; White KL; Feng JY; Sarafianos SG; Tuske S; Tu X; Clark AD; Boyer PL; Hou X
• Synthesis of Boranoate, Selenoate, and Thioate Analogs of AZTp(4)A and Ap(4)A.
  Tetrahedron Volume: 65 Page(s): 7915 - 7920
  09/19/2009 Authors: Han Q; Sarafianos SG; Arnold E; Parniak MA; Gaffney BL; Jones RA
• Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-nave patients.
  Antiviral Res Volume: 82 Page(s): 115 - 121
  06/01/2009 Authors: Hachiya A; Shimane K; Sarafianos SG; Kodama EN; Sakagami Y; Negishi F; Koizumi H; Gatanaga H; Matsuoka M; Takiguchi M
• SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide.
  Antimicrob Agents Chemother Volume: 53 Page(s): 1013 - 1018
  03/01/2009 Authors: Naito T; Izumi K; Kodama E; Sakagami Y; Kajiwara K; Nishikawa H; Watanabe K; Sarafianos SG; Oishi S; Fujii N
• Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20.
  J Biol Chem Volume: 284 Page(s): 4914 - 4920
  02/20/2009 Authors: Izumi K; Kodama E; Shimura K; Sakagami Y; Watanabe K; Ito S; Watabe T; Terakawa Y; Nishikawa H; Sarafianos SG
• Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.
  J Mol Biol Volume: 385 Page(s): 693 - 713
  01/23/2009 Authors: Sarafianos SG; Marchand B; Das K; Himmel DM; Parniak MA; Hughes SH; Arnold E
• Mechanisms of inhibition and resistance to translocation deficient reverse transcriptase inhibitors
  Volume: 14 Page(s): A22 - A22
  01/01/2009 Authors: Marchand B; Michailidis L; Kodama EI; Ryan E; Do R; Matsuoka M; Ashida N; Nagy E; Mirsuya H; Parniak MA
• Biochemistry. RT slides home..
  Science Volume: 322 Page(s): 1059 - 1060
  11/14/2008 Authors: Sarafianos SG; Arnold E
• The RNA polymerase "switch region" is a target for inhibitors.
  Cell Volume: 135 Page(s): 295 - 307
  10/17/2008 Authors: Mukhopadhyay J; Das K; Ismail S; Koppstein D; Jang M; Hudson B; Sarafianos S; Tuske S; Patel J; Jansen R
• MEDI 332-Probing the interaction of HIV reverse transcriptase with conformationally locked threosyl nucleoside phosphonates: A stereochemical approach
  Volume: 236
  08/17/2008 Authors: Saneyoshi H; Vu BC; Hughes SH; Boyer PL; Sarafianos SG; Marquez VE
• Novel inhibition mechanism and potent activity of trans location-deficient reverse transcriptase inhibitors
  Volume: 12 Page(s): S24 - S25
  06/01/2008 Authors: Michailidis L; Marchand B; Kodama E-I; Fopoussi AOM; Sawani A; Ryan E; Eisele N; Matsuoka M; Ashida N; Nagy E
• Molecular biology: an HIV secret uncovered.
  Nature Volume: 453 Page(s): 169 - 170
  05/08/2008 Authors: Arnold E; Sarafianos SG
• Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.
  J Virol Volume: 82 Page(s): 3261 - 3270
  04/01/2008 Authors: Hachiya A; Kodama EN; Sarafianos SG; Schuckmann MM; Sakagami Y; Matsuoka M; Takiguchi M; Gatanaga H; Oka S
• Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.
  Nucleic Acids Res Volume: 36 Page(s): 1482 - 1496
  03/01/2008 Authors: Kaushik-Basu N; Bopda-Waffo A; Talele TT; Basu A; Costa PRR; da Silva AJM; Sarafianos SG; Nol F
• Structural basis for K65R function: tenofovir resistance, reduced nucleotide incorporation and excision antagonism
  Volume: 13 Page(s): A44 - A44
  01/01/2008 Authors: Das K; Bandwar R; White KL; Feng JY; Sarafianos SG; Tuske S; Tu X; Clark AD; Boyer PL; Gaffney BL
• 2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants.
  Int J Biochem Cell Biol Volume: 40 Page(s): 2410 - 2420
  01/01/2008 Authors: Kawamoto A; Kodama E; Sarafianos SG; Sakagami Y; Kohgo S; Kitano K; Ashida N; Iwai Y; Hayakawa H; Nakata H
• Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.
  Nucleic Acids Symp Ser (Oxf) Page(s): 623 - 624
  01/01/2008 Authors: Saneyoshi H; Vu BC; Hughes SH; Boyer PL; Sarafianos SG; Marquez VE
• Synthesis of AZTpSpCX2ppSA and AZTpSpCX2ppSAZT: hydrolysis-resistant potential inhibitors of the AZT excision reaction of HIV-1 RT.
  Org Lett Volume: 9 Page(s): 5243 - 5246
  12/06/2007 Authors: Han Q; Sarafianos SG; Arnold E; Parniak MA; Gaffney BL; Jones RA
• Structures of wild-type and AZT-Resistant HIV-1 reverse transcriptase complexed with AZTppppA yield insights into the nucleotide excision mechanism
  Volume: 21 Page(s): A640 - A640
  04/01/2007 Authors: Tu X; Sarafianos SG; Han Q; Das K; Hou X; Bauman J; Clark AD; Gaffney BL; Jones RA; Boyer PL
• 3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase.
  Biochemistry Volume: 46 Page(s): 828 - 836
  01/23/2007 Authors: Dharmasena S; Pongracz Z; Arnold E; Sarafianos SG; Parniak MA
• Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.
  J Mol Biol Volume: 365 Page(s): 77 - 89
  01/05/2007 Authors: Das K; Sarafianos SG; Clark AD; Boyer PL; Hughes SH; Arnold E
• HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
  ACS Chem Biol Volume: 1 Page(s): 702 - 712
  12/20/2006 Authors: Himmel DM; Sarafianos SG; Dharmasena S; Hossain MM; McCoy-Simandle K; Ilina T; Clark AD; Knight JL; Julias JG; Clark PK
• Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization.
  Virology Volume: 348 Page(s): 378 - 388
  05/10/2006 Authors: McWilliams MJ; Julias JG; Sarafianos SG; Alvord WG; Arnold E; Hughes SH
• Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase.
  J Biol Chem Volume: 281 Page(s): 7421 - 7428
  03/17/2006 Authors: Hamburgh ME; Curr KA; Monaghan M; Rao VR; Tripathi S; Preston BD; Sarafianos S; Arnold E; Darden T; Prasad VR
• Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?
  PLoS Pathog Volume: 2 Page(s): e10
  02/01/2006 Authors: Boyer PL; Sarafianos SG; Clark PK; Arnold E; Hughes SH
• Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
  Cell Volume: 122 Page(s): 541 - 552
  08/26/2005 Authors: Tuske S; Sarafianos SG; Wang X; Hudson B; Sineva E; Mukhopadhyay J; Birktoft JJ; Leroy O; Ismail S; Clark AD
• Expression and purification of SARS coronavirus proteins using SUMO-fusions.
  Protein Expr Purif Volume: 42 Page(s): 100 - 110
  07/01/2005 Authors: Zuo X; Mattern MR; Tan R; Li S; Hall J; Sterner DE; Shoo J; Tran H; Lim P; Sarafianos SG
• Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions.
  J Mol Biol Volume: 349 Page(s): 673 - 684
  06/17/2005 Authors: Mulky A; Sarafianos SG; Jia Y; Arnold E; Kappes JC
• Expression, purification, and characterization of SARS coronavirus RNA polymerase.
  Virology Volume: 335 Page(s): 165 - 176
  05/10/2005 Authors: Cheng A; Zhang W; Xie Y; Jiang W; Arnold E; Sarafianos SG; Ding J
• AZT resistance: why do HIV-1 and HIV-2 choose different pathways?
  Volume: 10 Page(s): S92 - S92
  01/01/2005 Authors: Boyer PL; Sarafianos SG; Arnold E; Hughes SH
• X-ray Structure for an RNase H Inhibitor Bound to HIV-1 Reverse Transcriptase
  Volume: 61 Page(s): C249 - C249
  01/01/2005 Authors: Himmel DM; Sarafianos SG; Dharmasena S; Hossain M; McCoy-Simandle K; Clark PK; Clark AD; Knight JL; Levy RM; Hughes SH
• Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage.
  J Virol Volume: 78 Page(s): 13315 - 13324
  12/01/2004 Authors: Julias JG; McWilliams MJ; Sarafianos SG; Alvord WG; Arnold E; Hughes SH
• Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases.
  Curr Opin Struct Biol Volume: 14 Page(s): 716 - 730
  12/01/2004 Authors: Sarafianos SG; Das K; Hughes SH; Arnold E
• Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.
  J Virol Volume: 78 Page(s): 9987 - 9997
  09/01/2004 Authors: Boyer PL; Imamichi T; Sarafianos SG; Arnold E; Hughes SH
• Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs.
  Int J Biochem Cell Biol Volume: 36 Page(s): 1706 - 1715
  09/01/2004 Authors: Sarafianos SG; Hughes SH; Arnold E
• Subunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo.
  J Virol Volume: 78 Page(s): 7089 - 7096
  07/01/2004 Authors: Mulky A; Sarafianos SG; Arnold E; Wu X; Kappes JC
• Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.
  Nat Struct Mol Biol Volume: 11 Page(s): 469 - 474
  05/01/2004 Authors: Tuske S; Sarafianos SG; Clark AD; Ding J; Naeger LK; White KL; Miller MD; Gibbs CS; Boyer PL; Clark P
• Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design.
  Nucleic Acids Res Volume: 31 Page(s): 7117 - 7130
  12/15/2003 Authors: Xu X; Liu Y; Weiss S; Arnold E; Sarafianos SG; Ding J
• Mutations in the 5' end of the human immunodeficiency virus type 1 polypurine tract affect RNase H cleavage specificity and virus titer.
  J Virol Volume: 77 Page(s): 11150 - 11157
  10/01/2003 Authors: McWilliams MJ; Julias JG; Sarafianos SG; Alvord WG; Arnold E; Hughes SH
• Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity.
  J Virol Volume: 77 Page(s): 8548 - 8554
  08/01/2003 Authors: Julias JG; McWilliams MJ; Sarafianos SG; Alvord WG; Arnold E; Hughes SH
• The Delta 67 complex of mutations enhances the ability of HIV-1 reverse transcriptase to excise zidovudine, stavudine and PMPA from blocked primers
  Volume: 8 Page(s): U42 - U42
  06/01/2003 Authors: Boyer PL; Imamichi T; Sarafianos SG; Arnold E; Hughes SH
• Trapping HIV-1 reverse transcriptase before and after translocation on DNA.
  J Biol Chem Volume: 278 Page(s): 16280 - 16288
  05/02/2003 Authors: Sarafianos SG; Clark AD; Tuske S; Squire CJ; Das K; Sheng D; Ilankumaran P; Ramesha AR; Kroth H; Sayer JM
• Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.
  EMBO J Volume: 21 Page(s): 6614 - 6624
  12/02/2002 Authors: Sarafianos SG; Clark AD; Das K; Tuske S; Birktoft JJ; Ilankumaran P; Ramesha AR; Sayer JM; Jerina DM; Boyer PL
• Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.
  J Virol Volume: 76 Page(s): 9143 - 9151
  09/01/2002 Authors: Boyer PL; Sarafianos SG; Arnold E; Hughes SH
• Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.
  Proc Natl Acad Sci U S A Volume: 99 Page(s): 9515 - 9520
  07/09/2002 Authors: Julias JG; McWilliams MJ; Sarafianos SG; Arnold E; Hughes SH
• The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1.
  J Virol Volume: 76 Page(s): 3248 - 3256
  04/01/2002 Authors: Boyer PL; Sarafianos SG; Arnold E; Hughes SH
• Biochemical and structural rationalization of the favorable cross-resistance profile and lack of resistance emergence observed in clinical studies of adefovir dipivoxil for HBV infection.
  Volume: 53 Page(s): A72 - A72
  03/01/2002 Authors: Gibbs C; Delaney W; Westland C; Yang H; Xiong S; Naeger L; Miller M; Brosgart C; Das K; Tuske S
• Mechanisms of nucleoside analogue resistance
  Volume: 7 Page(s): S32 - S32
  01/01/2002 Authors: Boyer PL; Sarafianos SG; Arnold E; Hughes SH
• RNase H cleavage of the 5' end of the human immunodeficiency virus type 1 genome.
  J Virol Volume: 75 Page(s): 11874 - 11880
  12/01/2001 Authors: Gao HQ; Sarafianos SG; Arnold E; Hughes SH
• YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.
  J Virol Volume: 75 Page(s): 6321 - 6328
  07/01/2001 Authors: Boyer PL; Gao HQ; Clark PK; Sarafianos SG; Arnold E; Hughes SH
• Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase.
  Proc Natl Acad Sci U S A Volume: 98 Page(s): 7188 - 7193
  06/19/2001 Authors: Tachedjian G; Orlova M; Sarafianos SG; Arnold E; Goff SP
• Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase.
  J Virol Volume: 75 Page(s): 4832 - 4842
  05/01/2001 Authors: Boyer PL; Sarafianos SG; Arnold E; Hughes SH
• Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC).
  J Virol Volume: 75 Page(s): 4771 - 4779
  05/01/2001 Authors: Das K; Xiong X; Yang H; Westland CE; Gibbs CS; Sarafianos SG; Arnold E
• Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.
  EMBO J Volume: 20 Page(s): 1449 - 1461
  03/15/2001 Authors: Sarafianos SG; Das K; Tantillo C; Clark AD; Ding J; Whitcomb JM; Boyer PL; Hughes SH; Arnold E
• Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.
  Biochemistry Volume: 39 Page(s): 11205 - 11215
  09/19/2000 Authors: Mu L; Sarafianos SG; Nicklaus MC; Russ P; Siddiqui MA; Ford H; Mitsuya H; Le R; Kodama E; Meier C
• The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.
  J Mol Biol Volume: 300 Page(s): 403 - 418
  07/07/2000 Authors: Gao HQ; Boyer PL; Sarafianos SG; Arnold E; Hughes SH
• Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.
  Proc Natl Acad Sci U S A Volume: 97 Page(s): 3056 - 3061
  03/28/2000 Authors: Boyer PL; Sarafianos SG; Arnold E; Hughes SH
• Dynamic conformation changes of furanose ring: A major influence of nucleoside structure on enzyme catalytic activity and inhibition.
  Volume: 219 Page(s): U602 - U602
  03/26/2000 Authors: Mu L; Nicklaus M; Sarafianos S; Ford H; Mitsuya H; Marquez V
• Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and Moloney murine leukemia virus reverse transcriptase.
  J Mol Biol Volume: 294 Page(s): 1097 - 1113
  12/17/1999 Authors: Gao HQ; Sarafianos SG; Arnold E; Hughes SH
• Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
  Proc Natl Acad Sci U S A Volume: 96 Page(s): 10027 - 10032
  08/31/1999 Authors: Sarafianos SG; Das K; Clark AD; Ding J; Boyer PL; Hughes SH; Arnold E
• Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site.
  Chem Biol Volume: 6 Page(s): R137 - R146
  05/01/1999 Authors: Sarafianos SG; Das K; Ding J; Boyer PL; Hughes SH; Arnold E
• Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution.
  J Mol Biol Volume: 284 Page(s): 1095 - 1111
  12/11/1998 Authors: Ding J; Das K; Hsiou Y; Sarafianos SG; Clark AD; Jacobo-Molina A; Tantillo C; Hughes SH; Arnold E
• Mechanism of polyoxometalate-mediated inactivation of DNA polymerases: an analysis with HIV-1 reverse transcriptase indicates specificity for the DNA-binding cleft.
  Biochem J Volume: 319 ( Pt 2) Page(s): 619 - 626
  10/15/1996 Authors: Sarafianos SG; Kortz U; Pope MT; Modak MJ
• Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase.
  Biochemistry Volume: 35 Page(s): 11536 - 11546
  09/10/1996 Authors: Kaushik N; Rege N; Yadav PN; Sarafianos SG; Modak MJ; Pandey VN
• Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis.
  Biochemistry Volume: 35 Page(s): 2168 - 2179
  02/20/1996 Authors: Pandey VN; Kaushik N; Rege N; Sarafianos SG; Yadav PN; Modak MJ
• Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity.
  J Biol Chem Volume: 270 Page(s): 19729 - 19735
  08/25/1995 Authors: Sarafianos SG; Pandey VN; Kaushik N; Modak MJ
• Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase.
  Biochemistry Volume: 34 Page(s): 7207 - 7216
  05/30/1995 Authors: Sarafianos SG; Pandey VN; Kaushik N; Modak MJ
• ARG78 PARTICIPATES IN THE DNA-BINDING FUNCTION OF HIV-1 REVERSE-TRANSCRIPTASE
  Volume: 8 Page(s): 64 - 64
  01/01/1995 Authors: SARAFIANOS SG; PANDEY VN; KAUSHIK N; MODAK MJ
• AT32P-dependent estimation of nanomoles of fatty acids: its use in the assay of phospholipase A2 activity.
  Anal Biochem Volume: 186 Page(s): 374 - 379
  05/01/1990 Authors: Sarafianos SG; Nair PP; Kumar S