Leda Bassit

Department of Pediatrics
Assistant Professor

lbassit@emory.edu

Academic Appointment

Assistant Professor, Laboratory of Biochemical Pharmacology, Emory University, SOM: Pediatrics

Education

Degrees

Doctor of Philosophy from University of Sao Paulo (USP)
BS from Santo Amaro University
Master Science from University of Sao Paulo (USP)

Research

Focus

Design de novo projects, experiments, and work flow directly streamlined to facilitate the foundation for various K01, R21, and R01 applications Development of high throughput systems for screening novel antiviral targets against HBV, HCV, HIV and Dengue virus.

Publications

The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
J Med Chem Volume: 67 Page(s): 21126 - 21142
12/12/2024 Authors: Vendeville S; Amblard F; Bassit L; Beigelman LN; Blatt LM; Chen X; Chou L; Kum DB; Chanda S; Deval J
Protocol for the creation and characterization of SARS-CoV-2 variant testing panels using remnant clinical samples for diagnostic assay testing.
STAR Protoc Volume: 5 Page(s): 103146
09/20/2024 Authors: Bassit L; Bowers HB; Greenleaf M; Sabino C; Lai E; Yu G; Piantadosi A; Wang E; O'Sick W; McLendon K
Biophysics-Guided Lead Discovery of HBV Capsid Assembly Modifiers.
ACS Infect Dis Volume: 10 Page(s): 1162 - 1173
04/12/2024 Authors: Fan Z; Pavlova A; Jenkins MC; Bassit L; Salman M; Lynch DL; Patel D; Korablyov M; Finn MG; Schinazi RF
Performance of the Xpert Mpox PCR assay with oropharyngeal, anorectal, and cutaneous lesion swab specimens.
J Clin Virol Volume: 171 Page(s): 105659
04/01/2024 Authors: Damhorst GL; McLendon K; Morales E; Solis ZM; Fitts E; Bowers HB; Sabino C; Sullivan J; Greenleaf M; Roback JD
Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant.
Heliyon Volume: 10 Page(s): e27188
03/30/2024 Authors: Damhorst GL; Lin J; Frediani JK; Sullivan JA; Westbrook A; McLendon K; Baugh TJ; O'Sick WH; Roback JD; Piantadosi AL
Multisite Mpox Infection and Viral Dynamics Among Persons With HIV in Metro Atlanta.
J Infect Dis Volume: 229 Page(s): S213 - S218
03/26/2024 Authors: Damhorst GL; Fujita AW; Fitts E; Szabo B; Bowers HB; Sabino C; Ahmed A; Wang E; Piantadosi A; McLendon K
Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs).
Bioorg Chem Volume: 141 Page(s): 106923
12/01/2023 Authors: Amblard F; Chen Z; Wiseman J; Zhou S; Liu P; Salman M; Verma K; Azadi N; Downs-Bowen J; Tao S
Standardization and Comparison of Emergency Use Authorized COVID-19 Assays and Testing Laboratories.
medRxiv
11/08/2023 Authors: Rao A; Lin J; Parsons R; Greenleaf M; Westbrook A; Lai E; Bowers HB; McClendon K; O'Sick W; Baugh T
Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants.
J Clin Microbiol Volume: 61 Page(s): e0013823
10/24/2023 Authors: Rao A; Westbrook A; Bassit L; Parsons R; Fitts E; Greenleaf M; McLendon K; Sullivan JA; O'Sick W; Baugh T
SARS-CoV-2 molecular testing and whole genome sequencing following RNA recovery from used BinaxNOW COVID-19 antigen self tests.
J Clin Virol Volume: 162 Page(s): 105426
05/01/2023 Authors: Nguyen P-V; Carmola LR; Wang E; Bassit L; Rao A; Greenleaf M; Sullivan JA; Martin GS; Lam WA; Waggoner JJ
Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants.
medRxiv
02/10/2023 Authors: Rao A; Westbrook A; Bassit L; Parsons R; Fitts E; Greenleaf M; McLendon K; Sullivan JA; O'Sick W; Baugh T
SARS-CoV-2 molecular testing and whole genome sequencing following RNA recovery from used BinaxNOW COVID-19 Antigen Self Tests.
medRxiv
01/09/2023 Authors: Nguyen P-V; Carmola LR; Wang E; Bassit L; Rao A; Greenleaf M; Sullivan JA; Martin GS; Lam WA; Waggoner JJ
Effect of swab pooling on the Accula point-of-care RT-PCR for SARS-CoV-2 detection.
Front Microbiol Volume: 14 Page(s): 1219214
01/01/2023 Authors: Lancelot M; Fibben K; Sullivan J; O'Sick W; McLendon K; Wu H; Rao A; Bassit LC; Greenleaf M; Miller P
The premise of capsid assembly modulators towards eliminating HBV persistence.
Expert Opin Drug Discov Volume: 18 Page(s): 1031 - 1041
01/01/2023 Authors: Bassit L; Amblard F; Patel D; Biteau N; Chen Z; Kasthuri M; Zhou S; Schinazi RF
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.
Cell Volume: 185 Page(s): 3603 - 3616.e13
09/15/2022 Authors: Frank F; Keen MM; Rao A; Bassit L; Liu X; Bowers HB; Patel AB; Cato ML; Sullivan JA; Greenleaf M
Assessment of a Computational Approach to Predict Drug Resistance Mutations for HIV, HBV and SARS-CoV-2.
Molecules Volume: 27
08/24/2022 Authors: Patel D; Ono SK; Bassit L; Verma K; Amblard F; Schinazi RF
In silico design of a novel nucleotide antiviral agent by free energy perturbation.
Chem Biol Drug Des Volume: 99 Page(s): 801 - 815
06/01/2022 Authors: Patel D; Cox BD; Kasthuri M; Mengshetti S; Bassit L; Verma K; Ollinger-Russell O; Amblard F; Schinazi RF
The Mechanism of Action of Hepatitis B Virus Capsid Assembly Modulators Can Be Predicted from Binding to Early Assembly Intermediates.
J Med Chem Volume: 65 Page(s): 4854 - 4864
03/24/2022 Authors: Pavlova A; Bassit L; Cox BD; Korablyov M; Chipot C; Patel D; Lynch DL; Amblard F; Schinazi RF; Gumbart JC
Assessment of the Abbott BinaxNOW SARS-CoV-2 rapid antigen test against viral variants of concern.
iScience Volume: 25 Page(s): 103968
03/18/2022 Authors: Rao A; Bassit L; Lin J; Verma K; Bowers HB; Pachura K; Greenleaf M; Sullivan J; Lai E; Creager RS
Elimination of Aicardi-Goutires syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication.
J Biol Chem Volume: 298 Page(s): 101635
03/01/2022 Authors: Oo A; Zandi K; Shepard C; Bassit LC; Musall K; Goh SL; Cho Y-J; Kim D-H; Schinazi RF; Kim B
Inactivation of SARS-CoV-2 and COVID-19 Patient Samples for Contemporary Immunology and Metabolomics Studies.
Immunohorizons Volume: 6 Page(s): 144 - 155
02/16/2022 Authors: Eddins DJ; Bassit LC; Chandler JD; Haddad NS; Musall KL; Yang J; Kosters A; Dobosh BS; Hernndez MR; Ramonell RP
Where is Omicron? Comparison of SARS-CoV-2 RT-PCR and Antigen Test Sensitivity at Commonly Sampled Anatomic Sites Over the Course of Disease.
medRxiv
02/09/2022 Authors: Lin J; Frediani JK; Damhorst GL; Sullivan JA; Westbrook A; McLendon K; Baugh TJ; O'Sick WH; Roback JD; Piantadosi AL
An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza.
Pathog Immun Volume: 7 Page(s): 104 - 121
01/01/2022 Authors: Merigeon EY; Yang D; Ihms EA; Bassit LC; Fitzpatrick EA; Jonsson CB; Schinazi RF; Block DS; Olsen HS
Single-Amplicon Multiplex Real-Time Reverse Transcription-PCR with Tiled Probes To Detect SARS-CoV-2 spike Mutations Associated with Variants of Concern.
J Clin Microbiol Volume: 59 Page(s): e0144621
11/18/2021 Authors: Babiker A; Immergluck K; Stampfer SD; Rao A; Bassit L; Su M; Nguyen V; Stittleburg V; Ingersoll JM; Bradley HL
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration.
Sci Rep Volume: 11 Page(s): 14604
07/16/2021 Authors: Frediani JK; Levy JM; Rao A; Bassit L; Figueroa J; Vos MB; Wood A; Jerris R; Van Leung-Pineda; Gonzalez MD
Occult and active hepatitis B virus detection in donated blood in So Paulo, Brazil.
Transfusion Volume: 61 Page(s): 1495 - 1504
05/01/2021 Authors: Nishiya AS; Levi JE; de Almeida-Neto C; Witkin SS; Ferreira SC; Bassit L; Sabino EC; Di-Lorenzo-Oliveira C; Salles NA; Coutinho AS
The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change.
IEEE Open J Eng Med Biol Volume: 2 Page(s): 142 - 151
04/28/2021 Authors: Nehl E; Heilman S; Ku D; Gottfried D; Farmer S; Mannino R; Tyburski E; Sullivan J; Suessmith A; Bassit L
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase.
Microorganisms Volume: 9
04/22/2021 Authors: Zandi K; Musall K; Oo A; Cao D; Liang B; Hassandarvish P; Lan S; Slack RL; Kirby KA; Bassit L
Discovery and structure activity relationship of glyoxamide derivatives as anti-hepatitis B virus agents.
Bioorg Med Chem Volume: 31 Page(s): 115952
02/01/2021 Authors: Amblard F; Boucle S; Bassit L; Chen Z; Sari O; Cox B; Verma K; Ozturk T; Ollinger-Russell O; Schinazi RF
Covid-19 will not "magically disappear": Why access to widespread testing is paramount.
Am J Hematol Volume: 96 Page(s): 174 - 178
02/01/2021 Authors: George PE; Stokes CL; Bassit LC; Chahroudi A; Figueroa J; Griffiths MA; Heilman S; Ku DN; Nehl EJ; Leong T
Studies on the Efficacy, Potential Cardiotoxicity and Monkey Pharmacokinetics of GLP-26 as a Potent Hepatitis B Virus Capsid Assembly Modulator.
Viruses Volume: 13
01/15/2021 Authors: Hurwitz SJ; McBrearty N; Arzumanyan A; Bichenkov E; Tao S; Bassit L; Chen Z; Kohler JJ; Amblard F; Feitelson MA
RADx Variant Task Force Program for Assessing the Impact of Variants on SARS-CoV-2 Molecular and Antigen Tests.
IEEE Open J Eng Med Biol Volume: 2 Page(s): 286 - 290
01/01/2021 Authors: Creager R; Blackwood J; Pribyl T; Bassit L; Rao A; Greenleaf M; Frank F; Lam W; Ortlund E; Schinazi R
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ
Moving Fast Toward Hepatitis B Virus Elimination.
Adv Exp Med Biol Volume: 1322 Page(s): 115 - 138
01/01/2021 Authors: Bassit L; Ono SK; Schinazi RF
Repurposing Nucleoside Analogs for Human Coronaviruses.
Antimicrob Agents Chemother Volume: 65
12/16/2020 Authors: Zandi K; Amblard F; Musall K; Downs-Bowen J; Kleinbard R; Oo A; Cao D; Liang B; Russell OO; McBrayer T
Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020.
Emerg Infect Dis Volume: 26 Page(s): 2974 - 2978
12/01/2020 Authors: Hu WT; Howell JC; Ozturk T; Benameur K; Bassit LC; Ramonell R; Cashman KS; Pirmohammed S; Roback JD; Marconi VC
Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020.
Emerg Infect Dis Volume: 26 Page(s): 2016 - 2021
09/01/2020 Authors: Benameur K; Agarwal A; Auld SC; Butters MP; Webster AS; Ozturk T; Howell JC; Bassit LC; Velasquez A; Schinazi RF
Erratum for Amblard et al., "Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice".
Antimicrob Agents Chemother Volume: 64
08/20/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O
Novel cell culture 3D model for HBV/HIV co-infection and antiviral evaluation
Volume: 73 Page(s): S871 - S872
08/01/2020 Authors: Bassit L; Gavegnano C; Verma K; Kleinbard R; Kohler J; Mead J; Schinazi RF
Multivariant surface quasispecies in a hepatitis B virus chronically infected individual with concomitant and continually positive surface antigen and anti-HBS biomarkers
Volume: 73 Page(s): S847 - S848
08/01/2020 Authors: Ono SK; Craig J; Bassit L; Abreu R; Gonzalez D; Carrilho FJ; Schinazi RF
7-Deaza-7-fluoro-2'-C-methyladenosine inhibits Zika virus infection and viral-induced neuroinflammation.
Antiviral Res Volume: 180 Page(s): 104855
08/01/2020 Authors: Del Sarto JL; Rocha RDPF; Bassit L; Olmo IG; Valiate B; Queiroz-Junior CM; Pedrosa CDSG; Ribeiro FM; Guimares MZ; Rehen S
Cross-sectional IgM and IgG profiles in SARS-CoV-2 infection.
medRxiv
05/14/2020 Authors: Ozturk T; Howell JC; Benameur K; Ramonell R; Cashman KS; Pirmohammed S; Bassit LC; Roback JD; Marconi VC; Schinazi RF
Synthesis of 4'-Substituted-2'-Deoxy-2'--Fluoro Nucleoside Analogs as Potential Antiviral Agents.
Molecules Volume: 25
03/11/2020 Authors: Kasthuri M; Li C; Verma K; Russell OO; Dickson L; McCormick L; Bassit L; Amblard F; Schinazi RF
Potent in vitro activity of -D-4'-chloromethyl-2'-deoxy-2'-fluorocytidine against Nipah virus.
Antiviral Res Volume: 175 Page(s): 104712
03/01/2020 Authors: Lo MK; Amblard F; Flint M; Chatterjee P; Kasthuri M; Li C; Russell O; Verma K; Bassit L; Schinazi RF
Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.
Antimicrob Agents Chemother Volume: 64
01/27/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O
Novel 1'-homo-N-2'-deoxy--nucleosides: synthesis, characterization and biological activity.
RSC Adv Volume: 10 Page(s): 15815 - 15824
01/01/2020 Authors: Carnero A; Martn-Nieves V; Sanghvi YS; Russel OO; Bassit L; Schinazi RF; Fernndez S; Ferrero M
Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.
Nucleosides Nucleotides Nucleic Acids Volume: 39 Page(s): 671 - 687
01/01/2020 Authors: Cho JH; Bassit LC; Amblard F; Schinazi RF
Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus.
Viruses Volume: 11
11/08/2019 Authors: Liu D; Tedbury PR; Lan S; Huber AD; Puray-Chavez MN; Ji J; Michailidis E; Saeed M; Ndongwe TP; Bassit LC
Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
Antimicrob Agents Chemother Volume: 63
09/01/2019 Authors: Zandi K; Amblard F; Amichai S; Bassit L; Tao S; Jiang Y; Zhou L; Ollinger Russell O; Mengshetti S; Schinazi RF
Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses.
Antimicrob Agents Chemother Volume: 63
07/01/2019 Authors: Zandi K; Bassit L; Amblard F; Cox BD; Hassandarvish P; Moghaddam E; Yueh A; Libanio Rodrigues GO; Passos I; Costa VV
Novel HBV capsid assembly modulator inhibits pregenomic RNA encapsidation by accelerating capsid assembly kinetics and disrupting core protein dephosphorylation
Volume: 70 Page(s): E457 - E457
04/01/2019 Authors: Bassit L; Verma K; Ono SK; Cox B; Amblard F; Schinazi RF
Efficient synthetic methods of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their phosphoramidate prodrugs
Volume: 257
03/31/2019 Authors: Cho JH; Choi SM; Kim JS; Amblard F; Bassit LC; Schinazi RF
Discovery of a Series of 2'--Fluoro,2'--bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
J Med Chem Volume: 62 Page(s): 1859 - 1874
02/28/2019 Authors: Mengshetti S; Zhou L; Sari O; De Schutter C; Zhang H; Cho JH; Tao S; Bassit LC; Verma K; Domaoal RA
Synthesis and anti-HCV activity of -d-2'-deoxy-2'--chloro-2'--fluoro and -d-2'-deoxy-2'--bromo-2'--fluoro nucleosides and their phosphoramidate prodrugs.
Bioorg Med Chem Volume: 27 Page(s): 664 - 676
02/15/2019 Authors: Ovadia R; Khalil A; Li H; De Schutter C; Mengshetti S; Zhou S; Bassit L; Coats SJ; Amblard F; Schinazi RF
Long-term virological and adherence outcomes to antiviral treatment in a 4-year cohort chronic HBV study.
Antivir Ther Volume: 24 Page(s): 567 - 579
01/01/2019 Authors: Abreu RM; Bassit LC; Tao S; Jiang Y; Ferreira AS; Hori PC; Ganova-Raeva LM; Khudyakov Y; Schinazi RF; Carrilho FJ
Rational development of HBV capsid assembly modifiers aided by molecular dynamics
Volume: 256
08/19/2018 Authors: Pavlova A; Bassit L; Cox B; Korablyov M; Chipot C; Schinazi R; Gumbart J
Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient.
Hepatology Volume: 67 Page(s): 2051 - 2054
05/01/2018 Authors: Ono SK; Bassit L; Van Vaisberg V; Avancini Ferreira Alves V; Caldini EG; Herman BD; Shabman R; Fedorova NB; Paranagu-Vezozzo D; Sampaio CT
Towards HBV curative therapies.
Liver Int Volume: 38 Suppl 1 Page(s): 102 - 114
02/01/2018 Authors: Schinazi RF; Ehteshami M; Bassit L; Asselah T
Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector.
Eur J Med Chem Volume: 138 Page(s): 407 - 421
09/29/2017 Authors: Sari O; Boucle S; Cox BD; Ozturk T; Russell OO; Bassit L; Amblard F; Schinazi RF
Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network.
Antiviral Res Volume: 144 Page(s): 223 - 246
08/01/2017 Authors: Aliota MT; Bassit L; Bradrick SS; Cox B; Garcia-Blanco MA; Gavegnano C; Friedrich TC; Golos TG; Griffin DE; Haddow AD
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
J Med Chem Volume: 60 Page(s): 5424 - 5437
07/13/2017 Authors: Zhou S; Mahmoud S; Liu P; Zhou L; Ehteshami M; Bassit L; Tao S; Domaoal RA; Sari O; Schutter CD
Synthesis and antiviral evaluation of 2',2',3',3'-tetrafluoro nucleoside analogs.
Tetrahedron Lett Volume: 58 Page(s): 642 - 644
02/15/2017 Authors: Sari O; Bassit L; Gavegnano C; McBrayer TR; McCormick L; Cox B; Coats SJ; Amblard F; Schinazi RF
Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.
Bioorg Med Chem Lett Volume: 27 Page(s): 904 - 910
02/15/2017 Authors: Boucle S; Lu X; Bassit L; Ozturk T; Russell OO; Amblard F; Coats SJ; Schinazi RF
Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates.
Nucleosides Nucleotides Nucleic Acids Volume: 36 Page(s): 66 - 82
01/02/2017 Authors: Mahmoud S; Li H; McBrayer TR; Bassit L; Hammad SF; Coats SJ; Amblard F; Schinazi RF
Jak Inhibitors Modulate Production of Replication-Competent Zika Virus in Human Hofbauer, Trophoblasts, and Neuroblastoma cells.
Pathog Immun Volume: 2 Page(s): 199 - 218
01/01/2017 Authors: Gavegnano C; Bassit LC; Cox BD; Hsiao H-M; Johnson EL; Suthar M; Chakraborty R; Schinazi RF
Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities.
Clin Liver Dis Volume: 20 Page(s): 737 - 749
11/01/2016 Authors: Boucle S; Bassit L; Ehteshami M; Schinazi RF
Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study.
Lancet Gastroenterol Hepatol Volume: 1 Page(s): 97 - 104
10/01/2016 Authors: Lau G; Benhamou Y; Chen G; Li J; Shao Q; Ji D; Li F; Li B; Liu J; Hou J
Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells.
Virology Volume: 493 Page(s): 162 - 172
06/01/2016 Authors: Clark KB; Hsiao H-M; Bassit L; Crowe JE; Schinazi RF; Perng GC; Villinger F
NOVEL CAPSID ASSEMBLY EFFECTORS INHIBIT HBV CCCDNA FORMATION IN AN HBEAG REPORTER CELL-BASED ASSAY
Volume: 64 Page(s): S162 - S162
01/01/2016 Authors: Bassit L; Boucle S; Amblard F; Zhou L; Zhang HW; Hsiao H-M; Ozturk T; Russell O; Schinazi RF
Four years real-life experience with antiviral adherence in chronic hepatitis B infection in a tertiary university hospital
Volume: 62 Page(s): 963A - 963A
10/01/2015 Authors: Abreu RM; Bassit LC; Tao S; Jiang Y; Paranagua-Vezozzo D; Schinazi RF; Carrilho FJ; Ono SK
Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial.
Clin Infect Dis Volume: 60 Page(s): 1708 - 1714
06/01/2015 Authors: Vanpouille C; Lisco A; Grivel J-C; Bassit LC; Kauffman RC; Sanchez J; Schinazi RF; Lederman MM; Rodriguez B; Margolis L
-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
J Med Chem Volume: 58 Page(s): 3445 - 3458
04/23/2015 Authors: Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Pradere U; Cho JH
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease.
Virology Volume: 476 Page(s): 196 - 205
02/01/2015 Authors: Kennedy EM; Bassit LC; Mueller H; Kornepati AVR; Bogerd HP; Nie T; Chatterjee P; Javanbakht H; Schinazi RF; Cullen BR
Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.
Bioorg Med Chem Volume: 22 Page(s): 6665 - 6671
12/01/2014 Authors: Cho JH; Bondana L; Detorio MA; Montero C; Bassit LC; Amblard F; Coats SJ; Schinazi RF
Approaches to hepatitis C treatment and cure using NS5A inhibitors.
Infect Drug Resist Volume: 7 Page(s): 41 - 56
01/01/2014 Authors: Kohler JJ; Nettles JH; Amblard F; Hurwitz SJ; Bassit L; Stanton RA; Ehteshami M; Schinazi RF
Phosphoramidate Prodrugs of beta-D-2 '-C-Me-2,6-diaminopurine Ribonucleoside are Potent Inhibitors of Hepatitis C Virus (HCV) Replication Delivering Two Active Nucleoside Triphosphates
Volume: 58 Page(s): 437A - 437A
10/01/2013 Authors: Schinazi RF; Zhou L; Zhang H; Ehteshami M; Tao S; Bassit LC; Suesserman J; Whitaker T; McBrayer TR; Cho J-H
Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses.
ACS Med Chem Lett Volume: 4 Page(s): 747 - 751
08/08/2013 Authors: Bondada L; Detorio M; Bassit L; Tao S; Montero CM; Singletary TM; Zhang H; Zhou L; Cho J-H; Coats SJ
Epigenetic effects of viral proteins on global levels of 5-hydroxymethylcytosine in HBV- and HCV-associated hepatocellular carcinoma in mice
CANCER RESEARCH Volume: 73
07/01/2013 Authors: Jiang Y; Nie T; Kohler J; Bassit L; Goldenberg D; Feitelson M; Schinazi RF
NOVEL EFFECTOR OF HBV CAPSID ASSEMBLY REDUCES THE ACTIVITY OF cccDNA AND INTERACTS SYNERGISTICALLY WITH NUCLEOSIDE ANALOGS IN THE HUMAN HEPATOCYTES
Volume: 58 Page(s): S298 - S299
04/01/2013 Authors: Bassit L; Ozturk T; Tao S; Boucle SR; Ehteshami M; Zlotnick A; Feitelson MA; Schinazi RF
Cellular pharmacology and potency of HIV-1 nucleoside analogs in primary human macrophages.
Antimicrob Agents Chemother Volume: 57 Page(s): 1262 - 1269
03/01/2013 Authors: Gavegnano C; Detorio MA; Bassit L; Hurwitz SJ; North TW; Schinazi RF
Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication.
Antimicrob Agents Chemother Volume: 56 Page(s): 6186 - 6191
12/01/2012 Authors: Schinazi RF; Bassit L; Clayton MM; Sun B; Kohler JJ; Obikhod A; Arzumanyan A; Feitelson MA
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.
Bioorg Med Chem Lett Volume: 21 Page(s): 7094 - 7098
12/01/2011 Authors: Shi J; Zhou L; Zhang H; McBrayer TR; Detorio MA; Johns M; Bassit L; Powdrill MH; Whitaker T; Coats SJ
Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
Eur J Med Chem Volume: 46 Page(s): 3832 - 3844
09/01/2011 Authors: Zhang H-W; Detorio M; Herman BD; Solomon S; Bassit L; Nettles JH; Obikhod A; Tao S-J; Mellors JW; Sluis-Cremer N
Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome.
PLoS One Volume: 5 Page(s): e9948
04/01/2010 Authors: Singh IR; Gorzynski JE; Drobysheva D; Bassit L; Schinazi RF
HCV drug discovery aimed at viral eradication.
J Viral Hepat Volume: 17 Page(s): 77 - 90
02/01/2010 Authors: Schinazi RF; Bassit L; Gavegnano C
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Antimicrob Agents Chemother Volume: 53 Page(s): 3715 - 3719
09/01/2009 Authors: Sluis-Cremer N; Koontz D; Bassit L; Hernandez-Santiago BI; Detorio M; Rapp KL; Amblard F; Bondada L; Grier J; Coats SJ
Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.
Cardiovasc Toxicol Volume: 9 Page(s): 1 - 12
03/01/2009 Authors: Kline ER; Bassit L; Hernandez-Santiago BI; Detorio MA; Liang B; Kleinhenz DJ; Walp ER; Dikalov S; Jones DP; Schinazi RF
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.
J Med Chem Volume: 52 Page(s): 206 - 213
01/08/2009 Authors: Kim H-J; Sharon A; Bal C; Wang J; Allu M; Huang Z; Murray MG; Bassit L; Schinazi RF; Korba B
Approaches for the development of antiviral compounds: the case of hepatitis C virus.
Handb Exp Pharmacol Page(s): 25 - 51
01/01/2009 Authors: Schinazi RF; Coats SJ; Bassit LC; Lennerstrand J; Nettles JH; Hurwitz SJ
Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system.
Antivir Chem Chemother Volume: 19 Page(s): 25 - 31
01/01/2008 Authors: Bassit L; Grier J; Bennett M; Schinazi RF
Anti-HCV activity and cellular pharmacology of 2 '-methyleytidine alone and in combination with non-toxic concentrations of ribavirin in the HCV replicon system
Volume: 12 Page(s): S28 - S28
01/01/2007 Authors: Hernandez-Santiago BI; Bassit L; Grier J; Schinazi RF
Combinations of 2'-methylcytidine analogs with interferon alpha-2b lead to synergistic inhibition of hepatitis C virus replication in a replicon system
Volume: 46 Page(s): S217 - S217
01/01/2007 Authors: Bassit L; Grier J; Bennett M; Schinazi RF
Quantifying mixed populations of drug-resistant human immunodeficiency virus type 1.
Antimicrob Agents Chemother Volume: 49 Page(s): 3334 - 3340
08/01/2005 Authors: Moser MJ; Ruckstuhl M; Larsen CA; Swearingen AJ; Kozlowski M; Bassit L; Sharma PL; Schinazi RF; Prudent JR
Hepatitis B virus infection in Haemodialysis Centres from Santa Catarina State, Southern Brazil. Predictive risk factors for infection and molecular epidemiology.
BMC Public Health Volume: 4 Page(s): 13
04/27/2004 Authors: Carrilho FJ; Moraes CR; Pinho JRR; Mello IMVGC; Bertolini DA; Lemos MF; Moreira RC; Bassit LC; Cardoso RA; Ribeiro-dos-Santos G
A prospective study of the prevalence of hepatitis B and C virus co-infection among patients with chronic renal disease under hemodialysis.
J Hepatol Volume: 40 Page(s): 715 - 716
04/01/2004 Authors: Ono-Nita SK; de Moraes CR; Carrilho FJ; Pinho JRR; Bassit L; da Silva LC
Genotype distribution of the GB virus C in citizens of So Paulo City, Brazil.
Rev Inst Med Trop Sao Paulo Volume: 45 Page(s): 213 - 216
01/01/2003 Authors: Nishiya AS; Ribeiro-dos-Santos G; Bassit L; Focaccia R; Chamone DF; Sabino EC
High resistance to therapy in cirrhotic patients carrying HCV RNA genotype 3
Volume: 7 Page(s): L128 - L129
12/01/2002 Authors: Da Silva LC; Ono-Nita SK; Madruga CL; Bassit L; Pinho JRR; Mello IMVGC; Malta FM; Yamaguchi M; Carrilho FJ
HCV RNA genotype 3 is frequently found among Brazilian patients with liver cirrhosis (LC) unresponsive to combined therapy with interferon and ribavirin (IFN plus RB).
Volume: 36 Page(s): 598A - 598A
10/01/2002 Authors: Da Silva LC; Ono-Nita SK; Madruga CL; Bassit L; Pinho JRR; Carrilho FJ
Prevalence of GB virus C (hepatitis G virus) and risk factors for infection in So Paulo, Brazil.
Eur J Clin Microbiol Infect Dis Volume: 21 Page(s): 438 - 443
06/01/2002 Authors: Ribeiro-dos-Santos G; Nishiya AS; Nascimento CMR; Bassit L; Chamone DF; Focaccia R; Eluf-Neto J; Sabino EC
Comparative study of two anti-HCV screening tests in a large genotyped population of Brazilian dialysis patients.
Eur J Clin Microbiol Infect Dis Volume: 21 Page(s): 404 - 406
05/01/2002 Authors: Bassit L; Van Heuverswyn H; De Bosschere K; Nishiya AS; Carrilho F-J; Moraes CR; Sablon E
Phylogenetic classification of TT virus groups based on the N22 region is unreliable.
Virus Res Volume: 85 Page(s): 47 - 59
04/23/2002 Authors: Lemey P; Salemi M; Bassit L; Vandamme A-M
High rate of sustained response to consensus interferon plus ribavirin in chronic hepatitis C patients resistant to alpha-interferon and ribavirin: a pilot study.
J Gastroenterol Volume: 37 Page(s): 732 - 736
01/01/2002 Authors: da Silva LC; Bassit L; Ono-Nita SK; Pinho JRR; Nishiya A; Madruga CL; Carrilho FJ
New prevalence estimate of TT virus (TTV) infection in low- and high-risk population from So Paulo, Brazil.
Rev Inst Med Trop Sao Paulo Volume: 44 Page(s): 233 - 234
01/01/2002 Authors: Bassit L; Takei K; Hoshino-Shimizu S; Nishiya AS; Sabino EC; Bassitt RP; Focaccia R; D'Amico E; Chamone DF; Ribeiro-Dos-Santos G
Hepatitis B virus infection in hemodialysis centers from Santa Catarina State, southern Brazil. Predictive risk factors for infection and molecular epidemiology.
HEPATOLOGY Volume: 34 Page(s): 612A - 612A
10/01/2001 Authors: Carrilho FJ; De Moraes CR; Pinho JRR; Moreira R; Bertolini D; Mello IM; Gatura S; Bassit L; Cardoso RA; Da Silva LC
HCV genotype 3a: High degree of resistance to antiviral therapy in chronic hepatitis C patients non responding to previous combined therapy with interferon (IFN) plus ribavirin (RB).
HEPATOLOGY Volume: 34 Page(s): 605A - 605A
10/01/2001 Authors: Da Silva LC; Bassit LC; Ono-Nita SK; Pinho JR; Carrilho FJ
High rate of sustained response after consensus interferon (CIFN) plus ribavirin (RB) in chronic hepatitis C patients previously resistant to combined therapy (IFN plus RB).
HEPATOLOGY Volume: 34 Page(s): 586A - 586A
10/01/2001 Authors: Da Silva LC; Bassit LC; Ono-Nita SK; Nishiya A; Madruga CL; Carrilho FJ
Early hepatitis C virus (HCV) kinetics during daily therapy with consensus interferon (CIFN) and ribavirin (RB) in patients infected with genotype 3 or 1 previously resistant to IFN and RB.
HEPATOLOGY Volume: 32 Page(s): 566A - 566A
10/01/2000 Authors: Da Silva LC; Bassit L; Carrilho FJ; Pinho JRR
Usage of hepatitis C virus (HCV) confirmatory tests (PCR and 3rd generation line immuneassay, LIA-3) for the diagnosis of anti-HCV seroreactive Brazilian blood donors.
TRANSFUSION Volume: 40 Page(s): 91S - 92S
10/01/2000 Authors: Barreto AM; Bassit L; Takei K; Nishiya A; Bellesa MA; Salles NA; Chamone DF; Sabino EC
Hepatitis C virus infection in hemodialysis patients from Southern Brazil. Epidemiological data and genotypes.
HEPATOLOGY Volume: 32 Page(s): 546A - 546A
10/01/2000 Authors: Moraes CR; Carrilho FJ; Bassit L; Renato J; Pinho R; Curi M; Antonelli RC; Da Silva LC; Laudana AA
Additional detection of an unexpectedly high number of HCV positive Brazilian blood donors by the new 4th generation assay INNOTEST HCV Ab IV.
HEPATOLOGY Volume: 30 Page(s): 206A - 206A
10/01/1999 Authors: Bassit L; Saez-Alquezar A; Dekeyser F; Otani M; Sabino E; Chamone DF; Maertens G
Chronic hepatitis C virus infections in brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy.
Rev Inst Med Trop Sao Paulo Volume: 41 Page(s): 183 - 189
05/01/1999 Authors: Bassit L; Da Silva LC; Ribeiro-Dos-Santos G; Maertens G; Carrilho FJ; Fonseca LE; Alves VA; Gayotto LC; Pereira AN; Takei K
Genotype distributions of hepatitis C virus in So Paulo, Brazil: rare subtype found.
Hepatology Volume: 29 Page(s): 994 - 995
03/01/1999 Authors: Bassit L; Ribeiro-Dos-Santos G; Da Silva LC; Takei K; Villaa P; David-Neto E; Chamone D; Sez-Alquzar A
Estimated Prevalence of Viral Hepatitis in the General Population of the Municipality of So Paulo, Measured by a Serologic Survey of a Stratified, Randomized and Residence-Based Population.
Braz J Infect Dis Volume: 2 Page(s): 269 - 284
12/01/1998 Authors: Focaccia R; da Conceio OJ; Sette H; Sabino E; Bassit L; Nitrini DR; Lomar AV; Loreno R; Vieira De Souza F; Kiffer CR
HGV prevalence in the city of Sao Paulo, Brazil, according to age.
TRANSFUSION Volume: 38 Page(s): 57S - 57S
10/01/1998 Authors: Sabino EC; Saez-Alquezar AA; Nishiva AS; dos Santos GR; Bassit L; Chamone DF; Foccacia R; Sette H; Neto JE; Murta C
Hepatitis G virus: prevalence and sequence analysis in blood donors of So Paulo, Brazil.
Vox Sang Volume: 74 Page(s): 83 - 87
01/01/1998 Authors: Bassit L; Kleter B; Ribeiro-dos-Santos G; Maertens G; Sabino E; Chamone D; Quint W; Sez-Alquzar A
Genotypes 1 and 3 as predictors of response to alpha interferon ribavirin combination in Brazilians with chronic hepatitis C.
HEPATOLOGY Volume: 26 Page(s): 353 - 353
10/01/1997 Authors: Bassit L; RibeirodosSantos G; SaezAlquezar A; Chamone DF; Barros MFA; Marujo WC; Curry RA; SetteJunior H
Hepatitis C virus genotypes in renal transplanted patients in Brazil: Rare subtype found.
HEPATOLOGY Volume: 26 Page(s): 1401 - 1401
10/01/1997 Authors: Bassit L; RibeirodosSantos G; SaezAlquezar A; Chamone D; Abdallah KA; DavidNeto E
Anti-HCV antibody is sensitive but not sufficient to detect HCV active infection in renal transplanted patients: the role of PCR for HCV-RNA.
Transplant Proc Volume: 29 Page(s): 781 - 782
01/01/1997 Authors: David-Neto E; Abdallah KA; Bassit L; Pereira AN; Alquezar AS; Fonseca JA; Ianhez LE; Sabbaga E
Spontaneous hepatitis B surface antigen clearance in a long-term follow-up study of patients with chronic type B hepatitis. Lack of correlation with hepatitis C and D virus superinfection.
J Gastroenterol Volume: 31 Page(s): 696 - 701
10/01/1996 Authors: Da Silva LC; Madruga CL; Carrilho FJ; Pinho JR; Saz-Alquezar A; Santos C; Bassit L; Barreto C; Fonseca LE; Alves VA
Genotype 2, rather than 1 and 3a, is predictive responsive factor to therapy in Brazilian patients with chronic hepatitis C infection.
HEPATOLOGY Volume: 24 Page(s): 137 - 137
10/01/1996 Authors: Bassit L; daSilva LC; Carrilho FJ; Mendes LCA; Fonseca LEP; Pereira AL; Alves VAF; Gayotto LCC; SaezAlquezar A
High prevalence of hepatitis G virus among blood donors in Sao Paulo, Brazil.
HEPATOLOGY Volume: 24 Page(s): 1418 - 1418
10/01/1996 Authors: Bassit L; SaezAlquezar A; Stuyer L; Kleter B; vanHoek K; Quint W; RibeirodosSantos G; Sabino E; Chamone DAF
Hepatitis C virus genotyping by means of 5'-UR/core line probe assays and molecular analysis of untypeable samples.
Virus Res Volume: 38 Page(s): 137 - 157
10/01/1995 Authors: Stuyver L; Wyseur A; van Arnhem W; Lunel F; Laurent-Puig P; Pawlotsky JM; Kleter B; Bassit L; Nkengasong J; van Doorn LJ
MOLECULAR ANALYSIS OF THE HCV 5'UR/CORE REGION IN COMBINATION WITH PHYLOGENETIC ANALYSIS OF THE NS5B REGION PROVIDES EVIDENCE FOR 10 TYPES AND AT LEAST 52 SUBTYPES
HEPATOLOGY Volume: 22 Page(s): 1557 - 1557
10/01/1995 Authors: STUYVER L; WYSEUR A; VANARNHEM W; LUNEL F; LAURENTPUIG P; KLETER B; BASSIT L; NKENGASONG J; VANDOORN LJ; MAERTENS G
Human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in So Paulo, Brazil.
Clin Infect Dis Volume: 20 Page(s): 1540 - 1542
06/01/1995 Authors: Domingues RB; Muniz MR; Pinho JR; Bassit L; Jorge ML; Alquezar AS; Marchiori PE; Chamone DF; Scaff M
SUBTYPING OF HEPATITIS-C VIRUS IN PATIENTS WITH CHRONIC HEPATITIS USING A LINE PROBE ASSAY (LIPA)
GASTROENTEROLOGY Volume: 108 Page(s): A1030 - A1030
04/01/1995 Authors: BASSIT L; DASILVA LC; CARRILHO FJ; VANDERBORGHT B; CHAMONE DAF; SAEZALQUEZAR A
ANTIBODIES TO HEPATITIS-C VIRUS AND HEPATITIS-C VIRUS-RNA IN BRAZILIAN BLOOD-DONORS DETERMINED BY ELISA, SYNTHETIC PEPTIDES IMMUNOBLOT ASSAY AND POLYMERASE CHAIN-REACTION
GASTROENTEROLOGY Volume: 108 Page(s): A1160 - A1160
04/01/1995 Authors: SAEZALQUEZAI A; BASSIT L; DORLHIACLLACER PE; CHAMONE DAF
ANTI-HCV CPCR POSITIVITY, AND HCV SUBTYPES AMONG SCREENING POSITIVE BLOOD-DONORS FROM SAO-PAULO, BRAZIL
TRANSFUSION Volume: 34 Page(s): S38 - S38
10/01/1994 Authors: BASSIT L; VANDERBORGHT B; DORLHIACLLACER PE; CHAMONE DAF; SAEZALQUEZAR A
POSTTRANSFUSION HEPATITIS - PRELIMINARY-RESULTS OF A PROSPECTIVE AND CONTROLLED SURVEY
HEPATOLOGY Volume: 20 Page(s): A404 - A404
10/01/1994 Authors: STRAUSS E; MACEDO AC; ARAUJO VLS; CAVALHEIRO C; RACHED RA; BASSIT L; SAEZALQUEZAR A; CHAMONE DAF
Detection of hepatitis B virus DNA by the polymerase chain reaction in anti-HBe positive chronic hepatitis B patients.
Rev Inst Med Trop Sao Paulo Volume: 35 Page(s): 515 - 520
01/01/1993 Authors: Pinho JR; Santos CA; Gonzalez CL; Bassit L; Barreto CC; Saez-Alquezar A; Frana AV; Carrilho FJ; Fonseca LE; Chamone DA