Publications

• The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
  J Med Chem Volume: 67 Page(s): 21126 - 21142
  12/12/2024 Authors: Vendeville S; Amblard F; Bassit L; Beigelman LN; Blatt LM; Chen X; Chou L; Kum DB; Chanda S; Deval J
• The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
  mBio Volume: 15 Page(s): e0046524
  11/13/2024 Authors: Dinh T; Tber Z; Rey JS; Mengshetti S; Annamalai AS; Haney R; Briganti L; Amblard F; Fuchs JR; Cherepanov P
• N4-Hydroxycytidine/molnupiravir inhibits RNA virus-induced encephalitis by producing less fit mutated viruses.
  PLoS Pathog Volume: 20 Page(s): e1012574
  09/01/2024 Authors: Ojha D; Hill CS; Zhou S; Evans A; Leung JM; Schneider CA; Amblard F; Woods TA; Schinazi RF; Baric RS
• Development of robust antiviral assays using relevant apical-out human airway organoids.
  bioRxiv
  07/12/2024 Authors: Lee J-H; LeCher JC; Parigoris E; Shinagawa N; Sentosa J; Manfredi C; Goh SL; De R; Tao S; Zandi K
• Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections.
  Viruses Volume: 16
  04/22/2024 Authors: Hurwitz SJ; De R; LeCher JC; Downs-Bowen JA; Goh SL; Zandi K; McBrayer T; Amblard F; Patel D; Kohler JJ
• Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
  Eur J Med Chem Volume: 268 Page(s): 116263
  03/15/2024 Authors: Amblard F; LeCher JC; De R; Zhou S; Liu P; Goh SL; Tao S; Patel D; Downs-Bowen J; Zandi K
• The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
  bioRxiv
  01/26/2024 Authors: Dinh T; Tber Z; Rey JS; Mengshetti S; Annamalai AS; Haney R; Briganti L; Amblard F; Fuchs JR; Cherepanov P
• Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs).
  Bioorg Chem Volume: 141 Page(s): 106923
  12/01/2023 Authors: Amblard F; Chen Z; Wiseman J; Zhou S; Liu P; Salman M; Verma K; Azadi N; Downs-Bowen J; Tao S
• N4 -Hydroxycytidine/Molnupiravir Inhibits RNA-Virus Induced Encephalitis by Producing Mutated Viruses with Reduced Fitness.
  bioRxiv
  08/23/2023 Authors: Ojha D; Hill CS; Zhou S; Evans AB; Leung JM; Lewis CS; Amblard F; Schinazi RF; Baric RS; Peterson KE
• Synthesis of 4'-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents.
  Viruses Volume: 15
  02/16/2023 Authors: Biteau NG; Amichai SA; Azadi N; De R; Downs-Bowen J; Lecher JC; MacBrayer T; Schinazi RF; Amblard F
• The premise of capsid assembly modulators towards eliminating HBV persistence.
  Expert Opin Drug Discov Volume: 18 Page(s): 1031 - 1041
  01/01/2023 Authors: Bassit L; Amblard F; Patel D; Biteau N; Chen Z; Kasthuri M; Zhou S; Schinazi RF
• Discovery of a 2'-Fluoro,2'-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice.
  Microorganisms Volume: 10
  10/22/2022 Authors: LeCher JC; Zandi K; Costa VV; Amblard F; Tao S; Patel D; Lee S; da Silva Santos FR; Goncalves MR; Queroz-Junior CM
• HIV nucleoside reverse transcriptase inhibitors.
  Eur J Med Chem Volume: 240 Page(s): 114554
  10/05/2022 Authors: Amblard F; Patel D; Michailidis E; Coats SJ; Kasthuri M; Biteau N; Tber Z; Ehteshami M; Schinazi RF
• Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents.
  Pharmaceuticals (Basel) Volume: 15
  09/14/2022 Authors: Amblard F; LeCher JC; De R; Goh SL; Li C; Kasthuri M; Biteau N; Zhou L; Tber Z; Downs-Bowen J
• Assessment of a Computational Approach to Predict Drug Resistance Mutations for HIV, HBV and SARS-CoV-2.
  Molecules Volume: 27
  08/24/2022 Authors: Patel D; Ono SK; Bassit L; Verma K; Amblard F; Schinazi RF
• In silico design of a novel nucleotide antiviral agent by free energy perturbation.
  Chem Biol Drug Des Volume: 99 Page(s): 801 - 815
  06/01/2022 Authors: Patel D; Cox BD; Kasthuri M; Mengshetti S; Bassit L; Verma K; Ollinger-Russell O; Amblard F; Schinazi RF
• The Mechanism of Action of Hepatitis B Virus Capsid Assembly Modulators Can Be Predicted from Binding to Early Assembly Intermediates.
  J Med Chem Volume: 65 Page(s): 4854 - 4864
  03/24/2022 Authors: Pavlova A; Bassit L; Cox BD; Korablyov M; Chipot C; Patel D; Lynch DL; Amblard F; Schinazi RF; Gumbart JC
• Diastereoselective Synthesis of 2'-Dihalopyrimidine Ribonucleoside Inhibitors of Hepatitis C Virus Replication.
  ACS Omega Volume: 7 Page(s): 1452 - 1461
  01/11/2022 Authors: Zhou L; Zhang H; Li C; De Schutter C; Sari O; Mengshetti S; Zhou S; Kasthuri M; Coats SJ; Schinazi RF
• Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase.
  Microorganisms Volume: 9
  04/22/2021 Authors: Zandi K; Musall K; Oo A; Cao D; Liang B; Hassandarvish P; Lan S; Slack RL; Kirby KA; Bassit L
• Discovery and structure activity relationship of glyoxamide derivatives as anti-hepatitis B virus agents.
  Bioorg Med Chem Volume: 31 Page(s): 115952
  02/01/2021 Authors: Amblard F; Boucle S; Bassit L; Chen Z; Sari O; Cox B; Verma K; Ozturk T; Ollinger-Russell O; Schinazi RF
• Studies on the Efficacy, Potential Cardiotoxicity and Monkey Pharmacokinetics of GLP-26 as a Potent Hepatitis B Virus Capsid Assembly Modulator.
  Viruses Volume: 13
  01/15/2021 Authors: Hurwitz SJ; McBrearty N; Arzumanyan A; Bichenkov E; Tao S; Bassit L; Chen Z; Kohler JJ; Amblard F; Feitelson MA
• Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
  Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
  01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ
• Repurposing Nucleoside Analogs for Human Coronaviruses.
  Antimicrob Agents Chemother Volume: 65
  12/16/2020 Authors: Zandi K; Amblard F; Musall K; Downs-Bowen J; Kleinbard R; Oo A; Cao D; Liang B; Russell OO; McBrayer T
• Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122.
  Gastroenterology Volume: 159 Page(s): 999 - 1014.e9
  09/01/2020 Authors: Chai C; Cox B; Yaish D; Gross D; Rosenberg N; Amblard F; Shemuelian Z; Gefen M; Korach A; Tirosh O
• Erratum for Amblard et al., "Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice".
  Antimicrob Agents Chemother Volume: 64
  08/20/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O
• 7-Deaza-7-fluoro-2'-C-methyladenosine inhibits Zika virus infection and viral-induced neuroinflammation.
  Antiviral Res Volume: 180 Page(s): 104855
  08/01/2020 Authors: Del Sarto JL; Rocha RDPF; Bassit L; Olmo IG; Valiate B; Queiroz-Junior CM; Pedrosa CDSG; Ribeiro FM; Guimares MZ; Rehen S
• Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".
  J Virol Volume: 94
  03/31/2020 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B
• Synthesis of 4'-Substituted-2'-Deoxy-2'--Fluoro Nucleoside Analogs as Potential Antiviral Agents.
  Molecules Volume: 25
  03/11/2020 Authors: Kasthuri M; Li C; Verma K; Russell OO; Dickson L; McCormick L; Bassit L; Amblard F; Schinazi RF
• Potent in vitro activity of -D-4'-chloromethyl-2'-deoxy-2'-fluorocytidine against Nipah virus.
  Antiviral Res Volume: 175 Page(s): 104712
  03/01/2020 Authors: Lo MK; Amblard F; Flint M; Chatterjee P; Kasthuri M; Li C; Russell O; Verma K; Bassit L; Schinazi RF
• Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.
  Antimicrob Agents Chemother Volume: 64
  01/27/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O
• Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.
  Nucleosides Nucleotides Nucleic Acids Volume: 39 Page(s): 671 - 687
  01/01/2020 Authors: Cho JH; Bassit LC; Amblard F; Schinazi RF
• Intracellular metabolism and potential cardiotoxicity of a -D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication.
  Nucleosides Nucleotides Nucleic Acids Volume: 39 Page(s): 204 - 224
  01/01/2020 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Ehteshami M; Jiang Y; Amblard F; Coats SJ
• Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection.
  Bioorg Med Chem Lett Volume: 29 Page(s): 126639
  10/15/2019 Authors: Zhang H; Zhou L; Amichai S; Zandi K; Cox B; Schinazi R; Amblard F
• Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
  Antimicrob Agents Chemother Volume: 63
  09/01/2019 Authors: Zandi K; Amblard F; Amichai S; Bassit L; Tao S; Jiang Y; Zhou L; Ollinger Russell O; Mengshetti S; Schinazi RF
• Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses.
  Antimicrob Agents Chemother Volume: 63
  07/01/2019 Authors: Zandi K; Bassit L; Amblard F; Cox BD; Hassandarvish P; Moghaddam E; Yueh A; Libanio Rodrigues GO; Passos I; Costa VV
• Novel HBV capsid assembly modulator inhibits pregenomic RNA encapsidation by accelerating capsid assembly kinetics and disrupting core protein dephosphorylation
  Volume: 70 Page(s): E457 - E457
  04/01/2019 Authors: Bassit L; Verma K; Ono SK; Cox B; Amblard F; Schinazi RF
• Synthetic efforts towards the preparation of 2 '-dihalogenated nucleotide prodrugs
  Volume: 257
  03/31/2019 Authors: Mengshetti S; Zhou L; Sari O; De Shutter C; Zhou S; Chen Z; Zhang H; Khalil A; Li H; Ovadia R
• Efficient synthetic methods of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their phosphoramidate prodrugs
  Volume: 257
  03/31/2019 Authors: Cho JH; Choi SM; Kim JS; Amblard F; Bassit LC; Schinazi RF
• Synthesis of 2-fluoro-substituted and 2,6-modified purine 2',3'-dideoxy-2',3'-difluoro-d-arabinofuranosyl nucleosides from d-xylose.
  Tetrahedron Volume: 75 Page(s): 2037 - 2046
  03/29/2019 Authors: Sivets GG; Amblard F; Schinazi RF
• Discovery of a Series of 2'--Fluoro,2'--bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
  J Med Chem Volume: 62 Page(s): 1859 - 1874
  02/28/2019 Authors: Mengshetti S; Zhou L; Sari O; De Schutter C; Zhang H; Cho JH; Tao S; Bassit LC; Verma K; Domaoal RA
• Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.
  Biochemistry Volume: 58 Page(s): 900 - 907
  02/19/2019 Authors: Muzzarelli KM; Kuiper B; Spellmon N; Brunzelle J; Hackett J; Amblard F; Zhou S; Liu P; Kovari IA; Yang Z
• Synthesis and anti-HCV activity of -d-2'-deoxy-2'--chloro-2'--fluoro and -d-2'-deoxy-2'--bromo-2'--fluoro nucleosides and their phosphoramidate prodrugs.
  Bioorg Med Chem Volume: 27 Page(s): 664 - 676
  02/15/2019 Authors: Ovadia R; Khalil A; Li H; De Schutter C; Mengshetti S; Zhou S; Bassit L; Coats SJ; Amblard F; Schinazi RF
• Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".
  J Virol Volume: 93
  02/01/2019 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B
• Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.
  J Virol Volume: 92
  09/15/2018 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B
• Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.
  Bioorg Med Chem Lett Volume: 28 Page(s): 2165 - 2170
  07/01/2018 Authors: Amblard F; Zhou S; Liu P; Yoon J; Cox B; Muzzarelli K; Kuiper BD; Kovari LC; Schinazi RF
• Expression, Purification and Characterization of a GII.4 Norovirus Protease from Minerva Virus.
  Infect Disord Drug Targets Volume: 18 Page(s): 224 - 232
  01/01/2018 Authors: Kuiper BD; Muzzarelli KM; Keusch BJ; Holcomb J; Amblard F; Liu P; Zhou S; Kovari IA; Yang Z; Schinazi RF
• Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination.
  J Org Chem Volume: 82 Page(s): 13171 - 13178
  12/15/2017 Authors: De Schutter C; Sari O; Coats SJ; Amblard F; Schinazi RF
• Synthesis and anti-HCV activity of a series of -d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.
  Bioorg Med Chem Lett Volume: 27 Page(s): 5296 - 5299
  12/01/2017 Authors: Chen Z; Cox BD; Garnier-Amblard EC; McBrayer TR; Coats SJ; Schinazi RF; Amblard F
• Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease.
  Biochem Biophys Res Commun Volume: 492 Page(s): 668 - 673
  10/28/2017 Authors: Kuiper BD; Slater K; Spellmon N; Holcomb J; Medapureddy P; Muzzarelli KM; Yang Z; Ovadia R; Amblard F; Kovari IA
• Metabolism of Nucleosides and Nucleotides Prodrugs.
  Curr Pharm Des
  10/11/2017 Authors: De Schutter C; Ehteshami M; Hammond ET; Amblard F; Schinazi RF
• Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector.
  Eur J Med Chem Volume: 138 Page(s): 407 - 421
  09/29/2017 Authors: Sari O; Boucle S; Cox BD; Ozturk T; Russell OO; Bassit L; Amblard F; Schinazi RF
• Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.
  Antimicrob Agents Chemother Volume: 61
  08/01/2017 Authors: Ehteshami M; Zhou L; Amiralaei S; Shelton JR; Cho JH; Zhang H; Li H; Lu X; Ozturk T; Stanton R
• 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
  J Med Chem Volume: 60 Page(s): 5424 - 5437
  07/13/2017 Authors: Zhou S; Mahmoud S; Liu P; Zhou L; Ehteshami M; Bassit L; Tao S; Domaoal RA; Sari O; Schutter CD
• Characterization of -d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
  Antimicrob Agents Chemother Volume: 61
  04/01/2017 Authors: Ehteshami M; Tao S; Zandi K; Hsiao H-M; Jiang Y; Hammond E; Amblard F; Russell OO; Merits A; Schinazi RF
• Synthesis and antiviral evaluation of 2',2',3',3'-tetrafluoro nucleoside analogs.
  Tetrahedron Lett Volume: 58 Page(s): 642 - 644
  02/15/2017 Authors: Sari O; Bassit L; Gavegnano C; McBrayer TR; McCormick L; Cox B; Coats SJ; Amblard F; Schinazi RF
• Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.
  Bioorg Med Chem Lett Volume: 27 Page(s): 904 - 910
  02/15/2017 Authors: Boucle S; Lu X; Bassit L; Ozturk T; Russell OO; Amblard F; Coats SJ; Schinazi RF
• Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates.
  Nucleosides Nucleotides Nucleic Acids Volume: 36 Page(s): 66 - 82
  01/02/2017 Authors: Mahmoud S; Li H; McBrayer TR; Bassit L; Hammad SF; Coats SJ; Amblard F; Schinazi RF
• Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs.
  Chem Rev Volume: 116 Page(s): 14379 - 14455
  12/14/2016 Authors: Shelton J; Lu X; Hollenbaugh JA; Cho JH; Amblard F; Schinazi RF
• Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
  Antimicrob Agents Chemother Volume: 60 Page(s): 4659 - 4669
  08/01/2016 Authors: Ehteshami M; Tao S; Ozturk T; Zhou L; Cho JH; Zhang H; Amiralaei S; Shelton JR; Lu X; Khalil A
• Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.
  ACS Med Chem Lett Volume: 7 Page(s): 17 - 22
  01/14/2016 Authors: Zhou L; Zhang H; Tao S; Ehteshami M; Cho JH; McBrayer TR; Tharnish P; Whitaker T; Amblard F; Coats SJ
• NOVEL CAPSID ASSEMBLY EFFECTORS INHIBIT HBV CCCDNA FORMATION IN AN HBEAG REPORTER CELL-BASED ASSAY
  Volume: 64 Page(s): S162 - S162
  01/01/2016 Authors: Bassit L; Boucle S; Amblard F; Zhou L; Zhang HW; Hsiao H-M; Ozturk T; Russell O; Schinazi RF
• Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.
  Bioorg Med Chem Lett Volume: 25 Page(s): 3711 - 3715
  09/01/2015 Authors: Boucle S; Tao S; Amblard F; Stanton RA; Nettles JH; Li C; McBrayer TR; Whitaker T; Coats SJ; Schinazi RF
• -D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
  J Med Chem Volume: 58 Page(s): 3445 - 3458
  04/23/2015 Authors: Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Pradere U; Cho JH
• Structural informatics modeling of Daclatasvir and analogs reveals asymmetric binding to HCV-NS5A: Dual mechanisms responsible for picomolar activity and acquired resistance
  Volume: 249
  03/22/2015 Authors: Nettles J; Stanton R; Broyde J; Amblard F; Zhang H; Zhou L; Shi J; McBrayer T; Whitaker T; Coats S
• Synthesis and antiviral evaluation of 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl 2,6-disubstituted purine nucleosides.
  Heterocycl Comm Volume: 21 Page(s): 315 - 327
  01/01/2015 Authors: Schinazi RF; Sivets GG; Detorio MA; McBrayer TR; Whitaker T; Coats SJ; Amblard F
• Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition.
  J Med Chem Volume: 57 Page(s): 10031 - 10043
  12/11/2014 Authors: Nettles JH; Stanton RA; Broyde J; Amblard F; Zhang H; Zhou L; Shi J; McBrayer TR; Whitaker T; Coats SJ
• Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.
  Bioorg Med Chem Volume: 22 Page(s): 6665 - 6671
  12/01/2014 Authors: Cho JH; Bondana L; Detorio MA; Montero C; Bassit LC; Amblard F; Coats SJ; Schinazi RF
• Synthesis of nucleoside phosphate and phosphonate prodrugs.
  Chem Rev Volume: 114 Page(s): 9154 - 9218
  09/24/2014 Authors: Pradere U; Garnier-Amblard EC; Coats SJ; Amblard F; Schinazi RF
• Chutes and ladders in hepatitis C nucleoside drug development.
  Antiviral Res Volume: 102 Page(s): 119 - 147
  02/01/2014 Authors: Coats SJ; Garnier-Amblard EC; Amblard F; Ehteshami M; Amiralaei S; Zhang H; Zhou L; Boucle SRL; Lu X; Bondada L
• HCV Nucleoside Inhibitors can Exhibit Genotype Specific Differences in Activity
  Volume: 60 Page(s): 1169A - 1170A
  01/01/2014 Authors: Anton ED; Strommen K; Huang W; Rivera AA; Petropoulos CJ; Amblard F; Schinazi RF; Reeves JD
• A 4-N-Hydroxycytidine Ribonucleoside Phosphoramidate Delivers Intracellularly Three Distinct Active 5 '-Triphosphate Nucleosides that are Potent Inhibitors of HCV Polymerase
  Volume: 60 Page(s): 1162A - 1162A
  01/01/2014 Authors: Schinazi RF; Amblard F; Tao S; Ehteshami M; Amiralaei S; Li H; Shelton J; Whitaker T; McBrayer TR; Coats SJ
• Approaches to hepatitis C treatment and cure using NS5A inhibitors.
  Infect Drug Resist Volume: 7 Page(s): 41 - 56
  01/01/2014 Authors: Kohler JJ; Nettles JH; Amblard F; Hurwitz SJ; Bassit L; Stanton RA; Ehteshami M; Schinazi RF
• Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.
  Bioorg Med Chem Lett Volume: 23 Page(s): 6325 - 6330
  12/01/2013 Authors: Bondada L; Rondla R; Pradere U; Liu P; Li C; Bobeck D; McBrayer T; Tharnish P; Courcambeck J; Halfon P
• Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
  Bioorg Med Chem Lett Volume: 23 Page(s): 3385 - 3388
  06/01/2013 Authors: Zhou L; Amblard F; Zhang H; McBrayer TR; Detorio MA; Whitaker T; Coats SJ; Schinazi RF
• Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
  Bioorg Med Chem Lett Volume: 23 Page(s): 2031 - 2034
  04/01/2013 Authors: Amblard F; Zhang H; Zhou L; Shi J; Bobeck DR; Nettles JH; Chavre S; McBrayer TR; Tharnish P; Whitaker T
• Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach.
  J Org Chem Volume: 78 Page(s): 723 - 727
  01/18/2013 Authors: Cho JH; Amblard F; Coats SJ; Schinazi RF
• Synthesis of 5'-methylene-phosphonate furanonucleoside prodrugs: application to D-2'-deoxy-2'--fluoro-2'--C-methyl nucleosides.
  Org Lett Volume: 14 Page(s): 4426 - 4429
  09/07/2012 Authors: Pradere U; Amblard F; Coats SJ; Schinazi RF
• Synthesis and evaluation of novel potent HCV NS5A inhibitors.
  Bioorg Med Chem Lett Volume: 22 Page(s): 4864 - 4868
  07/15/2012 Authors: Zhang H; Zhou L; Amblard F; Shi J; Bobeck DR; Tao S; McBrayer TR; Tharnish PM; Whitaker T; Coats SJ
• Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors.
  Bioorg Med Chem Lett Volume: 22 Page(s): 3488 - 3491
  05/15/2012 Authors: Shi J; Zhou L; Amblard F; Bobeck DR; Zhang H; Liu P; Bondada L; McBrayer TR; Tharnish PM; Whitaker T
• Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection.
  Tetrahedron Volume: 67 Page(s): 5487 - 5493
  07/29/2011 Authors: Cho JH; Amblard F; Coats SJ; Schinazi RF
• Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
  Bioorg Med Chem Lett Volume: 20 Page(s): 60 - 64
  01/01/2010 Authors: Zhang H-W; Coats SJ; Bondada L; Amblard F; Detorio M; Asif G; Fromentin E; Solomon S; Obikhod A; Whitaker T
• Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
  Eur J Med Chem Volume: 44 Page(s): 3845 - 3851
  10/01/2009 Authors: Amblard F; Fromentin E; Detorio M; Obikhod A; Rapp KL; McBrayer TR; Whitaker T; Coats SJ; Schinazi RF
• Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
  Antimicrob Agents Chemother Volume: 53 Page(s): 3715 - 3719
  09/01/2009 Authors: Sluis-Cremer N; Koontz D; Bassit L; Hernandez-Santiago BI; Detorio M; Rapp KL; Amblard F; Bondada L; Grier J; Coats SJ
• Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.
  Chem Rev Volume: 109 Page(s): 4207 - 4220
  09/01/2009 Authors: Amblard F; Cho JH; Schinazi RF
• Synthesis and anti-HIV activity of 5-haloethynyl and 5-(1,2-dihalo)vinyl analogues of AZT and FLT.
  Tetrahedron Volume: 64 Page(s): 4444 - 4452
  05/01/2008 Authors: Joubert N; Amblard F; Rapp KL; Schinazi RF; Agrofoglio LA
• Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
  Bioorg Med Chem Lett Volume: 17 Page(s): 4428 - 4431
  08/15/2007 Authors: Amblard F; Govindarajan B; Lefkove B; Rapp KL; Detorio M; Arbiser JL; Schinazi RF
• Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
  Int J Oncol Volume: 30 Page(s): 1529 - 1537
  06/01/2007 Authors: Wolf I; O'Kelly J; Wakimoto N; Nguyen A; Amblard F; Karlan BY; Arbiser JL; Koeffler HP
• Facile purification of honokiol and its antiviral and cytotoxic properties.
  J Med Chem Volume: 49 Page(s): 3426 - 3427
  06/01/2006 Authors: Amblard F; Delinsky D; Arbiser JL; Schinazi RF
• Honokiol and Magnolol: New potent antitumor compounds
  Volume: 231
  03/26/2006 Authors: Amblard F; Delinsky D; Arbiser JL; Schinazi RF
• Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series.
  Bioorg Med Chem Volume: 13 Page(s): 1239 - 1248
  02/15/2005 Authors: Amblard F; Aucagne V; Guenot P; Schinazi RF; Agrofoglio LA
• Enantioselective syntheses of L-carbanucleosides, using ring-closure metathesis
  ANTIVIRAL RESEARCH Volume: 53 Page(s): A48 - A48
  03/01/2002 Authors: Agrofoglio LA; Amblard F; Charamon S; Gillaizeau I